ALPPL2

Functionⁱ

Miscellaneous

In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).

Catalytic activityⁱ

A phosphate monoester + H₂O = an alcohol + phosphate.PROSITE-ProRule annotation

Cofactorⁱ

Protein has several cofactor binding sites:

Mg²⁺By similarityNote: Binds 1 Mg²⁺ ion.By similarity
Zn²⁺By similarityNote: Binds 2 Zn²⁺ ions.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	61	MagnesiumBy similarity	1
Metal bindingⁱ	61	Zinc 1By similarity	1
Active siteⁱ	111	Phosphoserine intermediate	1
Metal bindingⁱ	111	Zinc 1By similarity	1
Metal bindingⁱ	174	MagnesiumBy similarity	1
Metal bindingⁱ	330	MagnesiumBy similarity	1
Metal bindingⁱ	335	Zinc 2By similarity	1
Metal bindingⁱ	339	Zinc 2; via tele nitrogenBy similarity	1
Metal bindingⁱ	376	Zinc 1By similarity	1
Metal bindingⁱ	377	Zinc 1; via tele nitrogenBy similarity	1
Metal bindingⁱ	451	Zinc 2; via tele nitrogenBy similarity	1

GO - Molecular functionⁱ

alkaline phosphatase activity
Source: HGNC
Inferred from direct assayⁱ
- 1939159
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Ligand	Magnesium, Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Reactomeⁱ

R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alkaline phosphatase, placental-like (EC:3.1.3.1) Alternative name(s): ALP-1 Alkaline phosphatase Nagao isozyme Germ cell alkaline phosphatase Short name: GCAP Placental alkaline phosphatase-like Short name: PLAP-like
Gene namesⁱ	Name:ALPPL2 Synonyms:ALPPL
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163286.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:441 ALPPL2
MIMⁱ	171810 gene
neXtProtⁱ	NX_P10696

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	251
Open Targets More...OpenTargetsⁱ	ENSG00000163286
PharmGKBⁱ	PA24731

Chemistry databases

ChEMBLⁱ	CHEMBL3402
Drug and drug target database More...DrugBankⁱ	DB01143 Amifostine DB00848 Levamisole DB09322 Zinc sulfate

Polymorphism and mutation databases

BioMutaⁱ	ALPPL2
DMDMⁱ	145559564

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST	19
ChainⁱPRO_0000024033	20 – 503	Alkaline phosphatase, placental-likeAdd BLAST	484
PropeptideⁱPRO_0000024034	504 – 532	Removed in mature formBy similarityAdd BLAST	29

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	140 ↔ 202	By similarity
Glycosylationⁱ	141	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	268	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	486 ↔ 493	By similarity
Lipidationⁱ	503	GPI-anchor amidated aspartateBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDⁱ	P10696
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P10696
PaxDbⁱ	P10696
PeptideAtlas More...PeptideAtlasⁱ	P10696
PRIDEⁱ	P10696
ProteomicsDBⁱ	52638

PTM databases

DEPODⁱ	P10696
iPTMnetⁱ	P10696
PhosphoSitePlusⁱ	P10696

Expressionⁱ

Tissue specificityⁱ

Trace amounts in the testis and thymus, and in elevated amounts in germ cell tumors.

Gene expression databases

Bgeeⁱ	ENSG00000163286 Expressed in 56 organ(s), highest expression level in placenta
CleanExⁱ	HS_ALPPL2
Genevisibleⁱ	P10696 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB020698 HPA038764 HPA038765 HPA051699

HPAⁱ

CAB020698
HPA038764
HPA038765
HPA051699

Interactionⁱ

Subunit structureⁱ

Homodimer.

Protein-protein interaction databases

BioGridⁱ	106752, 9 interactors
IntActⁱ	P10696, 3 interactors
STRINGⁱ	9606.ENSP00000295453

Chemistry databases

BindingDBⁱ	P10696

BindingDBⁱ

P10696

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P10696
SMRⁱ	P10696
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the alkaline phosphatase family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG4126 Eukaryota COG1785 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008704
HOGENOMⁱ	HOG000099118
HOVERGENⁱ	HBG007345
InParanoidⁱ	P10696
KEGG Orthology (KO) More...KOⁱ	K01077
OMAⁱ	MKNKDFM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G067H
PhylomeDBⁱ	P10696
TreeFamⁱ	TF323513

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd16012 ALP, 1 hit
Gene3Dⁱ	3.40.720.10, 1 hit
InterProⁱ	View protein in InterPro IPR017849 Alkaline_Pase-like_a/b/a IPR001952 Alkaline_phosphatase IPR018299 Alkaline_phosphatase_AS IPR017850 Alkaline_phosphatase_core_sf
PANTHERⁱ	PTHR11596 PTHR11596, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00245 Alk_phosphatase, 1 hit
PRINTSⁱ	PR00113 ALKPHPHTASE
SMARTⁱ	View protein in SMART SM00098 alkPPc, 1 hit
SUPFAMⁱ	SSF53649 SSF53649, 1 hit
PROSITEⁱ	View protein in PROSITE PS00123 ALKALINE_PHOSPHATASE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P10696-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQGPWVLLLL GLRLQLSLGI IPVEEENPDF WNRQAAEALG AAKKLQPAQT 
        60         70         80         90        100
AAKNLIIFLG DGMGVSTVTA ARILKGQKKD KLGPETFLAM DRFPYVALSK 
       110        120        130        140        150
TYSVDKHVPD SGATATAYLC GVKGNFQTIG LSAAARFNQC NTTRGNEVIS 
       160        170        180        190        200
VMNRAKKAGK SVGVVTTTRV QHASPAGAYA HTVNRNWYSD ADVPASARQE 
       210        220        230        240        250
GCQDIATQLI SNMDIDVILG GGRKYMFPMG TPDPEYPDDY SQGGTRLDGK 
       260        270        280        290        300
NLVQEWLAKH QGARYVWNRT ELLQASLDPS VTHLMGLFEP GDMKYEIHRD 
       310        320        330        340        350
STLDPSLMEM TEAALLLLSR NPRGFFLFVE GGRIDHGHHE SRAYRALTET 
       360        370        380        390        400
IMFDDAIERA GQLTSEEDTL SLVTADHSHV FSFGGYPLRG SSIFGLAPGK 
       410        420        430        440        450
ARDRKAYTVL LYGNGPGYVL KDGARPDVTE SESGSPEYRQ QSAVPLDGET 
       460        470        480        490        500
HAGEDVAVFA RGPQAHLVHG VQEQTFIAHV MAFAACLEPY TACDLAPRAG 
       510        520        530 
TTDAAHPGPS VVPALLPLLA GTLLLLGTAT AP

Length:532

Mass (Da):57,377

Last modified:March 6, 2007 - v4

Checksum:ⁱ25EB56C901B61505

GO

Sequence cautionⁱ

The sequence CAA30232 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	57	I → M in AAA98616 (PubMed:2834730).Curated	1
Sequence conflictⁱ	152	M → V in AAA98616 (PubMed:2834730).Curated	1
Sequence conflictⁱ	152	M → V in CAA39425 (PubMed:2162249).Curated	1
Sequence conflictⁱ	178	A → T in AAA98616 (PubMed:2834730).Curated	1
Sequence conflictⁱ	178	A → T in AAA51700 (PubMed:2745460).Curated	1
Sequence conflictⁱ	178	A → T in CAA39425 (PubMed:2162249).Curated	1
Sequence conflictⁱ	260	H → R in AAH14139 (PubMed:15489334).Curated	1
Sequence conflictⁱ	380	V → L in AAA51700 (PubMed:2745460).Curated	1
Sequence conflictⁱ	498	R → P in AAA98616 (PubMed:2834730).Curated	1
Sequence conflictⁱ	498	R → P in CAA39425 (PubMed:2162249).Curated	1
Sequence conflictⁱ	498	R → S in CAA37374 (PubMed:2297757).Curated	1
Sequence conflictⁱ	531	A → T in CAA37374 (PubMed:2297757).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_027553	273	L → M2 PublicationsCorresponds to variant dbSNP:rs17416141Ensembl.	1
Natural variantⁱVAR_027554	316	L → R5 PublicationsCorresponds to variant dbSNP:rs183793479Ensembl.	1
Natural variantⁱVAR_027555	527	G → E. Corresponds to variant dbSNP:rs1048999Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03252 Genomic DNA Translation: AAA98616.1 J04948 mRNA Translation: AAA51700.1 X53279 mRNA Translation: CAA37374.1 X55958 mRNA Translation: CAA39425.1 AK293017 mRNA Translation: BAF85706.1 AC068134 Genomic DNA Translation: AAY24088.1 CH471063 Genomic DNA Translation: EAW70994.1 BC014139 mRNA Translation: AAH14139.1 M19160 Genomic DNA Translation: AAA51707.1 X07247 Genomic DNA Translation: CAA30232.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2491.1
PIRⁱ	S12076
NCBI Reference Sequences More...RefSeqⁱ	NP_112603.2, NM_031313.2
UniGeneⁱ	Hs.333509

Genome annotation databases

Ensemblⁱ	ENST00000295453; ENSP00000295453; ENSG00000163286
GeneIDⁱ	251
KEGGⁱ	hsa:251
UCSC genome browser More...UCSCⁱ	uc002vss.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P10696	Alkaline phosphatase, placental type	)	HUMAN		535	UniRef90_P05187
Alkaline phosphatase		PANTR		534
Alkaline phosphatase		PANPA		534
Alkaline phosphatase		CERAT		532
UPI000B7B8ADA		PAPAN		626
+6

Protein	Similar proteins		Species	Score	Length	Source
P10696	Alkaline phosphatase, placental type	)	HUMAN		535	UniRef50_P05187
Alkaline phosphatase		PANTR		534
Alkaline phosphatase		PANPA		534
Alkaline phosphatase		CERAT		532
Alkaline phosphatase		MACNE		533
+21

Entry informationⁱ

Entry nameⁱ	PPBN_HUMAN
Accessionⁱ	P10696Primary (citable) accession number: P10696 Secondary accession number(s): A8KAF2 , Q16727, Q53S81, Q96CM1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
	Last sequence update:	March 6, 2007
	Last modified:	September 12, 2018
	This is version 180 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P10696 (PPBN_HUMAN)

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Alkaline phosphatase, placental-like

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ