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Protein

Cytochrome P450 2D6

Gene

CYP2D6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.1 Publication

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.1 Publication

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei301SubstrateCurated1
Metal bindingi443Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processLipid metabolism, Steroid metabolism, Sterol metabolism
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.14.14.1 2681
1.14.99.38 2681
ReactomeiR-HSA-211935 Fatty acids
R-HSA-211958 Miscellaneous substrates
R-HSA-211981 Xenobiotics
R-HSA-211999 CYP2E1 reactions
R-HSA-9027307 Biosynthesis of maresin-like SPMs
SABIO-RKiP10635

Chemistry databases

SwissLipidsiSLP:000001204

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D6 (EC:1.14.14.11 Publication)
Alternative name(s):
CYPIID6
Cholesterol 25-hydroxylase1 Publication
Cytochrome P450-DB1
Debrisoquine 4-hydroxylase
Gene namesi
Name:CYP2D6
Synonyms:CYP2DL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100197.20
HGNCiHGNC:2625 CYP2D6
MIMi124030 gene
neXtProtiNX_P10635

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi1565
MalaCardsiCYP2D6
MIMi608902 phenotype
OpenTargetsiENSG00000100197
Orphaneti413667 Antidepressant or antipsychotic toxicity or dose selection
240867 Codeine toxicity
240947 Resistance to tamoxifene
PharmGKBiPA128

Chemistry databases

ChEMBLiCHEMBL289
DrugBankiDB01562 1-(2-Phenylethyl)-4-phenyl-4-acetoxypiperidine
DB01472 4-Methoxyamphetamine
DB05812 Abiraterone
DB01193 Acebutolol
DB00316 Acetaminophen
DB03128 Acetylcholine
DB01426 Ajmaline
DB00918 Almotriptan
DB06203 Alogliptin
DB00866 Alprenolol
DB01424 Aminophenazone
DB01118 Amiodarone
DB00321 Amitriptyline
DB00381 Amlodipine
DB00613 Amodiaquine
DB00543 Amoxapine
DB00182 Amphetamine
DB00701 Amprenavir
DB00276 Amsacrine
DB01435 Antipyrine
DB01429 Aprindine
DB01274 Arformoterol
DB01238 Aripiprazole
DB06697 Artemether
DB06216 Asenapine
DB00637 Astemizole
DB00289 Atomoxetine
DB01076 Atorvastatin
DB00972 Azelastine
DB00245 Benzatropine
DB06770 Benzyl alcohol
DB01244 Bepridil
DB00195 Betaxolol
DB01128 Bicalutamide
DB04889 Bicifadine
DB00810 Biperiden
DB00612 Bisoprolol
DB00188 Bortezomib
DB09128 Brexpiprazole
DB00835 Brompheniramine
DB06726 Bufuralol
DB00297 Bupivacaine
DB00921 Buprenorphine
DB01156 Bupropion
DB00490 Buspirone
DB00201 Caffeine
DB01197 Captopril
DB00748 Carbinoxamine
DB06016 Cariprazine
DB00521 Carteolol
DB01136 Carvedilol
DB00482 Celecoxib
DB00567 Cephalexin
DB00439 Cerivastatin
DB00185 Cevimeline
DB00475 Chlordiazepoxide
DB00608 Chloroquine
DB01114 Chlorphenamine
DB00477 Chlorpromazine
DB00356 Chlorzoxazone
DB00169 Cholecalciferol
DB01410 Ciclesonide
DB01166 Cilostazol
DB00501 Cimetidine
DB01012 Cinacalcet
DB00568 Cinnarizine
DB00604 Cisapride
DB00215 Citalopram
DB00283 Clemastine
DB04920 Clevidipine
DB00349 Clobazam
DB01242 Clomipramine
DB00575 Clonidine
DB00257 Clotrimazole
DB00363 Clozapine
DB09065 Cobicistat
DB00907 Cocaine
DB00318 Codeine
DB00924 Cyclobenzaprine
DB00531 Cyclophosphamide
DB00091 Cyclosporine
DB04839 Cyproterone acetate
DB06292 Dapagliflozin
DB00496 Darifenacin
DB09183 Dasabuvir
DB04840 Debrisoquin
DB00705 Delavirdine
DB06512 Deramciclane
DB01151 Desipramine
DB00967 Desloratadine
DB01234 Dexamethasone
DB09555 Dexchlorpheniramine maleate
DB01191 Dexfenfluramine
DB00633 Dexmedetomidine
DB06701 Dexmethylphenidate
DB01576 Dextroamphetamine
DB00514 Dextromethorphan
DB00647 Dextropropoxyphene
DB01551 Dihydrocodeine
DB00343 Diltiazem
DB01093 Dimethyl sulfoxide
DB01075 Diphenhydramine
DB00822 Disulfiram
DB00757 Dolasetron
DB01184 Domperidone
DB00843 Donepezil
DB00988 Dopamine
DB00590 Doxazosin
DB01142 Doxepin
DB00997 Doxorubicin
DB04855 Dronedarone
DB00476 Duloxetine
DB00625 Efavirenz
DB00216 Eletriptan
DB09039 Eliglustat
DB01228 Encainide
DB06735 Enclomiphene
DB00494 Entacapone
DB08899 Enzalutamide
DB00751 Epinastine
DB00530 Erlotinib
DB01175 Escitalopram
DB06678 Esmirtazapine
DB01466 Ethylmorphine
DB01628 Etoricoxib
DB01023 Felodipine
DB00574 Fenfluramine
DB06702 Fesoterodine
DB00950 Fexofenadine
DB08868 Fingolimod
DB01195 Flecainide
DB04841 Flunarizine
DB00472 Fluoxetine
DB00623 Fluphenazine
DB01095 Fluvastatin
DB00176 Fluvoxamine
DB00983 Formoterol
DB00674 Galantamine
DB00317 Gefitinib
DB01437 Glutethimide
DB08909 Glycerol Phenylbutyrate
DB00889 Granisetron
DB01218 Halofantrine
DB00502 Haloperidol
DB01159 Halothane
DB05381 Histamine
DB00956 Hydrocodone
DB00327 Hydromorphone
DB01611 Hydroxychloroquine
DB01005 Hydroxyurea
DB00557 Hydroxyzine
DB09053 Ibrutinib
DB01177 Idarubicin
DB04946 Iloperidone
DB00619 Imatinib
DB00458 Imipramine
DB00224 Indinavir
DB00332 Ipratropium bromide
DB01029 Irbesartan
DB00951 Isoniazid
DB01167 Itraconazole
DB09570 Ixazomib
DB01026 Ketoconazole
DB00598 Labetalol
DB00448 Lansoprazole
DB00528 Lercanidipine
DB01235 Levodopa
DB08918 Levomilnacipran
DB13139 Levosalbutamol
DB00281 Lidocaine
DB00589 Lisuride
DB01206 Lomustine
DB00836 Loperamide
DB01601 Lopinavir
DB00455 Loratadine
DB04871 Lorcaserin
DB00227 Lovastatin
DB06708 Lumefantrine
DB00934 Maprotiline
DB00358 Mefloquine
DB00532 Mephenytoin
DB06691 Mepyramine
DB01071 Mequitazine
DB00933 Mesoridazine
DB00333 Methadone
DB01577 Methamphetamine
DB00703 Methazolamide
DB00763 Methimazole
DB01403 Methotrimeprazine
DB00553 Methoxsalen
DB01028 Methoxyflurane
DB09543 Methyl salicylate
DB06800 Methylnaltrexone
DB00422 Methylphenidate
DB01107 Methyprylon
DB01233 Metoclopramide
DB00264 Metoprolol
DB00379 Mexiletine
DB06148 Mianserin
DB01388 Mibefradil
DB01110 Miconazole
DB00211 Midodrine
DB00834 Mifepristone
DB00805 Minaprine
DB08893 Mirabegron
DB00370 Mirtazapine
DB01171 Moclobemide
DB00295 Morphine
DB09049 Naloxegol
DB00731 Nateglinide
DB04861 Nebivolol
DB01149 Nefazodone
DB00220 Nelfinavir
DB09048 Netupitant
DB00238 Nevirapine
DB00627 Niacin
DB00622 Nicardipine
DB00699 Nicergoline
DB02701 Nicotinamide
DB00184 Nicotine
DB01115 Nifedipine
DB04868 Nilotinib
DB00336 Nitrofural
DB00540 Nortriptyline
DB00334 Olanzapine
DB00338 Omeprazole
DB00904 Ondansetron
DB04938 Ospemifene
DB01096 Oxamniquine
DB01580 Oxprenolol
DB01062 Oxybutynin
DB00497 Oxycodone
DB06412 Oxymetholone
DB01192 Oxymorphone
DB01267 Paliperidone
DB00377 Palonosetron
DB06603 Panobinostat
DB00715 Paroxetine
DB06589 Pazopanib
DB00022 Peginterferon alfa-2b
DB00738 Pentamidine
DB01186 Pergolide
DB01074 Perhexiline
DB00850 Perphenazine
DB00454 Pethidine
DB03783 Phenacetin
DB00914 Phenformin
DB00191 Phentermine
DB01100 Pimozide
DB00960 Pindolol
DB01132 Pioglitazone
DB00592 Piperazine
DB01621 Pipotiazine
DB08901 Ponatinib
DB00175 Pravastatin
DB01058 Praziquantel
DB01087 Primaquine
DB01035 Procainamide
DB00433 Prochlorperazine
DB00396 Progesterone
DB01131 Proguanil
DB00420 Promazine
DB01069 Promethazine
DB01182 Propafenone
DB00818 Propofol
DB09396 Propoxyphene napsylate
DB00571 Propranolol
DB00344 Protriptyline
DB00852 Pseudoephedrine
DB00205 Pyrimethamine
DB01224 Quetiapine
DB00908 Quinidine
DB00468 Quinine
DB01129 Rabeprazole
DB00863 Ranitidine
DB00243 Ranolazine
DB00234 Reboxetine
DB00409 Remoxipride
DB01201 Rifapentine
DB00734 Risperidone
DB00503 Ritonavir
DB00989 Rivastigmine
DB09291 Rolapitant
DB00268 Ropinirole
DB00296 Ropivacaine
DB00412 Rosiglitazone
DB05271 Rotigotine
DB12332 Rucaparib
DB01698 Rutin
DB01232 Saquinavir
DB01037 Selegiline
DB06144 Sertindole
DB01104 Sertraline
DB00203 Sildenafil
DB00641 Simvastatin
DB06819 Sodium phenylbutyrate
DB00398 Sorafenib
DB06727 Sparteine
DB09118 Stiripentol
DB06820 Sulconazole
DB00259 Sulfanilamide
DB06729 Sulfaphenazole
DB00675 Tamoxifen
DB00706 Tamsulosin
DB06204 Tapentadol
DB01079 Tegaserod
DB00976 Telithromycin
DB06287 Temsirolimus
DB00857 Terbinafine
DB00342 Terfenadine
DB04905 Tesmilifene
DB04844 Tetrabenazine
DB00277 Theophylline
DB00679 Thioridazine
DB01623 Thiothixene
DB08816 Ticagrelor
DB00208 Ticlopidine
DB00373 Timolol
DB01007 Tioconazole
DB01409 Tiotropium
DB00932 Tipranavir
DB01036 Tolterodine
DB05109 Trabectedin
DB00193 Tramadol
DB00752 Tranylcypromine
DB00656 Trazodone
DB00726 Trimipramine
DB00792 Tripelennamine
DB00427 Triprolidine
DB00209 Trospium
DB09076 Umeclidinium
DB08881 Vemurafenib
DB00285 Venlafaxine
DB00661 Verapamil
DB06684 Vilazodone
DB00570 Vinblastine
DB00361 Vinorelbine
DB09068 Vortioxetine
DB01392 Yohimbine
DB00549 Zafirlukast
DB00943 Zalcitabine
DB00246 Ziprasidone
DB00425 Zolpidem
DB01624 Zuclopenthixol
GuidetoPHARMACOLOGYi1329

Polymorphism and mutation databases

BioMutaiCYP2D6
DMDMi84028191

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517311 – 497Cytochrome P450 2D6Add BLAST497

Proteomic databases

EPDiP10635
PaxDbiP10635
PeptideAtlasiP10635
PRIDEiP10635
ProteomicsDBi52623

PTM databases

iPTMnetiP10635
PhosphoSitePlusiP10635

Expressioni

Inductioni

By pregnancy.

Gene expression databases

BgeeiENSG00000100197 Expressed in 89 organ(s), highest expression level in liver
CleanExiHS_CYP2D6
ExpressionAtlasiP10635 baseline and differential
GenevisibleiP10635 HS

Organism-specific databases

HPAiHPA045223

Interactioni

Protein-protein interaction databases

BioGridi107940, 4 interactors
STRINGi9606.ENSP00000353820

Chemistry databases

BindingDBiP10635

Structurei

Secondary structure

1497
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP10635
SMRiP10635
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10635

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140799
HOVERGENiHBG015789
InParanoidiP10635
KOiK17712
OMAiVLFEVMG
OrthoDBiEOG091G0BT8
PhylomeDBiP10635
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008069 Cyt_P450_E_grp-I_CYP2D-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01686 EP450ICYP2D
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P10635-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLEALVPLA VIVAIFLLLV DLMHRRQRWA ARYPPGPLPL PGLGNLLHVD
60 70 80 90 100
FQNTPYCFDQ LRRRFGDVFS LQLAWTPVVV LNGLAAVREA LVTHGEDTAD
110 120 130 140 150
RPPVPITQIL GFGPRSQGVF LARYGPAWRE QRRFSVSTLR NLGLGKKSLE
160 170 180 190 200
QWVTEEAACL CAAFANHSGR PFRPNGLLDK AVSNVIASLT CGRRFEYDDP
210 220 230 240 250
RFLRLLDLAQ EGLKEESGFL REVLNAVPVL LHIPALAGKV LRFQKAFLTQ
260 270 280 290 300
LDELLTEHRM TWDPAQPPRD LTEAFLAEME KAKGNPESSF NDENLRIVVA
310 320 330 340 350
DLFSAGMVTT STTLAWGLLL MILHPDVQRR VQQEIDDVIG QVRRPEMGDQ
360 370 380 390 400
AHMPYTTAVI HEVQRFGDIV PLGVTHMTSR DIEVQGFRIP KGTTLITNLS
410 420 430 440 450
SVLKDEAVWE KPFRFHPEHF LDAQGHFVKP EAFLPFSAGR RACLGEPLAR
460 470 480 490
MELFLFFTSL LQHFSFSVPT GQPRPSHHGV FAFLVSPSPY ELCAVPR
Length:497
Mass (Da):55,769
Last modified:December 20, 2005 - v2
Checksum:i542B1D505DF3CDAC
GO
Isoform 2 (identifier: P10635-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-168: Missing.

Note: No experimental confirmation available.
Show »
Length:446
Mass (Da):50,061
Checksum:iD1FB49C5A4B10965
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6NWU0Q6NWU0_HUMAN
Cytochrome P450 2D6
CYP2D6
497Annotation score:
Q38LG0Q38LG0_HUMAN
CYP2D6
CYP2D6
497Annotation score:
A0A1B0GV74A0A1B0GV74_HUMAN
Cytochrome P450 2D6
CYP2D6
446Annotation score:
A0A0G2JLK7A0A0G2JLK7_HUMAN
Cytochrome P450 2D6
CYP2D6
446Annotation score:
C1ID54C1ID54_HUMAN
Cytochrome P450 2D6
CYP2D6
497Annotation score:
E7ENE7E7ENE7_HUMAN
Cytochrome P450 2D6
CYP2D6
494Annotation score:
A0A1B0GUD8A0A1B0GUD8_HUMAN
Cytochrome P450 2D6
CYP2D6
180Annotation score:
A0A1B0GU72A0A1B0GU72_HUMAN
Cytochrome P450 2D6
CYP2D6
494Annotation score:
A0A0G2JSD7A0A0G2JSD7_HUMAN
Cytochrome P450 2D6
CYP2D6
494Annotation score:
H7BY38H7BY38_HUMAN
Cytochrome P450 2D6
CYP2D6
180Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti374V → M in AAA52153 (PubMed:3410476).Curated1
Sequence conflicti374V → M in CAA30807 (PubMed:3123997).Curated1

Polymorphismi

Genetic variations in CYP2D6 are the cause of poor drug metabolism CYP2D6-related [MIMi:608902]. The CYP2D6 gene is highly polymorphic. CYP2D6 activity ranges widely within a population comprising ultrarapid (UM), extensive (EM), intermediate (IM) and poor (PM) metabolizer phenotypes. UM and PM are those most at risk for treatment failure or dose-dependent drug toxicity, respectively. Of the Caucasian populations of Europe and North America, 5%-10% are of the PM phenotype and are unable to metabolize the antihypersensitive drug debrisoquine and numerous other drugs. Different alleles are known, including CYP2D6*1 (PubMed:15768052), CYP2D6*2 (PubMed:25469868), CYP2D6*6B/6C (PubMed:7868129), CYP2D6*7 also known CYP2D6E (PubMed:7845481), CYP2D6*9 also known CYP2D6C (PubMed:1844820), CYP2D6*10 also known CYP2D6J (PubMed:8287064, PubMed:25469868), CYP2D6*12 (PubMed:8655150), CYP2D6*14 (PubMed:10064570), CYP2D6*17 also known CYP2D6Z (PubMed:8971426), CYP2D6*41B (PubMed:15768052), CYP2D6*45A (PubMed:15768052), CYP2D6*45B (PubMed:15768052), CYP2D6*46 (PubMed:15768052), CYP2D6*87 (PubMed:25469868), CYP2D6*88 (PubMed:25469868), CYP2D6*89 (PubMed:25469868), CYP2D6*90 (PubMed:25469868), CYP2D6*91 (PubMed:25469868), CYP2D6*93 (PubMed:25469868), C CYP2D6*94 (PubMed:25469868), CYP2D6*97 (PubMed:25469868) and CYP2D6*98 (PubMed:25469868). Isozymes CYP2D6.45 (Lys-155, Cys-296 and Thr-486) and CYP2D6.46 (His-26, Lys-155, Cys-296 and Thr-486) are functional (PubMed:15768052). The sequence shown is that of isozyme CYP2D6.1 corresponding to allele CYP2D6*1.9 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0727645A → V in allele CYP2D6*87. 1 PublicationCorresponds to variant dbSNP:rs773790593Ensembl.1
Natural variantiVAR_00836611V → M in allele CYP2D6*35. 1 PublicationCorresponds to variant dbSNP:rs769258Ensembl.1
Natural variantiVAR_07276525R → Q1 PublicationCorresponds to variant dbSNP:rs138417770Ensembl.1
Natural variantiVAR_00836726R → H in allele CYP2D6*21 and allele CYP2D6*46. 3 PublicationsCorresponds to variant dbSNP:rs28371696Ensembl.1
Natural variantiVAR_00836828R → C in allele CYP2D6*22. Corresponds to variant dbSNP:rs138100349Ensembl.1
Natural variantiVAR_00833634P → S in allele CYP2D6*10 and allele CYP2D6*14; poor debrisquone metabolism. 3 PublicationsCorresponds to variant dbSNP:rs1065852EnsemblClinVar.1
Natural variantiVAR_00125642G → R in allele CYP2D6*12; impaired metabolism of sparteine. 1 PublicationCorresponds to variant dbSNP:rs5030862Ensembl.1
Natural variantiVAR_00836985A → V in allele CYP2D6*23. Corresponds to variant dbSNP:rs267608310Ensembl.1
Natural variantiVAR_02472091L → M1 PublicationCorresponds to variant dbSNP:rs28371703Ensembl.1
Natural variantiVAR_02472194H → R1 PublicationCorresponds to variant dbSNP:rs28371704Ensembl.1
Natural variantiVAR_072766104V → A in allele CYP2D6*88. 1 PublicationCorresponds to variant dbSNP:rs76187628Ensembl.1
Natural variantiVAR_008337107T → I in allele CYP2D6*17; poor debrisquone metabolism. 2 PublicationsCorresponds to variant dbSNP:rs28371706Ensembl.1
Natural variantiVAR_024722120F → I1 PublicationCorresponds to variant dbSNP:rs1135822Ensembl.1
Natural variantiVAR_072767142L → S in allele CYP2D6*89; >90% decrease of monooxygenase activity towards dextromethorphan and bufuralol. 1 PublicationCorresponds to variant dbSNP:rs375135093Ensembl.1
Natural variantiVAR_072768147K → R in allele CYP2D6*90. 1 PublicationCorresponds to variant dbSNP:rs569229126Ensembl.1
Natural variantiVAR_024723155E → K in allele CYP2D6*45A, allele CYP2D6*45B and allele CYP2D6*46. 2 PublicationsCorresponds to variant dbSNP:rs28371710Ensembl.1
Natural variantiVAR_072769161C → S in allele CYP2D6*91. 1 Publication1
Natural variantiVAR_072770164F → L1 Publication1
Natural variantiVAR_008338169G → R in allele CYP2D6*14; poor debrisquone metabolism. 1 PublicationCorresponds to variant dbSNP:rs5030865Ensembl.1
Natural variantiVAR_008339212G → E in allele CYP2D6*6B and allele CYP2D6*6C. 1 PublicationCorresponds to variant dbSNP:rs5030866Ensembl.1
Natural variantiVAR_072771215E → K >90% decrease of monooxygenase activity towards dextromethorphan and bufuralol. 1 PublicationCorresponds to variant dbSNP:rs567606867Ensembl.1
Natural variantiVAR_072772219F → S1 PublicationCorresponds to variant dbSNP:rs371793722Ensembl.1
Natural variantiVAR_045679231L → P. Corresponds to variant dbSNP:rs17002853Ensembl.1
Natural variantiVAR_008370237A → S in allele CYP2D6*33. 1 PublicationCorresponds to variant dbSNP:rs28371717EnsemblClinVar.1
Natural variantiVAR_072773249T → P in allele CYP2D6*93; >90% decrease of monooxygenase activity towards dextromethorphan and bufuralol. 1 Publication1
Natural variantiVAR_008347281Missing in allele CYP2D6*9. 1 Publication1
Natural variantiVAR_008340296R → C in allele CYP2D6*2, allele CYP2D6*12, allele CYP2D6*14, allele CYP2D6*17, allele CYP2D6*45A, allele CYP2D6*45B and allele CYP2D6*46; slightly decrease of monooxygenase activity towards bufuralol. 5 PublicationsCorresponds to variant dbSNP:rs16947EnsemblClinVar.1
Natural variantiVAR_008371297I → L in allele CYP2D6*24. Corresponds to variant dbSNP:rs949717872Ensembl.1
Natural variantiVAR_045680300A → G. Corresponds to variant dbSNP:rs1058170Ensembl.1
Natural variantiVAR_014633311S → L. Corresponds to variant dbSNP:rs1800754Ensembl.1
Natural variantiVAR_008348324H → P in allele CYP2D6*7; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs5030867Ensembl.1
Natural variantiVAR_072774327V → M1 Publication1
Natural variantiVAR_059150329R → L. Corresponds to variant dbSNP:rs3915951Ensembl.1
Natural variantiVAR_072775336D → N1 PublicationCorresponds to variant dbSNP:rs745746329Ensembl.1
Natural variantiVAR_072776337D → G in allele CYP2D6*94. 1 PublicationCorresponds to variant dbSNP:rs748712690Ensembl.1
Natural variantiVAR_072777342V → M1 PublicationCorresponds to variant dbSNP:rs750996195Ensembl.1
Natural variantiVAR_008372343R → G in allele CYP2D6*25. Corresponds to variant dbSNP:rs267608295Ensembl.1
Natural variantiVAR_072778344R → Q1 PublicationCorresponds to variant dbSNP:rs76088846Ensembl.1
Natural variantiVAR_045681365R → H. Corresponds to variant dbSNP:rs1058172Ensembl.1
Natural variantiVAR_008373369I → T in allele CYP2D6*26. 1
Natural variantiVAR_059151373G → S. Corresponds to variant dbSNP:rs61737946Ensembl.1
Natural variantiVAR_008374410E → K in allele CYP2D6*27. Corresponds to variant dbSNP:rs769157652Ensembl.1
Natural variantiVAR_024724418E → K1 PublicationCorresponds to variant dbSNP:rs28371733Ensembl.1
Natural variantiVAR_072779440R → C >90% decrease of monooxygenase activity towards dextromethorphan and bufuralol. 1 PublicationCorresponds to variant dbSNP:rs777560972Ensembl.1
Natural variantiVAR_072780457F → L in allele CYP2D6*97. 1 Publication1
Natural variantiVAR_072781463H → D in allele CYP2D6*98. 1 Publication1
Natural variantiVAR_024725469P → A1 PublicationCorresponds to variant dbSNP:rs1135833Ensembl.1
Natural variantiVAR_024726478H → Y1 PublicationCorresponds to variant dbSNP:rs28371735Ensembl.1
Natural variantiVAR_008341486S → T in allele CYP2D6*2, allele CYP2D6*10, allele CYP2D6*12, allele CYP2D6*14, allele CYP2D6*17, allele CYP2D6*45A, allele CYP2D6*45B and allele CYP2D6*46; impaired metabolism of sparteine. 6 PublicationsCorresponds to variant dbSNP:rs1135840EnsemblClinVar.1
Natural variantiVAR_072782497R → C1 PublicationCorresponds to variant dbSNP:rs370580423Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044486118 – 168Missing in isoform 2. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20403 mRNA Translation: AAA52153.1
X08006 mRNA Translation: CAA30807.1
M33388 Genomic DNA Translation: AAA53500.1
AY545216 Genomic DNA Translation: AAS55001.1
DQ282144 Genomic DNA Translation: ABB77895.1
DQ282145 Genomic DNA Translation: ABB77896.1
DQ282146 Genomic DNA Translation: ABB77897.1
DQ282151 Genomic DNA Translation: ABB77899.1
DQ282154 Genomic DNA Translation: ABB77902.1
DQ282155 Genomic DNA Translation: ABB77903.1
BX247885 Genomic DNA No translation available.
BC066877 mRNA Translation: AAH66877.1
BC075023 mRNA Translation: AAH75023.1
BC075024 mRNA Translation: AAH75024.1
CCDSiCCDS33657.1 [P10635-2]
CCDS46721.1 [P10635-1]
PIRiS01199 O4HUD1
RefSeqiNP_000097.3, NM_000106.5 [P10635-1]
NP_001020332.2, NM_001025161.2 [P10635-2]
UniGeneiHs.648256

Genome annotation databases

EnsembliENST00000359033; ENSP00000351927; ENSG00000100197 [P10635-2]
ENST00000360608; ENSP00000353820; ENSG00000100197 [P10635-1]
ENST00000612990; ENSP00000483677; ENSG00000275211
ENST00000645361; ENSP00000496150; ENSG00000100197 [P10635-1]
ENST00000645508; ENSP00000496296; ENSG00000100197 [P10635-1]
GeneIDi1565
KEGGihsa:1565
UCSCiuc003bce.4 human [P10635-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP2D6 alleles

Wikipedia

CYP2D6 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20403 mRNA Translation: AAA52153.1
X08006 mRNA Translation: CAA30807.1
M33388 Genomic DNA Translation: AAA53500.1
AY545216 Genomic DNA Translation: AAS55001.1
DQ282144 Genomic DNA Translation: ABB77895.1
DQ282145 Genomic DNA Translation: ABB77896.1
DQ282146 Genomic DNA Translation: ABB77897.1
DQ282151 Genomic DNA Translation: ABB77899.1
DQ282154 Genomic DNA Translation: ABB77902.1
DQ282155 Genomic DNA Translation: ABB77903.1
BX247885 Genomic DNA No translation available.
BC066877 mRNA Translation: AAH66877.1
BC075023 mRNA Translation: AAH75023.1
BC075024 mRNA Translation: AAH75024.1
CCDSiCCDS33657.1 [P10635-2]
CCDS46721.1 [P10635-1]
PIRiS01199 O4HUD1
RefSeqiNP_000097.3, NM_000106.5 [P10635-1]
NP_001020332.2, NM_001025161.2 [P10635-2]
UniGeneiHs.648256

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F9QX-ray3.00A/B/C/D34-497[»]
3QM4X-ray2.85A/B34-497[»]
3TBGX-ray2.10A/B/C/D34-497[»]
3TDAX-ray2.67A/B/C/D34-497[»]
4WNTX-ray2.60A/B34-497[»]
4WNUX-ray2.26A/B/C/D34-497[»]
4WNVX-ray2.35A/B/C/D48-497[»]
4WNWX-ray3.30A/B34-497[»]
4XRYX-ray2.50A/B/C/D34-497[»]
4XRZX-ray2.40A/B/C/D34-497[»]
5TFTX-ray2.71A/B/C/D34-497[»]
5TFUX-ray2.75A/B/C/D34-497[»]
ProteinModelPortaliP10635
SMRiP10635
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107940, 4 interactors
STRINGi9606.ENSP00000353820

Chemistry databases

BindingDBiP10635
ChEMBLiCHEMBL289
DrugBankiDB01562 1-(2-Phenylethyl)-4-phenyl-4-acetoxypiperidine
DB01472 4-Methoxyamphetamine
DB05812 Abiraterone
DB01193 Acebutolol
DB00316 Acetaminophen
DB03128 Acetylcholine
DB01426 Ajmaline
DB00918 Almotriptan
DB06203 Alogliptin
DB00866 Alprenolol
DB01424 Aminophenazone
DB01118 Amiodarone
DB00321 Amitriptyline
DB00381 Amlodipine
DB00613 Amodiaquine
DB00543 Amoxapine
DB00182 Amphetamine
DB00701 Amprenavir
DB00276 Amsacrine
DB01435 Antipyrine
DB01429 Aprindine
DB01274 Arformoterol
DB01238 Aripiprazole
DB06697 Artemether
DB06216 Asenapine
DB00637 Astemizole
DB00289 Atomoxetine
DB01076 Atorvastatin
DB00972 Azelastine
DB00245 Benzatropine
DB06770 Benzyl alcohol
DB01244 Bepridil
DB00195 Betaxolol
DB01128 Bicalutamide
DB04889 Bicifadine
DB00810 Biperiden
DB00612 Bisoprolol
DB00188 Bortezomib
DB09128 Brexpiprazole
DB00835 Brompheniramine
DB06726 Bufuralol
DB00297 Bupivacaine
DB00921 Buprenorphine
DB01156 Bupropion
DB00490 Buspirone
DB00201 Caffeine
DB01197 Captopril
DB00748 Carbinoxamine
DB06016 Cariprazine
DB00521 Carteolol
DB01136 Carvedilol
DB00482 Celecoxib
DB00567 Cephalexin
DB00439 Cerivastatin
DB00185 Cevimeline
DB00475 Chlordiazepoxide
DB00608 Chloroquine
DB01114 Chlorphenamine
DB00477 Chlorpromazine
DB00356 Chlorzoxazone
DB00169 Cholecalciferol
DB01410 Ciclesonide
DB01166 Cilostazol
DB00501 Cimetidine
DB01012 Cinacalcet
DB00568 Cinnarizine
DB00604 Cisapride
DB00215 Citalopram
DB00283 Clemastine
DB04920 Clevidipine
DB00349 Clobazam
DB01242 Clomipramine
DB00575 Clonidine
DB00257 Clotrimazole
DB00363 Clozapine
DB09065 Cobicistat
DB00907 Cocaine
DB00318 Codeine
DB00924 Cyclobenzaprine
DB00531 Cyclophosphamide
DB00091 Cyclosporine
DB04839 Cyproterone acetate
DB06292 Dapagliflozin
DB00496 Darifenacin
DB09183 Dasabuvir
DB04840 Debrisoquin
DB00705 Delavirdine
DB06512 Deramciclane
DB01151 Desipramine
DB00967 Desloratadine
DB01234 Dexamethasone
DB09555 Dexchlorpheniramine maleate
DB01191 Dexfenfluramine
DB00633 Dexmedetomidine
DB06701 Dexmethylphenidate
DB01576 Dextroamphetamine
DB00514 Dextromethorphan
DB00647 Dextropropoxyphene
DB01551 Dihydrocodeine
DB00343 Diltiazem
DB01093 Dimethyl sulfoxide
DB01075 Diphenhydramine
DB00822 Disulfiram
DB00757 Dolasetron
DB01184 Domperidone
DB00843 Donepezil
DB00988 Dopamine
DB00590 Doxazosin
DB01142 Doxepin
DB00997 Doxorubicin
DB04855 Dronedarone
DB00476 Duloxetine
DB00625 Efavirenz
DB00216 Eletriptan
DB09039 Eliglustat
DB01228 Encainide
DB06735 Enclomiphene
DB00494 Entacapone
DB08899 Enzalutamide
DB00751 Epinastine
DB00530 Erlotinib
DB01175 Escitalopram
DB06678 Esmirtazapine
DB01466 Ethylmorphine
DB01628 Etoricoxib
DB01023 Felodipine
DB00574 Fenfluramine
DB06702 Fesoterodine
DB00950 Fexofenadine
DB08868 Fingolimod
DB01195 Flecainide
DB04841 Flunarizine
DB00472 Fluoxetine
DB00623 Fluphenazine
DB01095 Fluvastatin
DB00176 Fluvoxamine
DB00983 Formoterol
DB00674 Galantamine
DB00317 Gefitinib
DB01437 Glutethimide
DB08909 Glycerol Phenylbutyrate
DB00889 Granisetron
DB01218 Halofantrine
DB00502 Haloperidol
DB01159 Halothane
DB05381 Histamine
DB00956 Hydrocodone
DB00327 Hydromorphone
DB01611 Hydroxychloroquine
DB01005 Hydroxyurea
DB00557 Hydroxyzine
DB09053 Ibrutinib
DB01177 Idarubicin
DB04946 Iloperidone
DB00619 Imatinib
DB00458 Imipramine
DB00224 Indinavir
DB00332 Ipratropium bromide
DB01029 Irbesartan
DB00951 Isoniazid
DB01167 Itraconazole
DB09570 Ixazomib
DB01026 Ketoconazole
DB00598 Labetalol
DB00448 Lansoprazole
DB00528 Lercanidipine
DB01235 Levodopa
DB08918 Levomilnacipran
DB13139 Levosalbutamol
DB00281 Lidocaine
DB00589 Lisuride
DB01206 Lomustine
DB00836 Loperamide
DB01601 Lopinavir
DB00455 Loratadine
DB04871 Lorcaserin
DB00227 Lovastatin
DB06708 Lumefantrine
DB00934 Maprotiline
DB00358 Mefloquine
DB00532 Mephenytoin
DB06691 Mepyramine
DB01071 Mequitazine
DB00933 Mesoridazine
DB00333 Methadone
DB01577 Methamphetamine
DB00703 Methazolamide
DB00763 Methimazole
DB01403 Methotrimeprazine
DB00553 Methoxsalen
DB01028 Methoxyflurane
DB09543 Methyl salicylate
DB06800 Methylnaltrexone
DB00422 Methylphenidate
DB01107 Methyprylon
DB01233 Metoclopramide
DB00264 Metoprolol
DB00379 Mexiletine
DB06148 Mianserin
DB01388 Mibefradil
DB01110 Miconazole
DB00211 Midodrine
DB00834 Mifepristone
DB00805 Minaprine
DB08893 Mirabegron
DB00370 Mirtazapine
DB01171 Moclobemide
DB00295 Morphine
DB09049 Naloxegol
DB00731 Nateglinide
DB04861 Nebivolol
DB01149 Nefazodone
DB00220 Nelfinavir
DB09048 Netupitant
DB00238 Nevirapine
DB00627 Niacin
DB00622 Nicardipine
DB00699 Nicergoline
DB02701 Nicotinamide
DB00184 Nicotine
DB01115 Nifedipine
DB04868 Nilotinib
DB00336 Nitrofural
DB00540 Nortriptyline
DB00334 Olanzapine
DB00338 Omeprazole
DB00904 Ondansetron
DB04938 Ospemifene
DB01096 Oxamniquine
DB01580 Oxprenolol
DB01062 Oxybutynin
DB00497 Oxycodone
DB06412 Oxymetholone
DB01192 Oxymorphone
DB01267 Paliperidone
DB00377 Palonosetron
DB06603 Panobinostat
DB00715 Paroxetine
DB06589 Pazopanib
DB00022 Peginterferon alfa-2b
DB00738 Pentamidine
DB01186 Pergolide
DB01074 Perhexiline
DB00850 Perphenazine
DB00454 Pethidine
DB03783 Phenacetin
DB00914 Phenformin
DB00191 Phentermine
DB01100 Pimozide
DB00960 Pindolol
DB01132 Pioglitazone
DB00592 Piperazine
DB01621 Pipotiazine
DB08901 Ponatinib
DB00175 Pravastatin
DB01058 Praziquantel
DB01087 Primaquine
DB01035 Procainamide
DB00433 Prochlorperazine
DB00396 Progesterone
DB01131 Proguanil
DB00420 Promazine
DB01069 Promethazine
DB01182 Propafenone
DB00818 Propofol
DB09396 Propoxyphene napsylate
DB00571 Propranolol
DB00344 Protriptyline
DB00852 Pseudoephedrine
DB00205 Pyrimethamine
DB01224 Quetiapine
DB00908 Quinidine
DB00468 Quinine
DB01129 Rabeprazole
DB00863 Ranitidine
DB00243 Ranolazine
DB00234 Reboxetine
DB00409 Remoxipride
DB01201 Rifapentine
DB00734 Risperidone
DB00503 Ritonavir
DB00989 Rivastigmine
DB09291 Rolapitant
DB00268 Ropinirole
DB00296 Ropivacaine
DB00412 Rosiglitazone
DB05271 Rotigotine
DB12332 Rucaparib
DB01698 Rutin
DB01232 Saquinavir
DB01037 Selegiline
DB06144 Sertindole
DB01104 Sertraline
DB00203 Sildenafil
DB00641 Simvastatin
DB06819 Sodium phenylbutyrate
DB00398 Sorafenib
DB06727 Sparteine
DB09118 Stiripentol
DB06820 Sulconazole
DB00259 Sulfanilamide
DB06729 Sulfaphenazole
DB00675 Tamoxifen
DB00706 Tamsulosin
DB06204 Tapentadol
DB01079 Tegaserod
DB00976 Telithromycin
DB06287 Temsirolimus
DB00857 Terbinafine
DB00342 Terfenadine
DB04905 Tesmilifene
DB04844 Tetrabenazine
DB00277 Theophylline
DB00679 Thioridazine
DB01623 Thiothixene
DB08816 Ticagrelor
DB00208 Ticlopidine
DB00373 Timolol
DB01007 Tioconazole
DB01409 Tiotropium
DB00932 Tipranavir
DB01036 Tolterodine
DB05109 Trabectedin
DB00193 Tramadol
DB00752 Tranylcypromine
DB00656 Trazodone
DB00726 Trimipramine
DB00792 Tripelennamine
DB00427 Triprolidine
DB00209 Trospium
DB09076 Umeclidinium
DB08881 Vemurafenib
DB00285 Venlafaxine
DB00661 Verapamil
DB06684 Vilazodone
DB00570 Vinblastine
DB00361 Vinorelbine
DB09068 Vortioxetine
DB01392 Yohimbine
DB00549 Zafirlukast
DB00943 Zalcitabine
DB00246 Ziprasidone
DB00425 Zolpidem
DB01624 Zuclopenthixol
GuidetoPHARMACOLOGYi1329
SwissLipidsiSLP:000001204

PTM databases

iPTMnetiP10635
PhosphoSitePlusiP10635

Polymorphism and mutation databases

BioMutaiCYP2D6
DMDMi84028191

Proteomic databases

EPDiP10635
PaxDbiP10635
PeptideAtlasiP10635
PRIDEiP10635
ProteomicsDBi52623

Protocols and materials databases

DNASUi1565
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359033; ENSP00000351927; ENSG00000100197 [P10635-2]
ENST00000360608; ENSP00000353820; ENSG00000100197 [P10635-1]
ENST00000612990; ENSP00000483677; ENSG00000275211
ENST00000645361; ENSP00000496150; ENSG00000100197 [P10635-1]
ENST00000645508; ENSP00000496296; ENSG00000100197 [P10635-1]
GeneIDi1565
KEGGihsa:1565
UCSCiuc003bce.4 human [P10635-1]

Organism-specific databases

CTDi1565
DisGeNETi1565
EuPathDBiHostDB:ENSG00000100197.20
GeneCardsiCYP2D6
HGNCiHGNC:2625 CYP2D6
HPAiHPA045223
MalaCardsiCYP2D6
MIMi124030 gene
608902 phenotype
neXtProtiNX_P10635
OpenTargetsiENSG00000100197
Orphaneti413667 Antidepressant or antipsychotic toxicity or dose selection
240867 Codeine toxicity
240947 Resistance to tamoxifene
PharmGKBiPA128
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140799
HOVERGENiHBG015789
InParanoidiP10635
KOiK17712
OMAiVLFEVMG
OrthoDBiEOG091G0BT8
PhylomeDBiP10635
TreeFamiTF352043

Enzyme and pathway databases

BRENDAi1.14.14.1 2681
1.14.99.38 2681
ReactomeiR-HSA-211935 Fatty acids
R-HSA-211958 Miscellaneous substrates
R-HSA-211981 Xenobiotics
R-HSA-211999 CYP2E1 reactions
R-HSA-9027307 Biosynthesis of maresin-like SPMs
SABIO-RKiP10635

Miscellaneous databases

EvolutionaryTraceiP10635
GeneWikiiCYP2D6
GenomeRNAii1565
PROiPR:P10635
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100197 Expressed in 89 organ(s), highest expression level in liver
CleanExiHS_CYP2D6
ExpressionAtlasiP10635 baseline and differential
GenevisibleiP10635 HS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008069 Cyt_P450_E_grp-I_CYP2D-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01686 EP450ICYP2D
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCP2D6_HUMAN
AccessioniPrimary (citable) accession number: P10635
Secondary accession number(s): Q16752
, Q2XND6, Q2XND7, Q2XNE0, Q6B012, Q6NXU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: December 20, 2005
Last modified: November 7, 2018
This is version 203 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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