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Entry version 228 (16 Oct 2019)
Sequence version 1 (01 Jul 1989)
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Protein

Tissue factor pathway inhibitor

Gene

TFPI

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei64 – 65Reactive bond2
Sitei135 – 136Reactive bond2
Sitei227 – 228Reactive bond2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
Biological processBlood coagulation, Hemostasis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-140834 Extrinsic Pathway of Fibrin Clot Formation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P10646

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I02.950

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tissue factor pathway inhibitor
Short name:
TFPI
Alternative name(s):
Extrinsic pathway inhibitor
Short name:
EPI
Lipoprotein-associated coagulation inhibitor
Short name:
LACI
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TFPI
Synonyms:LACI, TFPI1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11760 TFPI

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
152310 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P10646

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi64K → I: Abolishes inhibition of VII(a)/TF. 1
Mutagenesisi135R → L: Abolishes inhibition of X(a). 1
Mutagenesisi227R → L: Abolishes inhibition of VII(a)/TF. 1

Organism-specific databases

DisGeNET

More...
DisGeNETi
7035

Open Targets

More...
OpenTargetsi
ENSG00000003436

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36475

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P10646

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3713062

Drug and drug target database

More...
DrugBanki
DB14562 Andexanet alfa
DB00036 Coagulation factor VIIa Recombinant Human
DB06779 Dalteparin

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TFPI

Domain mapping of disease mutations (DMDM)

More...
DMDMi
125932

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 283 PublicationsAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001687129 – 304Tissue factor pathway inhibitor1 PublicationAdd BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi42O-linked (GalNAc...) threonine; partial1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi54 ↔ 104PROSITE-ProRule annotation
Disulfide bondi63 ↔ 87PROSITE-ProRule annotation
Disulfide bondi79 ↔ 100PROSITE-ProRule annotation
Disulfide bondi125 ↔ 175
Disulfide bondi134 ↔ 158
Glycosylationi145N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi150 ↔ 171
Glycosylationi195N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi202O-linked (GalNAc...) serine; partial2 Publications1
Glycosylationi203O-linked (GalNAc...) threonine2 Publications1
Disulfide bondi217 ↔ 267
Disulfide bondi226 ↔ 250
Disulfide bondi242 ↔ 263

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei256Not glycosylated1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
non-CPTAC-1163

Encyclopedia of Proteome Dynamics

More...
EPDi
P10646

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P10646

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P10646

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P10646

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P10646

PeptideAtlas

More...
PeptideAtlasi
P10646

PRoteomics IDEntifications database

More...
PRIDEi
P10646

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
52636 [P10646-1]
52637 [P10646-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
602

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P10646

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P10646

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P10646

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P10646

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mostly in endothelial cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000003436 Expressed in 200 organ(s), highest expression level in placenta

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P10646 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P10646 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB020842
HPA005575

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112893, 13 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P10646

Protein interaction database and analysis system

More...
IntActi
P10646, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000233156

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1304
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P10646

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P10646

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 104BPTI/Kunitz inhibitor 1PROSITE-ProRule annotationAdd BLAST51
Domaini125 – 175BPTI/Kunitz inhibitor 2PROSITE-ProRule annotationAdd BLAST51
Domaini217 – 267BPTI/Kunitz inhibitor 3PROSITE-ProRule annotationAdd BLAST51

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4295 Eukaryota
ENOG410XQNP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160767

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231818

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P10646

KEGG Orthology (KO)

More...
KOi
K03909

Identification of Orthologs from Complete Genome Data

More...
OMAi
EFYGPSW

Database of Orthologous Groups

More...
OrthoDBi
1009074at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P10646

TreeFam database of animal gene trees

More...
TreeFami
TF315349

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00109 KU, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.410.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR020901 Prtase_inh_Kunz-CS
IPR008296 TFPI-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00014 Kunitz_BPTI, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001620 TFPI, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00759 BASICPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00131 KU, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57362 SSF57362, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00280 BPTI_KUNITZ_1, 3 hits
PS50279 BPTI_KUNITZ_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform Alpha (identifier: P10646-1) [UniParc]FASTAAdd to basket
Also known as: TFPIalpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIYTMKKVHA LWASVCLLLN LAPAPLNADS EEDEEHTIIT DTELPPLKLM
60 70 80 90 100
HSFCAFKADD GPCKAIMKRF FFNIFTRQCE EFIYGGCEGN QNRFESLEEC
110 120 130 140 150
KKMCTRDNAN RIIKTTLQQE KPDFCFLEED PGICRGYITR YFYNNQTKQC
160 170 180 190 200
ERFKYGGCLG NMNNFETLEE CKNICEDGPN GFQVDNYGTQ LNAVNNSLTP
210 220 230 240 250
QSTKVPSLFE FHGPSWCLTP ADRGLCRANE NRFYYNSVIG KCRPFKYSGC
260 270 280 290 300
GGNENNFTSK QECLRACKKG FIQRISKGGL IKTKRKRKKQ RVKIAYEEIF

VKNM
Length:304
Mass (Da):35,015
Last modified:July 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5281E32B758B44FE
GO
Isoform Beta (identifier: P10646-2) [UniParc]FASTAAdd to basket
Also known as: TFPIbeta

The sequence of this isoform differs from the canonical sequence as follows:
     210-251: EFHGPSWCLT...CRPFKYSGCG → VTKEGTNDGW...LGLDSISCLC
     252-304: Missing.

Note: GPI-anchored.
Show »
Length:251
Mass (Da):28,653
Checksum:i9B3F276A52B4F0B9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JKV3C9JKV3_HUMAN
Tissue factor pathway inhibitor
TFPI
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQ14C9JQ14_HUMAN
Tissue factor pathway inhibitor
TFPI
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JT76C9JT76_HUMAN
Tissue factor pathway inhibitor
TFPI
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J103C9J103_HUMAN
Tissue factor pathway inhibitor
TFPI
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JP39C9JP39_HUMAN
Tissue factor pathway inhibitor
TFPI
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_012004292V → M1 PublicationCorresponds to variant dbSNP:rs5940Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003030210 – 251EFHGP…YSGCG → VTKEGTNDGWKNAAHIYQVF LNAFCIHASMFFLGLDSISC LC in isoform Beta. 2 PublicationsAdd BLAST42
Alternative sequenceiVSP_003031252 – 304Missing in isoform Beta. 2 PublicationsAdd BLAST53

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J03225 mRNA Translation: AAA52022.1
M58650
, M58644, M58645, M58646, M58647, M58648, M58649 Genomic DNA Translation: AAA59480.1
M59499
, M59493, M59494, M59495, M59496, M59497, M59498 Genomic DNA Translation: AAA59526.1
AF021834 mRNA Translation: AAD01700.1
AY263365 Genomic DNA Translation: AAO89075.1
AC007319 Genomic DNA Translation: AAY14807.1
CH471058 Genomic DNA Translation: EAX10921.1
CH471058 Genomic DNA Translation: EAX10922.1
BC015514 mRNA Translation: AAH15514.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS2294.1 [P10646-1]
CCDS33349.1 [P10646-2]

Protein sequence database of the Protein Information Resource

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PIRi
A23712 TIHUGK

NCBI Reference Sequences

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RefSeqi
NP_001027452.1, NM_001032281.3 [P10646-2]
NP_001305870.1, NM_001318941.2 [P10646-2]
NP_001316168.1, NM_001329239.1 [P10646-1]
NP_001316169.1, NM_001329240.1 [P10646-1]
NP_001316170.1, NM_001329241.1 [P10646-1]
NP_006278.1, NM_006287.5 [P10646-1]
XP_005246876.1, XM_005246819.1
XP_006712783.1, XM_006712720.3 [P10646-1]
XP_011510011.1, XM_011511709.2 [P10646-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000233156; ENSP00000233156; ENSG00000003436 [P10646-1]
ENST00000339091; ENSP00000342306; ENSG00000003436 [P10646-2]
ENST00000392365; ENSP00000376172; ENSG00000003436 [P10646-1]
ENST00000409676; ENSP00000386344; ENSG00000003436 [P10646-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7035

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7035

UCSC genome browser

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UCSCi
uc002upy.4 human [P10646-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

TFPI entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03225 mRNA Translation: AAA52022.1
M58650
, M58644, M58645, M58646, M58647, M58648, M58649 Genomic DNA Translation: AAA59480.1
M59499
, M59493, M59494, M59495, M59496, M59497, M59498 Genomic DNA Translation: AAA59526.1
AF021834 mRNA Translation: AAD01700.1
AY263365 Genomic DNA Translation: AAO89075.1
AC007319 Genomic DNA Translation: AAY14807.1
CH471058 Genomic DNA Translation: EAX10921.1
CH471058 Genomic DNA Translation: EAX10922.1
BC015514 mRNA Translation: AAH15514.1
CCDSiCCDS2294.1 [P10646-1]
CCDS33349.1 [P10646-2]
PIRiA23712 TIHUGK
RefSeqiNP_001027452.1, NM_001032281.3 [P10646-2]
NP_001305870.1, NM_001318941.2 [P10646-2]
NP_001316168.1, NM_001329239.1 [P10646-1]
NP_001316169.1, NM_001329240.1 [P10646-1]
NP_001316170.1, NM_001329241.1 [P10646-1]
NP_006278.1, NM_006287.5 [P10646-1]
XP_005246876.1, XM_005246819.1
XP_006712783.1, XM_006712720.3 [P10646-1]
XP_011510011.1, XM_011511709.2 [P10646-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ADZNMR-A118-182[»]
1IRHNMR-A210-270[»]
1TFXX-ray2.60C/D121-178[»]
4BQDX-ray2.48A/B29-107[»]
4DTGX-ray1.80K119-178[»]
5NMVX-ray1.65K29-107[»]
6BX8X-ray1.98B/D/F/H50-107[»]
SMRiP10646
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi112893, 13 interactors
CORUMiP10646
IntActiP10646, 1 interactor
STRINGi9606.ENSP00000233156

Chemistry databases

ChEMBLiCHEMBL3713062
DrugBankiDB14562 Andexanet alfa
DB00036 Coagulation factor VIIa Recombinant Human
DB06779 Dalteparin

Protein family/group databases

MEROPSiI02.950

PTM databases

GlyConnecti602
iPTMnetiP10646
PhosphoSitePlusiP10646
UniCarbKBiP10646

Polymorphism and mutation databases

BioMutaiTFPI
DMDMi125932

Proteomic databases

CPTACinon-CPTAC-1163
EPDiP10646
jPOSTiP10646
MassIVEiP10646
MaxQBiP10646
PaxDbiP10646
PeptideAtlasiP10646
PRIDEiP10646
ProteomicsDBi52636 [P10646-1]
52637 [P10646-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
P10646

The DNASU plasmid repository

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DNASUi
7035

Genome annotation databases

EnsembliENST00000233156; ENSP00000233156; ENSG00000003436 [P10646-1]
ENST00000339091; ENSP00000342306; ENSG00000003436 [P10646-2]
ENST00000392365; ENSP00000376172; ENSG00000003436 [P10646-1]
ENST00000409676; ENSP00000386344; ENSG00000003436 [P10646-2]
GeneIDi7035
KEGGihsa:7035
UCSCiuc002upy.4 human [P10646-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7035
DisGeNETi7035

GeneCards: human genes, protein and diseases

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GeneCardsi
TFPI
HGNCiHGNC:11760 TFPI
HPAiCAB020842
HPA005575
MIMi152310 gene
neXtProtiNX_P10646
OpenTargetsiENSG00000003436
PharmGKBiPA36475

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4295 Eukaryota
ENOG410XQNP LUCA
GeneTreeiENSGT00940000160767
HOGENOMiHOG000231818
InParanoidiP10646
KOiK03909
OMAiEFYGPSW
OrthoDBi1009074at2759
PhylomeDBiP10646
TreeFamiTF315349

Enzyme and pathway databases

ReactomeiR-HSA-140834 Extrinsic Pathway of Fibrin Clot Formation
SIGNORiP10646

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TFPI human
EvolutionaryTraceiP10646

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Tissue_factor_pathway_inhibitor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7035
PharosiP10646
PMAP-CutDBiP10646

Protein Ontology

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PROi
PR:P10646

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000003436 Expressed in 200 organ(s), highest expression level in placenta
ExpressionAtlasiP10646 baseline and differential
GenevisibleiP10646 HS

Family and domain databases

CDDicd00109 KU, 3 hits
Gene3Di4.10.410.10, 3 hits
InterProiView protein in InterPro
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR020901 Prtase_inh_Kunz-CS
IPR008296 TFPI-like
PfamiView protein in Pfam
PF00014 Kunitz_BPTI, 3 hits
PIRSFiPIRSF001620 TFPI, 1 hit
PRINTSiPR00759 BASICPTASE
SMARTiView protein in SMART
SM00131 KU, 3 hits
SUPFAMiSSF57362 SSF57362, 3 hits
PROSITEiView protein in PROSITE
PS00280 BPTI_KUNITZ_1, 3 hits
PS50279 BPTI_KUNITZ_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTFPI1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10646
Secondary accession number(s): O95103, Q53TS4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 16, 2019
This is version 228 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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