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UniProtKB - P10696 (PPBN_HUMAN)

Entry version 201 (23 Feb 2022)
Sequence version 4 (06 Mar 2007)
Previous versions | rss
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Protein

Alkaline phosphatase, germ cell type

Gene

ALPG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Alkaline phosphatase that can hydrolyze various phosphate compounds.

1 Publication

Miscellaneous

In most mammals there are four different isozymes: placental (ALPP), germ cell (ALPG), intestinal (ALPI) and tissue non-specific (liver/bone/kidney) (ALPL/TNAP).Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by L-leucine, EDTA and heat.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi61MagnesiumBy similarity1
Metal bindingi61Zinc 1By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei111Phosphoserine intermediatePROSITE-ProRule annotation1
Metal bindingi111Zinc 1By similarity1
Metal bindingi174MagnesiumBy similarity1
Metal bindingi235CalciumBy similarity1
Metal bindingi288Calcium; via carbonyl oxygenBy similarity1
Metal bindingi289CalciumBy similarity1
Metal bindingi304CalciumBy similarity1
Metal bindingi330MagnesiumBy similarity1
Metal bindingi335Zinc 2By similarity1
Metal bindingi339Zinc 2; via tele nitrogenBy similarity1
Metal bindingi376Zinc 1By similarity1
Metal bindingi377Zinc 1; via tele nitrogenBy similarity1
Metal bindingi451Zinc 2; via tele nitrogenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • alkaline phosphatase activity Source: HGNC
  • metal ion binding Source: UniProtKB-KW
Complete GO annotation on QuickGO ...

GO - Biological processi

  • dephosphorylation Source: GO_Central
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandCalcium, Magnesium, Metal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P10696

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-163125, Post-translational modification: synthesis of GPI-anchored proteins

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P10696

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alkaline phosphatase, germ cell typeCurated (EC:3.1.3.1PROSITE-ProRule annotation1 Publication)
Alternative name(s):
ALP-1
Alkaline phosphatase Nagao isozyme
Alkaline phosphatase, placental-like
Germ cell alkaline phosphatase1 Publication
Short name:
GCAP1 Publication
Placental alkaline phosphatase-like
Short name:
PLAP-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ALPGImported
Synonyms:ALPPL, ALPPL2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:441, ALPG

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		171810, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P10696

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000163286

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		251

Open Targets

More...OpenTargetsi		ENSG00000163286

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24731

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P10696, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3402

Drug and drug target database

More...DrugBanki		DB01143, Amifostine
DB11091, Hydrogen peroxide
DB00848, Levamisole
DB09498, Strontium chloride Sr-89
DB09322, Zinc sulfate

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ALPPL2

Domain mapping of disease mutations (DMDM)

More...DMDMi		145559564

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002403320 – 503Alkaline phosphatase, germ cell typeAdd BLAST484
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000024034504 – 532Removed in mature formSequence analysisAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi140 ↔ 202By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi268N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi486 ↔ 493By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi503GPI-anchor amidated aspartateSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P10696

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P10696

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P10696

MaxQB - The MaxQuant DataBase

More...MaxQBi		P10696

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P10696

PeptideAtlas

More...PeptideAtlasi		P10696

PRoteomics IDEntifications database

More...PRIDEi		P10696

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52638

PTM databases

DEPOD human dephosphorylation database

More...DEPODi		ALPG

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P10696, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P10696

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P10696

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Trace amounts in the testis and thymus, and in elevated amounts in germ cell tumors.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163286, Expressed in placenta and 64 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P10696, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163286, Not detected

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106752, 30 interactors

Protein interaction database and analysis system

More...IntActi		P10696, 12 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000295453

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P10696

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P10696, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P10696

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni422 – 443DisorderedSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the alkaline phosphatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4126, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183063

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P10696

Identification of Orthologs from Complete Genome Data

More...OMAi		FEYSHME

Database of Orthologous Groups

More...OrthoDBi		454880at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P10696

TreeFam database of animal gene trees

More...TreeFami		TF323513

Family and domain databases

Conserved Domains Database

More...CDDi		cd16012, ALP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.720.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001952, Alkaline_phosphatase
IPR018299, Alkaline_phosphatase_AS
IPR017850, Alkaline_phosphatase_core_sf

The PANTHER Classification System

More...PANTHERi		PTHR11596, PTHR11596, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00245, Alk_phosphatase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00113, ALKPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00098, alkPPc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53649, SSF53649, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00123, ALKALINE_PHOSPHATASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P10696-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQGPWVLLLL GLRLQLSLGI IPVEEENPDF WNRQAAEALG AAKKLQPAQT 
        60         70         80         90        100
AAKNLIIFLG DGMGVSTVTA ARILKGQKKD KLGPETFLAM DRFPYVALSK 
       110        120        130        140        150
TYSVDKHVPD SGATATAYLC GVKGNFQTIG LSAAARFNQC NTTRGNEVIS 
       160        170        180        190        200
VMNRAKKAGK SVGVVTTTRV QHASPAGAYA HTVNRNWYSD ADVPASARQE 
       210        220        230        240        250
GCQDIATQLI SNMDIDVILG GGRKYMFPMG TPDPEYPDDY SQGGTRLDGK 
       260        270        280        290        300
NLVQEWLAKH QGARYVWNRT ELLQASLDPS VTHLMGLFEP GDMKYEIHRD 
       310        320        330        340        350
STLDPSLMEM TEAALLLLSR NPRGFFLFVE GGRIDHGHHE SRAYRALTET 
       360        370        380        390        400
IMFDDAIERA GQLTSEEDTL SLVTADHSHV FSFGGYPLRG SSIFGLAPGK 
       410        420        430        440        450
ARDRKAYTVL LYGNGPGYVL KDGARPDVTE SESGSPEYRQ QSAVPLDGET 
       460        470        480        490        500
HAGEDVAVFA RGPQAHLVHG VQEQTFIAHV MAFAACLEPY TACDLAPRAG 
       510        520        530 
TTDAAHPGPS VVPALLPLLA GTLLLLGTAT AP
Length:532
Mass (Da):57,377
Last modified:March 6, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i25EB56C901B61505
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA30232 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti57I → M in AAA98616 (PubMed:2834730).Curated1
Sequence conflicti152M → V in AAA98616 (PubMed:2834730).Curated1
Sequence conflicti152M → V in CAA39425 (PubMed:2162249).Curated1
Sequence conflicti178A → T in AAA98616 (PubMed:2834730).Curated1
Sequence conflicti178A → T in AAA51700 (PubMed:2745460).Curated1
Sequence conflicti178A → T in CAA39425 (PubMed:2162249).Curated1
Sequence conflicti260H → R in AAH14139 (PubMed:15489334).Curated1
Sequence conflicti380V → L in AAA51700 (PubMed:2745460).Curated1
Sequence conflicti498R → P in AAA98616 (PubMed:2834730).Curated1
Sequence conflicti498R → P in CAA39425 (PubMed:2162249).Curated1
Sequence conflicti498R → S in CAA37374 (PubMed:2297757).Curated1
Sequence conflicti531A → T in CAA37374 (PubMed:2297757).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027553273L → M2 PublicationsCorresponds to variant dbSNP:rs17416141Ensembl.1
Natural variantiVAR_027554316L → R5 PublicationsCorresponds to variant dbSNP:rs183793479Ensembl.1
Natural variantiVAR_027555527G → E. Corresponds to variant dbSNP:rs1048999Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J03252 Genomic DNA Translation: AAA98616.1
J04948 mRNA Translation: AAA51700.1
X53279 mRNA Translation: CAA37374.1
X55958 mRNA Translation: CAA39425.1
AK293017 mRNA Translation: BAF85706.1
AC068134 Genomic DNA Translation: AAY24088.1
CH471063 Genomic DNA Translation: EAW70994.1
BC014139 mRNA Translation: AAH14139.1
M19160 Genomic DNA Translation: AAA51707.1
X07247 Genomic DNA Translation: CAA30232.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2491.1

Protein sequence database of the Protein Information Resource

More...PIRi		S12076

NCBI Reference Sequences

More...RefSeqi		NP_112603.2, NM_031313.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000295453; ENSP00000295453; ENSG00000163286

Database of genes from NCBI RefSeq genomes

More...GeneIDi		251

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:251

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000295453.8; ENSP00000295453.3; NM_031313.3; NP_112603.2

UCSC genome browser

More...UCSCi		uc002vss.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03252 Genomic DNA Translation: AAA98616.1
J04948 mRNA Translation: AAA51700.1
X53279 mRNA Translation: CAA37374.1
X55958 mRNA Translation: CAA39425.1
AK293017 mRNA Translation: BAF85706.1
AC068134 Genomic DNA Translation: AAY24088.1
CH471063 Genomic DNA Translation: EAW70994.1
BC014139 mRNA Translation: AAH14139.1
M19160 Genomic DNA Translation: AAA51707.1
X07247 Genomic DNA Translation: CAA30232.1 Sequence problems.
CCDSiCCDS2491.1
PIRiS12076
RefSeqiNP_112603.2, NM_031313.2

3D structure databases

SMRiP10696
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi106752, 30 interactors
IntActiP10696, 12 interactors
STRINGi9606.ENSP00000295453

Chemistry databases

BindingDBiP10696
ChEMBLiCHEMBL3402
DrugBankiDB01143, Amifostine
DB11091, Hydrogen peroxide
DB00848, Levamisole
DB09498, Strontium chloride Sr-89
DB09322, Zinc sulfate

PTM databases

DEPODiALPG
GlyGeniP10696, 2 sites
iPTMnetiP10696
PhosphoSitePlusiP10696

Genetic variation databases

BioMutaiALPPL2
DMDMi145559564

Proteomic databases

EPDiP10696
jPOSTiP10696
MassIVEiP10696
MaxQBiP10696
PaxDbiP10696
PeptideAtlasiP10696
PRIDEiP10696
ProteomicsDBi52638

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		20216, 221 antibodies from 30 providers

The DNASU plasmid repository

More...DNASUi		251

Genome annotation databases

EnsembliENST00000295453; ENSP00000295453; ENSG00000163286
GeneIDi251
KEGGihsa:251
MANE-SelectiENST00000295453.8; ENSP00000295453.3; NM_031313.3; NP_112603.2
UCSCiuc002vss.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		251
DisGeNETi251

GeneCards: human genes, protein and diseases

More...GeneCardsi		ALPG
HGNCiHGNC:441, ALPG
HPAiENSG00000163286, Not detected
MIMi171810, gene
neXtProtiNX_P10696
OpenTargetsiENSG00000163286
PharmGKBiPA24731
VEuPathDBiHostDB:ENSG00000163286

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4126, Eukaryota
GeneTreeiENSGT00950000183063
InParanoidiP10696
OMAiFEYSHME
OrthoDBi454880at2759
PhylomeDBiP10696
TreeFamiTF323513

Enzyme and pathway databases

PathwayCommonsiP10696
ReactomeiR-HSA-163125, Post-translational modification: synthesis of GPI-anchored proteins
SignaLinkiP10696

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		251, 3 hits in 965 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		251
PharosiP10696, Tchem

Protein Ontology

More...PROi		PR:P10696
RNActiP10696, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163286, Expressed in placenta and 64 other tissues
GenevisibleiP10696, HS

Family and domain databases

CDDicd16012, ALP, 1 hit
Gene3Di3.40.720.10, 1 hit
InterProiView protein in InterPro
IPR001952, Alkaline_phosphatase
IPR018299, Alkaline_phosphatase_AS
IPR017850, Alkaline_phosphatase_core_sf
PANTHERiPTHR11596, PTHR11596, 1 hit
PfamiView protein in Pfam
PF00245, Alk_phosphatase, 1 hit
PRINTSiPR00113, ALKPHPHTASE
SMARTiView protein in SMART
SM00098, alkPPc, 1 hit
SUPFAMiSSF53649, SSF53649, 1 hit
PROSITEiView protein in PROSITE
PS00123, ALKALINE_PHOSPHATASE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPBN_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10696
Secondary accession number(s): A8KAF2
, Q16727, Q53S81, Q96CM1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: March 6, 2007
Last modified: February 23, 2022
This is version 201 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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