CHGA

Functionⁱ

Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas.

Catestatin: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172 and PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522).1 Publication4 Publications

Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.By similarity

Miscellaneous

Binds calcium with a low-affinity.

GO - Biological processⁱ

adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation Source: BHF-UCL
antimicrobial humoral response Source: Reactome
defense response to fungus Source: UniProtKB-KW
defense response to Gram-negative bacterium
Source: UniProtKB
Inferred from direct assayⁱ
- 15723172
defense response to Gram-positive bacterium
Source: UniProtKB
Inferred from direct assayⁱ
- 15723172
innate immune response
Source: UniProtKB
Non-traceable author statementⁱ
- 15723172
killing of cells of other organism Source: UniProtKB-KW
mast cell activation
Source: UniProtKB
Inferred from direct assayⁱ
- 21214543
mast cell chemotaxis
Source: UniProtKB
Inferred from direct assayⁱ
- 21214543
mast cell cytokine production
Source: UniProtKB
Inferred from direct assayⁱ
- 21214543
mast cell degranulation
Source: UniProtKB
Inferred from direct assayⁱ
- 21214543
negative regulation of blood vessel diameter Source: BHF-UCL
negative regulation of catecholamine secretion
Source: UniProtKB
Inferred from direct assayⁱ
- 15326220
negative regulation of neuron death Source: BHF-UCL
organelle organization Source: BHF-UCL
positive regulation of cardiac muscle contraction Source: BHF-UCL
positive regulation of dense core granule biogenesis Source: UniProtKB
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway Source: BHF-UCL
positive regulation of relaxation of cardiac muscle Source: BHF-UCL
regulation of blood pressure
Source: ProtInc
Traceable author statementⁱ
- 8406464
regulation of the force of heart contraction Source: BHF-UCL

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Antibiotic, Antimicrobial, Fungicide
Ligand	Calcium

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6803157 Antimicrobial peptides
SIGNORⁱ	P10645

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Chromogranin-A Short name: CgA Alternative name(s): Pituitary secretory protein I Short name: SP-I Cleaved into the following 18 chains: Vasostatin-1 Alternative name(s): Vasostatin I Vasostatin-2 Alternative name(s): Vasostatin II EA-92 ES-43 Pancreastatin SS-18 WA-8 WE-14 LF-19 Catestatin2 Publications Alternative name(s): SL211 Publication AL-11 GV-19 GR-44 ER-37 GE-251 Publication Serpinin-RRG Serpinin p-Glu serpinin precursor
Gene namesⁱ	Name:CHGA
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100604.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1929 CHGA
MIMⁱ	118910 gene
neXtProtⁱ	NX_P10645

Keywords - Cellular componentⁱ

Cytoplasmic vesicle, Membrane, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1113
Open Targets More...OpenTargetsⁱ	ENSG00000100604
PharmGKBⁱ	PA26461

Polymorphism and mutation databases

BioMutaⁱ	CHGA
DMDMⁱ	215274270

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 18	2 PublicationsAdd BLAST	18
ChainⁱPRO_0000005408	19 – 457	Chromogranin-AAdd BLAST	439
PeptideⁱPRO_0000005409	19 – 131	Vasostatin-21 PublicationAdd BLAST	113
PeptideⁱPRO_0000005410	19 – 94	Vasostatin-11 PublicationAdd BLAST	76
PeptideⁱPRO_0000005411	134 – 225	EA-921 PublicationAdd BLAST	92
PeptideⁱPRO_0000005412	228 – 260	ES-431 PublicationAdd BLAST	33
PeptideⁱPRO_0000005413	272 – 319	Pancreastatin1 PublicationAdd BLAST	48
PeptideⁱPRO_0000005414	322 – 339	SS-181 PublicationAdd BLAST	18
PeptideⁱPRO_0000005415	342 – 355	WE-141 PublicationAdd BLAST	14
PeptideⁱPRO_0000005416	342 – 349	WA-81 Publication	8
PeptideⁱPRO_0000005417	358 – 376	LF-191 PublicationAdd BLAST	19
PeptideⁱPRO_0000432682	370 – 390	Catestatin1 PublicationAdd BLAST	21
PeptideⁱPRO_0000005418	380 – 390	AL-111 PublicationAdd BLAST	11
PeptideⁱPRO_0000432683	393 – 417	GE-251 PublicationAdd BLAST	25
PeptideⁱPRO_0000005419	393 – 411	GV-191 PublicationAdd BLAST	19
PeptideⁱPRO_0000005420	413 – 456	GR-441 PublicationAdd BLAST	44
PeptideⁱPRO_0000005421	420 – 456	ER-371 PublicationAdd BLAST	37
PeptideⁱPRO_0000432684	429 – 457	Serpinin-RRGBy similarityAdd BLAST	29
PeptideⁱPRO_0000432685	429 – 454	SerpininBy similarityAdd BLAST	26
PeptideⁱPRO_0000432686	432 – 454	p-Glu serpinin precursorBy similarityAdd BLAST	23

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	35 ↔ 56	1 Publication
Modified residueⁱ	142	PhosphoserineBy similarity	1
GlycosylationⁱCAR_000116	181	O-linked (GalNAc...) threonine1 Publication	1
GlycosylationⁱCAR_000117	183	O-linked (GalNAc...) threonine1 Publication	1
Modified residueⁱ	194	PhosphotyrosineBy similarity	1
Modified residueⁱ	203	PhosphoserineCombined sources	1
Modified residueⁱ	218	Phosphoserine1 Publication	1
GlycosylationⁱCAR_000118	251	O-linked (GalNAc...) threonine1 Publication	1
Modified residueⁱ	270	Phosphoserine1 Publication	1
Modified residueⁱ	300	PhosphoserineCombined sources	1
Modified residueⁱ	319	Glycine amide2 Publications	1
Modified residueⁱ	322	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	333	Phosphoserine1 Publication	1
Modified residueⁱ	371	PhosphoserineBy similarity	1
Modified residueⁱ	372	Methionine sulfoxide1 Publication	1
Modified residueⁱ	398	PhosphoserineBy similarity	1
Modified residueⁱ	402	PhosphoserineCombined sources	1
Modified residueⁱ	424	PhosphoserineBy similarity	1
Modified residueⁱ	438	PhosphoserineBy similarity	1
Modified residueⁱ	456	Arginine amide1 Publication	1

Post-translational modificationⁱ

Sulfated on tyrosine residues and/or contains sulfated glycans.

O-glycosylated with core 1 or possibly core 8 glycans.3 Publications

Proteolytic processing gives rise to an additional longer form of catestatin (residues 358-390) which displays a less potent catecholamine release-inhibitory activity (PubMed:10781584). Plasmin-mediated proteolytic processing can give rise to additional shorter and longer forms of catestatin peptides (PubMed:17991725).2 Publications

Keywords - PTMⁱ

Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Oxidation, Phosphoprotein, Sulfation

Proteomic databases

EPDⁱ	P10645
PaxDbⁱ	P10645
PeptideAtlas More...PeptideAtlasⁱ	P10645
PRIDEⁱ	P10645
ProteomicsDBⁱ	52635
TopDownProteomicsⁱ	P10645

PTM databases

GlyConnectⁱ	93
iPTMnetⁱ	P10645
PhosphoSitePlusⁱ	P10645
UniCarbKBⁱ	P10645

Miscellaneous databases

PMAP-CutDBⁱ	Q6NR84

PMAP-CutDBⁱ

Q6NR84

Expressionⁱ

Tissue specificityⁱ

GE-25 is found in the brain.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000100604 Expressed in 151 organ(s), highest expression level in type B pancreatic cell
CleanExⁱ	HS_CHGA
ExpressionAtlasⁱ	P10645 baseline and differential
Genevisibleⁱ	P10645 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB000023 CAB040544 CAB055506 CAB058688 HPA017369

HPAⁱ

CAB000023
CAB040544
CAB055506
CAB058688
HPA017369

Interactionⁱ

Subunit structureⁱ

Interacts with SCG3.By similarity

Protein-protein interaction databases

BioGridⁱ	107538, 12 interactors
IntActⁱ	P10645, 3 interactors
Molecular INTeraction database More...MINTⁱ	P10645
STRINGⁱ	9606.ENSP00000216492

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Beta strandⁱ	380 – 383	Combined sources		4
Beta strandⁱ	385 – 387	Combined sources		3

Show more details

3D structure databases

ProteinModelPortalⁱ	P10645
SMRⁱ	P10645
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P10645

EvolutionaryTraceⁱ

P10645

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	41 – 59	O-glycosylated at one site only in cerebrospinal fluidAdd BLAST		19
Regionⁱ	181 – 191	O-glycosylated at one site only in cerebrospinal fluidAdd BLAST		11

Sequence similaritiesⁱ

Belongs to the chromogranin/secretogranin protein family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410II3Z Eukaryota ENOG410YGBX LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111266
HOVERGENⁱ	HBG001272
InParanoidⁱ	P10645
KEGG Orthology (KO) More...KOⁱ	K19990
OMAⁱ	VNSPMNK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0I4D
PhylomeDBⁱ	P10645
TreeFamⁱ	TF336596

Family and domain databases

InterProⁱ	View protein in InterPro IPR001819 Chromogranin_AB IPR018054 Chromogranin_CS IPR001990 Granin
PANTHERⁱ	PTHR10583 PTHR10583, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01271 Granin, 2 hits
PRINTSⁱ	PR00659 CHROMOGRANIN
PROSITEⁱ	View protein in PROSITE PS00422 GRANINS_1, 1 hit PS00423 GRANINS_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.ⁱShow all

P10645-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRSAAVLALL LCAGQVTALP VNSPMNKGDT EVMKCIVEVI SDTLSKPSPM 
        60         70         80         90        100
PVSQECFETL RGDERILSIL RHQNLLKELQ DLALQGAKER AHQQKKHSGF 
       110        120        130        140        150
EDELSEVLEN QSSQAELKEA VEEPSSKDVM EKREDSKEAE KSGEATDGAR 
       160        170        180        190        200
PQALPEPMQE SKAEGNNQAP GEEEEEEEEA TNTHPPASLP SQKYPGPQAE 
       210        220        230        240        250
GDSEGLSQGL VDREKGLSAE PGWQAKREEE EEEEEEAEAG EEAVPEEEGP 
       260        270        280        290        300
TVVLNPHPSL GYKEIRKGES RSEALAVDGA GKPGAEEAQD PEGKGEQEHS 
       310        320        330        340        350
QQKEEEEEMA VVPQGLFRGG KSGELEQEEE RLSKEWEDSK RWSKMDQLAK 
       360        370        380        390        400
ELTAEKRLEG QEEEEDNRDS SMKLSFRARA YGFRGPGPQL RRGWRPSSRE 
       410        420        430        440        450
DSLEAGLPLQ VRGYPEEKKE EEGSANRRPE DQELESLSAI EAELEKVAHQ 

LQALRRG

Length:457

Mass (Da):50,688

Last modified:November 25, 2008 - v7

Checksum:ⁱ2F634E1A83FF0BB1

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	G5E968	G5E968_HUMAN		Chromogranin A (Parathyroid secreto... Chromogranin A (Parathyroid secretory protein 1), isoform CRA_b (Chromogranin-A)	CHGA hCG_21274	306	Annotation score:
	G3V2Q7	G3V2Q7_HUMAN		Chromogranin-A Chromogranin-A	CHGA	38	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	41	S → Y in AAA52018 (PubMed:2445752).Curated	1
Sequence conflictⁱ	54	Q → K in AAA52018 (PubMed:2445752).Curated	1
Sequence conflictⁱ	87	A → R in AAA52018 (PubMed:2445752).Curated	1
Sequence conflictⁱ	119	E → Q in AAA52018 (PubMed:2445752).Curated	1
Sequence conflictⁱ	167	N → K in AAA52018 (PubMed:2445752).Curated	1
Sequence conflictⁱ	200	E → K in AAA52018 (PubMed:2445752).Curated	1
Sequence conflictⁱ	219	A → V in AAA52018 (PubMed:2445752).Curated	1
Sequence conflictⁱ	339 – 340	SK → TN in AAA52018 (PubMed:2445752).Curated	2
Sequence conflictⁱ	370	S → R in AAA52018 (PubMed:2445752).Curated	1
Sequence conflictⁱ	373	K → R in AAA52018 (PubMed:2445752).Curated	1
Sequence conflictⁱ	380	A → G in AAA52018 (PubMed:2445752).Curated	1
Sequence conflictⁱ	394	W → S in AAA52018 (PubMed:2445752).Curated	1
Sequence conflictⁱ	397	S → N in AAA52018 (PubMed:2445752).Curated	1
Sequence conflictⁱ	416	E → Q in AAA52018 (PubMed:2445752).Curated	1

Mass spectrometryⁱ

Molecular mass is 2051.89 Da from positions 357 - 373. Determined by MALDI. 1 Publication

Molecular mass is 3770 Da from positions 358 - 390. Determined by MALDI. 1 Publication

Molecular mass is 3787 Da from positions 358 - 390. Determined by MALDI. With methionine sulfoxide at Met-372.1 Publication

Molecular mass is 1070.54 Da from positions 369 - 377. Determined by MALDI. 1 Publication

Molecular mass is 840.45 Da from positions 378 - 384. Determined by MALDI. 1 Publication

Molecular mass is 1389.74 Da from positions 378 - 390. Determined by MALDI. 1 Publication

Molecular mass is 1419.8 Da from positions 378 - 390. Determined by MALDI. With variant Ser-382.1 Publication

Molecular mass is 1545.84 Da from positions 378 - 391. Determined by MALDI. 1 Publication

Molecular mass is 1575.9 Da from positions 378 - 391. Determined by MALDI. With variant Ser-382.1 Publication

Molecular mass is 1701.96 Da from positions 378 - 392. Determined by MALDI. 1 Publication

Molecular mass is 1318.71 Da from positions 380 - 391. Determined by MALDI. 1 Publication

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_047417	61	R → Q. Corresponds to variant dbSNP:rs3742712Ensembl.	1
Natural variantⁱVAR_025636	176	E → K. Corresponds to variant dbSNP:rs9658654Ensembl.	1
Natural variantⁱVAR_025637	264	E → D1 PublicationCorresponds to variant dbSNP:rs9658655Ensembl.	1
Natural variantⁱVAR_025638	271	R → W. Corresponds to variant dbSNP:rs9658662Ensembl.	1
Natural variantⁱVAR_025639	274	A → G. Corresponds to variant dbSNP:rs9658663Ensembl.	1
Natural variantⁱVAR_025640	315	G → S. Corresponds to variant dbSNP:rs9658664Ensembl.	1
Natural variantⁱVAR_025641	332	L → P. Corresponds to variant dbSNP:rs9658665Ensembl.	1
Natural variantⁱVAR_025642	369	D → N. Corresponds to variant dbSNP:rs2228575Ensembl.	1
Natural variantⁱVAR_025643	382	G → S Polymorphism; may be associated with a reduced risk for hypertension especially in men; reduces activity 4.7 fold; no effect on plasmin-mediated proteolytic processing; increase in ability to inhibit nicotine-evoked catecholamine secretion in vitro; displays alterations in baroreceptor function. 4 PublicationsCorresponds to variant dbSNP:rs9658667Ensembl.	1
Natural variantⁱVAR_025644	388	P → L Polymorphism; increases activity 2.3 fold; decrease in plasmin-mediated proteolytic processing; decrease in ability to inhibit nicotine-evoked catecholamine secretion in vitro. 3 PublicationsCorresponds to variant dbSNP:rs9658668Ensembl.	1
Natural variantⁱVAR_072687	392	R → Q Polymorphism; no effect on plasmin-mediated proteolytic processing; decrease in ability to inhibit nicotine-evoked catecholamine secretion in vitro. 2 PublicationsCorresponds to variant dbSNP:rs9658669Ensembl.	1
Natural variantⁱVAR_025645	399	R → W3 PublicationsCorresponds to variant dbSNP:rs729940Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03483 mRNA Translation: AAA52017.1 J03915 mRNA Translation: AAA52018.1 U03749 U03747 Genomic DNA Translation: AAB53685.1 BT006869 mRNA Translation: AAP35515.1 AK223381 mRNA Translation: BAD97101.1 AL117192 Genomic DNA No translation available. AK313757 mRNA Translation: BAG36496.1 CH471061 Genomic DNA Translation: EAW81505.1 BC001059 mRNA Translation: AAH01059.1 BC006459 mRNA Translation: AAH06459.1 BC009384 mRNA Translation: AAH09384.2 BC012755 mRNA Translation: AAH12755.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9906.1
PIRⁱ	A54376 A28468
NCBI Reference Sequences More...RefSeqⁱ	NP_001266.1, NM_001275.3 NP_001288619.1, NM_001301690.1 XP_011534672.1, XM_011536370.1
UniGeneⁱ	Hs.150793

Genome annotation databases

Ensemblⁱ	ENST00000216492; ENSP00000216492; ENSG00000100604 ENST00000613166; ENSP00000478198; ENSG00000276781
GeneIDⁱ	1113
KEGGⁱ	hsa:1113
UCSC genome browser More...UCSCⁱ	uc001ybc.6 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P10645	Chromogranin A		MACNE		543	UniRef90_P10645
Uncharacterized protein		MACFA		463
Chromogranin A		NOMLE		460
CHGA isoform 1		PANTR		459
Chromogranin A		PANPA		459
+9

Protein	Similar proteins		Species	Score	Length	Source
P10645	Chromogranin-A	)	BOVIN		449	UniRef50_P10645
Chromogranin-A (Fragment)		PIG		446
Chromogranin-A	)	MOUSE		463
Chromogranin-A		RAT		466
Chromogranin A		MACNE		543
+107

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03483 mRNA Translation: AAA52017.1 J03915 mRNA Translation: AAA52018.1 U03749 U03747 Genomic DNA Translation: AAB53685.1 BT006869 mRNA Translation: AAP35515.1 AK223381 mRNA Translation: BAD97101.1 AL117192 Genomic DNA No translation available. AK313757 mRNA Translation: BAG36496.1 CH471061 Genomic DNA Translation: EAW81505.1 BC001059 mRNA Translation: AAH01059.1 BC006459 mRNA Translation: AAH06459.1 BC009384 mRNA Translation: AAH09384.2 BC012755 mRNA Translation: AAH12755.2
CCDSⁱ	CCDS9906.1
PIRⁱ	A54376 A28468
RefSeqⁱ	NP_001266.1, NM_001275.3 NP_001288619.1, NM_001301690.1 XP_011534672.1, XM_011536370.1
UniGeneⁱ	Hs.150793

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1LV4	NMR	-	A	370-390	[»]
ProteinModelPortalⁱ	P10645
SMRⁱ	P10645
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107538, 12 interactors
IntActⁱ	P10645, 3 interactors
MINTⁱ	P10645
STRINGⁱ	9606.ENSP00000216492

PTM databases

GlyConnectⁱ	93
iPTMnetⁱ	P10645
PhosphoSitePlusⁱ	P10645
UniCarbKBⁱ	P10645

Polymorphism and mutation databases

BioMutaⁱ	CHGA
DMDMⁱ	215274270

Proteomic databases

EPDⁱ	P10645
PaxDbⁱ	P10645
PeptideAtlasⁱ	P10645
PRIDEⁱ	P10645
ProteomicsDBⁱ	52635
TopDownProteomicsⁱ	P10645

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1113
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000216492; ENSP00000216492; ENSG00000100604 ENST00000613166; ENSP00000478198; ENSG00000276781
GeneIDⁱ	1113
KEGGⁱ	hsa:1113
UCSCⁱ	uc001ybc.6 human

Organism-specific databases

CTDⁱ	1113
DisGeNETⁱ	1113
EuPathDBⁱ	HostDB:ENSG00000100604.12
GeneCardsⁱ	CHGA
HGNCⁱ	HGNC:1929 CHGA
HPAⁱ	CAB000023 CAB040544 CAB055506 CAB058688 HPA017369
MIMⁱ	118910 gene
neXtProtⁱ	NX_P10645
OpenTargetsⁱ	ENSG00000100604
PharmGKBⁱ	PA26461
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410II3Z Eukaryota ENOG410YGBX LUCA
GeneTreeⁱ	ENSGT00730000111266
HOVERGENⁱ	HBG001272
InParanoidⁱ	P10645
KOⁱ	K19990
OMAⁱ	VNSPMNK
OrthoDBⁱ	EOG091G0I4D
PhylomeDBⁱ	P10645
TreeFamⁱ	TF336596

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6803157 Antimicrobial peptides
SIGNORⁱ	P10645

Miscellaneous databases

ChiTaRSⁱ	CHGA human
EvolutionaryTraceⁱ	P10645
GeneWikiⁱ	Chromogranin_A
GenomeRNAiⁱ	1113
PMAP-CutDBⁱ	Q6NR84
Protein Ontology More...PROⁱ	PR:P10645
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000100604 Expressed in 151 organ(s), highest expression level in type B pancreatic cell
CleanExⁱ	HS_CHGA
ExpressionAtlasⁱ	P10645 baseline and differential
Genevisibleⁱ	P10645 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001819 Chromogranin_AB IPR018054 Chromogranin_CS IPR001990 Granin
PANTHERⁱ	PTHR10583 PTHR10583, 1 hit
Pfamⁱ	View protein in Pfam PF01271 Granin, 2 hits
PRINTSⁱ	PR00659 CHROMOGRANIN
PROSITEⁱ	View protein in PROSITE PS00422 GRANINS_1, 1 hit PS00423 GRANINS_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CMGA_HUMAN
Accessionⁱ	P10645Primary (citable) accession number: P10645 Secondary accession number(s): B2R9E9 , Q53FA8, Q6NR84, Q96E84, Q96GL7, Q9BQB5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	November 25, 2008
	Last modified:	September 12, 2018
	This is version 195 of the entry and version 7 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P10645 (CMGA_HUMAN)

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Chromogranin-A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Other locations

Extracellular region or secreted

Other locations

Extracellular region or secreted

Lysosome

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Mass spectrometryⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ