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UniProtKB - P10645 (CMGA_HUMAN)

Entry version 207 (17 Jun 2020)
Sequence version 7 (25 Nov 2008)
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Protein

Chromogranin-A

Gene

CHGA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Strongly inhibits glucose induced insulin release from the pancreas.
Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172 and PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522).1 Publication4 Publications
Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.By similarity

Miscellaneous

Binds calcium with a low-affinity.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntibiotic, Antimicrobial, Fungicide
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6803157 Antimicrobial peptides

SIGNOR Signaling Network Open Resource

More...SIGNORi		P10645

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chromogranin-A
Short name:
CgA
Alternative name(s):
Pituitary secretory protein I
Short name:
SP-I
Cleaved into the following 18 chains:
Vasostatin-1
Alternative name(s):
Vasostatin I
Vasostatin-2
Alternative name(s):
Vasostatin II
EA-92
ES-43
Pancreastatin
SS-18
WA-8
WE-14
LF-19
Catestatin2 Publications
Alternative name(s):
SL211 Publication
AL-11
GV-19
GR-44
ER-37
GE-251 Publication
Serpinin-RRG
Serpinin
p-Glu serpinin precursor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHGA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000100604.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:1929 CHGA

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		118910 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P10645

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1113

Open Targets

More...OpenTargetsi		ENSG00000100604

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26461

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P10645 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CHGA

Domain mapping of disease mutations (DMDM)

More...DMDMi		215274270

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 182 PublicationsAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000540819 – 457Chromogranin-AAdd BLAST439
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000000540919 – 131Vasostatin-21 PublicationAdd BLAST113
PeptideiPRO_000000541019 – 94Vasostatin-11 PublicationAdd BLAST76
PeptideiPRO_0000005411134 – 225EA-921 PublicationAdd BLAST92
PeptideiPRO_0000005412228 – 260ES-431 PublicationAdd BLAST33
PeptideiPRO_0000005413272 – 319Pancreastatin1 PublicationAdd BLAST48
PeptideiPRO_0000005414322 – 339SS-181 PublicationAdd BLAST18
PeptideiPRO_0000005415342 – 355WE-141 PublicationAdd BLAST14
PeptideiPRO_0000005416342 – 349WA-81 Publication8
PeptideiPRO_0000005417358 – 376LF-191 PublicationAdd BLAST19
PeptideiPRO_0000432682370 – 390Catestatin1 PublicationAdd BLAST21
PeptideiPRO_0000005418380 – 390AL-111 PublicationAdd BLAST11
PeptideiPRO_0000432683393 – 417GE-251 PublicationAdd BLAST25
PeptideiPRO_0000005419393 – 411GV-191 PublicationAdd BLAST19
PeptideiPRO_0000005420413 – 456GR-441 PublicationAdd BLAST44
PeptideiPRO_0000005421420 – 456ER-371 PublicationAdd BLAST37
PeptideiPRO_0000432684429 – 457Serpinin-RRGBy similarityAdd BLAST29
PeptideiPRO_0000432685429 – 454SerpininBy similarityAdd BLAST26
PeptideiPRO_0000432686432 – 454p-Glu serpinin precursorBy similarityAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi35 ↔ 561 Publication
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei142PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>GlycosylationiCAR_000116181O-linked (GalNAc...) threonine1 Publication1
GlycosylationiCAR_000117183O-linked (GalNAc...) threonine1 Publication1
Modified residuei194PhosphotyrosineBy similarity1
Modified residuei203PhosphoserineCombined sources1
Modified residuei218Phosphoserine1 Publication1
GlycosylationiCAR_000118251O-linked (GalNAc...) threonine1 Publication1
Modified residuei270Phosphoserine1 Publication1
Modified residuei300PhosphoserineCombined sources1
Modified residuei319Glycine amide2 Publications1
Modified residuei322PhosphoserineCombined sources1 Publication1
Modified residuei333Phosphoserine1 Publication1
Modified residuei371PhosphoserineBy similarity1
Modified residuei372Methionine sulfoxide1 Publication1
Modified residuei398PhosphoserineBy similarity1
Modified residuei402PhosphoserineCombined sources1
Modified residuei424PhosphoserineBy similarity1
Modified residuei438PhosphoserineBy similarity1
Modified residuei456Arginine amide1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sulfated on tyrosine residues and/or contains sulfated glycans.
O-glycosylated with core 1 or possibly core 8 glycans.3 Publications
Proteolytic processing gives rise to an additional longer form of catestatin (residues 358-390) which displays a less potent catecholamine release-inhibitory activity (PubMed:10781584). Plasmin-mediated proteolytic processing can give rise to additional shorter and longer forms of catestatin peptides (PubMed:17991725).2 Publications

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Oxidation, Phosphoprotein, Sulfation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P10645

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P10645

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P10645

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P10645

PeptideAtlas

More...PeptideAtlasi		P10645

PRoteomics IDEntifications database

More...PRIDEi		P10645

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52635

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P10645

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		93

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P10645

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P10645

UniCarbKB; an annotated and curated database of glycan structures

More...UniCarbKBi		P10645

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

GE-25 is found in the brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100604 Expressed in type B pancreatic cell and 150 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P10645 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P10645 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000100604 Tissue enriched (parathyroid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SCG3.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107538, 12 interactors

Protein interaction database and analysis system

More...IntActi		P10645, 7 interactors

Molecular INTeraction database

More...MINTi		P10645

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000216492

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P10645 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1457
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P10645

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P10645

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni41 – 59O-glycosylated at one site only in cerebrospinal fluidAdd BLAST19
Regioni181 – 191O-glycosylated at one site only in cerebrospinal fluidAdd BLAST11

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the chromogranin/secretogranin protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410II3Z Eukaryota
ENOG410YGBX LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154206

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P10645

KEGG Orthology (KO)

More...KOi		K19990

Identification of Orthologs from Complete Genome Data

More...OMAi		NSPMTKG

Database of Orthologous Groups

More...OrthoDBi		1127088at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P10645

TreeFam database of animal gene trees

More...TreeFami		TF336596

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001819 Chromogranin_AB
IPR018054 Chromogranin_CS
IPR001990 Granin

The PANTHER Classification System

More...PANTHERi		PTHR10583 PTHR10583, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01271 Granin, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00659 CHROMOGRANIN

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00422 GRANINS_1, 1 hit
PS00423 GRANINS_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P10645-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSAAVLALL LCAGQVTALP VNSPMNKGDT EVMKCIVEVI SDTLSKPSPM 
        60         70         80         90        100
PVSQECFETL RGDERILSIL RHQNLLKELQ DLALQGAKER AHQQKKHSGF 
       110        120        130        140        150
EDELSEVLEN QSSQAELKEA VEEPSSKDVM EKREDSKEAE KSGEATDGAR 
       160        170        180        190        200
PQALPEPMQE SKAEGNNQAP GEEEEEEEEA TNTHPPASLP SQKYPGPQAE 
       210        220        230        240        250
GDSEGLSQGL VDREKGLSAE PGWQAKREEE EEEEEEAEAG EEAVPEEEGP 
       260        270        280        290        300
TVVLNPHPSL GYKEIRKGES RSEALAVDGA GKPGAEEAQD PEGKGEQEHS 
       310        320        330        340        350
QQKEEEEEMA VVPQGLFRGG KSGELEQEEE RLSKEWEDSK RWSKMDQLAK 
       360        370        380        390        400
ELTAEKRLEG QEEEEDNRDS SMKLSFRARA YGFRGPGPQL RRGWRPSSRE 
       410        420        430        440        450
DSLEAGLPLQ VRGYPEEKKE EEGSANRRPE DQELESLSAI EAELEKVAHQ 

LQALRRG
Length:457
Mass (Da):50,688
Last modified:November 25, 2008 - v7
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F634E1A83FF0BB1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E968G5E968_HUMAN
Chromogranin A (Parathyroid secreto...
CHGA hCG_21274
306Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2Q7G3V2Q7_HUMAN
Chromogranin-A
CHGA
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti41S → Y in AAA52018 (PubMed:2445752).Curated1
Sequence conflicti54Q → K in AAA52018 (PubMed:2445752).Curated1
Sequence conflicti87A → R in AAA52018 (PubMed:2445752).Curated1
Sequence conflicti119E → Q in AAA52018 (PubMed:2445752).Curated1
Sequence conflicti167N → K in AAA52018 (PubMed:2445752).Curated1
Sequence conflicti200E → K in AAA52018 (PubMed:2445752).Curated1
Sequence conflicti219A → V in AAA52018 (PubMed:2445752).Curated1
Sequence conflicti339 – 340SK → TN in AAA52018 (PubMed:2445752).Curated2
Sequence conflicti370S → R in AAA52018 (PubMed:2445752).Curated1
Sequence conflicti373K → R in AAA52018 (PubMed:2445752).Curated1
Sequence conflicti380A → G in AAA52018 (PubMed:2445752).Curated1
Sequence conflicti394W → S in AAA52018 (PubMed:2445752).Curated1
Sequence conflicti397S → N in AAA52018 (PubMed:2445752).Curated1
Sequence conflicti416E → Q in AAA52018 (PubMed:2445752).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04741761R → Q. Corresponds to variant dbSNP:rs3742712Ensembl.1
Natural variantiVAR_025636176E → K. Corresponds to variant dbSNP:rs9658654Ensembl.1
Natural variantiVAR_025637264E → D1 PublicationCorresponds to variant dbSNP:rs9658655Ensembl.1
Natural variantiVAR_025638271R → W. Corresponds to variant dbSNP:rs9658662Ensembl.1
Natural variantiVAR_025639274A → G. Corresponds to variant dbSNP:rs9658663Ensembl.1
Natural variantiVAR_025640315G → S. Corresponds to variant dbSNP:rs9658664Ensembl.1
Natural variantiVAR_025641332L → P. Corresponds to variant dbSNP:rs9658665Ensembl.1
Natural variantiVAR_025642369D → N. Corresponds to variant dbSNP:rs2228575Ensembl.1
Natural variantiVAR_025643382G → S Polymorphism; may be associated with a reduced risk for hypertension especially in men; reduces activity 4.7 fold; no effect on plasmin-mediated proteolytic processing; increase in ability to inhibit nicotine-evoked catecholamine secretion in vitro; displays alterations in baroreceptor function. 4 PublicationsCorresponds to variant dbSNP:rs9658667Ensembl.1
Natural variantiVAR_025644388P → L Polymorphism; increases activity 2.3 fold; decrease in plasmin-mediated proteolytic processing; decrease in ability to inhibit nicotine-evoked catecholamine secretion in vitro. 3 PublicationsCorresponds to variant dbSNP:rs9658668Ensembl.1
Natural variantiVAR_072687392R → Q Polymorphism; no effect on plasmin-mediated proteolytic processing; decrease in ability to inhibit nicotine-evoked catecholamine secretion in vitro. 2 PublicationsCorresponds to variant dbSNP:rs9658669Ensembl.1
Natural variantiVAR_025645399R → W3 PublicationsCorresponds to variant dbSNP:rs729940Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J03483 mRNA Translation: AAA52017.1
J03915 mRNA Translation: AAA52018.1
U03749 U03747 Genomic DNA Translation: AAB53685.1
BT006869 mRNA Translation: AAP35515.1
AK223381 mRNA Translation: BAD97101.1
AL117192 Genomic DNA No translation available.
AK313757 mRNA Translation: BAG36496.1
CH471061 Genomic DNA Translation: EAW81505.1
BC001059 mRNA Translation: AAH01059.1
BC006459 mRNA Translation: AAH06459.1
BC009384 mRNA Translation: AAH09384.2
BC012755 mRNA Translation: AAH12755.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9906.1

Protein sequence database of the Protein Information Resource

More...PIRi		A54376 A28468

NCBI Reference Sequences

More...RefSeqi		NP_001266.1, NM_001275.3
NP_001288619.1, NM_001301690.1
XP_011534672.1, XM_011536370.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000216492; ENSP00000216492; ENSG00000100604
ENST00000613166; ENSP00000478198; ENSG00000276781

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1113

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1113

UCSC genome browser

More...UCSCi		uc001ybc.6 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03483 mRNA Translation: AAA52017.1
J03915 mRNA Translation: AAA52018.1
U03749 U03747 Genomic DNA Translation: AAB53685.1
BT006869 mRNA Translation: AAP35515.1
AK223381 mRNA Translation: BAD97101.1
AL117192 Genomic DNA No translation available.
AK313757 mRNA Translation: BAG36496.1
CH471061 Genomic DNA Translation: EAW81505.1
BC001059 mRNA Translation: AAH01059.1
BC006459 mRNA Translation: AAH06459.1
BC009384 mRNA Translation: AAH09384.2
BC012755 mRNA Translation: AAH12755.2
CCDSiCCDS9906.1
PIRiA54376 A28468
RefSeqiNP_001266.1, NM_001275.3
NP_001288619.1, NM_001301690.1
XP_011534672.1, XM_011536370.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LV4NMR-A370-390[»]
6R2XNMR-A57-81[»]
SMRiP10645
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107538, 12 interactors
IntActiP10645, 7 interactors
MINTiP10645
STRINGi9606.ENSP00000216492

PTM databases

GlyConnecti93
iPTMnetiP10645
PhosphoSitePlusiP10645
UniCarbKBiP10645

Polymorphism and mutation databases

BioMutaiCHGA
DMDMi215274270

Proteomic databases

EPDiP10645
jPOSTiP10645
MassIVEiP10645
PaxDbiP10645
PeptideAtlasiP10645
PRIDEiP10645
ProteomicsDBi52635
TopDownProteomicsiP10645

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		738 2804 antibodies

The DNASU plasmid repository

More...DNASUi		1113

Genome annotation databases

EnsembliENST00000216492; ENSP00000216492; ENSG00000100604
ENST00000613166; ENSP00000478198; ENSG00000276781
GeneIDi1113
KEGGihsa:1113
UCSCiuc001ybc.6 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1113
DisGeNETi1113
EuPathDBiHostDB:ENSG00000100604.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		CHGA
HGNCiHGNC:1929 CHGA
HPAiENSG00000100604 Tissue enriched (parathyroid)
MIMi118910 gene
neXtProtiNX_P10645
OpenTargetsiENSG00000100604
PharmGKBiPA26461

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410II3Z Eukaryota
ENOG410YGBX LUCA
GeneTreeiENSGT00940000154206
InParanoidiP10645
KOiK19990
OMAiNSPMTKG
OrthoDBi1127088at2759
PhylomeDBiP10645
TreeFamiTF336596

Enzyme and pathway databases

ReactomeiR-HSA-6803157 Antimicrobial peptides
SIGNORiP10645

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1113 168 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CHGA human
EvolutionaryTraceiP10645

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Chromogranin_A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1113
PharosiP10645 Tbio

Protein Ontology

More...PROi		PR:P10645
RNActiP10645 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100604 Expressed in type B pancreatic cell and 150 other tissues
ExpressionAtlasiP10645 baseline and differential
GenevisibleiP10645 HS

Family and domain databases

InterProiView protein in InterPro
IPR001819 Chromogranin_AB
IPR018054 Chromogranin_CS
IPR001990 Granin
PANTHERiPTHR10583 PTHR10583, 1 hit
PfamiView protein in Pfam
PF01271 Granin, 2 hits
PRINTSiPR00659 CHROMOGRANIN
PROSITEiView protein in PROSITE
PS00422 GRANINS_1, 1 hit
PS00423 GRANINS_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCMGA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10645
Secondary accession number(s): B2R9E9
, Q53FA8, Q6NR84, Q96E84, Q96GL7, Q9BQB5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 25, 2008
Last modified: June 17, 2020
This is version 207 of the entry and version 7 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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