UniProtKB - P10644 (KAP0_HUMAN)
cAMP-dependent protein kinase type I-alpha regulatory subunit
PRKAR1A
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 202 | cAMP 1 | 1 | |
Binding sitei | 211 | cAMP 1 | 1 | |
Binding sitei | 326 | cAMP 2 | 1 | |
Binding sitei | 335 | cAMP 2 | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 137 – 254 | cAMP 1Add BLAST | 118 | |
Nucleotide bindingi | 255 – 381 | cAMP 2Add BLAST | 127 |
GO - Molecular functioni
- cAMP binding Source: UniProtKB-KW
- cAMP-dependent protein kinase inhibitor activity Source: BHF-UCL
- cAMP-dependent protein kinase regulator activity Source: BHF-UCL
- protein domain specific binding Source: UniProtKB
- protein kinase A catalytic subunit binding Source: UniProtKB
- ubiquitin protein ligase binding Source: UniProtKB
GO - Biological processi
- activation of protein kinase A activity Source: Reactome
- blood coagulation Source: Reactome
- cardiac muscle cell proliferation Source: Ensembl
- cellular response to glucagon stimulus Source: Reactome
- chemical synaptic transmission Source: Reactome
- female meiotic nuclear division Source: Ensembl
- intracellular signal transduction Source: ProtInc
- mesoderm formation Source: Ensembl
- negative regulation of activated T cell proliferation Source: UniProtKB
- negative regulation of cAMP-dependent protein kinase activity Source: BHF-UCL
- negative regulation of inflammatory response to antigenic stimulus Source: Reactome
- negative regulation of meiotic nuclear division Source: Ensembl
- regulation of cAMP-mediated signaling Source: GO_Central
- regulation of protein kinase A signaling Source: GO_Central
- regulation of transcription by RNA polymerase II Source: ProtInc
- renal water homeostasis Source: Reactome
- sarcomere organization Source: Ensembl
Keywordsi
Ligand | cAMP, cAMP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P10644 |
Reactomei | R-HSA-163615, PKA activation R-HSA-164378, PKA activation in glucagon signalling R-HSA-180024, DARPP-32 events R-HSA-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-442720, CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-5610787, Hedgehog 'off' state R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production R-HSA-9664323, FCGR3A-mediated IL10 synthesis R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
SignaLinki | P10644 |
SIGNORi | P10644 |
Names & Taxonomyi
Protein namesi | Recommended name: cAMP-dependent protein kinase type I-alpha regulatory subunitAlternative name(s): Tissue-specific extinguisher 1 Short name: TSE1 |
Gene namesi | Name:PRKAR1A Synonyms:PKR1, PRKAR1, TSE1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9388, PRKAR1A |
MIMi | 188830, gene |
neXtProti | NX_P10644 |
VEuPathDBi | HostDB:ENSG00000108946.14 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication
Cytoskeleton
- centrosome Source: Ensembl
Cytosol
- cytosol Source: Reactome
Endosome
- multivesicular body Source: Ensembl
Plasma Membrane
- plasma membrane raft Source: UniProtKB
Other locations
- cAMP-dependent protein kinase complex Source: GO_Central
- ciliary base Source: Reactome
- cytoplasm Source: UniProtKB
- glutamatergic synapse Source: Ensembl
- membrane Source: UniProtKB
- neuromuscular junction Source: Ensembl
- nucleotide-activated protein kinase complex Source: BHF-UCL
- protein-containing complex Source: UniProtKB
- sperm connecting piece Source: Ensembl
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Carney complex 1 (CNC1)5 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_046894 | 9 | S → N in CNC1; exhibits increased PKA activity which is attributed to decreased binding to cAMP and/or the catalytic subunit. 1 Publication | 1 | |
Natural variantiVAR_046895 | 74 | R → C in CNC1; exhibits increased PKA activity which is attributed to decreased binding to cAMP and/or the catalytic subunit. 2 PublicationsCorresponds to variant dbSNP:rs137853303EnsemblClinVar. | 1 | |
Natural variantiVAR_046896 | 146 | R → S in CNC1; exhibits increased PKA activity which is attributed to decreased binding to cAMP and/or the catalytic subunit. 1 Publication | 1 | |
Natural variantiVAR_046897 | 183 | D → Y in CNC1; exhibits increased PKA activity which is attributed to decreased binding to cAMP and/or the catalytic subunit. 1 Publication | 1 | |
Natural variantiVAR_046898 | 213 | A → D in CNC1; exhibits increased PKA activity which is attributed to decreased binding to cAMP and/or the catalytic subunit; reduces protein degradation. 2 PublicationsCorresponds to variant dbSNP:rs281864786EnsemblClinVar. | 1 | |
Natural variantiVAR_046899 | 289 | G → W in CNC1; exhibits increased PKA activity which is attributed to decreased binding to cAMP and/or the catalytic subunit; accelerates protein degradation. 2 Publications | 1 |
Intracardiac myxoma (INTMYX)
Primary pigmented nodular adrenocortical disease 1 (PPNAD1)1 Publication
Acrodysostosis 1, with or without hormone resistance (ACRDYS1)7 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_075533 | 175 | Y → C in ACRDYS1; reduces PKA activity; decreases cAMP binding. 1 Publication | 1 | |
Natural variantiVAR_069456 | 213 | A → T in ACRDYS1; reduces PKA activity; decreases cAMP binding; reduces protein degradation. 2 Publications | 1 | |
Natural variantiVAR_069458 | 239 | T → A in ACRDYS1; impairs response of PKA to c-AMP. 1 Publication | 1 | |
Natural variantiVAR_069459 | 285 | Q → R in ACRDYS1; reduces PKA activity; decreases cAMP binding. 2 PublicationsCorresponds to variant dbSNP:rs1555814719EnsemblClinVar. | 1 | |
Natural variantiVAR_069460 | 289 | G → E in ACRDYS1; reduces PKA activity; decreases cAMP binding; reduces protein degradation. 2 Publications | 1 | |
Natural variantiVAR_069461 | 327 | I → T in ACRDYS1. 1 PublicationCorresponds to variant dbSNP:rs387906695EnsemblClinVar. | 1 | |
Natural variantiVAR_069462 | 328 | A → V in ACRDYS1; disrupts cAMP binding. 2 Publications | 1 | |
Natural variantiVAR_069464 | 335 | R → L in ACRDYS1; disrupts cAMP binding. 2 Publications | 1 | |
Natural variantiVAR_069463 | 335 | R → P in ACRDYS1. 1 PublicationCorresponds to variant dbSNP:rs387906694EnsemblClinVar. | 1 | |
Natural variantiVAR_069465 | 373 | Y → C in ACRDYS1. 1 Publication | 1 | |
Natural variantiVAR_068241 | 373 | Y → H in ACRDYS1. 1 PublicationCorresponds to variant dbSNP:rs387906693EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 373 | Y → A: Impairs response of PKA to c-AMP. 1 Publication | 1 |
Keywords - Diseasei
Cushing syndrome, Disease variantOrganism-specific databases
DisGeNETi | 5573 |
GeneReviewsi | PRKAR1A |
MalaCardsi | PRKAR1A |
MIMi | 101800, phenotype 160980, phenotype 255960, phenotype 610489, phenotype |
OpenTargetsi | ENSG00000108946 |
Orphaneti | 950, Acrodysostosis 280651, Acrodysostosis with multiple hormone resistance 520, Acute promyelocytic leukemia 1359, Carney complex 615, Familial atrial myxoma 189439, Primary pigmented nodular adrenocortical disease |
PharmGKBi | PA33754 |
Miscellaneous databases
Pharosi | P10644, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4928 |
DrugBanki | DB01790, (Rp)-cAMPS DB02527, Cyclic adenosine monophosphate DB02315, Cyclic GMP DB05798, GEM-231 |
GuidetoPHARMACOLOGYi | 1472 |
Genetic variation databases
BioMutai | PRKAR1A |
DMDMi | 125193 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000205377 | 1 – 381 | cAMP-dependent protein kinase type I-alpha regulatory subunitAdd BLAST | 381 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources1 Publication | 1 | |
Modified residuei | 3 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 18 | Interchain (with C-39)By similarity | ||
Disulfide bondi | 39 | Interchain (with C-18)By similarity | ||
Modified residuei | 75 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 77 | PhosphoserineCombined sources | 1 | |
Modified residuei | 83 | PhosphoserineCombined sources | 1 | |
Modified residuei | 101 | PhosphoserineBy similarity | 1 | |
Modified residuei | 258 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Disulfide bond, PhosphoproteinProteomic databases
EPDi | P10644 |
jPOSTi | P10644 |
MassIVEi | P10644 |
MaxQBi | P10644 |
PaxDbi | P10644 |
PeptideAtlasi | P10644 |
PRIDEi | P10644 |
ProteomicsDBi | 52634 [P10644-1] |
2D gel databases
OGPi | P10644 |
REPRODUCTION-2DPAGEi | IPI00021831 |
PTM databases
iPTMneti | P10644 |
MetOSitei | P10644 |
PhosphoSitePlusi | P10644 |
SwissPalmi | P10644 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000108946, Expressed in substantia nigra and 250 other tissues |
ExpressionAtlasi | P10644, baseline and differential |
Genevisiblei | P10644, HS |
Organism-specific databases
HPAi | ENSG00000108946, Low tissue specificity |
Interactioni
Subunit structurei
The inactive holoenzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP releases the two active catalytic monomers and the regulatory dimer. PRKAR1A also interacts with RFC2; the complex may be involved in cell survival.
Interacts with AKAP4.
Interacts with RARA; the interaction occurs in the presence of cAMP or FSH and regulates RARA transcriptional activity.
Interacts with the phosphorylated form of PJA2.
Interacts with CBFA2T3 (By similarity).
Interacts with PRKX; regulates this cAMP-dependent protein kinase.
Interacts with C2orf88/smAKAP; this interaction may target PRKAR1A to the plasma membrane.
Interacts with AICDA.
By similarity6 PublicationsBinary interactionsi
Hide detailsP10644
GO - Molecular functioni
- protein domain specific binding Source: UniProtKB
- protein kinase A catalytic subunit binding Source: UniProtKB
- ubiquitin protein ligase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 111559, 199 interactors |
DIPi | DIP-34368N |
IntActi | P10644, 184 interactors |
MINTi | P10644 |
STRINGi | 9606.ENSP00000376475 |
Chemistry databases
BindingDBi | P10644 |
Miscellaneous databases
RNActi | P10644, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P10644 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 136 | Dimerization and phosphorylationAdd BLAST | 136 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 96 – 100 | Pseudophosphorylation motif | 5 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG1113, Eukaryota |
GeneTreei | ENSGT00940000155148 |
HOGENOMi | CLU_018310_1_0_1 |
InParanoidi | P10644 |
OMAi | RPMGFLR |
PhylomeDBi | P10644 |
TreeFami | TF314920 |
Family and domain databases
CDDi | cd00038, CAP_ED, 2 hits |
Gene3Di | 2.60.120.10, 2 hits |
InterProi | View protein in InterPro IPR012198, cAMP_dep_PK_reg_su IPR003117, cAMP_dep_PK_reg_su_I/II_a/b IPR018490, cNMP-bd-like IPR018488, cNMP-bd_CS IPR000595, cNMP-bd_dom IPR014710, RmlC-like_jellyroll |
Pfami | View protein in Pfam PF00027, cNMP_binding, 2 hits PF02197, RIIa, 1 hit |
PIRSFi | PIRSF000548, PK_regulatory, 1 hit |
SMARTi | View protein in SMART SM00100, cNMP, 2 hits SM00394, RIIa, 1 hit |
SUPFAMi | SSF51206, SSF51206, 2 hits |
PROSITEi | View protein in PROSITE PS00888, CNMP_BINDING_1, 2 hits PS00889, CNMP_BINDING_2, 2 hits PS50042, CNMP_BINDING_3, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MESGSTAASE EARSLRECEL YVQKHNIQAL LKDSIVQLCT ARPERPMAFL
60 70 80 90 100
REYFERLEKE EAKQIQNLQK AGTRTDSRED EISPPPPNPV VKGRRRRGAI
110 120 130 140 150
SAEVYTEEDA ASYVRKVIPK DYKTMAALAK AIEKNVLFSH LDDNERSDIF
160 170 180 190 200
DAMFSVSFIA GETVIQQGDE GDNFYVIDQG ETDVYVNNEW ATSVGEGGSF
210 220 230 240 250
GELALIYGTP RAATVKAKTN VKLWGIDRDS YRRILMGSTL RKRKMYEEFL
260 270 280 290 300
SKVSILESLD KWERLTVADA LEPVQFEDGQ KIVVQGEPGD EFFIILEGSA
310 320 330 340 350
AVLQRRSENE EFVEVGRLGP SDYFGEIALL MNRPRAATVV ARGPLKCVKL
360 370 380
DRPRFERVLG PCSDILKRNI QQYNSFVSLS V
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EJ40 | K7EJ40_HUMAN | cAMP-dependent protein kinase type ... | PRKAR1A | 182 | Annotation score: | ||
K7EPB2 | K7EPB2_HUMAN | cAMP-dependent protein kinase type ... | PRKAR1A | 297 | Annotation score: | ||
K7EK41 | K7EK41_HUMAN | cAMP-dependent protein kinase type ... | PRKAR1A | 204 | Annotation score: | ||
K7EID3 | K7EID3_HUMAN | cAMP-dependent protein kinase type ... | PRKAR1A | 167 | Annotation score: | ||
K7EIE5 | K7EIE5_HUMAN | cAMP-dependent protein kinase type ... | PRKAR1A | 157 | Annotation score: | ||
K7EMU2 | K7EMU2_HUMAN | cAMP-dependent protein kinase type ... | PRKAR1A | 113 | Annotation score: | ||
K7EMZ6 | K7EMZ6_HUMAN | cAMP-dependent protein kinase type ... | PRKAR1A | 131 | Annotation score: | ||
K7EM13 | K7EM13_HUMAN | cAMP-dependent protein kinase type ... | PRKAR1A | 153 | Annotation score: | ||
K7EQK3 | K7EQK3_HUMAN | cAMP-dependent protein kinase type ... | PRKAR1A | 65 | Annotation score: | ||
K7EKR1 | K7EKR1_HUMAN | cAMP-dependent protein kinase type ... | PRKAR1A | 35 | Annotation score: | ||
There are more potential isoformsShow all |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_046894 | 9 | S → N in CNC1; exhibits increased PKA activity which is attributed to decreased binding to cAMP and/or the catalytic subunit. 1 Publication | 1 | |
Natural variantiVAR_046895 | 74 | R → C in CNC1; exhibits increased PKA activity which is attributed to decreased binding to cAMP and/or the catalytic subunit. 2 PublicationsCorresponds to variant dbSNP:rs137853303EnsemblClinVar. | 1 | |
Natural variantiVAR_046896 | 146 | R → S in CNC1; exhibits increased PKA activity which is attributed to decreased binding to cAMP and/or the catalytic subunit. 1 Publication | 1 | |
Natural variantiVAR_075533 | 175 | Y → C in ACRDYS1; reduces PKA activity; decreases cAMP binding. 1 Publication | 1 | |
Natural variantiVAR_046897 | 183 | D → Y in CNC1; exhibits increased PKA activity which is attributed to decreased binding to cAMP and/or the catalytic subunit. 1 Publication | 1 | |
Natural variantiVAR_046898 | 213 | A → D in CNC1; exhibits increased PKA activity which is attributed to decreased binding to cAMP and/or the catalytic subunit; reduces protein degradation. 2 PublicationsCorresponds to variant dbSNP:rs281864786EnsemblClinVar. | 1 | |
Natural variantiVAR_069456 | 213 | A → T in ACRDYS1; reduces PKA activity; decreases cAMP binding; reduces protein degradation. 2 Publications | 1 | |
Natural variantiVAR_069457 | 227 | D → N1 Publication | 1 | |
Natural variantiVAR_069458 | 239 | T → A in ACRDYS1; impairs response of PKA to c-AMP. 1 Publication | 1 | |
Natural variantiVAR_069459 | 285 | Q → R in ACRDYS1; reduces PKA activity; decreases cAMP binding. 2 PublicationsCorresponds to variant dbSNP:rs1555814719EnsemblClinVar. | 1 | |
Natural variantiVAR_069460 | 289 | G → E in ACRDYS1; reduces PKA activity; decreases cAMP binding; reduces protein degradation. 2 Publications | 1 | |
Natural variantiVAR_046899 | 289 | G → W in CNC1; exhibits increased PKA activity which is attributed to decreased binding to cAMP and/or the catalytic subunit; accelerates protein degradation. 2 Publications | 1 | |
Natural variantiVAR_069461 | 327 | I → T in ACRDYS1. 1 PublicationCorresponds to variant dbSNP:rs387906695EnsemblClinVar. | 1 | |
Natural variantiVAR_069462 | 328 | A → V in ACRDYS1; disrupts cAMP binding. 2 Publications | 1 | |
Natural variantiVAR_069464 | 335 | R → L in ACRDYS1; disrupts cAMP binding. 2 Publications | 1 | |
Natural variantiVAR_069463 | 335 | R → P in ACRDYS1. 1 PublicationCorresponds to variant dbSNP:rs387906694EnsemblClinVar. | 1 | |
Natural variantiVAR_069465 | 373 | Y → C in ACRDYS1. 1 Publication | 1 | |
Natural variantiVAR_068241 | 373 | Y → H in ACRDYS1. 1 PublicationCorresponds to variant dbSNP:rs387906693EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054833 | 326 – 337 | EIALL…RPRAA → HLIISRRSIPLG in isoform 2. CuratedAdd BLAST | 12 | |
Alternative sequenceiVSP_054834 | 338 – 381 | Missing in isoform 2. CuratedAdd BLAST | 44 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M18468 mRNA Translation: AAB50922.1 M33336 mRNA Translation: AAB50921.1 S54705 mRNA No translation available. S54707 mRNA No translation available. S54709 mRNA No translation available. S54711 mRNA No translation available. Y07642 mRNA Translation: CAA68925.1 AC079210 Genomic DNA No translation available. BC036285 mRNA Translation: AAH36285.1 BC093042 mRNA Translation: AAH93042.1 |
CCDSi | CCDS11678.1 [P10644-1] CCDS62307.1 [P10644-2] |
PIRi | A34627, OKHU1R |
RefSeqi | NP_001263218.1, NM_001276289.1 [P10644-1] NP_001263219.1, NM_001276290.1 [P10644-2] NP_001265362.1, NM_001278433.1 [P10644-1] NP_002725.1, NM_002734.4 [P10644-1] NP_997636.1, NM_212471.2 [P10644-1] NP_997637.1, NM_212472.2 [P10644-1] XP_011523285.1, XM_011524983.2 XP_011523286.1, XM_011524984.2 [P10644-1] XP_011523287.1, XM_011524985.2 |
Genome annotation databases
Ensembli | ENST00000358598; ENSP00000351410; ENSG00000108946 [P10644-1] ENST00000392711; ENSP00000376475; ENSG00000108946 [P10644-1] ENST00000536854; ENSP00000445625; ENSG00000108946 [P10644-1] ENST00000586397; ENSP00000466459; ENSG00000108946 [P10644-1] ENST00000588188; ENSP00000468106; ENSG00000108946 [P10644-2] ENST00000589228; ENSP00000464977; ENSG00000108946 [P10644-1] |
GeneIDi | 5573 |
KEGGi | hsa:5573 |
UCSCi | uc002jhg.5, human [P10644-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M18468 mRNA Translation: AAB50922.1 M33336 mRNA Translation: AAB50921.1 S54705 mRNA No translation available. S54707 mRNA No translation available. S54709 mRNA No translation available. S54711 mRNA No translation available. Y07642 mRNA Translation: CAA68925.1 AC079210 Genomic DNA No translation available. BC036285 mRNA Translation: AAH36285.1 BC093042 mRNA Translation: AAH93042.1 |
CCDSi | CCDS11678.1 [P10644-1] CCDS62307.1 [P10644-2] |
PIRi | A34627, OKHU1R |
RefSeqi | NP_001263218.1, NM_001276289.1 [P10644-1] NP_001263219.1, NM_001276290.1 [P10644-2] NP_001265362.1, NM_001278433.1 [P10644-1] NP_002725.1, NM_002734.4 [P10644-1] NP_997636.1, NM_212471.2 [P10644-1] NP_997637.1, NM_212472.2 [P10644-1] XP_011523285.1, XM_011524983.2 XP_011523286.1, XM_011524984.2 [P10644-1] XP_011523287.1, XM_011524985.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5KJX | X-ray | 1.90 | A | 234-381 | [»] | |
5KJY | X-ray | 2.00 | A | 234-381 | [»] | |
5KJZ | X-ray | 1.35 | A | 234-381 | [»] | |
SMRi | P10644 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111559, 199 interactors |
DIPi | DIP-34368N |
IntActi | P10644, 184 interactors |
MINTi | P10644 |
STRINGi | 9606.ENSP00000376475 |
Chemistry databases
BindingDBi | P10644 |
ChEMBLi | CHEMBL4928 |
DrugBanki | DB01790, (Rp)-cAMPS DB02527, Cyclic adenosine monophosphate DB02315, Cyclic GMP DB05798, GEM-231 |
GuidetoPHARMACOLOGYi | 1472 |
PTM databases
iPTMneti | P10644 |
MetOSitei | P10644 |
PhosphoSitePlusi | P10644 |
SwissPalmi | P10644 |
Genetic variation databases
BioMutai | PRKAR1A |
DMDMi | 125193 |
2D gel databases
OGPi | P10644 |
REPRODUCTION-2DPAGEi | IPI00021831 |
Proteomic databases
EPDi | P10644 |
jPOSTi | P10644 |
MassIVEi | P10644 |
MaxQBi | P10644 |
PaxDbi | P10644 |
PeptideAtlasi | P10644 |
PRIDEi | P10644 |
ProteomicsDBi | 52634 [P10644-1] |
Protocols and materials databases
Antibodypediai | 31783, 363 antibodies |
DNASUi | 5573 |
Genome annotation databases
Ensembli | ENST00000358598; ENSP00000351410; ENSG00000108946 [P10644-1] ENST00000392711; ENSP00000376475; ENSG00000108946 [P10644-1] ENST00000536854; ENSP00000445625; ENSG00000108946 [P10644-1] ENST00000586397; ENSP00000466459; ENSG00000108946 [P10644-1] ENST00000588188; ENSP00000468106; ENSG00000108946 [P10644-2] ENST00000589228; ENSP00000464977; ENSG00000108946 [P10644-1] |
GeneIDi | 5573 |
KEGGi | hsa:5573 |
UCSCi | uc002jhg.5, human [P10644-1] |
Organism-specific databases
CTDi | 5573 |
DisGeNETi | 5573 |
GeneCardsi | PRKAR1A |
GeneReviewsi | PRKAR1A |
HGNCi | HGNC:9388, PRKAR1A |
HPAi | ENSG00000108946, Low tissue specificity |
MalaCardsi | PRKAR1A |
MIMi | 101800, phenotype 160980, phenotype 188830, gene 255960, phenotype 610489, phenotype |
neXtProti | NX_P10644 |
OpenTargetsi | ENSG00000108946 |
Orphaneti | 950, Acrodysostosis 280651, Acrodysostosis with multiple hormone resistance 520, Acute promyelocytic leukemia 1359, Carney complex 615, Familial atrial myxoma 189439, Primary pigmented nodular adrenocortical disease |
PharmGKBi | PA33754 |
VEuPathDBi | HostDB:ENSG00000108946.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1113, Eukaryota |
GeneTreei | ENSGT00940000155148 |
HOGENOMi | CLU_018310_1_0_1 |
InParanoidi | P10644 |
OMAi | RPMGFLR |
PhylomeDBi | P10644 |
TreeFami | TF314920 |
Enzyme and pathway databases
PathwayCommonsi | P10644 |
Reactomei | R-HSA-163615, PKA activation R-HSA-164378, PKA activation in glucagon signalling R-HSA-180024, DARPP-32 events R-HSA-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-442720, CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-5610787, Hedgehog 'off' state R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production R-HSA-9664323, FCGR3A-mediated IL10 synthesis R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
SignaLinki | P10644 |
SIGNORi | P10644 |
Miscellaneous databases
BioGRID-ORCSi | 5573, 91 hits in 999 CRISPR screens |
ChiTaRSi | PRKAR1A, human |
GenomeRNAii | 5573 |
Pharosi | P10644, Tbio |
PROi | PR:P10644 |
RNActi | P10644, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000108946, Expressed in substantia nigra and 250 other tissues |
ExpressionAtlasi | P10644, baseline and differential |
Genevisiblei | P10644, HS |
Family and domain databases
CDDi | cd00038, CAP_ED, 2 hits |
Gene3Di | 2.60.120.10, 2 hits |
InterProi | View protein in InterPro IPR012198, cAMP_dep_PK_reg_su IPR003117, cAMP_dep_PK_reg_su_I/II_a/b IPR018490, cNMP-bd-like IPR018488, cNMP-bd_CS IPR000595, cNMP-bd_dom IPR014710, RmlC-like_jellyroll |
Pfami | View protein in Pfam PF00027, cNMP_binding, 2 hits PF02197, RIIa, 1 hit |
PIRSFi | PIRSF000548, PK_regulatory, 1 hit |
SMARTi | View protein in SMART SM00100, cNMP, 2 hits SM00394, RIIa, 1 hit |
SUPFAMi | SSF51206, SSF51206, 2 hits |
PROSITEi | View protein in PROSITE PS00888, CNMP_BINDING_1, 2 hits PS00889, CNMP_BINDING_2, 2 hits PS50042, CNMP_BINDING_3, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KAP0_HUMAN | |
Accessioni | P10644Primary (citable) accession number: P10644 Secondary accession number(s): K7ER48, Q567S7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | April 7, 2021 | |
This is version 236 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families