UniProtKB - P10645 (CMGA_HUMAN)
Chromogranin-A
CHGA
Functioni
Strongly inhibits glucose induced insulin release from the pancreas.
Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220).
Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172 and PubMed:24723458).
Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543).
Acts as a potent scavenger of free radicals in vitro (PubMed:24723458).
May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522).
1 Publication4 PublicationsRegulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.
By similarityMiscellaneous
GO - Biological processi
- adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation Source: BHF-UCL
- defense response to bacterium Source: GO_Central
- defense response to fungus Source: UniProtKB-KW
- defense response to Gram-negative bacterium Source: UniProtKB
- defense response to Gram-positive bacterium Source: UniProtKB
- innate immune response Source: UniProtKB
- killing of cells of another organism Source: UniProtKB-KW
- mast cell activation Source: UniProtKB
- mast cell chemotaxis Source: UniProtKB
- mast cell degranulation Source: UniProtKB
- negative regulation of catecholamine secretion Source: UniProtKB
- negative regulation of insulin secretion Source: GO_Central
- negative regulation of neuron death Source: BHF-UCL
- organelle organization Source: BHF-UCL
- positive regulation of cardiac muscle contraction Source: BHF-UCL
- positive regulation of dense core granule biogenesis Source: UniProtKB
- positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
- positive regulation of relaxation of cardiac muscle Source: BHF-UCL
- protein localization to secretory granule Source: Ensembl
- regulation of blood pressure Source: ProtInc
- regulation of the force of heart contraction Source: BHF-UCL
Keywordsi
Molecular function | Antibiotic, Antimicrobial, Fungicide |
Ligand | Calcium |
Enzyme and pathway databases
PathwayCommonsi | P10645 |
Reactomei | R-HSA-6803157, Antimicrobial peptides |
SignaLinki | P10645 |
SIGNORi | P10645 |
Names & Taxonomyi
Protein namesi | Recommended name: Chromogranin-AShort name: CgA Alternative name(s): Pituitary secretory protein I Short name: SP-I Cleaved into the following 18 chains: Alternative name(s): Vasostatin I Alternative name(s): Vasostatin II Catestatin2 Publications Alternative name(s): SL211 Publication GE-251 Publication |
Gene namesi | Name:CHGA |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1929, CHGA |
MIMi | 118910, gene |
neXtProti | NX_P10645 |
VEuPathDBi | HostDB:ENSG00000100604 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Other locations
- secretory vesicle By similarity
Note: Pyroglutaminated serpinin localizes to secretory vesicle.By similarity
Extracellular region or secreted
- Secreted By similarity
Other locations
- secretory vesicle By similarity
- neuronal dense core vesicle By similarity
Note: Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions. In pituitary gonadotropes, located in large secretory granules.By similarity
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: BHF-UCL
Other locations
- chromaffin granule Source: BHF-UCL
- neuronal dense core vesicle Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB
- secretory granule Source: BHF-UCL
- transport vesicle Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasmic vesicle, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 1113 |
OpenTargetsi | ENSG00000100604 |
PharmGKBi | PA26461 |
Miscellaneous databases
Pharosi | P10645, Tbio |
Genetic variation databases
BioMutai | CHGA |
DMDMi | 215274270 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | 2 PublicationsAdd BLAST | 18 | |
ChainiPRO_0000005408 | 19 – 457 | Chromogranin-AAdd BLAST | 439 | |
PeptideiPRO_0000005409 | 19 – 131 | Vasostatin-21 PublicationAdd BLAST | 113 | |
PeptideiPRO_0000005410 | 19 – 94 | Vasostatin-11 PublicationAdd BLAST | 76 | |
PeptideiPRO_0000005411 | 134 – 225 | EA-921 PublicationAdd BLAST | 92 | |
PeptideiPRO_0000005412 | 228 – 260 | ES-431 PublicationAdd BLAST | 33 | |
PeptideiPRO_0000005413 | 272 – 319 | Pancreastatin1 PublicationAdd BLAST | 48 | |
PeptideiPRO_0000005414 | 322 – 339 | SS-181 PublicationAdd BLAST | 18 | |
PeptideiPRO_0000005415 | 342 – 355 | WE-141 PublicationAdd BLAST | 14 | |
PeptideiPRO_0000005416 | 342 – 349 | WA-81 Publication | 8 | |
PeptideiPRO_0000005417 | 358 – 376 | LF-191 PublicationAdd BLAST | 19 | |
PeptideiPRO_0000432682 | 370 – 390 | Catestatin1 PublicationAdd BLAST | 21 | |
PeptideiPRO_0000005418 | 380 – 390 | AL-111 PublicationAdd BLAST | 11 | |
PeptideiPRO_0000432683 | 393 – 417 | GE-251 PublicationAdd BLAST | 25 | |
PeptideiPRO_0000005419 | 393 – 411 | GV-191 PublicationAdd BLAST | 19 | |
PeptideiPRO_0000005420 | 413 – 456 | GR-441 PublicationAdd BLAST | 44 | |
PeptideiPRO_0000005421 | 420 – 456 | ER-371 PublicationAdd BLAST | 37 | |
PeptideiPRO_0000432684 | 429 – 457 | Serpinin-RRGBy similarityAdd BLAST | 29 | |
PeptideiPRO_0000432685 | 429 – 454 | SerpininBy similarityAdd BLAST | 26 | |
PeptideiPRO_0000432686 | 432 – 454 | p-Glu serpinin precursorBy similarityAdd BLAST | 23 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 35 ↔ 56 | 1 Publication | ||
Modified residuei | 142 | PhosphoserineBy similarity | 1 | |
GlycosylationiCAR_000116 | 181 | O-linked (GalNAc...) threonine1 Publication | 1 | |
GlycosylationiCAR_000117 | 183 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Modified residuei | 194 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 203 | PhosphoserineCombined sources | 1 | |
Modified residuei | 218 | Phosphoserine1 Publication | 1 | |
GlycosylationiCAR_000118 | 251 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Modified residuei | 270 | Phosphoserine1 Publication | 1 | |
Modified residuei | 300 | PhosphoserineCombined sources | 1 | |
Modified residuei | 319 | Glycine amide2 Publications | 1 | |
Modified residuei | 322 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 333 | Phosphoserine1 Publication | 1 | |
Modified residuei | 371 | PhosphoserineBy similarity | 1 | |
Modified residuei | 372 | Methionine sulfoxide1 Publication | 1 | |
Modified residuei | 398 | PhosphoserineBy similarity | 1 | |
Modified residuei | 402 | PhosphoserineCombined sources | 1 | |
Modified residuei | 424 | PhosphoserineBy similarity | 1 | |
Modified residuei | 438 | PhosphoserineBy similarity | 1 | |
Modified residuei | 456 | Arginine amide1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Oxidation, Phosphoprotein, SulfationProteomic databases
EPDi | P10645 |
jPOSTi | P10645 |
MassIVEi | P10645 |
PaxDbi | P10645 |
PeptideAtlasi | P10645 |
PRIDEi | P10645 |
ProteomicsDBi | 52635 |
TopDownProteomicsi | P10645 |
PTM databases
GlyConnecti | 93, 4 O-Linked glycans (3 sites) |
GlyGeni | P10645, 5 sites, 8 O-linked glycans (5 sites) |
iPTMneti | P10645 |
PhosphoSitePlusi | P10645 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000100604, Expressed in type B pancreatic cell and 170 other tissues |
ExpressionAtlasi | P10645, baseline and differential |
Genevisiblei | P10645, HS |
Organism-specific databases
HPAi | ENSG00000100604, Tissue enriched (parathyroid) |
Interactioni
Subunit structurei
Interacts with SCG3.
By similarityProtein-protein interaction databases
BioGRIDi | 107538, 18 interactors |
IntActi | P10645, 7 interactors |
MINTi | P10645 |
STRINGi | 9606.ENSP00000216492 |
Miscellaneous databases
RNActi | P10645, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P10645 |
BMRBi | P10645 |
SMRi | P10645 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P10645 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 41 – 59 | O-glycosylated at one site only in cerebrospinal fluidAdd BLAST | 19 | |
Regioni | 88 – 440 | DisorderedSequence analysisAdd BLAST | 353 | |
Regioni | 181 – 191 | O-glycosylated at one site only in cerebrospinal fluidAdd BLAST | 11 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 88 – 104 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 105 – 119 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 120 – 145 | Basic and acidic residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 227 – 245 | Acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 285 – 311 | Basic and acidic residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 322 – 373 | Basic and acidic residuesSequence analysisAdd BLAST | 52 | |
Compositional biasi | 413 – 440 | Basic and acidic residuesSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502RZBD, Eukaryota |
GeneTreei | ENSGT00940000154206 |
InParanoidi | P10645 |
OMAi | NHIGKNF |
OrthoDBi | 1127088at2759 |
PhylomeDBi | P10645 |
TreeFami | TF336596 |
Family and domain databases
InterProi | View protein in InterPro IPR001819, Chromogranin_AB IPR018054, Chromogranin_CS IPR001990, Granin |
PANTHERi | PTHR10583, PTHR10583, 1 hit |
Pfami | View protein in Pfam PF01271, Granin, 2 hits |
PRINTSi | PR00659, CHROMOGRANIN |
PROSITEi | View protein in PROSITE PS00422, GRANINS_1, 1 hit PS00423, GRANINS_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MRSAAVLALL LCAGQVTALP VNSPMNKGDT EVMKCIVEVI SDTLSKPSPM
60 70 80 90 100
PVSQECFETL RGDERILSIL RHQNLLKELQ DLALQGAKER AHQQKKHSGF
110 120 130 140 150
EDELSEVLEN QSSQAELKEA VEEPSSKDVM EKREDSKEAE KSGEATDGAR
160 170 180 190 200
PQALPEPMQE SKAEGNNQAP GEEEEEEEEA TNTHPPASLP SQKYPGPQAE
210 220 230 240 250
GDSEGLSQGL VDREKGLSAE PGWQAKREEE EEEEEEAEAG EEAVPEEEGP
260 270 280 290 300
TVVLNPHPSL GYKEIRKGES RSEALAVDGA GKPGAEEAQD PEGKGEQEHS
310 320 330 340 350
QQKEEEEEMA VVPQGLFRGG KSGELEQEEE RLSKEWEDSK RWSKMDQLAK
360 370 380 390 400
ELTAEKRLEG QEEEEDNRDS SMKLSFRARA YGFRGPGPQL RRGWRPSSRE
410 420 430 440 450
DSLEAGLPLQ VRGYPEEKKE EEGSANRRPE DQELESLSAI EAELEKVAHQ
LQALRRG
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG5E968 | G5E968_HUMAN | Chromogranin A (Parathyroid secreto... | CHGA hCG_21274 | 306 | Annotation score: | ||
G3V2Q7 | G3V2Q7_HUMAN | Chromogranin-A | CHGA | 38 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 41 | S → Y in AAA52018 (PubMed:2445752).Curated | 1 | |
Sequence conflicti | 54 | Q → K in AAA52018 (PubMed:2445752).Curated | 1 | |
Sequence conflicti | 87 | A → R in AAA52018 (PubMed:2445752).Curated | 1 | |
Sequence conflicti | 119 | E → Q in AAA52018 (PubMed:2445752).Curated | 1 | |
Sequence conflicti | 167 | N → K in AAA52018 (PubMed:2445752).Curated | 1 | |
Sequence conflicti | 200 | E → K in AAA52018 (PubMed:2445752).Curated | 1 | |
Sequence conflicti | 219 | A → V in AAA52018 (PubMed:2445752).Curated | 1 | |
Sequence conflicti | 339 – 340 | SK → TN in AAA52018 (PubMed:2445752).Curated | 2 | |
Sequence conflicti | 370 | S → R in AAA52018 (PubMed:2445752).Curated | 1 | |
Sequence conflicti | 373 | K → R in AAA52018 (PubMed:2445752).Curated | 1 | |
Sequence conflicti | 380 | A → G in AAA52018 (PubMed:2445752).Curated | 1 | |
Sequence conflicti | 394 | W → S in AAA52018 (PubMed:2445752).Curated | 1 | |
Sequence conflicti | 397 | S → N in AAA52018 (PubMed:2445752).Curated | 1 | |
Sequence conflicti | 416 | E → Q in AAA52018 (PubMed:2445752).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047417 | 61 | R → Q. Corresponds to variant dbSNP:rs3742712Ensembl. | 1 | |
Natural variantiVAR_025636 | 176 | E → K. Corresponds to variant dbSNP:rs9658654Ensembl. | 1 | |
Natural variantiVAR_025637 | 264 | E → D1 PublicationCorresponds to variant dbSNP:rs9658655Ensembl. | 1 | |
Natural variantiVAR_025638 | 271 | R → W. Corresponds to variant dbSNP:rs9658662Ensembl. | 1 | |
Natural variantiVAR_025639 | 274 | A → G. Corresponds to variant dbSNP:rs9658663Ensembl. | 1 | |
Natural variantiVAR_025640 | 315 | G → S. Corresponds to variant dbSNP:rs9658664Ensembl. | 1 | |
Natural variantiVAR_025641 | 332 | L → P. Corresponds to variant dbSNP:rs9658665Ensembl. | 1 | |
Natural variantiVAR_025642 | 369 | D → N. Corresponds to variant dbSNP:rs2228575Ensembl. | 1 | |
Natural variantiVAR_025643 | 382 | G → S May be associated with a reduced risk for hypertension especially in men; reduces activity 4.7 fold; no effect on plasmin-mediated proteolytic processing; increase in ability to inhibit nicotine-evoked catecholamine secretion in vitro; displays alterations in baroreceptor function. 4 PublicationsCorresponds to variant dbSNP:rs9658667Ensembl. | 1 | |
Natural variantiVAR_025644 | 388 | P → L Increases activity 2.3 fold; decrease in plasmin-mediated proteolytic processing; decrease in ability to inhibit nicotine-evoked catecholamine secretion in vitro. 3 PublicationsCorresponds to variant dbSNP:rs9658668Ensembl. | 1 | |
Natural variantiVAR_072687 | 392 | R → Q No effect on plasmin-mediated proteolytic processing; decrease in ability to inhibit nicotine-evoked catecholamine secretion in vitro. 2 PublicationsCorresponds to variant dbSNP:rs9658669Ensembl. | 1 | |
Natural variantiVAR_025645 | 399 | R → W3 PublicationsCorresponds to variant dbSNP:rs729940Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03483 mRNA Translation: AAA52017.1 J03915 mRNA Translation: AAA52018.1 U03749 , U03742, U03743, U03744, U03748, U03745, U03746, U03747 Genomic DNA Translation: AAB53685.1 BT006869 mRNA Translation: AAP35515.1 AK223381 mRNA Translation: BAD97101.1 AL117192 Genomic DNA No translation available. AK313757 mRNA Translation: BAG36496.1 CH471061 Genomic DNA Translation: EAW81505.1 BC001059 mRNA Translation: AAH01059.1 BC006459 mRNA Translation: AAH06459.1 BC009384 mRNA Translation: AAH09384.2 BC012755 mRNA Translation: AAH12755.2 |
CCDSi | CCDS9906.1 |
PIRi | A54376, A28468 |
RefSeqi | NP_001266.1, NM_001275.3 NP_001288619.1, NM_001301690.1 XP_011534672.1, XM_011536370.1 |
Genome annotation databases
Ensembli | ENST00000216492.10; ENSP00000216492.5; ENSG00000100604.13 ENST00000613166.3; ENSP00000478198.1; ENSG00000276781.3 |
GeneIDi | 1113 |
KEGGi | hsa:1113 |
MANE-Selecti | ENST00000216492.10; ENSP00000216492.5; NM_001275.4; NP_001266.1 |
UCSCi | uc001ybc.6, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03483 mRNA Translation: AAA52017.1 J03915 mRNA Translation: AAA52018.1 U03749 , U03742, U03743, U03744, U03748, U03745, U03746, U03747 Genomic DNA Translation: AAB53685.1 BT006869 mRNA Translation: AAP35515.1 AK223381 mRNA Translation: BAD97101.1 AL117192 Genomic DNA No translation available. AK313757 mRNA Translation: BAG36496.1 CH471061 Genomic DNA Translation: EAW81505.1 BC001059 mRNA Translation: AAH01059.1 BC006459 mRNA Translation: AAH06459.1 BC009384 mRNA Translation: AAH09384.2 BC012755 mRNA Translation: AAH12755.2 |
CCDSi | CCDS9906.1 |
PIRi | A54376, A28468 |
RefSeqi | NP_001266.1, NM_001275.3 NP_001288619.1, NM_001301690.1 XP_011534672.1, XM_011536370.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1LV4 | NMR | - | A | 370-390 | [»] | |
6R2X | NMR | - | A | 57-81 | [»] | |
AlphaFoldDBi | P10645 | |||||
BMRBi | P10645 | |||||
SMRi | P10645 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107538, 18 interactors |
IntActi | P10645, 7 interactors |
MINTi | P10645 |
STRINGi | 9606.ENSP00000216492 |
PTM databases
GlyConnecti | 93, 4 O-Linked glycans (3 sites) |
GlyGeni | P10645, 5 sites, 8 O-linked glycans (5 sites) |
iPTMneti | P10645 |
PhosphoSitePlusi | P10645 |
Genetic variation databases
BioMutai | CHGA |
DMDMi | 215274270 |
Proteomic databases
EPDi | P10645 |
jPOSTi | P10645 |
MassIVEi | P10645 |
PaxDbi | P10645 |
PeptideAtlasi | P10645 |
PRIDEi | P10645 |
ProteomicsDBi | 52635 |
TopDownProteomicsi | P10645 |
Protocols and materials databases
Antibodypediai | 738, 2897 antibodies from 51 providers |
CPTCi | P10645, 3 antibodies |
DNASUi | 1113 |
Genome annotation databases
Ensembli | ENST00000216492.10; ENSP00000216492.5; ENSG00000100604.13 ENST00000613166.3; ENSP00000478198.1; ENSG00000276781.3 |
GeneIDi | 1113 |
KEGGi | hsa:1113 |
MANE-Selecti | ENST00000216492.10; ENSP00000216492.5; NM_001275.4; NP_001266.1 |
UCSCi | uc001ybc.6, human |
Organism-specific databases
CTDi | 1113 |
DisGeNETi | 1113 |
GeneCardsi | CHGA |
HGNCi | HGNC:1929, CHGA |
HPAi | ENSG00000100604, Tissue enriched (parathyroid) |
MIMi | 118910, gene |
neXtProti | NX_P10645 |
OpenTargetsi | ENSG00000100604 |
PharmGKBi | PA26461 |
VEuPathDBi | HostDB:ENSG00000100604 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RZBD, Eukaryota |
GeneTreei | ENSGT00940000154206 |
InParanoidi | P10645 |
OMAi | NHIGKNF |
OrthoDBi | 1127088at2759 |
PhylomeDBi | P10645 |
TreeFami | TF336596 |
Enzyme and pathway databases
PathwayCommonsi | P10645 |
Reactomei | R-HSA-6803157, Antimicrobial peptides |
SignaLinki | P10645 |
SIGNORi | P10645 |
Miscellaneous databases
BioGRID-ORCSi | 1113, 177 hits in 1067 CRISPR screens |
ChiTaRSi | CHGA, human |
EvolutionaryTracei | P10645 |
GeneWikii | Chromogranin_A |
GenomeRNAii | 1113 |
Pharosi | P10645, Tbio |
PROi | PR:P10645 |
RNActi | P10645, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100604, Expressed in type B pancreatic cell and 170 other tissues |
ExpressionAtlasi | P10645, baseline and differential |
Genevisiblei | P10645, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001819, Chromogranin_AB IPR018054, Chromogranin_CS IPR001990, Granin |
PANTHERi | PTHR10583, PTHR10583, 1 hit |
Pfami | View protein in Pfam PF01271, Granin, 2 hits |
PRINTSi | PR00659, CHROMOGRANIN |
PROSITEi | View protein in PROSITE PS00422, GRANINS_1, 1 hit PS00423, GRANINS_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CMGA_HUMAN | |
Accessioni | P10645Primary (citable) accession number: P10645 Secondary accession number(s): B2R9E9 Q9BQB5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | November 25, 2008 | |
Last modified: | May 25, 2022 | |
This is version 216 of the entry and version 7 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families