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Entry version 198 (31 Jul 2019)
Sequence version 2 (30 Aug 2005)
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Protein

Neither inactivation nor afterpotential protein C

Gene

ninaC

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for photoreceptor cell function. The ninaC proteins combines putative serine/threonine-protein kinase and myosin activities (PubMed:2449973). Essential for the expression and stability of the rtp protein in the photoreceptors (PubMed:20107052). The rtp/ninaC complex is required for stability of inad and inac and the normal termination of phototransduction in the retina (PubMed:20739554).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei45ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei145Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi22 – 30ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Kinase, Motor protein, Myosin, Serine/threonine-protein kinase, Transferase
Biological processSensory transduction, Vision
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neither inactivation nor afterpotential protein C (EC:2.7.11.1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ninaC
ORF Names:CG5125
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0002938 ninaC

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000864441 – 1501Neither inactivation nor afterpotential protein CAdd BLAST1501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei183Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P10676

PRoteomics IDEntifications database

More...
PRIDEi
P10676

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P10676

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the phototransducing compartment of photoreceptor cells, the rhabdomeres (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
FBgn0002938 Expressed in 9 organ(s), highest expression level in head

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P10676 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P10676 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with rtp.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
60158, 6 interactors

Protein interaction database and analysis system

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IntActi
P10676, 9 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0079064

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P10676

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 282Protein kinasePROSITE-ProRule annotationAdd BLAST267
Domaini332 – 1037Myosin motorPROSITE-ProRule annotationAdd BLAST706
Domaini1036 – 1065IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini1072 – 1101IQ 2PROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni913 – 934Actin-bindingBy similarityAdd BLAST22
Regioni1043 – 1271Interaction with rtp1 PublicationAdd BLAST229
Regioni1066 – 1501Non alpha-helical, C-terminal domainAdd BLAST436

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1284 – 1308Asn-richAdd BLAST25

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.Curated
In the N-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0587 Eukaryota
KOG4229 Eukaryota
COG5022 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P10676

KEGG Orthology (KO)

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KOi
K08834

Identification of Orthologs from Complete Genome Data

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OMAi
RAFHSDV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P10676

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR011009 Kinase-like_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027417 P-loop_NTPase
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00612 IQ, 2 hits
PF00063 Myosin_head, 1 hit
PF07714 Pkinase_Tyr, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00015 IQ, 2 hits
SM00242 MYSc, 1 hit
SM00219 TyrKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096 IQ, 2 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform B (identifier: P10676-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMYLPYAQLP DPTDKFEIYE EIAQGVNAKV FRAKELDNDR IVALKIQHYD
60 70 80 90 100
EEHQVSIEEE YRTLRDYCDH PNLPEFYGVY KLSKPNGPDE IWFVMEYCAG
110 120 130 140 150
GTAVDMVNKL LKLDRRMREE HIAYIIRETC RAAIELNRNH VLHRDIRGDN
160 170 180 190 200
ILLTKNGRVK LCDFGLSRQV DSTLGKRGTC IGSPCWMAPE VVSAMESREP
210 220 230 240 250
DITVRADVWA LGITTIELAD GKPPFADMHP TRAMFQIIRN PPPTLMRPTN
260 270 280 290 300
WSQQINDFIS ESLEKNAENR PMMVEMVEHP FLTELIENED EMRSDIAEML
310 320 330 340 350
ELSRDVKTLY KEPELFVDRG YVKRFDEKPE KMYPEDLAAL ENPVDENIIE
360 370 380 390 400
SLRHRILMGE SYSFIGDILL SLNSNEIKQE FPQEFHAKYR FKSRSENQPH
410 420 430 440 450
IFSVADIAYQ DMLHHKEPQH IVLSGESYSG KSTNARLLIK HLCYLGDGNR
460 470 480 490 500
GATGRVESSI KAILMLVNAG TPVNNDSTRC VLQYCLTFGK TGKMSGAVFN
510 520 530 540 550
MYMLEKLRVA TTDGTQHNFH IFYYFYDFIN QQNQLKEYNL KADRNYRYLR
560 570 580 590 600
VPPEVPPSKL KYRRDDPEGN VERYREFENI LRDIDFNHKQ LETVRKVLAA
610 620 630 640 650
ILNIGNIRFR QNGKYAEVEN TDIVSRIAEL LRVDEKKFMW SLTNFIMVKG
660 670 680 690 700
GIAERRQYTT EEARDARDAV ASTLYSRLVD FIINRINMNM SFPRAVFGDT
710 720 730 740 750
NAIIIHDMFG FECFNRNGLE QLMINTLNEQ MQYHYNQRIF ISEMLEMEAE
760 770 780 790 800
DIDTINLNFY DNKTALDNLL TKPDGLFYII DDASRSCQDQ DLIMDRVSEK
810 820 830 840 850
HSQFVKKHTA TEISVAHYTG RIIYDTRAFT DINRDFVPPE MIETFRSSLD
860 870 880 890 900
ESIMLMFTNQ LTKAGNLTMP FEAVQHKDES ERKSYALNTL SAGCISQVNN
910 920 930 940 950
LRTLAANFRF TCLTLLKMLS QNANLGVHFV RCIRADLEYK PRSFHSDVVQ
960 970 980 990 1000
QQMKALGVLD TVIARQKGFS SRLPFDEFLR RYQFLAFDFD EPVEMTKDNC
1010 1020 1030 1040 1050
RLLFLRLKME GWALGKTKVF LRYYNDEFLA RLYELQVKKV IKVQSMMRAL
1060 1070 1080 1090 1100
LARKRVKGGK VFKLGKKGPE HHDVAASKIQ KAFRGFRDRV RLPPLVNEKS
1110 1120 1130 1140 1150
GQLNENTADF IRPFAKKWRE KSIFQVLLHY RAARFQDFVN LSQQVHIYNQ
1160 1170 1180 1190 1200
RMVAGLNKCT RAVPFERINM REVNSSQLGP LPVPIKKMPF RLDQIPFYDT
1210 1220 1230 1240 1250
QYMVDPANSI SRQAFPNQLL TQHMEDDEPW DSPLQRNPSM TSCALTYNAY
1260 1270 1280 1290 1300
KKEQACQTNW DRMGESDNIY NQGYFRDPQQ LRRNQMQMNM NAYNNAYNSY
1310 1320 1330 1340 1350
NSNYNNQNWG VHRSGSRRNS LKGYAAPPPP PPPMPSSNYY RNNPNQQQRN
1360 1370 1380 1390 1400
YQQRSSYPPS DPVRELQNMA RNEGDNSEDP PFNFKAMLRK TNYPRGSETN
1410 1420 1430 1440 1450
TYDFNNRRGS DSGDQHTFQP PKLRSTGRRY QDDEGYNSSS GNYGVSRKFG
1460 1470 1480 1490 1500
QQQRAPTLRQ SPASVGRSFE DSNARSFEEA GSYVEEEIAP GITLSGYAVD

I
Length:1,501
Mass (Da):174,300
Last modified:August 30, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i164DF87DDA7EB3D1
GO
Isoform A (identifier: P10676-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1082-1135: AFRGFRDRVR...VLLHYRAARF → GKKTQVDRLR...AKIEQASAEE
     1136-1501: Missing.

Show »
Length:1,135
Mass (Da):131,836
Checksum:i55849D61DEF07B49
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PCU0M9PCU0_DROME
FI21215p1
ninaC 2.2, CG 5125, CG54125, CT16120, CT42491
1,135Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti253Q → K in AAA28718 (PubMed:2449973).Curated1
Sequence conflicti253Q → K in AAA28719 (PubMed:2449973).Curated1
Sequence conflicti426E → D in AAM50150 (PubMed:12537569).Curated1
Sequence conflicti791D → N in AAA28718 (PubMed:2449973).Curated1
Sequence conflicti791D → N in AAA28719 (PubMed:2449973).Curated1
Sequence conflicti791D → N in AAA28721 (PubMed:2449973).Curated1
Sequence conflicti791D → N in AAA28720 (PubMed:2449973).Curated1
Sequence conflicti986A → P in AAM50150 (PubMed:12537569).Curated1
Sequence conflicti1089R → P in AAA28718 (PubMed:2449973).Curated1
Sequence conflicti1311V → E in AAA28718 (PubMed:2449973).Curated1
Sequence conflicti1311V → E in AAA28721 (PubMed:2449973).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0049401082 – 1135AFRGF…RAARF → GKKTQVDRLREYDEEHIDIS ETPSEAEEMFLEARMDEALA AVRIAKIEQASAEE in isoform A. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_0049411136 – 1501Missing in isoform A. 1 PublicationAdd BLAST366

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
J03131 Genomic DNA Translation: AAA28718.1
J03131 Genomic DNA Translation: AAA28719.1
M20230 mRNA Translation: AAA28721.1
M20231 mRNA Translation: AAA28720.1
AE014134 Genomic DNA Translation: AAF52504.3
AE014134 Genomic DNA Translation: AAF52505.1
AY119496 mRNA Translation: AAM50150.1

Protein sequence database of the Protein Information Resource

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PIRi
A29813
B29813

NCBI Reference Sequences

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RefSeqi
NP_001260189.1, NM_001273260.1 [P10676-2]
NP_001260190.1, NM_001273261.1 [P10676-2]
NP_523503.2, NM_078779.3 [P10676-1]
NP_723271.1, NM_164747.1 [P10676-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0079436; FBpp0079064; FBgn0002938 [P10676-1]
FBtr0079437; FBpp0079065; FBgn0002938 [P10676-2]
FBtr0334835; FBpp0306863; FBgn0002938 [P10676-2]
FBtr0334836; FBpp0306864; FBgn0002938 [P10676-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
34012

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG5125

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03131 Genomic DNA Translation: AAA28718.1
J03131 Genomic DNA Translation: AAA28719.1
M20230 mRNA Translation: AAA28721.1
M20231 mRNA Translation: AAA28720.1
AE014134 Genomic DNA Translation: AAF52504.3
AE014134 Genomic DNA Translation: AAF52505.1
AY119496 mRNA Translation: AAM50150.1
PIRiA29813
B29813
RefSeqiNP_001260189.1, NM_001273260.1 [P10676-2]
NP_001260190.1, NM_001273261.1 [P10676-2]
NP_523503.2, NM_078779.3 [P10676-1]
NP_723271.1, NM_164747.1 [P10676-2]

3D structure databases

SMRiP10676
ModBaseiSearch...

Protein-protein interaction databases

BioGridi60158, 6 interactors
IntActiP10676, 9 interactors
STRINGi7227.FBpp0079064

PTM databases

iPTMnetiP10676

Proteomic databases

PaxDbiP10676
PRIDEiP10676

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0079436; FBpp0079064; FBgn0002938 [P10676-1]
FBtr0079437; FBpp0079065; FBgn0002938 [P10676-2]
FBtr0334835; FBpp0306863; FBgn0002938 [P10676-2]
FBtr0334836; FBpp0306864; FBgn0002938 [P10676-2]
GeneIDi34012
KEGGidme:Dmel_CG5125

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
34012
FlyBaseiFBgn0002938 ninaC

Phylogenomic databases

eggNOGiKOG0587 Eukaryota
KOG4229 Eukaryota
COG5022 LUCA
InParanoidiP10676
KOiK08834
OMAiRAFHSDV
PhylomeDBiP10676

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ninaC fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
34012

Protein Ontology

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PROi
PR:P10676

Gene expression databases

BgeeiFBgn0002938 Expressed in 9 organ(s), highest expression level in head
ExpressionAtlasiP10676 differential
GenevisibleiP10676 DM

Family and domain databases

InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR011009 Kinase-like_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027417 P-loop_NTPase
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF00612 IQ, 2 hits
PF00063 Myosin_head, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 2 hits
SM00242 MYSc, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 2 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNINAC_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10676
Secondary accession number(s): P10677
, Q8MRP1, Q9VM23, Q9VM24
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: August 30, 2005
Last modified: July 31, 2019
This is version 198 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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