Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Retinol-binding protein 3

Gene

RBP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina.

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

GO - Molecular functioni

  • retinal binding Source: UniProtKB-KW
  • retinoid binding Source: Reactome
  • retinol binding Source: GO_Central
  • serine-type peptidase activity Source: InterPro

GO - Biological processi

  • lipid metabolic process Source: ProtInc
  • retinoid metabolic process Source: Reactome
  • visual perception Source: ProtInc

Keywordsi

Biological processTransport
LigandVitamin A

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000107618-MONOMER
ReactomeiR-HSA-2187335 The retinoid cycle in cones (daylight vision)
R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision)
SIGNORiP10745

Protein family/group databases

MEROPSiS41.950

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol-binding protein 3
Alternative name(s):
Interphotoreceptor retinoid-binding protein
Short name:
IRBP
Interstitial retinol-binding protein
Gene namesi
Name:RBP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000265203.1
HGNCiHGNC:9921 RBP3
MIMi180290 gene
neXtProtiNX_P10745

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Retinitis pigmentosa 66 (RP66)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
See also OMIM:615233
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0697061080D → N in RP66; abolishes secretion; results in mis-folded insoluble complexes degraded via the ER-associated protein catabolic process. 2 PublicationsCorresponds to variant dbSNP:rs146150511EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Retinitis pigmentosa

Organism-specific databases

DisGeNETi5949
GeneReviewsiRBP3
MalaCardsiRBP3
MIMi615233 phenotype
OpenTargetsiENSG00000265203
Orphaneti791 Retinitis pigmentosa
PharmGKBiPA34288

Chemistry databases

DrugBankiDB00162 Vitamin A

Polymorphism and mutation databases

BioMutaiRBP3
DMDMi124894

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 171 PublicationAdd BLAST17
ChainiPRO_000002152318 – 1247Retinol-binding protein 3Add BLAST1230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi205N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP10745
PaxDbiP10745
PeptideAtlasiP10745
PRIDEiP10745
ProteomicsDBi52643

PTM databases

iPTMnetiP10745
PhosphoSitePlusiP10745

Expressioni

Gene expression databases

BgeeiENSG00000265203 Expressed in 31 organ(s), highest expression level in retina
CleanExiHS_RBP3
GenevisibleiP10745 HS

Organism-specific databases

HPAiHPA041301
HPA044239

Interactioni

Protein-protein interaction databases

BioGridi111883, 2 interactors
IntActiP10745, 13 interactors
STRINGi9606.ENSP00000224600

Structurei

3D structure databases

ProteinModelPortaliP10745
SMRiP10745
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 3201Add BLAST303
Repeati321 – 6302Add BLAST310
Repeati631 – 9313Add BLAST301
Repeati932 – 12304Add BLAST299

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni18 – 12304 X approximate tandem repeatsAdd BLAST1213

Sequence similaritiesi

Belongs to the peptidase S41A family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IJZP Eukaryota
ENOG4111K6J LUCA
GeneTreeiENSGT00390000014726
HOGENOMiHOG000139907
HOVERGENiHBG006175
InParanoidiP10745
OMAiCSYFFDE
OrthoDBiEOG091G01EO
PhylomeDBiP10745
TreeFamiTF332253

Family and domain databases

InterProiView protein in InterPro
IPR029045 ClpP/crotonase-like_dom_sf
IPR032956 RBP3
IPR005151 Tail-specific_protease
PANTHERiPTHR11261:SF3 PTHR11261:SF3, 1 hit
PfamiView protein in Pfam
PF03572 Peptidase_S41, 4 hits
SMARTiView protein in SMART
SM00245 TSPc, 4 hits
SUPFAMiSSF52096 SSF52096, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10745-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMREWVLLMS VLLCGLAGPT HLFQPSLVLD MAKVLLDNYC FPENLLGMQE
60 70 80 90 100
AIQQAIKSHE ILSISDPQTL ASVLTAGVQS SLNDPRLVIS YEPSTPEPPP
110 120 130 140 150
QVPALTSLSE EELLAWLQRG LRHEVLEGNV GYLRVDSVPG QEVLSMMGEF
160 170 180 190 200
LVAHVWGNLM GTSALVLDLR HCTGGQVSGI PYIISYLHPG NTILHVDTIY
210 220 230 240 250
NRPSNTTTEI WTLPQVLGER YGADKDVVVL TSSQTRGVAE DIAHILKQMR
260 270 280 290 300
RAIVVGERTG GGALDLRKLR IGESDFFFTV PVSRSLGPLG GGSQTWEGSG
310 320 330 340 350
VLPCVGTPAE QALEKALAIL TLRSALPGVV HCLQEVLKDY YTLVDRVPTL
360 370 380 390 400
LQHLASMDFS TVVSEEDLVT KLNAGLQAAS EDPRLLVRAI GPTETPSWPA
410 420 430 440 450
PDAAAEDSPG VAPELPEDEA IRQALVDSVF QVSVLPGNVG YLRFDSFADA
460 470 480 490 500
SVLGVLAPYV LRQVWEPLQD TEHLIMDLRH NPGGPSSAVP LLLSYFQGPE
510 520 530 540 550
AGPVHLFTTY DRRTNITQEH FSHMELPGPR YSTQRGVYLL TSHRTATAAE
560 570 580 590 600
EFAFLMQSLG WATLVGEITA GNLLHTRTVP LLDTPEGSLA LTVPVLTFID
610 620 630 640 650
NHGEAWLGGG VVPDAIVLAE EALDKAQEVL EFHQSLGALV EGTGHLLEAH
660 670 680 690 700
YARPEVVGQT SALLRAKLAQ GAYRTAVDLE SLASQLTADL QEVSGDHRLL
710 720 730 740 750
VFHSPGELVV EEAPPPPPAV PSPEELTYLI EALFKTEVLP GQLGYLRFDA
760 770 780 790 800
MAELETVKAV GPQLVRLVWQ QLVDTAALVI DLRYNPGSYS TAIPLLCSYF
810 820 830 840 850
FEAEPRQHLY SVFDRATSKV TEVWTLPQVA GQRYGSHKDL YILMSHTSGS
860 870 880 890 900
AAEAFAHTMQ DLQRATVIGE PTAGGALSVG IYQVGSSPLY ASMPTQMAMS
910 920 930 940 950
ATTGKAWDLA GVEPDITVPM SEALSIAQDI VALRAKVPTV LQTAGKLVAD
960 970 980 990 1000
NYASAELGAK MATKLSGLQS RYSRVTSEVA LAEILGADLQ MLSGDPHLKA
1010 1020 1030 1040 1050
AHIPENAKDR IPGIVPMQIP SPEVFEELIK FSFHTNVLED NIGYLRFDMF
1060 1070 1080 1090 1100
GDGELLTQVS RLLVEHIWKK IMHTDAMIID MRFNIGGPTS SIPILCSYFF
1110 1120 1130 1140 1150
DEGPPVLLDK IYSRPDDSVS ELWTHAQVVG ERYGSKKSMV ILTSSVTAGT
1160 1170 1180 1190 1200
AEEFTYIMKR LGRALVIGEV TSGGCQPPQT YHVDDTNLYL TIPTARSVGA
1210 1220 1230 1240
SDGSSWEGVG VTPHVVVPAE EALARAKEML QHNQLRVKRS PGLQDHL
Length:1,247
Mass (Da):135,363
Last modified:November 1, 1991 - v2
Checksum:i6C1841411E012E0F
GO

Sequence cautioni

The sequence AAC18875 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti757V → G in BAJ84061 (PubMed:21697133).Curated1
Sequence conflicti757V → G in AAH39844 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06966918G → V1 PublicationCorresponds to variant dbSNP:rs864621997EnsemblClinVar.1
Natural variantiVAR_069670122R → H1 Publication1
Natural variantiVAR_069671155V → M1 PublicationCorresponds to variant dbSNP:rs782157576EnsemblClinVar.1
Natural variantiVAR_069672163S → P1 Publication1
Natural variantiVAR_069673196V → M1 PublicationCorresponds to variant dbSNP:rs782398712EnsemblClinVar.1
Natural variantiVAR_069674267R → Q1 Publication1
Natural variantiVAR_069675282V → M1 Publication1
Natural variantiVAR_069676321T → I1 Publication1
Natural variantiVAR_069677325A → T1 PublicationCorresponds to variant dbSNP:rs368898051EnsemblClinVar.1
Natural variantiVAR_069678346R → H1 PublicationCorresponds to variant dbSNP:rs111245635EnsemblClinVar.1
Natural variantiVAR_069679379A → T1 Publication1
Natural variantiVAR_069680433S → L1 Publication1
Natural variantiVAR_069681443R → S1 PublicationCorresponds to variant dbSNP:rs864621999EnsemblClinVar.1
Natural variantiVAR_069682505H → L1 PublicationCorresponds to variant dbSNP:rs201808774EnsemblClinVar.1
Natural variantiVAR_069683518Q → R1 Publication1
Natural variantiVAR_069684523H → Q1 PublicationCorresponds to variant dbSNP:rs148093336EnsemblClinVar.1
Natural variantiVAR_035929530R → H in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_069685535R → C1 Publication1
Natural variantiVAR_069686544R → H1 Publication1
Natural variantiVAR_069687593V → A1 Publication1
Natural variantiVAR_069688599I → V1 Publication1
Natural variantiVAR_069689614D → N1 Publication1
Natural variantiVAR_069690615A → V1 Publication1
Natural variantiVAR_069691675T → I1 PublicationCorresponds to variant dbSNP:rs864622000EnsemblClinVar.1
Natural variantiVAR_069692688A → V1 Publication1
Natural variantiVAR_069693693V → M1 Publication1
Natural variantiVAR_069694723P → L1 Publication1
Natural variantiVAR_069695741G → S1 Publication1
Natural variantiVAR_069696747R → C1 PublicationCorresponds to variant dbSNP:rs782664364EnsemblClinVar.1
Natural variantiVAR_069697785N → K1 PublicationCorresponds to variant dbSNP:rs864622001EnsemblClinVar.1
Natural variantiVAR_069698833R → C1 PublicationCorresponds to variant dbSNP:rs142945423EnsemblClinVar.1
Natural variantiVAR_069699835G → S1 Publication1
Natural variantiVAR_051315884V → M1 PublicationCorresponds to variant dbSNP:rs11204213EnsemblClinVar.1
Natural variantiVAR_069700903T → R1 PublicationCorresponds to variant dbSNP:rs373766942EnsemblClinVar.1
Natural variantiVAR_069701921S → R1 PublicationCorresponds to variant dbSNP:rs548622709EnsemblClinVar.1
Natural variantiVAR_069702956E → K1 Publication1
Natural variantiVAR_069703963T → I1 PublicationCorresponds to variant dbSNP:rs200706310EnsemblClinVar.1
Natural variantiVAR_0697041021S → Y1 Publication1
Natural variantiVAR_0697051059V → I1 PublicationCorresponds to variant dbSNP:rs864622002EnsemblClinVar.1
Natural variantiVAR_0697061080D → N in RP66; abolishes secretion; results in mis-folded insoluble complexes degraded via the ER-associated protein catabolic process. 2 PublicationsCorresponds to variant dbSNP:rs146150511EnsemblClinVar.1
Natural variantiVAR_0697071194T → M1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33875
, M33864, M33865, M33866 Genomic DNA Translation: AAA59453.1
M22453 mRNA Translation: AAA36126.1
J05253 Genomic DNA Translation: AAC18875.1 Different initiation.
AB593121 mRNA Translation: BAJ84061.1
AL731561 Genomic DNA No translation available.
CH471251 Genomic DNA Translation: EAW50659.1
BC039844 mRNA Translation: AAH39844.1
J03912 mRNA Translation: AAA59188.1
X53044 Genomic DNA Translation: CAA37213.1
DQ426897 mRNA Translation: ABD90548.1
CCDSiCCDS73119.1
PIRiA33812
RefSeqiNP_002891.1, NM_002900.2
UniGeneiHs.591928

Genome annotation databases

EnsembliENST00000584701; ENSP00000463151; ENSG00000265203
GeneIDi5949
KEGGihsa:5949
UCSCiuc001jez.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33875
, M33864, M33865, M33866 Genomic DNA Translation: AAA59453.1
M22453 mRNA Translation: AAA36126.1
J05253 Genomic DNA Translation: AAC18875.1 Different initiation.
AB593121 mRNA Translation: BAJ84061.1
AL731561 Genomic DNA No translation available.
CH471251 Genomic DNA Translation: EAW50659.1
BC039844 mRNA Translation: AAH39844.1
J03912 mRNA Translation: AAA59188.1
X53044 Genomic DNA Translation: CAA37213.1
DQ426897 mRNA Translation: ABD90548.1
CCDSiCCDS73119.1
PIRiA33812
RefSeqiNP_002891.1, NM_002900.2
UniGeneiHs.591928

3D structure databases

ProteinModelPortaliP10745
SMRiP10745
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111883, 2 interactors
IntActiP10745, 13 interactors
STRINGi9606.ENSP00000224600

Chemistry databases

DrugBankiDB00162 Vitamin A

Protein family/group databases

MEROPSiS41.950

PTM databases

iPTMnetiP10745
PhosphoSitePlusiP10745

Polymorphism and mutation databases

BioMutaiRBP3
DMDMi124894

Proteomic databases

EPDiP10745
PaxDbiP10745
PeptideAtlasiP10745
PRIDEiP10745
ProteomicsDBi52643

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000584701; ENSP00000463151; ENSG00000265203
GeneIDi5949
KEGGihsa:5949
UCSCiuc001jez.3 human

Organism-specific databases

CTDi5949
DisGeNETi5949
EuPathDBiHostDB:ENSG00000265203.1
GeneCardsiRBP3
GeneReviewsiRBP3
HGNCiHGNC:9921 RBP3
HPAiHPA041301
HPA044239
MalaCardsiRBP3
MIMi180290 gene
615233 phenotype
neXtProtiNX_P10745
OpenTargetsiENSG00000265203
Orphaneti791 Retinitis pigmentosa
PharmGKBiPA34288
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJZP Eukaryota
ENOG4111K6J LUCA
GeneTreeiENSGT00390000014726
HOGENOMiHOG000139907
HOVERGENiHBG006175
InParanoidiP10745
OMAiCSYFFDE
OrthoDBiEOG091G01EO
PhylomeDBiP10745
TreeFamiTF332253

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000107618-MONOMER
ReactomeiR-HSA-2187335 The retinoid cycle in cones (daylight vision)
R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision)
SIGNORiP10745

Miscellaneous databases

GeneWikiiRBP3
GenomeRNAii5949
PROiPR:P10745
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000265203 Expressed in 31 organ(s), highest expression level in retina
CleanExiHS_RBP3
GenevisibleiP10745 HS

Family and domain databases

InterProiView protein in InterPro
IPR029045 ClpP/crotonase-like_dom_sf
IPR032956 RBP3
IPR005151 Tail-specific_protease
PANTHERiPTHR11261:SF3 PTHR11261:SF3, 1 hit
PfamiView protein in Pfam
PF03572 Peptidase_S41, 4 hits
SMARTiView protein in SMART
SM00245 TSPc, 4 hits
SUPFAMiSSF52096 SSF52096, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRET3_HUMAN
AccessioniPrimary (citable) accession number: P10745
Secondary accession number(s): Q0QD34, Q5VSR0, Q8IXN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1991
Last modified: September 12, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again