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Protein

Retinol-binding protein 3

Gene

RBP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina.

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • retinal binding Source: UniProtKB-KW
  • retinoid binding Source: Reactome
  • retinol binding Source: GO_Central
  • serine-type peptidase activity Source: InterPro

GO - Biological processi

  • lipid metabolic process Source: ProtInc
  • retinoid metabolic process Source: Reactome
  • visual perception Source: ProtInc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandVitamin A

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:ENSG00000107618-MONOMER

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-2187335 The retinoid cycle in cones (daylight vision)
R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision)

SIGNOR Signaling Network Open Resource

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SIGNORi
P10745

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S41.950

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Retinol-binding protein 3
Alternative name(s):
Interphotoreceptor retinoid-binding protein
Short name:
IRBP
Interstitial retinol-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RBP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000265203.1

Human Gene Nomenclature Database

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HGNCi
HGNC:9921 RBP3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
180290 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P10745

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Retinitis pigmentosa 66 (RP66)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
See also OMIM:615233
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0697061080D → N in RP66; abolishes secretion; results in mis-folded insoluble complexes degraded via the ER-associated protein catabolic process. 2 PublicationsCorresponds to variant dbSNP:rs146150511EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Retinitis pigmentosa

Organism-specific databases

DisGeNET

More...
DisGeNETi
5949

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
RBP3

MalaCards human disease database

More...
MalaCardsi
RBP3
MIMi615233 phenotype

Open Targets

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OpenTargetsi
ENSG00000265203

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
791 Retinitis pigmentosa

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA34288

Chemistry databases

Drug and drug target database

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DrugBanki
DB00162 Vitamin A

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
RBP3

Domain mapping of disease mutations (DMDM)

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DMDMi
124894

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 171 PublicationAdd BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002152318 – 1247Retinol-binding protein 3Add BLAST1230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi205N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P10745

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P10745

PeptideAtlas

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PeptideAtlasi
P10745

PRoteomics IDEntifications database

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PRIDEi
P10745

ProteomicsDB human proteome resource

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ProteomicsDBi
52643

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P10745

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P10745

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000265203 Expressed in 31 organ(s), highest expression level in retina

CleanEx database of gene expression profiles

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CleanExi
HS_RBP3

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P10745 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA041301
HPA044239

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111883, 2 interactors

Protein interaction database and analysis system

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IntActi
P10745, 13 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000224600

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P10745

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P10745

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati18 – 3201Add BLAST303
Repeati321 – 6302Add BLAST310
Repeati631 – 9313Add BLAST301
Repeati932 – 12304Add BLAST299

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni18 – 12304 X approximate tandem repeatsAdd BLAST1213

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S41A family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IJZP Eukaryota
ENOG4111K6J LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000014726

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000139907

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG006175

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P10745

Identification of Orthologs from Complete Genome Data

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OMAi
CSYFFDE

Database of Orthologous Groups

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OrthoDBi
116338at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P10745

TreeFam database of animal gene trees

More...
TreeFami
TF332253

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029045 ClpP/crotonase-like_dom_sf
IPR032956 RBP3
IPR005151 Tail-specific_protease

The PANTHER Classification System

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PANTHERi
PTHR11261:SF3 PTHR11261:SF3, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF03572 Peptidase_S41, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00245 TSPc, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52096 SSF52096, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P10745-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMREWVLLMS VLLCGLAGPT HLFQPSLVLD MAKVLLDNYC FPENLLGMQE
60 70 80 90 100
AIQQAIKSHE ILSISDPQTL ASVLTAGVQS SLNDPRLVIS YEPSTPEPPP
110 120 130 140 150
QVPALTSLSE EELLAWLQRG LRHEVLEGNV GYLRVDSVPG QEVLSMMGEF
160 170 180 190 200
LVAHVWGNLM GTSALVLDLR HCTGGQVSGI PYIISYLHPG NTILHVDTIY
210 220 230 240 250
NRPSNTTTEI WTLPQVLGER YGADKDVVVL TSSQTRGVAE DIAHILKQMR
260 270 280 290 300
RAIVVGERTG GGALDLRKLR IGESDFFFTV PVSRSLGPLG GGSQTWEGSG
310 320 330 340 350
VLPCVGTPAE QALEKALAIL TLRSALPGVV HCLQEVLKDY YTLVDRVPTL
360 370 380 390 400
LQHLASMDFS TVVSEEDLVT KLNAGLQAAS EDPRLLVRAI GPTETPSWPA
410 420 430 440 450
PDAAAEDSPG VAPELPEDEA IRQALVDSVF QVSVLPGNVG YLRFDSFADA
460 470 480 490 500
SVLGVLAPYV LRQVWEPLQD TEHLIMDLRH NPGGPSSAVP LLLSYFQGPE
510 520 530 540 550
AGPVHLFTTY DRRTNITQEH FSHMELPGPR YSTQRGVYLL TSHRTATAAE
560 570 580 590 600
EFAFLMQSLG WATLVGEITA GNLLHTRTVP LLDTPEGSLA LTVPVLTFID
610 620 630 640 650
NHGEAWLGGG VVPDAIVLAE EALDKAQEVL EFHQSLGALV EGTGHLLEAH
660 670 680 690 700
YARPEVVGQT SALLRAKLAQ GAYRTAVDLE SLASQLTADL QEVSGDHRLL
710 720 730 740 750
VFHSPGELVV EEAPPPPPAV PSPEELTYLI EALFKTEVLP GQLGYLRFDA
760 770 780 790 800
MAELETVKAV GPQLVRLVWQ QLVDTAALVI DLRYNPGSYS TAIPLLCSYF
810 820 830 840 850
FEAEPRQHLY SVFDRATSKV TEVWTLPQVA GQRYGSHKDL YILMSHTSGS
860 870 880 890 900
AAEAFAHTMQ DLQRATVIGE PTAGGALSVG IYQVGSSPLY ASMPTQMAMS
910 920 930 940 950
ATTGKAWDLA GVEPDITVPM SEALSIAQDI VALRAKVPTV LQTAGKLVAD
960 970 980 990 1000
NYASAELGAK MATKLSGLQS RYSRVTSEVA LAEILGADLQ MLSGDPHLKA
1010 1020 1030 1040 1050
AHIPENAKDR IPGIVPMQIP SPEVFEELIK FSFHTNVLED NIGYLRFDMF
1060 1070 1080 1090 1100
GDGELLTQVS RLLVEHIWKK IMHTDAMIID MRFNIGGPTS SIPILCSYFF
1110 1120 1130 1140 1150
DEGPPVLLDK IYSRPDDSVS ELWTHAQVVG ERYGSKKSMV ILTSSVTAGT
1160 1170 1180 1190 1200
AEEFTYIMKR LGRALVIGEV TSGGCQPPQT YHVDDTNLYL TIPTARSVGA
1210 1220 1230 1240
SDGSSWEGVG VTPHVVVPAE EALARAKEML QHNQLRVKRS PGLQDHL
Length:1,247
Mass (Da):135,363
Last modified:November 1, 1991 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6C1841411E012E0F
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC18875 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti757V → G in BAJ84061 (PubMed:21697133).Curated1
Sequence conflicti757V → G in AAH39844 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06966918G → V1 PublicationCorresponds to variant dbSNP:rs864621997EnsemblClinVar.1
Natural variantiVAR_069670122R → H1 PublicationCorresponds to variant dbSNP:rs41302693EnsemblClinVar.1
Natural variantiVAR_069671155V → M1 PublicationCorresponds to variant dbSNP:rs782157576EnsemblClinVar.1
Natural variantiVAR_069672163S → P1 PublicationCorresponds to variant dbSNP:rs35686775EnsemblClinVar.1
Natural variantiVAR_069673196V → M1 PublicationCorresponds to variant dbSNP:rs782398712EnsemblClinVar.1
Natural variantiVAR_069674267R → Q1 PublicationCorresponds to variant dbSNP:rs200239015EnsemblClinVar.1
Natural variantiVAR_069675282V → M1 PublicationCorresponds to variant dbSNP:rs782095820EnsemblClinVar.1
Natural variantiVAR_069676321T → I1 PublicationCorresponds to variant dbSNP:rs376854254EnsemblClinVar.1
Natural variantiVAR_069677325A → T1 PublicationCorresponds to variant dbSNP:rs368898051EnsemblClinVar.1
Natural variantiVAR_069678346R → H1 PublicationCorresponds to variant dbSNP:rs111245635EnsemblClinVar.1
Natural variantiVAR_069679379A → T1 PublicationCorresponds to variant dbSNP:rs781840247EnsemblClinVar.1
Natural variantiVAR_069680433S → L1 PublicationCorresponds to variant dbSNP:rs375761633EnsemblClinVar.1
Natural variantiVAR_069681443R → S1 PublicationCorresponds to variant dbSNP:rs864621999EnsemblClinVar.1
Natural variantiVAR_069682505H → L1 PublicationCorresponds to variant dbSNP:rs201808774EnsemblClinVar.1
Natural variantiVAR_069683518Q → R1 PublicationCorresponds to variant dbSNP:rs563600593EnsemblClinVar.1
Natural variantiVAR_069684523H → Q1 PublicationCorresponds to variant dbSNP:rs148093336EnsemblClinVar.1
Natural variantiVAR_035929530R → H in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_069685535R → C1 PublicationCorresponds to variant dbSNP:rs143632019EnsemblClinVar.1
Natural variantiVAR_069686544R → H1 PublicationCorresponds to variant dbSNP:rs41284962EnsemblClinVar.1
Natural variantiVAR_069687593V → A1 PublicationCorresponds to variant dbSNP:rs782233167EnsemblClinVar.1
Natural variantiVAR_069688599I → V1 PublicationCorresponds to variant dbSNP:rs144289912EnsemblClinVar.1
Natural variantiVAR_069689614D → N1 PublicationCorresponds to variant dbSNP:rs149642039EnsemblClinVar.1
Natural variantiVAR_069690615A → V1 PublicationCorresponds to variant dbSNP:rs368920246EnsemblClinVar.1
Natural variantiVAR_069691675T → I1 PublicationCorresponds to variant dbSNP:rs864622000EnsemblClinVar.1
Natural variantiVAR_069692688A → V1 PublicationCorresponds to variant dbSNP:rs200168559EnsemblClinVar.1
Natural variantiVAR_069693693V → M1 PublicationCorresponds to variant dbSNP:rs112888313EnsemblClinVar.1
Natural variantiVAR_069694723P → L1 PublicationCorresponds to variant dbSNP:rs148247227EnsemblClinVar.1
Natural variantiVAR_069695741G → S1 PublicationCorresponds to variant dbSNP:rs143110000EnsemblClinVar.1
Natural variantiVAR_069696747R → C1 PublicationCorresponds to variant dbSNP:rs782664364EnsemblClinVar.1
Natural variantiVAR_069697785N → K1 PublicationCorresponds to variant dbSNP:rs864622001EnsemblClinVar.1
Natural variantiVAR_069698833R → C1 PublicationCorresponds to variant dbSNP:rs142945423EnsemblClinVar.1
Natural variantiVAR_069699835G → S1 PublicationCorresponds to variant dbSNP:rs782480179EnsemblClinVar.1
Natural variantiVAR_051315884V → M1 PublicationCorresponds to variant dbSNP:rs11204213EnsemblClinVar.1
Natural variantiVAR_069700903T → R1 PublicationCorresponds to variant dbSNP:rs373766942EnsemblClinVar.1
Natural variantiVAR_069701921S → R1 PublicationCorresponds to variant dbSNP:rs548622709EnsemblClinVar.1
Natural variantiVAR_069702956E → K1 PublicationCorresponds to variant dbSNP:rs781847641EnsemblClinVar.1
Natural variantiVAR_069703963T → I1 PublicationCorresponds to variant dbSNP:rs200706310EnsemblClinVar.1
Natural variantiVAR_0697041021S → Y1 PublicationCorresponds to variant dbSNP:rs148591757EnsemblClinVar.1
Natural variantiVAR_0697051059V → I1 PublicationCorresponds to variant dbSNP:rs864622002EnsemblClinVar.1
Natural variantiVAR_0697061080D → N in RP66; abolishes secretion; results in mis-folded insoluble complexes degraded via the ER-associated protein catabolic process. 2 PublicationsCorresponds to variant dbSNP:rs146150511EnsemblClinVar.1
Natural variantiVAR_0697071194T → M1 PublicationCorresponds to variant dbSNP:rs782099994EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M33875
, M33864, M33865, M33866 Genomic DNA Translation: AAA59453.1
M22453 mRNA Translation: AAA36126.1
J05253 Genomic DNA Translation: AAC18875.1 Different initiation.
AB593121 mRNA Translation: BAJ84061.1
AL731561 Genomic DNA No translation available.
CH471251 Genomic DNA Translation: EAW50659.1
BC039844 mRNA Translation: AAH39844.1
J03912 mRNA Translation: AAA59188.1
X53044 Genomic DNA Translation: CAA37213.1
DQ426897 mRNA Translation: ABD90548.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS73119.1

Protein sequence database of the Protein Information Resource

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PIRi
A33812

NCBI Reference Sequences

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RefSeqi
NP_002891.1, NM_002900.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.591928

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000584701; ENSP00000463151; ENSG00000265203

Database of genes from NCBI RefSeq genomes

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GeneIDi
5949

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5949

UCSC genome browser

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UCSCi
uc001jez.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33875
, M33864, M33865, M33866 Genomic DNA Translation: AAA59453.1
M22453 mRNA Translation: AAA36126.1
J05253 Genomic DNA Translation: AAC18875.1 Different initiation.
AB593121 mRNA Translation: BAJ84061.1
AL731561 Genomic DNA No translation available.
CH471251 Genomic DNA Translation: EAW50659.1
BC039844 mRNA Translation: AAH39844.1
J03912 mRNA Translation: AAA59188.1
X53044 Genomic DNA Translation: CAA37213.1
DQ426897 mRNA Translation: ABD90548.1
CCDSiCCDS73119.1
PIRiA33812
RefSeqiNP_002891.1, NM_002900.2
UniGeneiHs.591928

3D structure databases

ProteinModelPortaliP10745
SMRiP10745
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111883, 2 interactors
IntActiP10745, 13 interactors
STRINGi9606.ENSP00000224600

Chemistry databases

DrugBankiDB00162 Vitamin A

Protein family/group databases

MEROPSiS41.950

PTM databases

iPTMnetiP10745
PhosphoSitePlusiP10745

Polymorphism and mutation databases

BioMutaiRBP3
DMDMi124894

Proteomic databases

EPDiP10745
PaxDbiP10745
PeptideAtlasiP10745
PRIDEiP10745
ProteomicsDBi52643

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000584701; ENSP00000463151; ENSG00000265203
GeneIDi5949
KEGGihsa:5949
UCSCiuc001jez.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5949
DisGeNETi5949
EuPathDBiHostDB:ENSG00000265203.1

GeneCards: human genes, protein and diseases

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GeneCardsi
RBP3
GeneReviewsiRBP3
HGNCiHGNC:9921 RBP3
HPAiHPA041301
HPA044239
MalaCardsiRBP3
MIMi180290 gene
615233 phenotype
neXtProtiNX_P10745
OpenTargetsiENSG00000265203
Orphaneti791 Retinitis pigmentosa
PharmGKBiPA34288

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJZP Eukaryota
ENOG4111K6J LUCA
GeneTreeiENSGT00390000014726
HOGENOMiHOG000139907
HOVERGENiHBG006175
InParanoidiP10745
OMAiCSYFFDE
OrthoDBi116338at2759
PhylomeDBiP10745
TreeFamiTF332253

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000107618-MONOMER
ReactomeiR-HSA-2187335 The retinoid cycle in cones (daylight vision)
R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision)
SIGNORiP10745

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RBP3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5949

Protein Ontology

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PROi
PR:P10745

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000265203 Expressed in 31 organ(s), highest expression level in retina
CleanExiHS_RBP3
GenevisibleiP10745 HS

Family and domain databases

InterProiView protein in InterPro
IPR029045 ClpP/crotonase-like_dom_sf
IPR032956 RBP3
IPR005151 Tail-specific_protease
PANTHERiPTHR11261:SF3 PTHR11261:SF3, 1 hit
PfamiView protein in Pfam
PF03572 Peptidase_S41, 4 hits
SMARTiView protein in SMART
SM00245 TSPc, 4 hits
SUPFAMiSSF52096 SSF52096, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRET3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10745
Secondary accession number(s): Q0QD34, Q5VSR0, Q8IXN0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1991
Last modified: January 16, 2019
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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