Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P10720 (PF4V_HUMAN)

Entry version 165 (17 Jun 2020)
Sequence version 1 (01 Jul 1989)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Platelet factor 4 variant

Gene

PF4V1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro).1 Publication

Miscellaneous

Binding to heparin is much weaker than in the close homolog PF4/CXCL4.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine, Heparin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-140875 Common Pathway of Fibrin Clot Formation
R-HSA-202733 Cell surface interactions at the vascular wall

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Platelet factor 4 variant
Alternative name(s):
C-X-C motif chemokine 4 variant
CXCL4L1
PF4alt
PF4var1
Cleaved into the following 3 chains:
Platelet factor 4 variant(4-74)
Platelet factor 4 variant(5-74)
Platelet factor 4 variant(6-74)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PF4V1
Synonyms:CXCL4V1, SCYB4V1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000109272.3

Human Gene Nomenclature Database

More...HGNCi		HGNC:8862 PF4V1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		173461 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P10720

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5197

Open Targets

More...OpenTargetsi		ENSG00000109272

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33204

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P10720 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PF4V1

Domain mapping of disease mutations (DMDM)

More...DMDMi		130306

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 301 PublicationAdd BLAST30
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000507131 – 104Platelet factor 4 variantAdd BLAST74
ChainiPRO_000000507234 – 104Platelet factor 4 variant(4-74)Add BLAST71
ChainiPRO_000000507335 – 104Platelet factor 4 variant(5-74)Add BLAST70
ChainiPRO_000000507436 – 104Platelet factor 4 variant(6-74)Add BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi44 ↔ 701 Publication
Disulfide bondi46 ↔ 861 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminal processed forms of platelet factor 4 variant seems to be produced by proteolytic cleavage. The most abundant form is Platelet factor 4 variant(5-74).

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P10720

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P10720

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P10720

PeptideAtlas

More...PeptideAtlasi		P10720

PRoteomics IDEntifications database

More...PRIDEi		P10720

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52639

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P10720

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P10720

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P10720

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000109272 Expressed in blood and 55 other tissues

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000109272 Tissue enhanced (blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111220, 5 interactors

Protein interaction database and analysis system

More...IntActi		P10720, 18 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000226524

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P10720 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1104
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P10720

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni95 – 101Heparin-binding7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intercrine alpha (chemokine CxC) family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410J314 Eukaryota
ENOG4111556 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163666

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_143902_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P10720

KEGG Orthology (KO)

More...KOi		K05407

Identification of Orthologs from Complete Genome Data

More...OMAi		RATHPEM

Database of Orthologous Groups

More...OrthoDBi		1617719at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P10720

TreeFam database of animal gene trees

More...TreeFami		TF333433

Family and domain databases

Conserved Domains Database

More...CDDi		cd00273 Chemokine_CXC, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
IPR027222 PF4

The PANTHER Classification System

More...PANTHERi		PTHR10179 PTHR10179, 1 hit
PTHR10179:SF38 PTHR10179:SF38, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00048 IL8, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00437 SMALLCYTKCXC

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00199 SCY, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54117 SSF54117, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P10720-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSAARSRLT RATRQEMLFL ALLLLPVVVA FARAEAEEDG DLQCLCVKTT 
        60         70         80         90        100
SQVRPRHITS LEVIKAGPHC PTAQLIATLK NGRKICLDLQ ALLYKKIIKE 

HLES
Length:104
Mass (Da):11,553
Last modified:July 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i786FE2B288532E28
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti77A → S no nucleotide entry (PubMed:1695112).Curated1

<p>This subsection of the 'Sequence' section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 8250.9 Da. Determined by ESI. Platelet factor 4 variant.1 Publication
Molecular mass is 7877.7 Da. Determined by ESI. Platelet factor 4 variant(4-74).1 Publication
Molecular mass is 7805.8 Da. Determined by ESI. Platelet factor 4 variant(5-74).1 Publication
Molecular mass is 7678.6 Da. Determined by ESI. Platelet factor 4 variant(6-74).1 Publication

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M26167 Genomic DNA Translation: AAA60067.1
CH471057 Genomic DNA Translation: EAX05692.1
BC130653 mRNA Translation: AAI30654.1
BC130657 mRNA Translation: AAI30658.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3561.1

Protein sequence database of the Protein Information Resource

More...PIRi		A31941 PFHU4A

NCBI Reference Sequences

More...RefSeqi		NP_002611.1, NM_002620.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000226524; ENSP00000226524; ENSG00000109272

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5197

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5197

UCSC genome browser

More...UCSCi		uc003hhg.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26167 Genomic DNA Translation: AAA60067.1
CH471057 Genomic DNA Translation: EAX05692.1
BC130653 mRNA Translation: AAI30654.1
BC130657 mRNA Translation: AAI30658.1
CCDSiCCDS3561.1
PIRiA31941 PFHU4A
RefSeqiNP_002611.1, NM_002620.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HSVX-ray2.08A/B/C/D35-104[»]
SMRiP10720
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111220, 5 interactors
IntActiP10720, 18 interactors
STRINGi9606.ENSP00000226524

PTM databases

iPTMnetiP10720
PhosphoSitePlusiP10720

Polymorphism and mutation databases

BioMutaiPF4V1
DMDMi130306

Proteomic databases

jPOSTiP10720
MassIVEiP10720
PaxDbiP10720
PeptideAtlasiP10720
PRIDEiP10720
ProteomicsDBi52639
TopDownProteomicsiP10720

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		44434 103 antibodies

The DNASU plasmid repository

More...DNASUi		5197

Genome annotation databases

EnsembliENST00000226524; ENSP00000226524; ENSG00000109272
GeneIDi5197
KEGGihsa:5197
UCSCiuc003hhg.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5197
DisGeNETi5197
EuPathDBiHostDB:ENSG00000109272.3

GeneCards: human genes, protein and diseases

More...GeneCardsi		PF4V1
HGNCiHGNC:8862 PF4V1
HPAiENSG00000109272 Tissue enhanced (blood, lymphoid tissue)
MIMi173461 gene
neXtProtiNX_P10720
OpenTargetsiENSG00000109272
PharmGKBiPA33204

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410J314 Eukaryota
ENOG4111556 LUCA
GeneTreeiENSGT00940000163666
HOGENOMiCLU_143902_1_2_1
InParanoidiP10720
KOiK05407
OMAiRATHPEM
OrthoDBi1617719at2759
PhylomeDBiP10720
TreeFamiTF333433

Enzyme and pathway databases

ReactomeiR-HSA-140875 Common Pathway of Fibrin Clot Formation
R-HSA-202733 Cell surface interactions at the vascular wall

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5197 3 hits in 780 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5197
PharosiP10720 Tbio

Protein Ontology

More...PROi		PR:P10720
RNActiP10720 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000109272 Expressed in blood and 55 other tissues

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
IPR027222 PF4
PANTHERiPTHR10179 PTHR10179, 1 hit
PTHR10179:SF38 PTHR10179:SF38, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPF4V_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10720
Secondary accession number(s): A1L4S0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 17, 2020
This is version 165 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again