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UniProtKB - P10644 (KAP0_HUMAN)

Entry version 238 (29 Sep 2021)
Sequence version 1 (01 Jul 1989)
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Protein

cAMP-dependent protein kinase type I-alpha regulatory subunit

Gene

PRKAR1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.

3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei2023',5'-cAMP 11
Binding sitei2113',5'-cAMP 11
Binding sitei3263',5'-cAMP 21
Binding sitei3353',5'-cAMP 21

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi137 – 2543',5'-cAMP 1Add BLAST118
Nucleotide bindingi255 – 3813',5'-cAMP 2Add BLAST127

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandcAMP, cAMP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P10644

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-163615, PKA activation
R-HSA-164378, PKA activation in glucagon signalling
R-HSA-180024, DARPP-32 events
R-HSA-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-442720, CREB1 phosphorylation through the activation of Adenylate Cyclase
R-HSA-5610787, Hedgehog 'off' state
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9664323, FCGR3A-mediated IL10 synthesis
R-HSA-983231, Factors involved in megakaryocyte development and platelet production

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P10644

SIGNOR Signaling Network Open Resource

More...SIGNORi		P10644

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
cAMP-dependent protein kinase type I-alpha regulatory subunit
Alternative name(s):
Tissue-specific extinguisher 1
Short name:
TSE1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRKAR1A
Synonyms:PKR1, PRKAR1, TSE1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9388, PRKAR1A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		188830, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P10644

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000108946

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Carney complex 1 (CNC1)5 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionCNC is a multiple neoplasia syndrome characterized by spotty skin pigmentation, cardiac and other myxomas, endocrine tumors, and psammomatous melanotic schwannomas.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0468949S → N in CNC1; exhibits increased PKA activity which is attributed to decreased binding to cAMP and/or the catalytic subunit. 1 Publication1
Natural variantiVAR_04689574R → C in CNC1; exhibits increased PKA activity which is attributed to decreased binding to cAMP and/or the catalytic subunit. 2 PublicationsCorresponds to variant dbSNP:rs137853303EnsemblClinVar.1
Natural variantiVAR_046896146R → S in CNC1; exhibits increased PKA activity which is attributed to decreased binding to cAMP and/or the catalytic subunit. 1 Publication1
Natural variantiVAR_046897183D → Y in CNC1; exhibits increased PKA activity which is attributed to decreased binding to cAMP and/or the catalytic subunit. 1 Publication1
Natural variantiVAR_046898213A → D in CNC1; exhibits increased PKA activity which is attributed to decreased binding to cAMP and/or the catalytic subunit; reduces protein degradation. 2 PublicationsCorresponds to variant dbSNP:rs281864786EnsemblClinVar.1
Natural variantiVAR_046899289G → W in CNC1; exhibits increased PKA activity which is attributed to decreased binding to cAMP and/or the catalytic subunit; accelerates protein degradation. 2 Publications1
Intracardiac myxoma (INTMYX)
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionInheritance is autosomal recessive.
Related information in OMIM
Primary pigmented nodular adrenocortical disease 1 (PPNAD1)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small pigmented micronodules observed in the cortex. Clinical manifestations of Cushing syndrome include facial and truncal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. PPNAD1 is most often diagnosed in patients with Carney complex, a multiple neoplasia syndrome. However it can also be observed in patients without other manifestations.
Related information in OMIM
Acrodysostosis 1, with or without hormone resistance (ACRDYS1)7 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of skeletal dysplasia characterized by short stature, severe brachydactyly, facial dysostosis, and nasal hypoplasia. Affected individuals often have advanced bone age and obesity. Laboratory studies show resistance to multiple hormones, including parathyroid, thyrotropin, calcitonin, growth hormone-releasing hormone, and gonadotropin. However, not all patients show endocrine abnormalities.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_075533175Y → C in ACRDYS1; reduces PKA activity; decreases cAMP binding. 1 Publication1
Natural variantiVAR_069456213A → T in ACRDYS1; reduces PKA activity; decreases cAMP binding; reduces protein degradation. 2 Publications1
Natural variantiVAR_069458239T → A in ACRDYS1; impairs response of PKA to c-AMP. 1 Publication1
Natural variantiVAR_069459285Q → R in ACRDYS1; reduces PKA activity; decreases cAMP binding. 2 PublicationsCorresponds to variant dbSNP:rs1555814719EnsemblClinVar.1
Natural variantiVAR_069460289G → E in ACRDYS1; reduces PKA activity; decreases cAMP binding; reduces protein degradation. 2 Publications1
Natural variantiVAR_069461327I → T in ACRDYS1. 1 PublicationCorresponds to variant dbSNP:rs387906695EnsemblClinVar.1
Natural variantiVAR_069462328A → V in ACRDYS1; disrupts cAMP binding. 2 Publications1
Natural variantiVAR_069464335R → L in ACRDYS1; disrupts cAMP binding. 2 Publications1
Natural variantiVAR_069463335R → P in ACRDYS1. 1 PublicationCorresponds to variant dbSNP:rs387906694EnsemblClinVar.1
Natural variantiVAR_069465373Y → C in ACRDYS1. 1 Publication1
Natural variantiVAR_068241373Y → H in ACRDYS1. 1 PublicationCorresponds to variant dbSNP:rs387906693EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi373Y → A: Impairs response of PKA to c-AMP. 1 Publication1

Keywords - Diseasei

Cushing syndrome, Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		5573

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		PRKAR1A

MalaCards human disease database

More...MalaCardsi		PRKAR1A
MIMi101800, phenotype
160980, phenotype
255960, phenotype
610489, phenotype

Open Targets

More...OpenTargetsi		ENSG00000108946

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		950, Acrodysostosis
280651, Acrodysostosis with multiple hormone resistance
520, Acute promyelocytic leukemia
1359, Carney complex
615, Familial atrial myxoma
189439, Primary pigmented nodular adrenocortical disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33754

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P10644, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4928

Drug and drug target database

More...DrugBanki		DB01790, (Rp)-cAMPS
DB02527, Cyclic adenosine monophosphate
DB02315, Cyclic GMP
DB05798, GEM-231

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1472

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PRKAR1A

Domain mapping of disease mutations (DMDM)

More...DMDMi		125193

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002053771 – 381cAMP-dependent protein kinase type I-alpha regulatory subunitAdd BLAST381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei3PhosphoserineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi18Interchain (with C-39)By similarity
Disulfide bondi39Interchain (with C-18)By similarity
Modified residuei75PhosphothreonineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei83PhosphoserineCombined sources1
Modified residuei101PhosphoserineBy similarity1
Modified residuei258PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P10644

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P10644

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P10644

MaxQB - The MaxQuant DataBase

More...MaxQBi		P10644

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P10644

PeptideAtlas

More...PeptideAtlasi		P10644

PRoteomics IDEntifications database

More...PRIDEi		P10644

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52634 [P10644-1]

2D gel databases

USC-OGP 2-DE database

More...OGPi		P10644

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00021831

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P10644

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P10644

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P10644

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P10644

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000108946, Expressed in substantia nigra and 251 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P10644, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P10644, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000108946, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The inactive holoenzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP releases the two active catalytic monomers and the regulatory dimer.

Interacts with PRKACA and PRKACB (PubMed:33058759). PRKAR1A also interacts with RFC2; the complex may be involved in cell survival.

Interacts with AKAP4.

Interacts with RARA; the interaction occurs in the presence of cAMP or FSH and regulates RARA transcriptional activity.

Interacts with the phosphorylated form of PJA2.

Interacts with CBFA2T3 (By similarity).

Interacts with PRKX; regulates this cAMP-dependent protein kinase.

Interacts with C2orf88/smAKAP; this interaction may target PRKAR1A to the plasma membrane.

Interacts with AICDA.

By similarity7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111559, 202 interactors

Database of interacting proteins

More...DIPi		DIP-34368N

Protein interaction database and analysis system

More...IntActi		P10644, 186 interactors

Molecular INTeraction database

More...MINTi		P10644

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000376475

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P10644

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P10644, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1381
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P10644

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 136Dimerization and phosphorylationAdd BLAST136
Regioni64 – 96DisorderedSequence analysisAdd BLAST33

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi96 – 100Pseudophosphorylation motif5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cAMP-dependent kinase regulatory chain family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1113, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155148

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_018310_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P10644

Identification of Orthologs from Complete Genome Data

More...OMAi		VESSFWA

Database for complete collections of gene phylogenies

More...PhylomeDBi		P10644

TreeFam database of animal gene trees

More...TreeFami		TF314920

Family and domain databases

Conserved Domains Database

More...CDDi		cd00038, CAP_ED, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012198, cAMP_dep_PK_reg_su
IPR003117, cAMP_dep_PK_reg_su_I/II_a/b
IPR018490, cNMP-bd-like
IPR018488, cNMP-bd_CS
IPR000595, cNMP-bd_dom
IPR014710, RmlC-like_jellyroll

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00027, cNMP_binding, 2 hits
PF02197, RIIa, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000548, PK_regulatory, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00100, cNMP, 2 hits
SM00394, RIIa, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51206, SSF51206, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00888, CNMP_BINDING_1, 2 hits
PS00889, CNMP_BINDING_2, 2 hits
PS50042, CNMP_BINDING_3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P10644-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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MESGSTAASE EARSLRECEL YVQKHNIQAL LKDSIVQLCT ARPERPMAFL 
        60         70         80         90        100
REYFERLEKE EAKQIQNLQK AGTRTDSRED EISPPPPNPV VKGRRRRGAI 
       110        120        130        140        150
SAEVYTEEDA ASYVRKVIPK DYKTMAALAK AIEKNVLFSH LDDNERSDIF 
       160        170        180        190        200
DAMFSVSFIA GETVIQQGDE GDNFYVIDQG ETDVYVNNEW ATSVGEGGSF 
       210        220        230        240        250
GELALIYGTP RAATVKAKTN VKLWGIDRDS YRRILMGSTL RKRKMYEEFL 
       260        270        280        290        300
SKVSILESLD KWERLTVADA LEPVQFEDGQ KIVVQGEPGD EFFIILEGSA 
       310        320        330        340        350
AVLQRRSENE EFVEVGRLGP SDYFGEIALL MNRPRAATVV ARGPLKCVKL 
       360        370        380 
DRPRFERVLG PCSDILKRNI QQYNSFVSLS V
Length:381
Mass (Da):42,982
Last modified:July 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D04F08CE8857A6D
GO
Isoform 2 (identifier: P10644-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     326-337: EIALLMNRPRAA → HLIISRRSIPLG
     338-381: Missing.

Show »
Length:337
Mass (Da):38,003
Checksum:i8C14AF540F3150CF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EPB2K7EPB2_HUMAN
cAMP-dependent protein kinase type ...
PRKAR1A
297Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJ40K7EJ40_HUMAN
cAMP-dependent protein kinase type ...
PRKAR1A
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EK41K7EK41_HUMAN
cAMP-dependent protein kinase type ...
PRKAR1A
204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EID3K7EID3_HUMAN
cAMP-dependent protein kinase type ...
PRKAR1A
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIE5K7EIE5_HUMAN
cAMP-dependent protein kinase type ...
PRKAR1A
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMU2K7EMU2_HUMAN
cAMP-dependent protein kinase type ...
PRKAR1A
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMZ6K7EMZ6_HUMAN
cAMP-dependent protein kinase type ...
PRKAR1A
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EM13K7EM13_HUMAN
cAMP-dependent protein kinase type ...
PRKAR1A
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQK3K7EQK3_HUMAN
cAMP-dependent protein kinase type ...
PRKAR1A
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPR5K7EPR5_HUMAN
cAMP-dependent protein kinase type ...
PRKAR1A
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0468949S → N in CNC1; exhibits increased PKA activity which is attributed to decreased binding to cAMP and/or the catalytic subunit. 1 Publication1
Natural variantiVAR_04689574R → C in CNC1; exhibits increased PKA activity which is attributed to decreased binding to cAMP and/or the catalytic subunit. 2 PublicationsCorresponds to variant dbSNP:rs137853303EnsemblClinVar.1
Natural variantiVAR_046896146R → S in CNC1; exhibits increased PKA activity which is attributed to decreased binding to cAMP and/or the catalytic subunit. 1 Publication1
Natural variantiVAR_075533175Y → C in ACRDYS1; reduces PKA activity; decreases cAMP binding. 1 Publication1
Natural variantiVAR_046897183D → Y in CNC1; exhibits increased PKA activity which is attributed to decreased binding to cAMP and/or the catalytic subunit. 1 Publication1
Natural variantiVAR_046898213A → D in CNC1; exhibits increased PKA activity which is attributed to decreased binding to cAMP and/or the catalytic subunit; reduces protein degradation. 2 PublicationsCorresponds to variant dbSNP:rs281864786EnsemblClinVar.1
Natural variantiVAR_069456213A → T in ACRDYS1; reduces PKA activity; decreases cAMP binding; reduces protein degradation. 2 Publications1
Natural variantiVAR_069457227D → N1 Publication1
Natural variantiVAR_069458239T → A in ACRDYS1; impairs response of PKA to c-AMP. 1 Publication1
Natural variantiVAR_069459285Q → R in ACRDYS1; reduces PKA activity; decreases cAMP binding. 2 PublicationsCorresponds to variant dbSNP:rs1555814719EnsemblClinVar.1
Natural variantiVAR_069460289G → E in ACRDYS1; reduces PKA activity; decreases cAMP binding; reduces protein degradation. 2 Publications1
Natural variantiVAR_046899289G → W in CNC1; exhibits increased PKA activity which is attributed to decreased binding to cAMP and/or the catalytic subunit; accelerates protein degradation. 2 Publications1
Natural variantiVAR_069461327I → T in ACRDYS1. 1 PublicationCorresponds to variant dbSNP:rs387906695EnsemblClinVar.1
Natural variantiVAR_069462328A → V in ACRDYS1; disrupts cAMP binding. 2 Publications1
Natural variantiVAR_069464335R → L in ACRDYS1; disrupts cAMP binding. 2 Publications1
Natural variantiVAR_069463335R → P in ACRDYS1. 1 PublicationCorresponds to variant dbSNP:rs387906694EnsemblClinVar.1
Natural variantiVAR_069465373Y → C in ACRDYS1. 1 Publication1
Natural variantiVAR_068241373Y → H in ACRDYS1. 1 PublicationCorresponds to variant dbSNP:rs387906693EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054833326 – 337EIALL…RPRAA → HLIISRRSIPLG in isoform 2. CuratedAdd BLAST12
Alternative sequenceiVSP_054834338 – 381Missing in isoform 2. CuratedAdd BLAST44

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M18468 mRNA Translation: AAB50922.1
M33336 mRNA Translation: AAB50921.1
S54705 mRNA No translation available.
S54707 mRNA No translation available.
S54709 mRNA No translation available.
S54711 mRNA No translation available.
Y07642 mRNA Translation: CAA68925.1
AC079210 Genomic DNA No translation available.
BC036285 mRNA Translation: AAH36285.1
BC093042 mRNA Translation: AAH93042.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11678.1 [P10644-1]
CCDS62307.1 [P10644-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A34627, OKHU1R

NCBI Reference Sequences

More...RefSeqi		NP_001263218.1, NM_001276289.1 [P10644-1]
NP_001263219.1, NM_001276290.1 [P10644-2]
NP_001265362.1, NM_001278433.1 [P10644-1]
NP_002725.1, NM_002734.4 [P10644-1]
NP_997636.1, NM_212471.2 [P10644-1]
NP_997637.1, NM_212472.2 [P10644-1]
XP_011523285.1, XM_011524983.2
XP_011523286.1, XM_011524984.2 [P10644-1]
XP_011523287.1, XM_011524985.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000358598; ENSP00000351410; ENSG00000108946 [P10644-1]
ENST00000392711; ENSP00000376475; ENSG00000108946 [P10644-1]
ENST00000536854; ENSP00000445625; ENSG00000108946 [P10644-1]
ENST00000586397; ENSP00000466459; ENSG00000108946 [P10644-1]
ENST00000588188; ENSP00000468106; ENSG00000108946 [P10644-2]
ENST00000589228; ENSP00000464977; ENSG00000108946 [P10644-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5573

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5573

UCSC genome browser

More...UCSCi		uc002jhg.5, human [P10644-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18468 mRNA Translation: AAB50922.1
M33336 mRNA Translation: AAB50921.1
S54705 mRNA No translation available.
S54707 mRNA No translation available.
S54709 mRNA No translation available.
S54711 mRNA No translation available.
Y07642 mRNA Translation: CAA68925.1
AC079210 Genomic DNA No translation available.
BC036285 mRNA Translation: AAH36285.1
BC093042 mRNA Translation: AAH93042.1
CCDSiCCDS11678.1 [P10644-1]
CCDS62307.1 [P10644-2]
PIRiA34627, OKHU1R
RefSeqiNP_001263218.1, NM_001276289.1 [P10644-1]
NP_001263219.1, NM_001276290.1 [P10644-2]
NP_001265362.1, NM_001278433.1 [P10644-1]
NP_002725.1, NM_002734.4 [P10644-1]
NP_997636.1, NM_212471.2 [P10644-1]
NP_997637.1, NM_212472.2 [P10644-1]
XP_011523285.1, XM_011524983.2
XP_011523286.1, XM_011524984.2 [P10644-1]
XP_011523287.1, XM_011524985.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5KJXX-ray1.90A234-381[»]
5KJYX-ray2.00A234-381[»]
5KJZX-ray1.35A234-381[»]
SMRiP10644
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111559, 202 interactors
DIPiDIP-34368N
IntActiP10644, 186 interactors
MINTiP10644
STRINGi9606.ENSP00000376475

Chemistry databases

BindingDBiP10644
ChEMBLiCHEMBL4928
DrugBankiDB01790, (Rp)-cAMPS
DB02527, Cyclic adenosine monophosphate
DB02315, Cyclic GMP
DB05798, GEM-231
GuidetoPHARMACOLOGYi1472

PTM databases

iPTMnetiP10644
MetOSiteiP10644
PhosphoSitePlusiP10644
SwissPalmiP10644

Genetic variation databases

BioMutaiPRKAR1A
DMDMi125193

2D gel databases

OGPiP10644
REPRODUCTION-2DPAGEiIPI00021831

Proteomic databases

EPDiP10644
jPOSTiP10644
MassIVEiP10644
MaxQBiP10644
PaxDbiP10644
PeptideAtlasiP10644
PRIDEiP10644
ProteomicsDBi52634 [P10644-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31783, 367 antibodies

The DNASU plasmid repository

More...DNASUi		5573

Genome annotation databases

EnsembliENST00000358598; ENSP00000351410; ENSG00000108946 [P10644-1]
ENST00000392711; ENSP00000376475; ENSG00000108946 [P10644-1]
ENST00000536854; ENSP00000445625; ENSG00000108946 [P10644-1]
ENST00000586397; ENSP00000466459; ENSG00000108946 [P10644-1]
ENST00000588188; ENSP00000468106; ENSG00000108946 [P10644-2]
ENST00000589228; ENSP00000464977; ENSG00000108946 [P10644-1]
GeneIDi5573
KEGGihsa:5573
UCSCiuc002jhg.5, human [P10644-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5573
DisGeNETi5573

GeneCards: human genes, protein and diseases

More...GeneCardsi		PRKAR1A
GeneReviewsiPRKAR1A
HGNCiHGNC:9388, PRKAR1A
HPAiENSG00000108946, Low tissue specificity
MalaCardsiPRKAR1A
MIMi101800, phenotype
160980, phenotype
188830, gene
255960, phenotype
610489, phenotype
neXtProtiNX_P10644
OpenTargetsiENSG00000108946
Orphaneti950, Acrodysostosis
280651, Acrodysostosis with multiple hormone resistance
520, Acute promyelocytic leukemia
1359, Carney complex
615, Familial atrial myxoma
189439, Primary pigmented nodular adrenocortical disease
PharmGKBiPA33754
VEuPathDBiHostDB:ENSG00000108946

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1113, Eukaryota
GeneTreeiENSGT00940000155148
HOGENOMiCLU_018310_1_0_1
InParanoidiP10644
OMAiVESSFWA
PhylomeDBiP10644
TreeFamiTF314920

Enzyme and pathway databases

PathwayCommonsiP10644
ReactomeiR-HSA-163615, PKA activation
R-HSA-164378, PKA activation in glucagon signalling
R-HSA-180024, DARPP-32 events
R-HSA-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-442720, CREB1 phosphorylation through the activation of Adenylate Cyclase
R-HSA-5610787, Hedgehog 'off' state
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9664323, FCGR3A-mediated IL10 synthesis
R-HSA-983231, Factors involved in megakaryocyte development and platelet production
SignaLinkiP10644
SIGNORiP10644

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5573, 91 hits in 1022 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PRKAR1A, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5573
PharosiP10644, Tbio

Protein Ontology

More...PROi		PR:P10644
RNActiP10644, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000108946, Expressed in substantia nigra and 251 other tissues
ExpressionAtlasiP10644, baseline and differential
GenevisibleiP10644, HS

Family and domain databases

CDDicd00038, CAP_ED, 2 hits
Gene3Di2.60.120.10, 2 hits
InterProiView protein in InterPro
IPR012198, cAMP_dep_PK_reg_su
IPR003117, cAMP_dep_PK_reg_su_I/II_a/b
IPR018490, cNMP-bd-like
IPR018488, cNMP-bd_CS
IPR000595, cNMP-bd_dom
IPR014710, RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027, cNMP_binding, 2 hits
PF02197, RIIa, 1 hit
PIRSFiPIRSF000548, PK_regulatory, 1 hit
SMARTiView protein in SMART
SM00100, cNMP, 2 hits
SM00394, RIIa, 1 hit
SUPFAMiSSF51206, SSF51206, 2 hits
PROSITEiView protein in PROSITE
PS00888, CNMP_BINDING_1, 2 hits
PS00889, CNMP_BINDING_2, 2 hits
PS50042, CNMP_BINDING_3, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKAP0_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10644
Secondary accession number(s): K7ER48, Q567S7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 29, 2021
This is version 238 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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