Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Microtubule-associated protein tau

Gene

Mapt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-264870 Caspase-mediated cleavage of cytoskeletal proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-associated protein tau
Alternative name(s):
Neurofibrillary tangle protein
Paired helical filament-tau
Short name:
PHF-tau
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mapt
Synonyms:Mtapt, Tau
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:97180 Mapt

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

May be involved in the pathogenesis of cytoplasmic inclusions (as Mallory bodies) in livers of mice chronically intoxicated with Griseofulvin or DDC (3,5-diethoxycarbonyl-2,4-dihydrocollidine), a model for human alcoholic hepatitis. Alteration of Tau (abnormal phosphorylation and cross-linking) could contribute to Mallory bodies formation and disturbance of microtubule function in alcoholic liver disease.

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000727422 – 733Microtubule-associated protein tauAdd BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei18Phosphotyrosine; by FYN1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki33Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei35PhosphoserineBy similarity1
Modified residuei50PhosphoserineBy similarity1
Modified residuei58Phosphothreonine1 Publication1
Modified residuei60PhosphothreonineBy similarity1
Modified residuei100Phosphothreonine1 Publication1
Modified residuei115Omega-N-methylarginine1 Publication1
Modified residuei188PhosphoserineCombined sources1
Modified residuei369PhosphoserineBy similarity1
Modified residuei445PhosphothreonineBy similarity1
Modified residuei447Omega-N-methylarginine1 Publication1
Modified residuei451Phosphoserine1 Publication1
Modified residuei455N6,N6-dimethyllysine; alternate1 Publication1
Modified residuei455N6-acetyllysine; alternate1 Publication1
Modified residuei461Phosphothreonine1 Publication1
Modified residuei467Phosphothreonine1 Publication1
Modified residuei468PhosphothreonineCombined sources1
Modified residuei470PhosphoserineCombined sources1 Publication1
Modified residuei473Phosphothreonine1 Publication1
Modified residuei477Phosphoserine1 Publication1
Modified residuei483Phosphoserine1 Publication1
Modified residuei487Phosphoserine1 Publication1
Modified residuei489PhosphotyrosineCombined sources1
Modified residuei490PhosphoserineCombined sources1 Publication1
Modified residuei491PhosphoserineCombined sources1 Publication1
Modified residuei494PhosphoserineCombined sources1 Publication1
Modified residuei497PhosphothreonineCombined sources1 Publication1
Modified residuei504Phosphothreonine1 Publication1
Modified residuei506Phosphoserine1 Publication1
Modified residuei509Phosphothreonine1 Publication1
Modified residuei517N6-acetyllysine1 Publication1
Modified residuei523PhosphothreonineCombined sources1 Publication1
Modified residuei527Phosphoserine1 Publication1
Modified residuei529Phosphoserine1 Publication1
Modified residuei531Phosphoserine1 Publication1
Cross-linki546Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei551N6-acetyllysine; alternate1 Publication1
Modified residuei551N6-methyllysine; alternate1 Publication1
Cross-linki551Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Modified residuei554Phosphoserine; by MARK1, BRSK1, BRSK2 and PHK3 Publications1
Cross-linki559Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei573N6-acetyllysine; alternate1 Publication1
Cross-linki573Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Modified residuei577PhosphoserineBy similarity1
Modified residuei581PhosphoserineBy similarity1
Modified residuei582N6-acetyllysine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi583 ↔ 614By similarity
Modified residuei585PhosphoserineBy similarity1
Modified residuei590N6-acetyllysine; alternate1 Publication1
Cross-linki590Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Modified residuei597PhosphoserineBy similarity1
Modified residuei603N6,N6-dimethyllysine; alternate1 Publication1
Modified residuei603N6-acetyllysine; alternate1 Publication1
Cross-linki603Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Modified residuei609N6-acetyllysine; alternate1 Publication1
Cross-linki609Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Modified residuei613N6-acetyllysine; alternate1 Publication1
Cross-linki613Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Modified residuei616PhosphoserineBy similarity1
Modified residuei623N6-acetyllysine; alternate1 Publication1
Cross-linki623Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Modified residuei635N6-acetyllysine; alternate1 Publication1
Cross-linki635Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Modified residuei639N6-acetyllysine; alternate1 Publication1
Cross-linki639Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Modified residuei641Omega-N-methylarginine1 Publication1
Modified residuei644PhosphoserineBy similarity1
Cross-linki645Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei648Phosphoserine1 Publication1
Modified residuei661N6-acetyllysine; alternate1 Publication1
Cross-linki661Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Cross-linki667Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei677N6-acetyllysine; alternate1 Publication1
Cross-linki677Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Modified residuei686PhosphotyrosineCombined sources1 Publication1
Modified residuei688PhosphoserineCombined sources1 Publication1
Modified residuei692Phosphoserine; alternateCombined sources1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi692O-linked (GlcNAc...) serine; alternate1 Publication1
Modified residuei695PhosphothreonineCombined sources1
Modified residuei696PhosphoserineCombined sources1
Modified residuei701PhosphoserineCombined sources1
Modified residuei708PhosphoserineCombined sources1 Publication1
Modified residuei714PhosphoserineCombined sources1
Modified residuei719PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Polyubiquitinated. Requires functional TRAF6 and may provoke SQSTM1-dependent degradation by the proteasome (By similarity).By similarity
Phosphorylation at various serine and threonine residues in S-P or T-P motifs by proline-directed protein kinases (PDPK1, CDK1, CDK5, GSK3, MAPK) (a few sites per protein in interphase, more in mitosis), and at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1, MARK2, MARK3, MARK4), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylated by PHK. Dephosphorylation at several serine and threonine residues by the serine/threonine phosphatase PPP5C. Phosphorylation at Ser-554 by BRSK1 and BRSK2 in neurons affects ability to bind microtubules and plays a role in neuron polarization. Phosphorylation at Ser-188 by SGK1 mediates microtubule depolymerization and neurite formation in hippocampal neurons (By similarity).By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P10637

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P10637

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P10637

PeptideAtlas

More...
PeptideAtlasi
P10637

PRoteomics IDEntifications database

More...
PRIDEi
P10637

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P10637

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P10637

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in neurons and at a lower level in the liver and kidney. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Shorter forms or low molecular weight tau (lMW-tau) are generally expressed at early development stages and longer forms or high molecular weight tau (hMW-tau) in the adult brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000018411 Expressed in 261 organ(s), highest expression level in forebrain

CleanEx database of gene expression profiles

More...
CleanExi
MM_MAPT

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P10637 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P10637 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MARK1, MARK2, MARK3 AND MARK4 (By similarity). Interacts with SQSTM1 when polyubiquitinated (By similarity). Interacts with PSMC2 through SQSTM1. Interacts with FKBP4. Binds to CSNK1D (By similarity). Interacts with SGK1 (By similarity). Interacts with EPM2A; the interaction dephosphorylates MAPT at Ser-369 (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
201589, 16 interactors

Protein interaction database and analysis system

More...
IntActi
P10637, 9 interactors

Molecular INTeraction database

More...
MINTi
P10637

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000097919

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1733
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6H0EX-ray1.95G/I/J/K698-721[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P10637

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P10637

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati536 – 566Tau/MAP 1PROSITE-ProRule annotationAdd BLAST31
Repeati567 – 597Tau/MAP 2PROSITE-ProRule annotationAdd BLAST31
Repeati598 – 628Tau/MAP 3PROSITE-ProRule annotationAdd BLAST31
Repeati629 – 660Tau/MAP 4PROSITE-ProRule annotationAdd BLAST32

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The tau/MAP repeat binds to tubulin. Type I isoforms contain 3 repeats while type II isoforms contain 4 repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2418 Eukaryota
ENOG4111J07 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155494

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000991

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P10637

KEGG Orthology (KO)

More...
KOi
K04380

Database of Orthologous Groups

More...
OrthoDBi
716848at2759

TreeFam database of animal gene trees

More...
TreeFami
TF316358

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001084 MAP_tubulin-bd_rpt
IPR002955 Tau

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00418 Tubulin-binding, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01261 TAUPROTEIN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00229 TAU_MAP_1, 4 hits
PS51491 TAU_MAP_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist. Isoforms differ from each other by the presence or absence of up to 5 of the 14 exons. One of these optional exons contains the additional tau/MAP repeat. Two different C-termini are obtained either by the retention or the splicing of intron 13/14.

This entry has 6 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform PNS-Tau (identifier: P10637-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADPRQEFDT MEDHAGDYTL LQDQEGDMDH GLKESPPQPP ADDGAEEPGS
60 70 80 90 100
ETSDAKSTPT AEDVTAPLVD ERAPDKQAAA QPHTEIPEGI TAEEAGIGDT
110 120 130 140 150
PNQEDQAAGH VTQGRREGQA PDLGTSDWTR QQVSSMSGAP LLPQGLREAT
160 170 180 190 200
CQPSGTRPED IEKSHPASEL LRRGPPQKEG WGQDRLGSEE EVDEDLTVDE
210 220 230 240 250
SSQDSPPSQA SLTPGRAAPQ AGSGSVCGET ASVPGLPTEG SVPLPADFFS
260 270 280 290 300
KVSAETQASQ PEGPGTGPME EGHEAAPEFT FHVEIKASTP KEQDLEGATV
310 320 330 340 350
VGVPGEEQKA QTQGPSVGKG TKEASLQEPP GKQPAAGLPG RPVSRVPQLK
360 370 380 390 400
ARVASKDRTG NDEKKAKTST PSCAKAPSHR PCLSPTRPTL GSSDPLIKPS
410 420 430 440 450
SPAVSPEPAT SPKHVSSVTP RNGSPGTKQM KLKGADGKTG AKIATPRGAA
460 470 480 490 500
SPAQKGTSNA TRIPAKTTPS PKTPPGSGEP PKSGERSGYS SPGSPGTPGS
510 520 530 540 550
RSRTPSLPTP PTREPKKVAV VRTPPKSPSA SKSRLQTAPV PMPDLKNVRS
560 570 580 590 600
KIGSTENLKH QPGGGKVQII NKKLDLSNVQ SKCGSKDNIK HVPGGGSVQI
610 620 630 640 650
VYKPVDLSKV TSKCGSLGNI HHKPGGGQVE VKSEKLDFKD RVQSKIGSLD
660 670 680 690 700
NITHVPGGGN KKIETHKLTF RENAKAKTDH GAEIVYKSPV VSGDTSPRHL
710 720 730
SNVSSTGSID MVDSPQLATL ADEVSASLAK QGL
Length:733
Mass (Da):76,243
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i80C0D50AC5F64E6F
GO
Isoform Tau-A (identifier: P10637-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-350: Missing.
     368-433: Missing.

Show »
Length:430
Mass (Da):44,893
Checksum:iE3C55BF8F2F901EC
GO
Isoform Tau-B (identifier: P10637-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-91: Missing.
     114-350: Missing.
     368-433: Missing.
     567-597: Missing.
     733-733: L → KAALLSSQVWNYSHDLATITDLGL

Show »
Length:364
Mass (Da):38,200
Checksum:iD1CAB2EF89CDD7C0
GO
Isoform Tau-C (identifier: P10637-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-91: Missing.
     114-350: Missing.
     368-433: Missing.
     567-597: Missing.

Show »
Length:341
Mass (Da):35,714
Checksum:i478641931A5A4143
GO
Isoform Tau-D (identifier: P10637-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-91: Missing.
     114-350: Missing.
     368-433: Missing.

Show »
Length:372
Mass (Da):38,961
Checksum:iB9427D315AD962B7
GO
Isoform Tau-E (identifier: P10637-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-91: Missing.
     92-113: Missing.
     114-350: Missing.
     368-433: Missing.

Show »
Length:350
Mass (Da):36,740
Checksum:i3FB530E1CF1E4CA5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A5Y6A2A5Y6_MOUSE
Microtubule-associated protein
Mapt
749Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AQW2B1AQW2_MOUSE
Microtubule-associated protein
Mapt
390Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQC7A0A0A0MQC7_MOUSE
Microtubule-associated protein
Mapt
733Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AQW5B1AQW5_MOUSE
Microtubule-associated protein tau
Mapt
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AQW4B1AQW4_MOUSE
Microtubule-associated protein tau
Mapt
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AQW6B1AQW6_MOUSE
Microtubule-associated protein tau
Mapt
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3D → N (PubMed:1374898).Curated1
Sequence conflicti9D → N (PubMed:1374898).Curated1
Sequence conflicti405S → C in CAM14797 (PubMed:19468303).Curated1
Sequence conflicti528P → T in CAA78121 (PubMed:7927211).Curated1
Sequence conflicti549R → G in AAH14748 (PubMed:15489334).Curated1
Sequence conflicti672E → Q (PubMed:1374898).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00318534 – 91Missing in isoform Tau-B, isoform Tau-C, isoform Tau-D and isoform Tau-E. 3 PublicationsAdd BLAST58
Alternative sequenceiVSP_00318692 – 113Missing in isoform Tau-E. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_003187114 – 350Missing in isoform Tau-A, isoform Tau-B, isoform Tau-C, isoform Tau-D and isoform Tau-E. 3 PublicationsAdd BLAST237
Alternative sequenceiVSP_003188368 – 433Missing in isoform Tau-A, isoform Tau-B, isoform Tau-C, isoform Tau-D and isoform Tau-E. 3 PublicationsAdd BLAST66
Alternative sequenceiVSP_003189567 – 597Missing in isoform Tau-B and isoform Tau-C. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_003190733L → KAALLSSQVWNYSHDLATIT DLGL in isoform Tau-B. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U12914 mRNA Translation: AAA58343.1
U12915 mRNA Translation: AAA58344.1
U12916 mRNA Translation: AAA58345.1
Z12133 mRNA Translation: CAA78121.1
M93266 mRNA No translation available.
M18775 mRNA Translation: AAA40165.1
M18776 mRNA Translation: AAA40166.1
D30627 Genomic DNA Translation: BAA18878.1
AL593843 Genomic DNA Translation: CAM14797.1
BC014748 mRNA Translation: AAH14748.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS25527.1 [P10637-2]
CCDS25528.1 [P10637-5]

Protein sequence database of the Protein Information Resource

More...
PIRi
A28820
A45301
B28820

NCBI Reference Sequences

More...
RefSeqi
NP_001033698.1, NM_001038609.2 [P10637-2]
NP_001272383.1, NM_001285454.1 [P10637-3]
NP_001272384.1, NM_001285455.1 [P10637-6]
NP_001272385.1, NM_001285456.1 [P10637-4]
NP_034968.3, NM_010838.4 [P10637-5]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.1287

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000100347; ENSMUSP00000097919; ENSMUSG00000018411 [P10637-2]
ENSMUST00000106992; ENSMUSP00000102605; ENSMUSG00000018411 [P10637-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
17762

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:17762

UCSC genome browser

More...
UCSCi
uc007lwf.2 mouse [P10637-3]
uc007lwg.2 mouse [P10637-2]
uc007lwi.2 mouse [P10637-4]
uc011yga.2 mouse [P10637-6]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12914 mRNA Translation: AAA58343.1
U12915 mRNA Translation: AAA58344.1
U12916 mRNA Translation: AAA58345.1
Z12133 mRNA Translation: CAA78121.1
M93266 mRNA No translation available.
M18775 mRNA Translation: AAA40165.1
M18776 mRNA Translation: AAA40166.1
D30627 Genomic DNA Translation: BAA18878.1
AL593843 Genomic DNA Translation: CAM14797.1
BC014748 mRNA Translation: AAH14748.1
CCDSiCCDS25527.1 [P10637-2]
CCDS25528.1 [P10637-5]
PIRiA28820
A45301
B28820
RefSeqiNP_001033698.1, NM_001038609.2 [P10637-2]
NP_001272383.1, NM_001285454.1 [P10637-3]
NP_001272384.1, NM_001285455.1 [P10637-6]
NP_001272385.1, NM_001285456.1 [P10637-4]
NP_034968.3, NM_010838.4 [P10637-5]
UniGeneiMm.1287

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6H0EX-ray1.95G/I/J/K698-721[»]
ProteinModelPortaliP10637
SMRiP10637
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201589, 16 interactors
IntActiP10637, 9 interactors
MINTiP10637
STRINGi10090.ENSMUSP00000097919

PTM databases

iPTMnetiP10637
PhosphoSitePlusiP10637

Proteomic databases

jPOSTiP10637
MaxQBiP10637
PaxDbiP10637
PeptideAtlasiP10637
PRIDEiP10637

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100347; ENSMUSP00000097919; ENSMUSG00000018411 [P10637-2]
ENSMUST00000106992; ENSMUSP00000102605; ENSMUSG00000018411 [P10637-5]
GeneIDi17762
KEGGimmu:17762
UCSCiuc007lwf.2 mouse [P10637-3]
uc007lwg.2 mouse [P10637-2]
uc007lwi.2 mouse [P10637-4]
uc011yga.2 mouse [P10637-6]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4137
MGIiMGI:97180 Mapt

Phylogenomic databases

eggNOGiKOG2418 Eukaryota
ENOG4111J07 LUCA
GeneTreeiENSGT00940000155494
HOVERGENiHBG000991
InParanoidiP10637
KOiK04380
OrthoDBi716848at2759
TreeFamiTF316358

Enzyme and pathway databases

ReactomeiR-MMU-264870 Caspase-mediated cleavage of cytoskeletal proteins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Mapt mouse

Protein Ontology

More...
PROi
PR:P10637

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000018411 Expressed in 261 organ(s), highest expression level in forebrain
CleanExiMM_MAPT
ExpressionAtlasiP10637 baseline and differential
GenevisibleiP10637 MM

Family and domain databases

InterProiView protein in InterPro
IPR001084 MAP_tubulin-bd_rpt
IPR002955 Tau
PfamiView protein in Pfam
PF00418 Tubulin-binding, 4 hits
PRINTSiPR01261 TAUPROTEIN
PROSITEiView protein in PROSITE
PS00229 TAU_MAP_1, 4 hits
PS51491 TAU_MAP_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAU_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10637
Secondary accession number(s): A2A5Y9
, P10638, Q60684, Q60685, Q60686, Q62286, Q91WK4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: January 16, 2019
This is version 204 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again