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UniProtKB - P10725 (ALR1_BACSU)
Protein
Alanine racemase 1
Gene
alr1
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.
UniRule annotationCatalytic activityi
- EC:5.1.1.1UniRule annotation
Cofactori
pyridoxal 5'-phosphateUniRule annotation
: D-alanine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 41 | Proton acceptor; specific for D-alanineUniRule annotation | 1 | |
Binding sitei | 137 | SubstrateUniRule annotation | 1 | |
Active sitei | 266 | Proton acceptor; specific for L-alanineUniRule annotation | 1 | |
Binding sitei | 313 | Substrate; via amide nitrogenUniRule annotation | 1 |
GO - Molecular functioni
- alanine racemase activity Source: GO_Central
- pyridoxal phosphate binding Source: GO_Central
GO - Biological processi
- D-alanine biosynthetic process Source: GO_Central
- peptidoglycan biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Isomerase |
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
BioCyci | BSUB:BSU04640-MONOMER |
BRENDAi | 5.1.1.1, 658 |
SABIO-RKi | P10725 |
UniPathwayi | UPA00042;UER00497 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:alr1 Synonyms:alr, dal Ordered Locus Names:BSU04640 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000114500 | 1 – 389 | Alanine racemase 1Add BLAST | 389 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 41 | N6-(pyridoxal phosphate)lysineUniRule annotation | 1 |
Proteomic databases
jPOSTi | P10725 |
PaxDbi | P10725 |
Family & Domainsi
Sequence similaritiesi
Belongs to the alanine racemase family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0787, Bacteria |
InParanoidi | P10725 |
OMAi | WEILCGF |
PhylomeDBi | P10725 |
Family and domain databases
Gene3Di | 2.40.37.10, 1 hit 3.20.20.10, 1 hit |
HAMAPi | MF_01201, Ala_racemase, 1 hit |
InterProi | View protein in InterPro IPR000821, Ala_racemase IPR009006, Ala_racemase/Decarboxylase_C IPR011079, Ala_racemase_C IPR001608, Ala_racemase_N IPR020622, Ala_racemase_pyridoxalP-BS IPR029066, PLP-binding_barrel |
Pfami | View protein in Pfam PF00842, Ala_racemase_C, 1 hit PF01168, Ala_racemase_N, 1 hit |
PRINTSi | PR00992, ALARACEMASE |
SMARTi | View protein in SMART SM01005, Ala_racemase_C, 1 hit |
SUPFAMi | SSF50621, SSF50621, 1 hit SSF51419, SSF51419, 1 hit |
TIGRFAMsi | TIGR00492, alr, 1 hit |
PROSITEi | View protein in PROSITE PS00395, ALANINE_RACEMASE, 1 hit |
i Sequence
Sequence statusi: Complete.
P10725-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTKPFYRDT WAEIDLSAIK ENVSNMKKHI GEHVHLMAVV KANAYGHGDA
60 70 80 90 100
ETAKAALDAG ASCLAVAILD EAISLRKKGL KAPILVLGAV PPEYVAIAAE
110 120 130 140 150
YDVTLTGYSV EWLQEAARHT KKGSLHFHLK VDTGMNRLGV KTEEEVQNVM
160 170 180 190 200
AILDRNPRLK CKGVFTHFAT ADEKERGYFL MQFERFKELI APLPLKNLMV
210 220 230 240 250
HCANSAAGLR LKKGFFNAVR FGIGMYGLRP SADMSDEIPF QLRPAFTLHS
260 270 280 290 300
TLSHVKLIRK GESVSYGAEY TAEKDTWIGT VPVGYADGWL RKLKGTDILV
310 320 330 340 350
KGKRLKIAGR ICMDQFMVEL DQEYPPGTKV TLIGRQGDEY ISMDEIAGRL
360 370 380
ETINYEVACT ISSRVPRMFL ENGSIMEVRN PLLQVNISN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 40 | V → E in AAA22378 (Ref. 1) Curated | 1 | |
Sequence conflicti | 66 | V → M in AAA22378 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M16207 Genomic DNA Translation: AAA22378.1 AB001488 Genomic DNA Translation: BAA19301.1 AL009126 Genomic DNA Translation: CAB12271.1 |
PIRi | JS0443 |
RefSeqi | NP_388345.1, NC_000964.3 WP_003234284.1, NZ_JNCM01000031.1 |
Genome annotation databases
EnsemblBacteriai | CAB12271; CAB12271; BSU_04640 |
GeneIDi | 939942 |
KEGGi | bsu:BSU04640 |
PATRICi | fig|224308.179.peg.492 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M16207 Genomic DNA Translation: AAA22378.1 AB001488 Genomic DNA Translation: BAA19301.1 AL009126 Genomic DNA Translation: CAB12271.1 |
PIRi | JS0443 |
RefSeqi | NP_388345.1, NC_000964.3 WP_003234284.1, NZ_JNCM01000031.1 |
3D structure databases
SMRi | P10725 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU04640 |
Proteomic databases
jPOSTi | P10725 |
PaxDbi | P10725 |
Genome annotation databases
EnsemblBacteriai | CAB12271; CAB12271; BSU_04640 |
GeneIDi | 939942 |
KEGGi | bsu:BSU04640 |
PATRICi | fig|224308.179.peg.492 |
Phylogenomic databases
eggNOGi | COG0787, Bacteria |
InParanoidi | P10725 |
OMAi | WEILCGF |
PhylomeDBi | P10725 |
Enzyme and pathway databases
UniPathwayi | UPA00042;UER00497 |
BioCyci | BSUB:BSU04640-MONOMER |
BRENDAi | 5.1.1.1, 658 |
SABIO-RKi | P10725 |
Family and domain databases
Gene3Di | 2.40.37.10, 1 hit 3.20.20.10, 1 hit |
HAMAPi | MF_01201, Ala_racemase, 1 hit |
InterProi | View protein in InterPro IPR000821, Ala_racemase IPR009006, Ala_racemase/Decarboxylase_C IPR011079, Ala_racemase_C IPR001608, Ala_racemase_N IPR020622, Ala_racemase_pyridoxalP-BS IPR029066, PLP-binding_barrel |
Pfami | View protein in Pfam PF00842, Ala_racemase_C, 1 hit PF01168, Ala_racemase_N, 1 hit |
PRINTSi | PR00992, ALARACEMASE |
SMARTi | View protein in SMART SM01005, Ala_racemase_C, 1 hit |
SUPFAMi | SSF50621, SSF50621, 1 hit SSF51419, SSF51419, 1 hit |
TIGRFAMsi | TIGR00492, alr, 1 hit |
PROSITEi | View protein in PROSITE PS00395, ALANINE_RACEMASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ALR1_BACSU | |
Accessioni | P10725Primary (citable) accession number: P10725 Secondary accession number(s): P96620 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | December 15, 1998 | |
Last modified: | April 7, 2021 | |
This is version 148 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families