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UniProtKB - P10733 (SEVE_DICDI)
Protein
Severin
Gene
sevA
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Severin blocks the ends of F-actin and causes the fragmentation and depolymerization of actin filaments in a Ca2+ dependent manner.
Miscellaneous
Severin changes its conformation upon binding of Ca2+ and then interacts with F-actin.
GO - Molecular functioni
- actin filament binding Source: dictyBase
- calcium-dependent protein binding Source: dictyBase
GO - Biological processi
- actin filament capping Source: UniProtKB-KW
- actin filament fragmentation Source: dictyBase
- actin filament severing Source: dictyBase
- actin polymerization or depolymerization Source: GO_Central
Keywordsi
Molecular function | Actin capping, Actin-binding |
Ligand | Calcium |
Enzyme and pathway databases
Reactomei | R-DDI-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Severin |
Gene namesi | Name:sevA ORF Names:DDB_G0289327 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0289327, sevA |
Subcellular locationi
Cytoskeleton
- actin cytoskeleton Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- phagocytic vesicle Source: dictyBase
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000218747 | 1 – 362 | SeverinAdd BLAST | 362 |
Proteomic databases
PaxDbi | P10733 |
Interactioni
GO - Molecular functioni
- actin filament binding Source: dictyBase
- calcium-dependent protein binding Source: dictyBase
Protein-protein interaction databases
STRINGi | 44689.DDB0232954 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P10733 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P10733 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 53 – 102 | Gelsolin-like 1Add BLAST | 50 | |
Repeati | 172 – 212 | Gelsolin-like 2Add BLAST | 41 | |
Repeati | 280 – 323 | Gelsolin-like 3Add BLAST | 44 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 162 – 170 | Polyphosphoinositide bindingBy similarity | 9 |
Sequence similaritiesi
Belongs to the villin/gelsolin family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0443, Eukaryota |
HOGENOMi | CLU_002568_0_1_1 |
InParanoidi | P10733 |
OMAi | EPAWNDG |
PhylomeDBi | P10733 |
Family and domain databases
Gene3Di | 3.40.20.10, 3 hits |
InterProi | View protein in InterPro IPR029006, ADF-H/Gelsolin-like_dom_sf IPR007123, Gelsolin-like_dom IPR007122, Villin/Gelsolin |
PANTHERi | PTHR11977, PTHR11977, 1 hit |
Pfami | View protein in Pfam PF00626, Gelsolin, 3 hits |
PRINTSi | PR00597, GELSOLIN |
SMARTi | View protein in SMART SM00262, GEL, 3 hits |
i Sequence
Sequence statusi: Complete.
P10733-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIKNRKLDIT STNVAGIGTD LDKKCRLDAA STEAQWKGVG QAPGLKIWRI
60 70 80 90 100
ENFKVVPVPE SSYGKFYDGD SYIILHTFKE GNSLKHDIHF FLGTFTTQDE
110 120 130 140 150
AGTAAYKTVE LDDFLGGAPI QYRQCQSYES PSFLSLFPKY FILSGGVESG
160 170 180 190 200
FNHVKPTEYK PRLLHISGDK NAKVAEVPLA TSSLNSGDCF LLDAGLTIYQ
210 220 230 240 250
FNGSKSSPQE KNKAAEVARA IDAERKGLPK VEVFCETDSD IPAEFWKLLG
260 270 280 290 300
GKGAIAAKHE TAPTKSEKVL YKLSDASGSL KFSEVSRGKI NKSSLKSEDV
310 320 330 340 350
FIIDLGNEIY TWIGSKSSPN EKKTAFSHAT QYLVNNKRCE YTPIVRVLEN
360
GTNQSFETLL SA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03515 mRNA Translation: AAA33250.1 AAFI02000139 Genomic DNA Translation: EAS66832.1 |
PIRi | A28517 |
RefSeqi | XP_001134515.1, XM_001134515.1 |
Genome annotation databases
EnsemblProtistsi | EAS66832; EAS66832; DDB_G0289327 |
GeneIDi | 8627096 |
KEGGi | ddi:DDB_G0289327 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03515 mRNA Translation: AAA33250.1 AAFI02000139 Genomic DNA Translation: EAS66832.1 |
PIRi | A28517 |
RefSeqi | XP_001134515.1, XM_001134515.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1SVQ | NMR | - | A | 149-262 | [»] | |
1SVR | NMR | - | A | 149-262 | [»] | |
1SVY | X-ray | 1.75 | A | 149-262 | [»] | |
SMRi | P10733 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 44689.DDB0232954 |
Proteomic databases
PaxDbi | P10733 |
Genome annotation databases
EnsemblProtistsi | EAS66832; EAS66832; DDB_G0289327 |
GeneIDi | 8627096 |
KEGGi | ddi:DDB_G0289327 |
Organism-specific databases
dictyBasei | DDB_G0289327, sevA |
Phylogenomic databases
eggNOGi | KOG0443, Eukaryota |
HOGENOMi | CLU_002568_0_1_1 |
InParanoidi | P10733 |
OMAi | EPAWNDG |
PhylomeDBi | P10733 |
Enzyme and pathway databases
Reactomei | R-DDI-6798695, Neutrophil degranulation |
Miscellaneous databases
EvolutionaryTracei | P10733 |
PROi | PR:P10733 |
Family and domain databases
Gene3Di | 3.40.20.10, 3 hits |
InterProi | View protein in InterPro IPR029006, ADF-H/Gelsolin-like_dom_sf IPR007123, Gelsolin-like_dom IPR007122, Villin/Gelsolin |
PANTHERi | PTHR11977, PTHR11977, 1 hit |
Pfami | View protein in Pfam PF00626, Gelsolin, 3 hits |
PRINTSi | PR00597, GELSOLIN |
SMARTi | View protein in SMART SM00262, GEL, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | SEVE_DICDI | |
Accessioni | P10733Primary (citable) accession number: P10733 Secondary accession number(s): Q1ZXC7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | February 23, 2022 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families