Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P10643 (CO7_HUMAN)

Entry version 207 (02 Dec 2020)
Sequence version 2 (15 Mar 2005)
Previous versions | rss
Add a publicationFeedback
Protein

Complement component C7

Gene

C7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processComplement alternate pathway, Complement pathway, Cytolysis, Immunity, Innate immunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P10643

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-166665, Terminal pathway of complement
R-HSA-977606, Regulation of Complement cascade

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Complement component C7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000112936.18

Human Gene Nomenclature Database

More...HGNCi		HGNC:1346, C7

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		217070, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P10643

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane attack complex, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Complement component 7 deficiency (C7D)3 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_012643220R → Q in C7D. 1 PublicationCorresponds to variant dbSNP:rs369349760Ensembl.1
Natural variantiVAR_012644379G → R in C7D. 1 PublicationCorresponds to variant dbSNP:rs121964921EnsemblClinVar.1
Natural variantiVAR_012645521R → S in C7D. 1 PublicationCorresponds to variant dbSNP:rs121964920EnsemblClinVar.1
Natural variantiVAR_012646682E → Q in C7D. 1 PublicationCorresponds to variant dbSNP:rs541873000Ensembl.1
Natural variantiVAR_012647687R → H in C7D. 1 PublicationCorresponds to variant dbSNP:rs113187203Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		730

MalaCards human disease database

More...MalaCardsi		C7
MIMi610102, phenotype

Open Targets

More...OpenTargetsi		ENSG00000112936

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		169150, Immunodeficiency due to a late component of complement deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25941

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P10643, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		C7

Domain mapping of disease mutations (DMDM)

More...DMDMi		61252057

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Add BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002358323 – 843Complement component C7Add BLAST821

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi36C-linked (Man) tryptophan1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi85 ↔ 96By similarity
Disulfide bondi91 ↔ 109By similarity
Disulfide bondi103 ↔ 119By similarity
Disulfide bondi128 ↔ 165By similarity
Glycosylationi202N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi337 ↔ 3531 Publication
Glycosylationi503C-linked (Man) tryptophan; partial1 Publication1
Glycosylationi506C-linked (Man) tryptophan; partial1 Publication1
Glycosylationi509C-linked (Man) tryptophan; partial1 Publication1
Disulfide bondi571 ↔ 613By similarity
Disulfide bondi599 ↔ 626By similarity
Disulfide bondi631 ↔ 673By similarity
Disulfide bondi659 ↔ 688By similarity
Glycosylationi696O-linked (GalNAc...) threonine1 Publication1
Disulfide bondi702 ↔ 7131 Publication
Disulfide bondi715 ↔ 7501 Publication
Disulfide bondi721 ↔ 7431 Publication
Disulfide bondi728 ↔ 7631 Publication
Glycosylationi754N-linked (GlcNAc...) (complex) asparagine2 Publications1
Disulfide bondi773 ↔ 7821 Publication
Disulfide bondi776 ↔ 7891 Publication
Disulfide bondi791 ↔ 8251 Publication
Disulfide bondi797 ↔ 8181 Publication
Disulfide bondi805 ↔ 8381 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

C7 has 28 disulfide bridges.
C-, N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.5 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		non-CPTAC-2655

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P10643

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P10643

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P10643

PeptideAtlas

More...PeptideAtlasi		P10643

PRoteomics IDEntifications database

More...PRIDEi		P10643

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52633

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		807, 2 N-Linked glycans (2 sites), 1 O-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P10643, 7 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P10643

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P10643

UniCarbKB; an annotated and curated database of glycan structures

More...UniCarbKBi		P10643

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000112936, Expressed in adrenal cortex and 207 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P10643, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000112936, Tissue enhanced (ovary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer or dimer; as a C5b-7 complex it can also form multimeric rosettes. MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107191, 4 interactors

Protein interaction database and analysis system

More...IntActi		P10643, 4 interactors

Molecular INTeraction database

More...MINTi		P10643

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000322061

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P10643, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1843
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P10643

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P10643

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P10643

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 80TSP type-1 1PROSITE-ProRule annotationAdd BLAST54
Domaini83 – 121LDL-receptor class APROSITE-ProRule annotationAdd BLAST39
Domaini124 – 456MACPFPROSITE-ProRule annotationAdd BLAST333
Domaini457 – 487EGF-likeAdd BLAST31
Domaini500 – 549TSP type-1 2PROSITE-ProRule annotationAdd BLAST50
Domaini569 – 628Sushi 1PROSITE-ProRule annotationAdd BLAST60
Domaini629 – 690Sushi 2PROSITE-ProRule annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni545 – 615CCP 1Add BLAST71
Regioni616 – 693CCP 2Add BLAST78
Regioni695 – 770Factor I module (FIM) 1Add BLAST76
Regioni771 – 843Factor I module (FIM) 2Add BLAST73

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complement C6/C7/C8/C9 family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QU3G, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156804

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014082_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P10643

Identification of Orthologs from Complete Genome Data

More...OMAi		CKLHVLH

Database of Orthologous Groups

More...OrthoDBi		100680at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P10643

TreeFam database of animal gene trees

More...TreeFami		TF330498

Family and domain databases

Conserved Domains Database

More...CDDi		cd00033, CCP, 2 hits
cd00112, LDLa, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.20.100.10, 2 hits
4.10.400.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037564, Complement_C7
IPR003884, FacI_MAC
IPR040729, Kazal_3
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR001862, MAC_perforin
IPR020864, MACPF
IPR020863, MACPF_CS
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf

The PANTHER Classification System

More...PANTHERi		PTHR45742:SF2, PTHR45742:SF2, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF18434, Kazal_3, 1 hit
PF00057, Ldl_recept_a, 1 hit
PF01823, MACPF, 1 hit
PF00084, Sushi, 2 hits
PF00090, TSP_1, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00764, COMPLEMENTC9

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00032, CCP, 2 hits
SM00057, FIMAC, 2 hits
SM00192, LDLa, 1 hit
SM00457, MACPF, 1 hit
SM00209, TSP1, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57535, SSF57535, 2 hits
SSF82895, SSF82895, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 1 hit
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 1 hit
PS00279, MACPF_1, 1 hit
PS51412, MACPF_2, 1 hit
PS50923, SUSHI, 2 hits
PS50092, TSP1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P10643-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVISLFILV GFIGEFQSFS SASSPVNCQW DFYAPWSECN GCTKTQTRRR 
        60         70         80         90        100
SVAVYGQYGG QPCVGNAFET QSCEPTRGCP TEEGCGERFR CFSGQCISKS 
       110        120        130        140        150
LVCNGDSDCD EDSADEDRCE DSERRPSCDI DKPPPNIELT GNGYNELTGQ 
       160        170        180        190        200
FRNRVINTKS FGGQCRKVFS GDGKDFYRLS GNVLSYTFQV KINNDFNYEF 
       210        220        230        240        250
YNSTWSYVKH TSTEHTSSSR KRSFFRSSSS SSRSYTSHTN EIHKGKSYQL 
       260        270        280        290        300
LVVENTVEVA QFINNNPEFL QLAEPFWKEL SHLPSLYDYS AYRRLIDQYG 
       310        320        330        340        350
THYLQSGSLG GEYRVLFYVD SEKLKQNDFN SVEEKKCKSS GWHFVVKFSS 
       360        370        380        390        400
HGCKELENAL KAASGTQNNV LRGEPFIRGG GAGFISGLSY LELDNPAGNK 
       410        420        430        440        450
RRYSAWAESV TNLPQVIKQK LTPLYELVKE VPCASVKKLY LKWALEEYLD 
       460        470        480        490        500
EFDPCHCRPC QNGGLATVEG THCLCHCKPY TFGAACEQGV LVGNQAGGVD 
       510        520        530        540        550
GGWSCWSSWS PCVQGKKTRS RECNNPPPSG GGRSCVGETT ESTQCEDEEL 
       560        570        580        590        600
EHLRLLEPHC FPLSLVPTEF CPSPPALKDG FVQDEGTMFP VGKNVVYTCN 
       610        620        630        640        650
EGYSLIGNPV ARCGEDLRWL VGEMHCQKIA CVLPVLMDGI QSHPQKPFYT 
       660        670        680        690        700
VGEKVTVSCS GGMSLEGPSA FLCGSSLKWS PEMKNARCVQ KENPLTQAVP 
       710        720        730        740        750
KCQRWEKLQN SRCVCKMPYE CGPSLDVCAQ DERSKRILPL TVCKMHVLHC 
       760        770        780        790        800
QGRNYTLTGR DSCTLPASAE KACGACPLWG KCDAESSKCV CREASECEEE 
       810        820        830        840 
GFSICVEVNG KEQTMSECEA GALRCRGQSI SVTSIRPCAA ETQ
Length:843
Mass (Da):93,518
Last modified:March 15, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDBD5D7C92DF71FA5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18S → G in BAF83038 (PubMed:14702039).Curated1
Sequence conflicti123E → G in BAF83038 (PubMed:14702039).Curated1
Sequence conflicti152R → V in CAA60121 (PubMed:7730625).Curated1
Sequence conflicti212S → P in BAF83038 (PubMed:14702039).Curated1
Sequence conflicti821 – 822GA → AL in CAA60121 (PubMed:7730625).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050480128C → R. Corresponds to variant dbSNP:rs2271708Ensembl.1
Natural variantiVAR_012643220R → Q in C7D. 1 PublicationCorresponds to variant dbSNP:rs369349760Ensembl.1
Natural variantiVAR_081726222R → H1 PublicationCorresponds to variant dbSNP:rs75345202Ensembl.1
Natural variantiVAR_012644379G → R in C7D. 1 PublicationCorresponds to variant dbSNP:rs121964921EnsemblClinVar.1
Natural variantiVAR_033798389S → T Polymorphism; confirmed at protein level. 2 PublicationsCorresponds to variant dbSNP:rs1063499Ensembl.1
Natural variantiVAR_022023420K → Q. Corresponds to variant dbSNP:rs3792646Ensembl.1
Natural variantiVAR_012645521R → S in C7D. 1 PublicationCorresponds to variant dbSNP:rs121964920EnsemblClinVar.1
Natural variantiVAR_033799587T → P Polymorphism; confirmed at protein level. 2 PublicationsCorresponds to variant dbSNP:rs13157656Ensembl.1
Natural variantiVAR_012646682E → Q in C7D. 1 PublicationCorresponds to variant dbSNP:rs541873000Ensembl.1
Natural variantiVAR_012647687R → H in C7D. 1 PublicationCorresponds to variant dbSNP:rs113187203Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J03507 mRNA Translation: AAA51861.1
AK290349 mRNA Translation: BAF83038.1
BC063851 mRNA Translation: AAH63851.1
X86328 X86344 Genomic DNA Translation: CAA60121.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47201.1

Protein sequence database of the Protein Information Resource

More...PIRi		A27340

NCBI Reference Sequences

More...RefSeqi		NP_000578.2, NM_000587.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000313164; ENSP00000322061; ENSG00000112936

Database of genes from NCBI RefSeq genomes

More...GeneIDi		730

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:730

UCSC genome browser

More...UCSCi		uc003jmh.5, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

C7base

C7 mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03507 mRNA Translation: AAA51861.1
AK290349 mRNA Translation: BAF83038.1
BC063851 mRNA Translation: AAH63851.1
X86328 X86344 Genomic DNA Translation: CAA60121.1
CCDSiCCDS47201.1
PIRiA27340
RefSeqiNP_000578.2, NM_000587.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WCYNMR-A693-843[»]
6H03electron microscopy5.60D23-843[»]
6H04electron microscopy5.60D23-843[»]
BMRBiP10643
SMRiP10643
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107191, 4 interactors
IntActiP10643, 4 interactors
MINTiP10643
STRINGi9606.ENSP00000322061

PTM databases

GlyConnecti807, 2 N-Linked glycans (2 sites), 1 O-Linked glycan (1 site)
GlyGeniP10643, 7 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
iPTMnetiP10643
PhosphoSitePlusiP10643
UniCarbKBiP10643

Polymorphism and mutation databases

BioMutaiC7
DMDMi61252057

Proteomic databases

CPTACinon-CPTAC-2655
jPOSTiP10643
MassIVEiP10643
PaxDbiP10643
PeptideAtlasiP10643
PRIDEiP10643
ProteomicsDBi52633

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		709, 274 antibodies

Genome annotation databases

EnsembliENST00000313164; ENSP00000322061; ENSG00000112936
GeneIDi730
KEGGihsa:730
UCSCiuc003jmh.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		730
DisGeNETi730
EuPathDBiHostDB:ENSG00000112936.18

GeneCards: human genes, protein and diseases

More...GeneCardsi		C7
HGNCiHGNC:1346, C7
HPAiENSG00000112936, Tissue enhanced (ovary)
MalaCardsiC7
MIMi217070, gene
610102, phenotype
neXtProtiNX_P10643
OpenTargetsiENSG00000112936
Orphaneti169150, Immunodeficiency due to a late component of complement deficiency
PharmGKBiPA25941

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QU3G, Eukaryota
GeneTreeiENSGT00940000156804
HOGENOMiCLU_014082_0_0_1
InParanoidiP10643
OMAiCKLHVLH
OrthoDBi100680at2759
PhylomeDBiP10643
TreeFamiTF330498

Enzyme and pathway databases

PathwayCommonsiP10643
ReactomeiR-HSA-166665, Terminal pathway of complement
R-HSA-977606, Regulation of Complement cascade

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		730, 1 hit in 846 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		C7, human
EvolutionaryTraceiP10643

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		730
PharosiP10643, Tbio

Protein Ontology

More...PROi		PR:P10643
RNActiP10643, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000112936, Expressed in adrenal cortex and 207 other tissues
GenevisibleiP10643, HS

Family and domain databases

CDDicd00033, CCP, 2 hits
cd00112, LDLa, 1 hit
Gene3Di2.20.100.10, 2 hits
4.10.400.10, 1 hit
InterProiView protein in InterPro
IPR037564, Complement_C7
IPR003884, FacI_MAC
IPR040729, Kazal_3
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR001862, MAC_perforin
IPR020864, MACPF
IPR020863, MACPF_CS
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
PANTHERiPTHR45742:SF2, PTHR45742:SF2, 1 hit
PfamiView protein in Pfam
PF18434, Kazal_3, 1 hit
PF00057, Ldl_recept_a, 1 hit
PF01823, MACPF, 1 hit
PF00084, Sushi, 2 hits
PF00090, TSP_1, 2 hits
PRINTSiPR00764, COMPLEMENTC9
SMARTiView protein in SMART
SM00032, CCP, 2 hits
SM00057, FIMAC, 2 hits
SM00192, LDLa, 1 hit
SM00457, MACPF, 1 hit
SM00209, TSP1, 2 hits
SUPFAMiSSF57535, SSF57535, 2 hits
SSF82895, SSF82895, 2 hits
PROSITEiView protein in PROSITE
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 1 hit
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 1 hit
PS00279, MACPF_1, 1 hit
PS51412, MACPF_2, 1 hit
PS50923, SUSHI, 2 hits
PS50092, TSP1, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCO7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10643
Secondary accession number(s): A8K2T4, Q6P3T5, Q92489
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: March 15, 2005
Last modified: December 2, 2020
This is version 207 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again