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UniProtKB - P10648 (GSTA2_MOUSE)
Protein
Glutathione S-transferase A2
Gene
Gsta2
Organism
Mus musculus (Mouse)
Status
Functioni
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Catalytic activityi
- EC:2.5.1.18
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 9 | GlutathioneBy similarity | 1 | |
Binding sitei | 45 | Glutathione1 Publication | 1 |
GO - Molecular functioni
- dinitrosyl-iron complex binding Source: MGI
- fatty acid binding Source: MGI
- glutathione binding Source: MGI
- glutathione peroxidase activity Source: MGI
- glutathione transferase activity Source: UniProtKB
- protein homodimerization activity Source: MGI
- steroid delta-isomerase activity Source: MGI
GO - Biological processi
- glutathione metabolic process Source: UniProtKB
- response to bacterium Source: MGI
- response to stilbenoid Source: UniProtKB
- xenobiotic catabolic process Source: MGI
- xenobiotic metabolic process Source: GO_Central
Keywordsi
Molecular function | Transferase |
Names & Taxonomyi
Protein namesi | Recommended name: Glutathione S-transferase A2 (EC:2.5.1.18)Alternative name(s): GST class-alpha member 2 Glutathione S-transferase GT41A |
Gene namesi | Name:Gsta2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95863, Gsta2 |
VEuPathDBi | HostDB:ENSMUSG00000057933 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000185789 | 2 – 222 | Glutathione S-transferase A2Add BLAST | 221 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 4 | N6-succinyllysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
jPOSTi | P10648 |
PaxDbi | P10648 |
PeptideAtlasi | P10648 |
PRIDEi | P10648 |
PTM databases
iPTMneti | P10648 |
PhosphoSitePlusi | P10648 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000057933, Expressed in adult mammalian kidney and 153 other tissues |
ExpressionAtlasi | P10648, baseline and differential |
Genevisiblei | P10648, MM |
Interactioni
Subunit structurei
Homodimer.
1 PublicationGO - Molecular functioni
- protein homodimerization activity Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000034902 |
Miscellaneous databases
RNActi | P10648, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P10648 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P10648 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 83 | GST N-terminalAdd BLAST | 81 | |
Domaini | 85 – 208 | GST C-terminalAdd BLAST | 124 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 54 – 55 | Glutathione binding1 Publication | 2 | |
Regioni | 67 – 68 | Glutathione binding1 Publication | 2 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1695, Eukaryota |
GeneTreei | ENSGT00940000154526 |
InParanoidi | P10648 |
OMAi | VFNITGP |
OrthoDBi | 1162336at2759 |
PhylomeDBi | P10648 |
TreeFami | TF105321 |
Family and domain databases
InterProi | View protein in InterPro IPR010987, Glutathione-S-Trfase_C-like IPR036282, Glutathione-S-Trfase_C_sf IPR040079, Glutathione_S-Trfase IPR004045, Glutathione_S-Trfase_N IPR003080, GST_alpha IPR004046, GST_C IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF00043, GST_C, 1 hit PF02798, GST_N, 1 hit |
PRINTSi | PR01266, GSTRNSFRASEA |
SFLDi | SFLDS00019, Glutathione_Transferase_(cytos, 1 hit |
SUPFAMi | SSF47616, SSF47616, 1 hit SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS50405, GST_CTER, 1 hit PS50404, GST_NTER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P10648-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGKPVLHYF NARGRMECIR WLLAAAGVEF EEKFIQSPED LEKLKKDGNL
60 70 80 90 100
MFDQVPMVEI DGMKLVQTRA ILNYIATKYD LYGKDMKERA LIDMYTEGIL
110 120 130 140 150
DLTEMIGQLV LCPPDQREAK TALAKDRTKN RYLPAFEKVL KSHGQDYLVG
160 170 180 190 200
NRLTRVDVHL LELLLYVEEL DASLLTPFPL LKAFKSRISS LPNVKKFLHP
210 220
GSQRKPPLDA KQIEEARKVF KF
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3YZV3 | D3YZV3_MOUSE | Glutathione S-transferase | Gsta2 | 182 | Annotation score: | ||
D3Z6A6 | D3Z6A6_MOUSE | Glutathione S-transferase | Gsta2 | 179 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 199 | H → Q in AAA37749 (PubMed:3417659).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03958 mRNA Translation: AAA37749.1 AC138587 Genomic DNA No translation available. CH466522 Genomic DNA Translation: EDL26384.1 CH466522 Genomic DNA Translation: EDL26385.1 CH466522 Genomic DNA Translation: EDL26386.1 CH466522 Genomic DNA Translation: EDL26387.1 BC061133 mRNA Translation: AAH61133.1 |
CCDSi | CCDS23359.1 |
RefSeqi | NP_032208.2, NM_008182.3 XP_006510877.1, XM_006510814.2 |
Genome annotation databases
Ensembli | ENSMUST00000034902; ENSMUSP00000034902; ENSMUSG00000057933 |
GeneIDi | 14858 |
KEGGi | mmu:14858 |
UCSCi | uc009quf.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03958 mRNA Translation: AAA37749.1 AC138587 Genomic DNA No translation available. CH466522 Genomic DNA Translation: EDL26384.1 CH466522 Genomic DNA Translation: EDL26385.1 CH466522 Genomic DNA Translation: EDL26386.1 CH466522 Genomic DNA Translation: EDL26387.1 BC061133 mRNA Translation: AAH61133.1 |
CCDSi | CCDS23359.1 |
RefSeqi | NP_032208.2, NM_008182.3 XP_006510877.1, XM_006510814.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ML6 | X-ray | 1.90 | A/B | 2-222 | [»] | |
SMRi | P10648 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000034902 |
PTM databases
iPTMneti | P10648 |
PhosphoSitePlusi | P10648 |
Proteomic databases
jPOSTi | P10648 |
PaxDbi | P10648 |
PeptideAtlasi | P10648 |
PRIDEi | P10648 |
Protocols and materials databases
DNASUi | 14858 |
Genome annotation databases
Ensembli | ENSMUST00000034902; ENSMUSP00000034902; ENSMUSG00000057933 |
GeneIDi | 14858 |
KEGGi | mmu:14858 |
UCSCi | uc009quf.1, mouse |
Organism-specific databases
CTDi | 2939 |
MGIi | MGI:95863, Gsta2 |
VEuPathDBi | HostDB:ENSMUSG00000057933 |
Phylogenomic databases
eggNOGi | KOG1695, Eukaryota |
GeneTreei | ENSGT00940000154526 |
InParanoidi | P10648 |
OMAi | VFNITGP |
OrthoDBi | 1162336at2759 |
PhylomeDBi | P10648 |
TreeFami | TF105321 |
Miscellaneous databases
BioGRID-ORCSi | 14858, 1 hit in 29 CRISPR screens |
ChiTaRSi | Gsta2, mouse |
EvolutionaryTracei | P10648 |
PROi | PR:P10648 |
RNActi | P10648, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000057933, Expressed in adult mammalian kidney and 153 other tissues |
ExpressionAtlasi | P10648, baseline and differential |
Genevisiblei | P10648, MM |
Family and domain databases
InterProi | View protein in InterPro IPR010987, Glutathione-S-Trfase_C-like IPR036282, Glutathione-S-Trfase_C_sf IPR040079, Glutathione_S-Trfase IPR004045, Glutathione_S-Trfase_N IPR003080, GST_alpha IPR004046, GST_C IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF00043, GST_C, 1 hit PF02798, GST_N, 1 hit |
PRINTSi | PR01266, GSTRNSFRASEA |
SFLDi | SFLDS00019, Glutathione_Transferase_(cytos, 1 hit |
SUPFAMi | SSF47616, SSF47616, 1 hit SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS50405, GST_CTER, 1 hit PS50404, GST_NTER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GSTA2_MOUSE | |
Accessioni | P10648Primary (citable) accession number: P10648 Secondary accession number(s): Q6P8Q1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | October 3, 2012 | |
Last modified: | February 23, 2022 | |
This is version 165 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families