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Entry version 201 (08 May 2019)
Sequence version 7 (25 Nov 2008)
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Protein

Chromogranin-A

Gene

CHGA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas.
Catestatin: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172 and PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522).1 Publication4 Publications
Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.By similarity

Miscellaneous

Binds calcium with a low-affinity.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntibiotic, Antimicrobial, Fungicide
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6803157 Antimicrobial peptides

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P10645

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chromogranin-A
Short name:
CgA
Alternative name(s):
Pituitary secretory protein I
Short name:
SP-I
Cleaved into the following 18 chains:
Alternative name(s):
Vasostatin I
Alternative name(s):
Vasostatin II
Catestatin2 Publications
Alternative name(s):
SL211 Publication
GE-251 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHGA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1929 CHGA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
118910 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P10645

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1113

Open Targets

More...
OpenTargetsi
ENSG00000100604

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26461

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CHGA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274270

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 182 PublicationsAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000540819 – 457Chromogranin-AAdd BLAST439
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000000540919 – 131Vasostatin-21 PublicationAdd BLAST113
PeptideiPRO_000000541019 – 94Vasostatin-11 PublicationAdd BLAST76
PeptideiPRO_0000005411134 – 225EA-921 PublicationAdd BLAST92
PeptideiPRO_0000005412228 – 260ES-431 PublicationAdd BLAST33
PeptideiPRO_0000005413272 – 319Pancreastatin1 PublicationAdd BLAST48
PeptideiPRO_0000005414322 – 339SS-181 PublicationAdd BLAST18
PeptideiPRO_0000005415342 – 355WE-141 PublicationAdd BLAST14
PeptideiPRO_0000005416342 – 349WA-81 Publication8
PeptideiPRO_0000005417358 – 376LF-191 PublicationAdd BLAST19
PeptideiPRO_0000432682370 – 390Catestatin1 PublicationAdd BLAST21
PeptideiPRO_0000005418380 – 390AL-111 PublicationAdd BLAST11
PeptideiPRO_0000432683393 – 417GE-251 PublicationAdd BLAST25
PeptideiPRO_0000005419393 – 411GV-191 PublicationAdd BLAST19
PeptideiPRO_0000005420413 – 456GR-441 PublicationAdd BLAST44
PeptideiPRO_0000005421420 – 456ER-371 PublicationAdd BLAST37
PeptideiPRO_0000432684429 – 457Serpinin-RRGBy similarityAdd BLAST29
PeptideiPRO_0000432685429 – 454SerpininBy similarityAdd BLAST26
PeptideiPRO_0000432686432 – 454p-Glu serpinin precursorBy similarityAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi35 ↔ 561 Publication
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei142PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>GlycosylationiCAR_000116181O-linked (GalNAc...) threonine1 Publication1
GlycosylationiCAR_000117183O-linked (GalNAc...) threonine1 Publication1
Modified residuei194PhosphotyrosineBy similarity1
Modified residuei203PhosphoserineCombined sources1
Modified residuei218Phosphoserine1 Publication1
GlycosylationiCAR_000118251O-linked (GalNAc...) threonine1 Publication1
Modified residuei270Phosphoserine1 Publication1
Modified residuei300PhosphoserineCombined sources1
Modified residuei319Glycine amide2 Publications1
Modified residuei322PhosphoserineCombined sources1 Publication1
Modified residuei333Phosphoserine1 Publication1
Modified residuei371PhosphoserineBy similarity1
Modified residuei372Methionine sulfoxide1 Publication1
Modified residuei398PhosphoserineBy similarity1
Modified residuei402PhosphoserineCombined sources1
Modified residuei424PhosphoserineBy similarity1
Modified residuei438PhosphoserineBy similarity1
Modified residuei456Arginine amide1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sulfated on tyrosine residues and/or contains sulfated glycans.
O-glycosylated with core 1 or possibly core 8 glycans.3 Publications
Proteolytic processing gives rise to an additional longer form of catestatin (residues 358-390) which displays a less potent catecholamine release-inhibitory activity (PubMed:10781584). Plasmin-mediated proteolytic processing can give rise to additional shorter and longer forms of catestatin peptides (PubMed:17991725).2 Publications

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Oxidation, Phosphoprotein, Sulfation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P10645

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P10645

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P10645

PeptideAtlas

More...
PeptideAtlasi
P10645

PRoteomics IDEntifications database

More...
PRIDEi
P10645

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52635

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P10645

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
93

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P10645

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P10645

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P10645

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

GE-25 is found in the brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100604 Expressed in 151 organ(s), highest expression level in type B pancreatic cell

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P10645 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P10645 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB000023
CAB040544
CAB055506
CAB058688
HPA017369

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SCG3.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107538, 12 interactors

Protein interaction database and analysis system

More...
IntActi
P10645, 4 interactors

Molecular INTeraction database

More...
MINTi
P10645

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000216492

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1457
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LV4NMR-A370-390[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P10645

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P10645

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni41 – 59O-glycosylated at one site only in cerebrospinal fluidAdd BLAST19
Regioni181 – 191O-glycosylated at one site only in cerebrospinal fluidAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410II3Z Eukaryota
ENOG410YGBX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154206

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P10645

KEGG Orthology (KO)

More...
KOi
K19990

Identification of Orthologs from Complete Genome Data

More...
OMAi
EWEDAKR

Database of Orthologous Groups

More...
OrthoDBi
390511at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P10645

TreeFam database of animal gene trees

More...
TreeFami
TF336596

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001819 Chromogranin_AB
IPR018054 Chromogranin_CS
IPR001990 Granin

The PANTHER Classification System

More...
PANTHERi
PTHR10583 PTHR10583, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01271 Granin, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00659 CHROMOGRANIN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00422 GRANINS_1, 1 hit
PS00423 GRANINS_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P10645-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSAAVLALL LCAGQVTALP VNSPMNKGDT EVMKCIVEVI SDTLSKPSPM
60 70 80 90 100
PVSQECFETL RGDERILSIL RHQNLLKELQ DLALQGAKER AHQQKKHSGF
110 120 130 140 150
EDELSEVLEN QSSQAELKEA VEEPSSKDVM EKREDSKEAE KSGEATDGAR
160 170 180 190 200
PQALPEPMQE SKAEGNNQAP GEEEEEEEEA TNTHPPASLP SQKYPGPQAE
210 220 230 240 250
GDSEGLSQGL VDREKGLSAE PGWQAKREEE EEEEEEAEAG EEAVPEEEGP
260 270 280 290 300
TVVLNPHPSL GYKEIRKGES RSEALAVDGA GKPGAEEAQD PEGKGEQEHS
310 320 330 340 350
QQKEEEEEMA VVPQGLFRGG KSGELEQEEE RLSKEWEDSK RWSKMDQLAK
360 370 380 390 400
ELTAEKRLEG QEEEEDNRDS SMKLSFRARA YGFRGPGPQL RRGWRPSSRE
410 420 430 440 450
DSLEAGLPLQ VRGYPEEKKE EEGSANRRPE DQELESLSAI EAELEKVAHQ

LQALRRG
Length:457
Mass (Da):50,688
Last modified:November 25, 2008 - v7
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F634E1A83FF0BB1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E968G5E968_HUMAN
Chromogranin A (Parathyroid secreto...
CHGA hCG_21274
306Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2Q7G3V2Q7_HUMAN
Chromogranin-A
CHGA
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti41S → Y in AAA52018 (PubMed:2445752).Curated1
Sequence conflicti54Q → K in AAA52018 (PubMed:2445752).Curated1
Sequence conflicti87A → R in AAA52018 (PubMed:2445752).Curated1
Sequence conflicti119E → Q in AAA52018 (PubMed:2445752).Curated1
Sequence conflicti167N → K in AAA52018 (PubMed:2445752).Curated1
Sequence conflicti200E → K in AAA52018 (PubMed:2445752).Curated1
Sequence conflicti219A → V in AAA52018 (PubMed:2445752).Curated1
Sequence conflicti339 – 340SK → TN in AAA52018 (PubMed:2445752).Curated2
Sequence conflicti370S → R in AAA52018 (PubMed:2445752).Curated1
Sequence conflicti373K → R in AAA52018 (PubMed:2445752).Curated1
Sequence conflicti380A → G in AAA52018 (PubMed:2445752).Curated1
Sequence conflicti394W → S in AAA52018 (PubMed:2445752).Curated1
Sequence conflicti397S → N in AAA52018 (PubMed:2445752).Curated1
Sequence conflicti416E → Q in AAA52018 (PubMed:2445752).Curated1

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 2051.89 Da from positions 357 - 373. Determined by MALDI. 1 Publication
Molecular mass is 3770 Da from positions 358 - 390. Determined by MALDI. 1 Publication
Molecular mass is 3787 Da from positions 358 - 390. Determined by MALDI. With methionine sulfoxide at Met-372.1 Publication
Molecular mass is 1070.54 Da from positions 369 - 377. Determined by MALDI. 1 Publication
Molecular mass is 840.45 Da from positions 378 - 384. Determined by MALDI. 1 Publication
Molecular mass is 1389.74 Da from positions 378 - 390. Determined by MALDI. 1 Publication
Molecular mass is 1419.8 Da from positions 378 - 390. Determined by MALDI. With variant Ser-382.1 Publication
Molecular mass is 1545.84 Da from positions 378 - 391. Determined by MALDI. 1 Publication
Molecular mass is 1575.9 Da from positions 378 - 391. Determined by MALDI. With variant Ser-382.1 Publication
Molecular mass is 1701.96 Da from positions 378 - 392. Determined by MALDI. 1 Publication
Molecular mass is 1318.71 Da from positions 380 - 391. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04741761R → Q. Corresponds to variant dbSNP:rs3742712Ensembl.1
Natural variantiVAR_025636176E → K. Corresponds to variant dbSNP:rs9658654Ensembl.1
Natural variantiVAR_025637264E → D1 PublicationCorresponds to variant dbSNP:rs9658655Ensembl.1
Natural variantiVAR_025638271R → W. Corresponds to variant dbSNP:rs9658662Ensembl.1
Natural variantiVAR_025639274A → G. Corresponds to variant dbSNP:rs9658663Ensembl.1
Natural variantiVAR_025640315G → S. Corresponds to variant dbSNP:rs9658664Ensembl.1
Natural variantiVAR_025641332L → P. Corresponds to variant dbSNP:rs9658665Ensembl.1
Natural variantiVAR_025642369D → N. Corresponds to variant dbSNP:rs2228575Ensembl.1
Natural variantiVAR_025643382G → S Polymorphism; may be associated with a reduced risk for hypertension especially in men; reduces activity 4.7 fold; no effect on plasmin-mediated proteolytic processing; increase in ability to inhibit nicotine-evoked catecholamine secretion in vitro; displays alterations in baroreceptor function. 4 PublicationsCorresponds to variant dbSNP:rs9658667Ensembl.1
Natural variantiVAR_025644388P → L Polymorphism; increases activity 2.3 fold; decrease in plasmin-mediated proteolytic processing; decrease in ability to inhibit nicotine-evoked catecholamine secretion in vitro. 3 PublicationsCorresponds to variant dbSNP:rs9658668Ensembl.1
Natural variantiVAR_072687392R → Q Polymorphism; no effect on plasmin-mediated proteolytic processing; decrease in ability to inhibit nicotine-evoked catecholamine secretion in vitro. 2 PublicationsCorresponds to variant dbSNP:rs9658669Ensembl.1
Natural variantiVAR_025645399R → W3 PublicationsCorresponds to variant dbSNP:rs729940Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J03483 mRNA Translation: AAA52017.1
J03915 mRNA Translation: AAA52018.1
U03749
, U03742, U03743, U03744, U03748, U03745, U03746, U03747 Genomic DNA Translation: AAB53685.1
BT006869 mRNA Translation: AAP35515.1
AK223381 mRNA Translation: BAD97101.1
AL117192 Genomic DNA No translation available.
AK313757 mRNA Translation: BAG36496.1
CH471061 Genomic DNA Translation: EAW81505.1
BC001059 mRNA Translation: AAH01059.1
BC006459 mRNA Translation: AAH06459.1
BC009384 mRNA Translation: AAH09384.2
BC012755 mRNA Translation: AAH12755.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS9906.1

Protein sequence database of the Protein Information Resource

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PIRi
A54376 A28468

NCBI Reference Sequences

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RefSeqi
NP_001266.1, NM_001275.3
NP_001288619.1, NM_001301690.1
XP_011534672.1, XM_011536370.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000216492; ENSP00000216492; ENSG00000100604
ENST00000613166; ENSP00000478198; ENSG00000276781

Database of genes from NCBI RefSeq genomes

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GeneIDi
1113

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1113

UCSC genome browser

More...
UCSCi
uc001ybc.6 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03483 mRNA Translation: AAA52017.1
J03915 mRNA Translation: AAA52018.1
U03749
, U03742, U03743, U03744, U03748, U03745, U03746, U03747 Genomic DNA Translation: AAB53685.1
BT006869 mRNA Translation: AAP35515.1
AK223381 mRNA Translation: BAD97101.1
AL117192 Genomic DNA No translation available.
AK313757 mRNA Translation: BAG36496.1
CH471061 Genomic DNA Translation: EAW81505.1
BC001059 mRNA Translation: AAH01059.1
BC006459 mRNA Translation: AAH06459.1
BC009384 mRNA Translation: AAH09384.2
BC012755 mRNA Translation: AAH12755.2
CCDSiCCDS9906.1
PIRiA54376 A28468
RefSeqiNP_001266.1, NM_001275.3
NP_001288619.1, NM_001301690.1
XP_011534672.1, XM_011536370.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LV4NMR-A370-390[»]
SMRiP10645
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107538, 12 interactors
IntActiP10645, 4 interactors
MINTiP10645
STRINGi9606.ENSP00000216492

PTM databases

GlyConnecti93
iPTMnetiP10645
PhosphoSitePlusiP10645
UniCarbKBiP10645

Polymorphism and mutation databases

BioMutaiCHGA
DMDMi215274270

Proteomic databases

EPDiP10645
jPOSTiP10645
PaxDbiP10645
PeptideAtlasiP10645
PRIDEiP10645
ProteomicsDBi52635
TopDownProteomicsiP10645

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1113
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216492; ENSP00000216492; ENSG00000100604
ENST00000613166; ENSP00000478198; ENSG00000276781
GeneIDi1113
KEGGihsa:1113
UCSCiuc001ybc.6 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1113
DisGeNETi1113

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CHGA
HGNCiHGNC:1929 CHGA
HPAiCAB000023
CAB040544
CAB055506
CAB058688
HPA017369
MIMi118910 gene
neXtProtiNX_P10645
OpenTargetsiENSG00000100604
PharmGKBiPA26461

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410II3Z Eukaryota
ENOG410YGBX LUCA
GeneTreeiENSGT00940000154206
InParanoidiP10645
KOiK19990
OMAiEWEDAKR
OrthoDBi390511at2759
PhylomeDBiP10645
TreeFamiTF336596

Enzyme and pathway databases

ReactomeiR-HSA-6803157 Antimicrobial peptides
SIGNORiP10645

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CHGA human
EvolutionaryTraceiP10645

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Chromogranin_A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1113

Protein Ontology

More...
PROi
PR:P10645

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100604 Expressed in 151 organ(s), highest expression level in type B pancreatic cell
ExpressionAtlasiP10645 baseline and differential
GenevisibleiP10645 HS

Family and domain databases

InterProiView protein in InterPro
IPR001819 Chromogranin_AB
IPR018054 Chromogranin_CS
IPR001990 Granin
PANTHERiPTHR10583 PTHR10583, 1 hit
PfamiView protein in Pfam
PF01271 Granin, 2 hits
PRINTSiPR00659 CHROMOGRANIN
PROSITEiView protein in PROSITE
PS00422 GRANINS_1, 1 hit
PS00423 GRANINS_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCMGA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10645
Secondary accession number(s): B2R9E9
, Q53FA8, Q6NR84, Q96E84, Q96GL7, Q9BQB5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 25, 2008
Last modified: May 8, 2019
This is version 201 of the entry and version 7 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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