We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - P10720 (PF4V_HUMAN)
Protein
Platelet factor 4 variant
Gene
PF4V1
Organism
Homo sapiens (Human)
Status
Functioni
Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro).
1 PublicationMiscellaneous
Binding to heparin is much weaker than in the close homolog PF4/CXCL4.
GO - Molecular functioni
- chemokine activity Source: GO_Central
- CXCR chemokine receptor binding Source: GO_Central
- heparin binding Source: UniProtKB-KW
GO - Biological processi
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: GO_Central
- cellular response to lipopolysaccharide Source: GO_Central
- chemokine-mediated signaling pathway Source: GO_Central
- inflammatory response Source: GO_Central
- neutrophil chemotaxis Source: GO_Central
- platelet activation Source: InterPro
Keywordsi
Molecular function | Cytokine, Heparin-binding |
Enzyme and pathway databases
PathwayCommonsi | P10720 |
Reactomei | R-HSA-140875, Common Pathway of Fibrin Clot Formation R-HSA-202733, Cell surface interactions at the vascular wall |
SignaLinki | P10720 |
Names & Taxonomyi
Protein namesi | Recommended name: Platelet factor 4 variantAlternative name(s): C-X-C motif chemokine 4 variant CXCL4L1 PF4alt PF4var1 Cleaved into the following 3 chains: |
Gene namesi | Name:PF4V1 Synonyms:CXCL4V1, SCYB4V1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8862, PF4V1 |
MIMi | 173461, gene |
neXtProti | NX_P10720 |
VEuPathDBi | HostDB:ENSG00000109272 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 5197 |
OpenTargetsi | ENSG00000109272 |
PharmGKBi | PA33204 |
Miscellaneous databases
Pharosi | P10720, Tbio |
Genetic variation databases
BioMutai | PF4V1 |
DMDMi | 130306 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 30 | 1 PublicationAdd BLAST | 30 | |
ChainiPRO_0000005071 | 31 – 104 | Platelet factor 4 variantAdd BLAST | 74 | |
ChainiPRO_0000005072 | 34 – 104 | Platelet factor 4 variant(4-74)Add BLAST | 71 | |
ChainiPRO_0000005073 | 35 – 104 | Platelet factor 4 variant(5-74)Add BLAST | 70 | |
ChainiPRO_0000005074 | 36 – 104 | Platelet factor 4 variant(6-74)Add BLAST | 69 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 44 ↔ 70 | 1 Publication | ||
Disulfide bondi | 46 ↔ 86 | 1 Publication |
Post-translational modificationi
The N-terminal processed forms of platelet factor 4 variant seems to be produced by proteolytic cleavage. The most abundant form is Platelet factor 4 variant(5-74).
Keywords - PTMi
Disulfide bond, Glycoprotein, ProteoglycanProteomic databases
jPOSTi | P10720 |
MassIVEi | P10720 |
PaxDbi | P10720 |
PeptideAtlasi | P10720 |
PRIDEi | P10720 |
ProteomicsDBi | 52639 |
TopDownProteomicsi | P10720 |
PTM databases
iPTMneti | P10720 |
PhosphoSitePlusi | P10720 |
Expressioni
Gene expression databases
Bgeei | ENSG00000109272, Expressed in monocyte and 74 other tissues |
Organism-specific databases
HPAi | ENSG00000109272, Tissue enhanced (intestine, lymphoid tissue) |
Interactioni
Subunit structurei
Homotetramer.
1 PublicationBinary interactionsi
P10720
GO - Molecular functioni
- chemokine activity Source: GO_Central
- CXCR chemokine receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 111220, 21 interactors |
IntActi | P10720, 18 interactors |
STRINGi | 9606.ENSP00000226524 |
Miscellaneous databases
RNActi | P10720, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P10720 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 95 – 101 | Heparin-binding | 7 |
Sequence similaritiesi
Belongs to the intercrine alpha (chemokine CxC) family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502TF57, Eukaryota |
GeneTreei | ENSGT00940000163666 |
HOGENOMi | CLU_143902_1_2_1 |
InParanoidi | P10720 |
OMAi | RATHPEM |
OrthoDBi | 1617719at2759 |
PhylomeDBi | P10720 |
TreeFami | TF333433 |
Family and domain databases
CDDi | cd00273, Chemokine_CXC, 1 hit |
InterProi | View protein in InterPro IPR001089, Chemokine_CXC IPR018048, Chemokine_CXC_CS IPR001811, Chemokine_IL8-like_dom IPR033899, CXC_Chemokine_domain IPR036048, Interleukin_8-like_sf IPR027222, PF4 |
PANTHERi | PTHR10179, PTHR10179, 1 hit PTHR10179:SF38, PTHR10179:SF38, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
PRINTSi | PR00437, SMALLCYTKCXC |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00471, SMALL_CYTOKINES_CXC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P10720-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSAARSRLT RATRQEMLFL ALLLLPVVVA FARAEAEEDG DLQCLCVKTT
60 70 80 90 100
SQVRPRHITS LEVIKAGPHC PTAQLIATLK NGRKICLDLQ ALLYKKIIKE
HLES
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 77 | A → S no nucleotide entry (PubMed:1695112).Curated | 1 |
Mass spectrometryi
Molecular mass is 8250.9 Da. Determined by ESI. Platelet factor 4 variant.1 Publication
Molecular mass is 7877.7 Da. Determined by ESI. Platelet factor 4 variant(4-74).1 Publication
Molecular mass is 7805.8 Da. Determined by ESI. Platelet factor 4 variant(5-74).1 Publication
Molecular mass is 7678.6 Da. Determined by ESI. Platelet factor 4 variant(6-74).1 Publication
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M26167 Genomic DNA Translation: AAA60067.1 CH471057 Genomic DNA Translation: EAX05692.1 BC130653 mRNA Translation: AAI30654.1 BC130657 mRNA Translation: AAI30658.1 |
CCDSi | CCDS3561.1 |
PIRi | A31941, PFHU4A |
RefSeqi | NP_002611.1, NM_002620.3 |
Genome annotation databases
Ensembli | ENST00000226524; ENSP00000226524; ENSG00000109272 |
GeneIDi | 5197 |
KEGGi | hsa:5197 |
MANE-Selecti | ENST00000226524.4; ENSP00000226524.3; NM_002620.4; NP_002611.1 |
UCSCi | uc003hhg.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M26167 Genomic DNA Translation: AAA60067.1 CH471057 Genomic DNA Translation: EAX05692.1 BC130653 mRNA Translation: AAI30654.1 BC130657 mRNA Translation: AAI30658.1 |
CCDSi | CCDS3561.1 |
PIRi | A31941, PFHU4A |
RefSeqi | NP_002611.1, NM_002620.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4HSV | X-ray | 2.08 | A/B/C/D | 35-104 | [»] | |
SMRi | P10720 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111220, 21 interactors |
IntActi | P10720, 18 interactors |
STRINGi | 9606.ENSP00000226524 |
PTM databases
iPTMneti | P10720 |
PhosphoSitePlusi | P10720 |
Genetic variation databases
BioMutai | PF4V1 |
DMDMi | 130306 |
Proteomic databases
jPOSTi | P10720 |
MassIVEi | P10720 |
PaxDbi | P10720 |
PeptideAtlasi | P10720 |
PRIDEi | P10720 |
ProteomicsDBi | 52639 |
TopDownProteomicsi | P10720 |
Protocols and materials databases
Antibodypediai | 44434, 105 antibodies from 20 providers |
DNASUi | 5197 |
Genome annotation databases
Ensembli | ENST00000226524; ENSP00000226524; ENSG00000109272 |
GeneIDi | 5197 |
KEGGi | hsa:5197 |
MANE-Selecti | ENST00000226524.4; ENSP00000226524.3; NM_002620.4; NP_002611.1 |
UCSCi | uc003hhg.2, human |
Organism-specific databases
CTDi | 5197 |
DisGeNETi | 5197 |
GeneCardsi | PF4V1 |
HGNCi | HGNC:8862, PF4V1 |
HPAi | ENSG00000109272, Tissue enhanced (intestine, lymphoid tissue) |
MIMi | 173461, gene |
neXtProti | NX_P10720 |
OpenTargetsi | ENSG00000109272 |
PharmGKBi | PA33204 |
VEuPathDBi | HostDB:ENSG00000109272 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TF57, Eukaryota |
GeneTreei | ENSGT00940000163666 |
HOGENOMi | CLU_143902_1_2_1 |
InParanoidi | P10720 |
OMAi | RATHPEM |
OrthoDBi | 1617719at2759 |
PhylomeDBi | P10720 |
TreeFami | TF333433 |
Enzyme and pathway databases
PathwayCommonsi | P10720 |
Reactomei | R-HSA-140875, Common Pathway of Fibrin Clot Formation R-HSA-202733, Cell surface interactions at the vascular wall |
SignaLinki | P10720 |
Miscellaneous databases
BioGRID-ORCSi | 5197, 5 hits in 1020 CRISPR screens |
GenomeRNAii | 5197 |
Pharosi | P10720, Tbio |
PROi | PR:P10720 |
RNActi | P10720, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000109272, Expressed in monocyte and 74 other tissues |
Family and domain databases
CDDi | cd00273, Chemokine_CXC, 1 hit |
InterProi | View protein in InterPro IPR001089, Chemokine_CXC IPR018048, Chemokine_CXC_CS IPR001811, Chemokine_IL8-like_dom IPR033899, CXC_Chemokine_domain IPR036048, Interleukin_8-like_sf IPR027222, PF4 |
PANTHERi | PTHR10179, PTHR10179, 1 hit PTHR10179:SF38, PTHR10179:SF38, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
PRINTSi | PR00437, SMALLCYTKCXC |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00471, SMALL_CYTOKINES_CXC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PF4V_HUMAN | |
Accessioni | P10720Primary (citable) accession number: P10720 Secondary accession number(s): A1L4S0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | February 23, 2022 | |
This is version 172 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families