UniProtKB - P10643 (CO7_HUMAN)

BLAST

>sp|P10643|CO7_HUMAN Complement component C7 OS=Homo sapiens OX=9606 GN=C7 PE=1 SV=2
MKVISLFILVGFIGEFQSFSSASSPVNCQWDFYAPWSECNGCTKTQTRRRSVAVYGQYGG
QPCVGNAFETQSCEPTRGCPTEEGCGERFRCFSGQCISKSLVCNGDSDCDEDSADEDRCE
DSERRPSCDIDKPPPNIELTGNGYNELTGQFRNRVINTKSFGGQCRKVFSGDGKDFYRLS
GNVLSYTFQVKINNDFNYEFYNSTWSYVKHTSTEHTSSSRKRSFFRSSSSSSRSYTSHTN
EIHKGKSYQLLVVENTVEVAQFINNNPEFLQLAEPFWKELSHLPSLYDYSAYRRLIDQYG
THYLQSGSLGGEYRVLFYVDSEKLKQNDFNSVEEKKCKSSGWHFVVKFSSHGCKELENAL
KAASGTQNNVLRGEPFIRGGGAGFISGLSYLELDNPAGNKRRYSAWAESVTNLPQVIKQK
LTPLYELVKEVPCASVKKLYLKWALEEYLDEFDPCHCRPCQNGGLATVEGTHCLCHCKPY
TFGAACEQGVLVGNQAGGVDGGWSCWSSWSPCVQGKKTRSRECNNPPPSGGGRSCVGETT
ESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCN
EGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCS
GGMSLEGPSAFLCGSSLKWSPEMKNARCVQKENPLTQAVPKCQRWEKLQNSRCVCKMPYE
CGPSLDVCAQDERSKRILPLTVCKMHVLHCQGRNYTLTGRDSCTLPASAEKACGACPLWG
KCDAESSKCVCREASECEEEGFSICVEVNGKEQTMSECEAGALRCRGQSISVTSIRPCAA
ETQ

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History
Entry version 191 (07 Nov 2018)
Sequence version 2 (15 Mar 2005)
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Protein

Complement component C7

Gene

C7

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor.

GO - Biological processⁱ

cellular sodium ion homeostasis Source: Ensembl
complement activation
Source: ProtInc
Traceable author statementⁱ
- 3335508
complement activation, alternative pathway Source: UniProtKB-KW
complement activation, classical pathway Source: UniProtKB-KW
cytolysis Source: UniProtKB-KW
regulation of complement activation Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Complement alternate pathway, Complement pathway, Cytolysis, Immunity, Innate immunity

Biological process

Complement alternate pathway, Complement pathway, Cytolysis, Immunity, Innate immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-166665 Terminal pathway of complement R-HSA-977606 Regulation of Complement cascade

Reactomeⁱ

R-HSA-166665 Terminal pathway of complement
R-HSA-977606 Regulation of Complement cascade

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Complement component C7
Gene namesⁱ	Name:C7
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000112936.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1346 C7
MIMⁱ	217070 gene
neXtProtⁱ	NX_P10643

Keywords - Cellular componentⁱ

Membrane attack complex, Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Complement component 7 deficiency (C7D)3 Publications

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_012643	220	R → Q in C7D. 1 PublicationCorresponds to variant dbSNP:rs369349760Ensembl.	1
Natural variantⁱVAR_012644	379	G → R in C7D. 1 PublicationCorresponds to variant dbSNP:rs121964921EnsemblClinVar.	1
Natural variantⁱVAR_012645	521	R → S in C7D. 1 PublicationCorresponds to variant dbSNP:rs121964920EnsemblClinVar.	1
Natural variantⁱVAR_012646	682	E → Q in C7D. 1 PublicationCorresponds to variant dbSNP:rs541873000Ensembl.	1
Natural variantⁱVAR_012647	687	R → H in C7D. 1 PublicationCorresponds to variant dbSNP:rs113187203Ensembl.	1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	730
MalaCards human disease database More...MalaCardsⁱ	C7
MIMⁱ	610102 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000112936
Orphanetⁱ	169150 Immunodeficiency due to a late component of complement deficiency
PharmGKBⁱ	PA25941

Polymorphism and mutation databases

BioMutaⁱ	C7
DMDMⁱ	61252057

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	Add BLAST		22
ChainⁱPRO_0000023583	23 – 843	Complement component C7Add BLAST		821

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	36	C-linked (Man) tryptophan1 Publication	1
Disulfide bondⁱ	85 ↔ 96	By similarity
Disulfide bondⁱ	91 ↔ 109	By similarity
Disulfide bondⁱ	103 ↔ 119	By similarity
Disulfide bondⁱ	128 ↔ 165	By similarity
Glycosylationⁱ	202	N-linked (GlcNAc...) asparagine2 Publications	1
Disulfide bondⁱ	337 ↔ 353	1 Publication
Glycosylationⁱ	503	C-linked (Man) tryptophan; partial1 Publication	1
Glycosylationⁱ	506	C-linked (Man) tryptophan; partial1 Publication	1
Glycosylationⁱ	509	C-linked (Man) tryptophan; partial1 Publication	1
Disulfide bondⁱ	571 ↔ 613	By similarity
Disulfide bondⁱ	599 ↔ 626	By similarity
Disulfide bondⁱ	631 ↔ 673	By similarity
Disulfide bondⁱ	659 ↔ 688	By similarity
Glycosylationⁱ	696	O-linked (GalNAc...) threonine1 Publication	1
Disulfide bondⁱ	702 ↔ 713	1 Publication
Disulfide bondⁱ	715 ↔ 750	1 Publication
Disulfide bondⁱ	721 ↔ 743	1 Publication
Disulfide bondⁱ	728 ↔ 763	1 Publication
Glycosylationⁱ	754	N-linked (GlcNAc...) (complex) asparagine2 Publications	1
Disulfide bondⁱ	773 ↔ 782	1 Publication
Disulfide bondⁱ	776 ↔ 789	1 Publication
Disulfide bondⁱ	791 ↔ 825	1 Publication
Disulfide bondⁱ	797 ↔ 818	1 Publication
Disulfide bondⁱ	805 ↔ 838	1 Publication

Post-translational modificationⁱ

C7 has 28 disulfide bridges.

C-, N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.5 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P10643
PeptideAtlas More...PeptideAtlasⁱ	P10643
PRIDEⁱ	P10643
ProteomicsDBⁱ	52633

PTM databases

GlyConnectⁱ	807
iPTMnetⁱ	P10643
PhosphoSitePlusⁱ	P10643
UniCarbKBⁱ	P10643

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000112936 Expressed in 195 organ(s), highest expression level in adrenal cortex
CleanExⁱ	HS_C7
Genevisibleⁱ	P10643 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA001465

HPAⁱ

HPA001465

Interactionⁱ

Subunit structureⁱ

Monomer or dimer; as a C5b-7 complex it can also form multimeric rosettes. MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9.

Protein-protein interaction databases

BioGridⁱ	107191, 4 interactors
CORUMⁱ	P10643
IntActⁱ	P10643, 3 interactors
Molecular INTeraction database More...MINTⁱ	P10643
STRINGⁱ	9606.ENSP00000322061

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	706 – 709	Combined sources	4
Beta strandⁱ	712 – 715	Combined sources	4
Helixⁱ	718 – 720	Combined sources	3
Beta strandⁱ	726 – 731	Combined sources	6
Turnⁱ	732 – 734	Combined sources	3
Beta strandⁱ	737 – 741	Combined sources	5
Helixⁱ	742 – 750	Combined sources	9
Beta strandⁱ	755 – 757	Combined sources	3
Beta strandⁱ	766 – 769	Combined sources	4
Beta strandⁱ	778 – 782	Combined sources	5
Beta strandⁱ	784 – 791	Combined sources	8
Helixⁱ	794 – 796	Combined sources	3
Beta strandⁱ	803 – 808	Combined sources	6
Beta strandⁱ	811 – 816	Combined sources	6
Helixⁱ	817 – 826	Combined sources	10
Beta strandⁱ	831 – 836	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	P10643
SMRⁱ	P10643
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P10643

EvolutionaryTraceⁱ

P10643

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	27 – 80	TSP type-1 1PROSITE-ProRule annotationAdd BLAST	54
Domainⁱ	83 – 121	LDL-receptor class APROSITE-ProRule annotationAdd BLAST	39
Domainⁱ	124 – 456	MACPFPROSITE-ProRule annotationAdd BLAST	333
Domainⁱ	457 – 487	EGF-likeAdd BLAST	31
Domainⁱ	500 – 549	TSP type-1 2PROSITE-ProRule annotationAdd BLAST	50
Domainⁱ	569 – 628	Sushi 1PROSITE-ProRule annotationAdd BLAST	60
Domainⁱ	629 – 690	Sushi 2PROSITE-ProRule annotationAdd BLAST	62

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	545 – 615	CCP 1Add BLAST	71
Regionⁱ	616 – 693	CCP 2Add BLAST	78
Regionⁱ	695 – 770	Factor I module (FIM) 1Add BLAST	76
Regionⁱ	771 – 843	Factor I module (FIM) 2Add BLAST	73

Sequence similaritiesⁱ

Belongs to the complement C6/C7/C8/C9 family.Curated

Keywords - Domainⁱ

EGF-like domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGⁱ	ENOG410IDXP Eukaryota ENOG410YJ70 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074478
HOGENOMⁱ	HOG000111868
HOVERGENⁱ	HBG005367
InParanoidⁱ	P10643
KEGG Orthology (KO) More...KOⁱ	K03996
OMAⁱ	YNSSWSY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07LK
PhylomeDBⁱ	P10643
TreeFamⁱ	TF330498

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00033 CCP, 2 hits cd00112 LDLa, 1 hit
Gene3Dⁱ	2.20.100.10, 2 hits
InterProⁱ	View protein in InterPro IPR037564 Complement_C7 IPR003884 FacI_MAC IPR023415 LDLR_class-A_CS IPR002172 LDrepeatLR_classA_rpt IPR001862 MAC_perforin IPR020864 MACPF IPR020863 MACPF_CS IPR035976 Sushi/SCR/CCP_sf IPR000436 Sushi_SCR_CCP_dom IPR000884 TSP1_rpt IPR036383 TSP1_rpt_sf
PANTHERⁱ	PTHR19325:SF389 PTHR19325:SF389, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00057 Ldl_recept_a, 1 hit PF01823 MACPF, 1 hit PF00084 Sushi, 2 hits PF00090 TSP_1, 2 hits
PRINTSⁱ	PR00764 COMPLEMENTC9
SMARTⁱ	View protein in SMART SM00032 CCP, 2 hits SM00057 FIMAC, 2 hits SM00192 LDLa, 1 hit SM00457 MACPF, 1 hit SM00209 TSP1, 2 hits
SUPFAMⁱ	SSF57535 SSF57535, 2 hits SSF82895 SSF82895, 2 hits
PROSITEⁱ	View protein in PROSITE PS00022 EGF_1, 1 hit PS01186 EGF_2, 1 hit PS01209 LDLRA_1, 1 hit PS50068 LDLRA_2, 1 hit PS00279 MACPF_1, 1 hit PS51412 MACPF_2, 1 hit PS50923 SUSHI, 2 hits PS50092 TSP1, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P10643-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MKVISLFILV GFIGEFQSFS SASSPVNCQW DFYAPWSECN GCTKTQTRRR 
        60         70         80         90        100
SVAVYGQYGG QPCVGNAFET QSCEPTRGCP TEEGCGERFR CFSGQCISKS 
       110        120        130        140        150
LVCNGDSDCD EDSADEDRCE DSERRPSCDI DKPPPNIELT GNGYNELTGQ 
       160        170        180        190        200
FRNRVINTKS FGGQCRKVFS GDGKDFYRLS GNVLSYTFQV KINNDFNYEF 
       210        220        230        240        250
YNSTWSYVKH TSTEHTSSSR KRSFFRSSSS SSRSYTSHTN EIHKGKSYQL 
       260        270        280        290        300
LVVENTVEVA QFINNNPEFL QLAEPFWKEL SHLPSLYDYS AYRRLIDQYG 
       310        320        330        340        350
THYLQSGSLG GEYRVLFYVD SEKLKQNDFN SVEEKKCKSS GWHFVVKFSS 
       360        370        380        390        400
HGCKELENAL KAASGTQNNV LRGEPFIRGG GAGFISGLSY LELDNPAGNK 
       410        420        430        440        450
RRYSAWAESV TNLPQVIKQK LTPLYELVKE VPCASVKKLY LKWALEEYLD 
       460        470        480        490        500
EFDPCHCRPC QNGGLATVEG THCLCHCKPY TFGAACEQGV LVGNQAGGVD 
       510        520        530        540        550
GGWSCWSSWS PCVQGKKTRS RECNNPPPSG GGRSCVGETT ESTQCEDEEL 
       560        570        580        590        600
EHLRLLEPHC FPLSLVPTEF CPSPPALKDG FVQDEGTMFP VGKNVVYTCN 
       610        620        630        640        650
EGYSLIGNPV ARCGEDLRWL VGEMHCQKIA CVLPVLMDGI QSHPQKPFYT 
       660        670        680        690        700
VGEKVTVSCS GGMSLEGPSA FLCGSSLKWS PEMKNARCVQ KENPLTQAVP 
       710        720        730        740        750
KCQRWEKLQN SRCVCKMPYE CGPSLDVCAQ DERSKRILPL TVCKMHVLHC 
       760        770        780        790        800
QGRNYTLTGR DSCTLPASAE KACGACPLWG KCDAESSKCV CREASECEEE 
       810        820        830        840 
GFSICVEVNG KEQTMSECEA GALRCRGQSI SVTSIRPCAA ETQ

Length:843

Mass (Da):93,518

Last modified:March 15, 2005 - v2

Checksum:ⁱDBD5D7C92DF71FA5

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	152	R → V in CAA60121 (PubMed:7730625).Curated		1
Sequence conflictⁱ	821 – 822	GA → AL (PubMed:7730625).Curated		2

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_050480	128	C → R. Corresponds to variant dbSNP:rs2271708Ensembl.	1
Natural variantⁱVAR_012643	220	R → Q in C7D. 1 PublicationCorresponds to variant dbSNP:rs369349760Ensembl.	1
Natural variantⁱVAR_012644	379	G → R in C7D. 1 PublicationCorresponds to variant dbSNP:rs121964921EnsemblClinVar.	1
Natural variantⁱVAR_033798	389	S → T Polymorphism; confirmed at protein level. 2 PublicationsCorresponds to variant dbSNP:rs1063499Ensembl.	1
Natural variantⁱVAR_022023	420	K → Q. Corresponds to variant dbSNP:rs3792646Ensembl.	1
Natural variantⁱVAR_012645	521	R → S in C7D. 1 PublicationCorresponds to variant dbSNP:rs121964920EnsemblClinVar.	1
Natural variantⁱVAR_033799	587	T → P Polymorphism; confirmed at protein level. 2 PublicationsCorresponds to variant dbSNP:rs13157656Ensembl.	1
Natural variantⁱVAR_012646	682	E → Q in C7D. 1 PublicationCorresponds to variant dbSNP:rs541873000Ensembl.	1
Natural variantⁱVAR_012647	687	R → H in C7D. 1 PublicationCorresponds to variant dbSNP:rs113187203Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03507 mRNA Translation: AAA51861.1 BC063851 mRNA Translation: AAH63851.1 X86328 X86344 Genomic DNA Translation: CAA60121.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47201.1
PIRⁱ	A27340
NCBI Reference Sequences More...RefSeqⁱ	NP_000578.2, NM_000587.3
UniGeneⁱ	Hs.669878 Hs.78065

Genome annotation databases

Ensemblⁱ	ENST00000313164; ENSP00000322061; ENSG00000112936
GeneIDⁱ	730
KEGGⁱ	hsa:730
UCSC genome browser More...UCSCⁱ	uc003jmh.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P10643	Complement component C7		PONAB		843	UniRef90_P10643
Uncharacterized protein		RHIBE		890
Complement component C7 (Fragment)		HUMAN		15
Uncharacterized protein		MACMU		855
Complement component C7 (Fragment)		MACFA		843
+30

Protein	Similar proteins		Species	Score	Length	Source
P10643	Complement component C7		PONAB		843	UniRef50_P10643
Complement component C7		PIG		843
Complement component C7		BOVIN		843
Uncharacterized protein		RHIBE		890
Complement component C7 (Fragment)		HUMAN		15
+274

Cross-referencesⁱ

Web resourcesⁱ

C7base

C7 mutation db

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03507 mRNA Translation: AAA51861.1 BC063851 mRNA Translation: AAH63851.1 X86328 X86344 Genomic DNA Translation: CAA60121.1
CCDSⁱ	CCDS47201.1
PIRⁱ	A27340
RefSeqⁱ	NP_000578.2, NM_000587.3
UniGeneⁱ	Hs.669878 Hs.78065

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2WCY	NMR	-	A	693-843	[»]
ProteinModelPortalⁱ	P10643
SMRⁱ	P10643
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107191, 4 interactors
CORUMⁱ	P10643
IntActⁱ	P10643, 3 interactors
MINTⁱ	P10643
STRINGⁱ	9606.ENSP00000322061

PTM databases

GlyConnectⁱ	807
iPTMnetⁱ	P10643
PhosphoSitePlusⁱ	P10643
UniCarbKBⁱ	P10643

Polymorphism and mutation databases

BioMutaⁱ	C7
DMDMⁱ	61252057

Proteomic databases

PaxDbⁱ	P10643
PeptideAtlasⁱ	P10643
PRIDEⁱ	P10643
ProteomicsDBⁱ	52633

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000313164; ENSP00000322061; ENSG00000112936
GeneIDⁱ	730
KEGGⁱ	hsa:730
UCSCⁱ	uc003jmh.5 human

Organism-specific databases

CTDⁱ	730
DisGeNETⁱ	730
EuPathDBⁱ	HostDB:ENSG00000112936.18
GeneCardsⁱ	C7
HGNCⁱ	HGNC:1346 C7
HPAⁱ	HPA001465
MalaCardsⁱ	C7
MIMⁱ	217070 gene 610102 phenotype
neXtProtⁱ	NX_P10643
OpenTargetsⁱ	ENSG00000112936
Orphanetⁱ	169150 Immunodeficiency due to a late component of complement deficiency
PharmGKBⁱ	PA25941
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IDXP Eukaryota ENOG410YJ70 LUCA
GeneTreeⁱ	ENSGT00550000074478
HOGENOMⁱ	HOG000111868
HOVERGENⁱ	HBG005367
InParanoidⁱ	P10643
KOⁱ	K03996
OMAⁱ	YNSSWSY
OrthoDBⁱ	EOG091G07LK
PhylomeDBⁱ	P10643
TreeFamⁱ	TF330498

Enzyme and pathway databases

Reactomeⁱ	R-HSA-166665 Terminal pathway of complement R-HSA-977606 Regulation of Complement cascade

Reactomeⁱ

R-HSA-166665 Terminal pathway of complement
R-HSA-977606 Regulation of Complement cascade

Miscellaneous databases

ChiTaRSⁱ	C7 human
EvolutionaryTraceⁱ	P10643
GenomeRNAiⁱ	730
Protein Ontology More...PROⁱ	PR:P10643
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000112936 Expressed in 195 organ(s), highest expression level in adrenal cortex
CleanExⁱ	HS_C7
Genevisibleⁱ	P10643 HS

Family and domain databases

CDDⁱ	cd00033 CCP, 2 hits cd00112 LDLa, 1 hit
Gene3Dⁱ	2.20.100.10, 2 hits
InterProⁱ	View protein in InterPro IPR037564 Complement_C7 IPR003884 FacI_MAC IPR023415 LDLR_class-A_CS IPR002172 LDrepeatLR_classA_rpt IPR001862 MAC_perforin IPR020864 MACPF IPR020863 MACPF_CS IPR035976 Sushi/SCR/CCP_sf IPR000436 Sushi_SCR_CCP_dom IPR000884 TSP1_rpt IPR036383 TSP1_rpt_sf
PANTHERⁱ	PTHR19325:SF389 PTHR19325:SF389, 1 hit
Pfamⁱ	View protein in Pfam PF00057 Ldl_recept_a, 1 hit PF01823 MACPF, 1 hit PF00084 Sushi, 2 hits PF00090 TSP_1, 2 hits
PRINTSⁱ	PR00764 COMPLEMENTC9
SMARTⁱ	View protein in SMART SM00032 CCP, 2 hits SM00057 FIMAC, 2 hits SM00192 LDLa, 1 hit SM00457 MACPF, 1 hit SM00209 TSP1, 2 hits
SUPFAMⁱ	SSF57535 SSF57535, 2 hits SSF82895 SSF82895, 2 hits
PROSITEⁱ	View protein in PROSITE PS00022 EGF_1, 1 hit PS01186 EGF_2, 1 hit PS01209 LDLRA_1, 1 hit PS50068 LDLRA_2, 1 hit PS00279 MACPF_1, 1 hit PS51412 MACPF_2, 1 hit PS50923 SUSHI, 2 hits PS50092 TSP1, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CO7_HUMAN
Accessionⁱ	P10643Primary (citable) accession number: P10643 Secondary accession number(s): Q6P3T5, Q92489
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	March 15, 2005
	Last modified:	November 7, 2018
	This is version 191 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

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UniRef

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Supporting data

UniProtKB - P10643 (CO7_HUMAN)

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Complement component C7

C7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Plasma Membrane

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ