UniProtKB - P10635 (CP2D6_HUMAN)
Protein
Cytochrome P450 2D6
Gene
CYP2D6
Organism
Homo sapiens (Human)
Status
Functioni
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids (PubMed:18698000, PubMed:19965576, PubMed:20972997, PubMed:21289075, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:18698000, PubMed:19965576, PubMed:20972997, PubMed:21289075, PubMed:21576599). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) (PubMed:19965576, PubMed:20972997). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:18698000, PubMed:21289075). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). Catalyzes the oxidative transformations of all-trans retinol to all-trans retinal, a precursor for the active form all-trans-retinoic acid (PubMed:10681376). Also involved in the oxidative metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.7 Publications
Catalytic activityi
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward1 Publication direction.
- N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH—hemoprotein reductase] = H+ + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward1 Publication direction.
- N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH—hemoprotein reductase] = H+ + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward1 Publication direction.
- N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH—hemoprotein reductase] = H+ + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward1 Publication direction.
- N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH—hemoprotein reductase] = H+ + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH—hemoprotein reductase] = (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH—hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH—hemoprotein reductase] = (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- cholesterol + O2 + reduced [NADPH—hemoprotein reductase] = 25-hydroxycholesterol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- all-trans-retinol + O2 + reduced [NADPH—hemoprotein reductase] = all-trans-retinal + H+ + 2 H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
Cofactori
Kineticsi
- KM=67 µM for all-trans retinol1 Publication
- KM=1.3 µM for anandamide (oxidation to 20-HETE)1 Publication
- KM=2.1 µM for anandamide (oxidation to 8,9-EpETrE-EA)1 Publication
- KM=2.6 µM for anandamide (oxidation to 11,12-EpETrE-EA)1 Publication
- KM=2.8 µM for anandamide (oxidation to 14,15-EpETrE-EA)1 Publication
- Vmax=193 pmol/min/nmol enzyme toward all-trans retinol1 Publication
- Vmax=3.7 pmol/min/nmol enzyme toward anandamide (oxidation to 20-HETE)1 Publication
- Vmax=1.6 pmol/min/nmol enzyme toward anandamide (oxidation to 8,9-EpETrE-EA)1 Publication
- Vmax=1.1 pmol/min/nmol enzyme toward anandamide (oxidation to 11,12-EpETrE-EA)1 Publication
- Vmax=1.3 pmol/min/nmol enzyme toward anandamide (oxidation to 14,15-EpETrE-EA)1 Publication
: retinol metabolism Pathwayi
This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.
Pathwayi: fatty acid metabolism
This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.2 PublicationsView all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.
Pathwayi: cholesterol metabolism
This protein is involved in the pathway cholesterol metabolism, which is part of Steroid metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway cholesterol metabolism and in Steroid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 301 | SubstrateCurated | 1 | |
Metal bindingi | 443 | Iron (heme axial ligand) | 1 |
GO - Molecular functioni
- anandamide 11,12 epoxidase activity Source: UniProtKB
- anandamide 14,15 epoxidase activity Source: UniProtKB
- anandamide 8,9 epoxidase activity Source: UniProtKB
- drug binding Source: BHF-UCL
- heme binding Source: UniProtKB
- iron ion binding Source: InterPro
- monooxygenase activity Source: BHF-UCL
- oxidoreductase activity Source: BHF-UCL
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: GO_Central
- steroid hydroxylase activity Source: GO_Central
GO - Biological processi
- alkaloid catabolic process Source: BHF-UCL
- alkaloid metabolic process Source: BHF-UCL
- arachidonic acid metabolic process Source: GO_Central
- cholesterol metabolic process Source: UniProtKB-UniPathway
- coumarin metabolic process Source: BHF-UCL
- drug catabolic process Source: BHF-UCL
- drug metabolic process Source: BHF-UCL
- estrogen metabolic process Source: UniProtKB
- exogenous drug catabolic process Source: GO_Central
- heterocycle metabolic process Source: BHF-UCL
- isoquinoline alkaloid metabolic process Source: BHF-UCL
- long-chain fatty acid biosynthetic process Source: Reactome
- monoterpenoid metabolic process Source: BHF-UCL
- negative regulation of binding Source: BHF-UCL
- negative regulation of cellular organofluorine metabolic process Source: BHF-UCL
- organic acid metabolic process Source: GO_Central
- oxidation-reduction process Source: BHF-UCL
- oxidative demethylation Source: BHF-UCL
- retinol metabolic process Source: UniProtKB
- steroid metabolic process Source: BHF-UCL
- xenobiotic metabolic process Source: GO_Central
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Biological process | Cholesterol metabolism, Fatty acid metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
BRENDAi | 1.14.14.1, 2681 1.14.99.38, 2681 |
PathwayCommonsi | P10635 |
Reactomei | R-HSA-211935, Fatty acids R-HSA-211958, Miscellaneous substrates R-HSA-211981, Xenobiotics R-HSA-211999, CYP2E1 reactions R-HSA-9027307, Biosynthesis of maresin-like SPMs |
SABIO-RKi | P10635 |
UniPathwayi | UPA00199 UPA00296 UPA00912 |
Chemistry databases
SwissLipidsi | SLP:000001204 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome P450 2D61 Publication (EC:1.14.14.-2 Publications)Alternative name(s): CYPIID6 Cholesterol 25-hydroxylase1 Publication Cytochrome P450-DB1 Debrisoquine 4-hydroxylase |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000100197.20 |
HGNCi | HGNC:2625, CYP2D6 |
MIMi | 124030, gene |
neXtProti | NX_P10635 |
Subcellular locationi
Endoplasmic reticulum
Endoplasmic reticulum
- endoplasmic reticulum Source: BHF-UCL
- endoplasmic reticulum membrane Source: Reactome
Mitochondrion
- mitochondrion Source: BHF-UCL
Other locations
- cytoplasm Source: GO_Central
- intracellular membrane-bounded organelle Source: GO_Central
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 1565 |
MalaCardsi | CYP2D6 |
MIMi | 608902, phenotype |
OpenTargetsi | ENSG00000100197 |
Orphaneti | 413667, Antidepressant or antipsychotic toxicity or dose selection 240867, Codeine toxicity 240947, Resistance to tamoxifene |
PharmGKBi | PA128 |
Miscellaneous databases
Pharosi | P10635, Tclin |
Chemistry databases
ChEMBLi | CHEMBL289 |
DrugBanki | DB01562, 1-(2-Phenylethyl)-4-phenyl-4-acetoxypiperidine DB01472, 4-Methoxyamphetamine DB14010, 5-methoxy-N,N-dimethyltryptamine DB12001, Abemaciclib DB05812, Abiraterone DB01193, Acebutolol DB00316, Acetaminophen DB00918, Almotriptan DB06203, Alogliptin DB00866, Alprenolol DB01424, Aminophenazone DB01118, Amiodarone DB00321, Amitriptyline DB00381, Amlodipine DB00613, Amodiaquine DB00543, Amoxapine DB00182, Amphetamine DB00701, Amprenavir DB11785, Anisodamine DB01435, Antipyrine DB01429, Aprindine DB01274, Arformoterol DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB09204, Arotinolol DB11638, Artenimol DB06216, Asenapine DB00637, Astemizole DB11586, Asunaprevir DB00335, Atenolol DB00289, Atomoxetine DB01076, Atorvastatin DB00972, Azelastine DB04957, Azimilide DB09013, Befunolol DB06770, Benzyl alcohol DB01244, Bepridil DB00195, Betaxolol DB01295, Bevantolol DB01128, Bicalutamide DB04889, Bicifadine DB00810, Biperiden DB13975, Black cohosh DB08807, Bopindolol DB00188, Bortezomib DB09128, Brexpiprazole DB12752, Bucindolol DB06726, Bufuralol DB00297, Bupivacaine DB08808, Bupranolol DB00921, Buprenorphine DB01156, Bupropion DB00490, Buspirone DB09173, Butyrfentanyl DB00201, Caffeine DB09061, Cannabidiol DB06016, Cariprazine DB00521, Carteolol DB01136, Carvedilol DB00482, Celecoxib DB04846, Celiprolol DB00439, Cerivastatin DB00185, Cevimeline DB00608, Chloroquine DB01114, Chlorpheniramine DB00477, Chlorpromazine DB00356, Chlorzoxazone DB01410, Ciclesonide DB01166, Cilostazol DB00501, Cimetidine DB01012, Cinacalcet DB00568, Cinnarizine DB00604, Cisapride DB00215, Citalopram DB00283, Clemastine DB04920, Clevidipine DB14025, Clinafloxacin DB00349, Clobazam DB00845, Clofazimine DB01242, Clomipramine DB00575, Clonidine DB13508, Cloranolol DB00257, Clotrimazole DB00363, Clozapine DB09065, Cobicistat DB00907, Cocaine DB00318, Codeine DB11672, Curcumin DB14635, Curcumin sulfate DB00924, Cyclobenzaprine DB00091, Cyclosporine DB11963, Dacomitinib DB06292, Dapagliflozin DB04884, Dapoxetine DB00496, Darifenacin DB01264, Darunavir DB09183, Dasabuvir DB04840, Debrisoquine DB00705, Delavirdine DB06512, Deramciclane DB01151, Desipramine DB06700, Desvenlafaxine DB12161, Deutetrabenazine DB13679, Dexchlorpheniramine DB09555, Dexchlorpheniramine maleate DB01191, Dexfenfluramine DB00633, Dexmedetomidine DB01576, Dextroamphetamine DB00514, Dextromethorphan DB00647, Dextropropoxyphene DB11994, Diacerein DB01551, Dihydrocodeine DB00343, Diltiazem DB01093, Dimethyl sulfoxide DB01075, Diphenhydramine DB00757, Dolasetron DB01184, Domperidone DB00843, Donepezil DB09167, Dosulepin DB00590, Doxazosin DB01142, Doxepin DB00997, Doxorubicin DB04855, Dronedarone DB00476, Duloxetine DB00625, Efavirenz DB11979, Elagolix DB00216, Eletriptan DB15444, Elexacaftor DB09039, Eliglustat DB13874, Enasidenib DB01228, Encainide DB06735, Enclomiphene DB11718, Encorafenib DB00494, Entacapone DB13757, Epanolol DB00751, Epinastine DB00530, Erlotinib DB13443, Esatenolol DB01175, Escitalopram DB06678, Esmirtazapine DB00187, Esmolol DB01466, Ethylmorphine DB01628, Etoricoxib DB01590, Everolimus DB12500, Fedratinib DB01023, Felodipine DB00574, Fenfluramine DB06702, Fesoterodine DB01195, Flecainide DB04841, Flunarizine DB00472, Fluoxetine DB00623, Fluphenazine DB01095, Fluvastatin DB00176, Fluvoxamine DB00983, Formoterol DB02703, Fusidic acid DB00674, Galantamine DB00317, Gefitinib DB08909, Glycerol phenylbutyrate DB01218, Halofantrine DB00502, Haloperidol DB00956, Hydrocodone DB01611, Hydroxychloroquine DB01005, Hydroxyurea DB00557, Hydroxyzine DB09053, Ibrutinib DB01177, Idarubicin DB04946, Iloperidone DB00619, Imatinib DB00458, Imipramine DB08952, Indenolol DB00224, Indinavir DB06370, Indisulam DB13293, Ipecac DB04818, Iproniazid DB11633, Isavuconazole DB00951, Isoniazid DB11757, Istradefylline DB09570, Ixazomib DB01026, Ketoconazole DB00598, Labetalol DB12212, Landiolol DB00448, Lansoprazole DB11732, Lasmiditan DB09078, Lenvatinib DB00528, Lercanidipine DB12070, Letermovir DB09351, Levobetaxolol DB01210, Levobunolol DB08918, Levomilnacipran DB13139, Levosalbutamol DB00281, Lidocaine DB01255, Lisdexamfetamine DB04948, Lofexidine DB01206, Lomustine DB00836, Loperamide DB01601, Lopinavir DB00455, Loratadine DB04871, Lorcaserin DB09195, Lorpiprazole DB06708, Lumefantrine DB04829, Lysergic acid diethylamide DB09238, Manidipine DB00934, Maprotiline DB00737, Meclizine DB14009, Medical Cannabis DB09224, Melperone DB00454, Meperidine DB00532, Mephenytoin DB13530, Mepindolol DB06691, Mepyramine DB01071, Mequitazine DB00933, Mesoridazine DB01577, Metamfetamine DB00333, Methadone DB00763, Methimazole DB01403, Methotrimeprazine DB01028, Methoxyflurane DB09241, Methylene blue DB01214, Metipranolol DB01233, Metoclopramide DB00264, Metoprolol DB00379, Mexiletine DB06148, Mianserin DB01388, Mibefradil DB01110, Miconazole DB00211, Midodrine DB01454, Midomafetamine DB06595, Midostaurin DB00834, Mifepristone DB00805, Minaprine DB08893, Mirabegron DB00370, Mirtazapine DB12523, Mizolastine DB01171, Moclobemide DB14011, Nabiximols DB09049, Naloxegol DB00731, Nateglinide DB04861, Nebivolol DB01149, Nefazodone DB00220, Nelfinavir DB09048, Netupitant DB00238, Nevirapine DB00627, Niacin DB00622, Nicardipine DB00699, Nicergoline DB02701, Nicotinamide DB00184, Nicotine DB01115, Nifedipine DB04868, Nilotinib DB00540, Nortriptyline DB00334, Olanzapine DB00338, Omeprazole DB00904, Ondansetron DB11130, Opium DB04911, Oritavancin DB01173, Orphenadrine DB11837, Osilodrostat DB04938, Ospemifene DB01096, Oxamniquine DB01580, Oxprenolol DB01062, Oxybutynin DB00497, Oxycodone DB06412, Oxymetholone DB01192, Oxymorphone DB01267, Paliperidone DB00377, Palonosetron DB06603, Panobinostat DB00715, Paroxetine DB06589, Pazopanib DB00022, Peginterferon alfa-2b DB01359, Penbutolol DB00738, Pentamidine DB01074, Perhexiline DB08922, Perospirone DB00850, Perphenazine DB03783, Phenacetin DB00780, Phenelzine DB00914, Phenformin DB06819, Phenylbutyric acid DB00252, Phenytoin DB01100, Pimozide DB00960, Pindolol DB00592, Piperazine DB01621, Pipotiazine DB11642, Pitolisant DB08901, Ponatinib DB01297, Practolol DB01087, Primaquine DB01035, Procainamide DB00433, Prochlorperazine DB00396, Progesterone DB01131, Proguanil DB00420, Promazine DB01069, Promethazine DB09288, Propacetamol DB01182, Propafenone DB00571, Propranolol DB01224, Quetiapine DB00908, Quinidine DB00468, Quinine DB01129, Rabeprazole DB00863, Ranitidine DB00243, Ranolazine DB00234, Reboxetine DB14761, Remdesivir DB00409, Remoxipride DB06506, Repinotan DB11855, Revefenacin DB13174, Rhein DB08864, Rilpivirine DB14840, Ripretinib DB00734, Risperidone DB12693, Ritanserin DB00503, Ritonavir DB09291, Rolapitant DB00412, Rosiglitazone DB05271, Rotigotine DB12332, Rucaparib DB11614, Rupatadine DB06654, Safinamide DB01232, Saquinavir DB01037, Selegiline DB06144, Sertindole DB01104, Sertraline DB00203, Sildenafil DB00641, Simvastatin DB01591, Solifenacin DB00398, Sorafenib DB00489, Sotalol DB06727, Sparteine DB01323, St. John's Wort DB09118, Stiripentol DB06820, Sulconazole DB00259, Sulfanilamide DB06729, Sulfaphenazole DB06608, Tafenoquine DB11770, Talinolol DB00675, Tamoxifen DB00706, Tamsulosin DB06204, Tapentadol DB01079, Tegaserod DB06287, Temsirolimus DB00857, Terbinafine DB00342, Terfenadine DB13775, Tertatolol DB04905, Tesmilifene DB04844, Tetrabenazine DB00277, Theophylline DB00679, Thioridazine DB01623, Thiothixene DB00208, Ticlopidine DB00373, Timolol DB01409, Tiotropium DB00932, Tipranavir DB01036, Tolterodine DB05109, Trabectedin DB00193, Tramadol DB00752, Tranylcypromine DB00656, Trazodone DB12245, Triclabendazole DB00726, Trimipramine DB00792, Tripelennamine DB00209, Trospium DB15328, Ubrogepant DB09076, Umeclidinium DB13609, Umifenovir DB15091, Upadacitinib DB11915, Valbenazine DB08881, Vemurafenib DB00285, Venlafaxine DB00661, Verapamil DB06217, Vernakalant DB06684, Vilazodone DB00570, Vinblastine DB00361, Vinorelbine DB09068, Vortioxetine DB01392, Yohimbine DB00425, Zolpidem DB01624, Zuclopenthixol |
DrugCentrali | P10635 |
GuidetoPHARMACOLOGYi | 1329 |
Polymorphism and mutation databases
BioMutai | CYP2D6 |
DMDMi | 84028191 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051731 | 1 – 497 | Cytochrome P450 2D6Add BLAST | 497 |
Proteomic databases
jPOSTi | P10635 |
MassIVEi | P10635 |
PaxDbi | P10635 |
PeptideAtlasi | P10635 |
PRIDEi | P10635 |
ProteomicsDBi | 52623 [P10635-1] 66778 |
PTM databases
iPTMneti | P10635 |
PhosphoSitePlusi | P10635 |
Expressioni
Inductioni
By pregnancy.
Gene expression databases
Bgeei | ENSG00000100197, Expressed in right lobe of liver and 111 other tissues |
ExpressionAtlasi | P10635, baseline and differential |
Genevisiblei | P10635, HS |
Organism-specific databases
HPAi | ENSG00000100197, Tissue enriched (liver) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 107940, 4 interactors |
STRINGi | 9606.ENSP00000353820 |
Chemistry databases
BindingDBi | P10635 |
Miscellaneous databases
RNActi | P10635, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P10635 |
SMRi | P10635 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P10635 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0156, Eukaryota |
GeneTreei | ENSGT00940000153331 |
HOGENOMi | CLU_001570_22_3_1 |
InParanoidi | P10635 |
OMAi | GGIWPVD |
PhylomeDBi | P10635 |
TreeFami | TF352043 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR008069, Cyt_P450_E_grp-I_CYP2D-like IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR01686, EP450ICYP2D PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P10635-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGLEALVPLA VIVAIFLLLV DLMHRRQRWA ARYPPGPLPL PGLGNLLHVD
60 70 80 90 100
FQNTPYCFDQ LRRRFGDVFS LQLAWTPVVV LNGLAAVREA LVTHGEDTAD
110 120 130 140 150
RPPVPITQIL GFGPRSQGVF LARYGPAWRE QRRFSVSTLR NLGLGKKSLE
160 170 180 190 200
QWVTEEAACL CAAFANHSGR PFRPNGLLDK AVSNVIASLT CGRRFEYDDP
210 220 230 240 250
RFLRLLDLAQ EGLKEESGFL REVLNAVPVL LHIPALAGKV LRFQKAFLTQ
260 270 280 290 300
LDELLTEHRM TWDPAQPPRD LTEAFLAEME KAKGNPESSF NDENLRIVVA
310 320 330 340 350
DLFSAGMVTT STTLAWGLLL MILHPDVQRR VQQEIDDVIG QVRRPEMGDQ
360 370 380 390 400
AHMPYTTAVI HEVQRFGDIV PLGVTHMTSR DIEVQGFRIP KGTTLITNLS
410 420 430 440 450
SVLKDEAVWE KPFRFHPEHF LDAQGHFVKP EAFLPFSAGR RACLGEPLAR
460 470 480 490
MELFLFFTSL LQHFSFSVPT GQPRPSHHGV FAFLVSPSPY ELCAVPR
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ6NWU0 | Q6NWU0_HUMAN | Cytochrome P450 2D6 | CYP2D6 | 497 | Annotation score: | ||
Q38LG0 | Q38LG0_HUMAN | CYP2D6 | CYP2D6 | 497 | Annotation score: | ||
A0A1B0GV74 | A0A1B0GV74_HUMAN | Cytochrome P450 2D6 | CYP2D6 | 446 | Annotation score: | ||
A0A0G2JLK7 | A0A0G2JLK7_HUMAN | Cytochrome P450 2D6 | CYP2D6 | 446 | Annotation score: | ||
C1ID54 | C1ID54_HUMAN | Cytochrome P450 2D6 | CYP2D6 | 497 | Annotation score: | ||
A0A1B0GUD8 | A0A1B0GUD8_HUMAN | Cytochrome P450 2D6 | CYP2D6 | 180 | Annotation score: | ||
E7ENE7 | E7ENE7_HUMAN | Cytochrome P450 2D6 | CYP2D6 | 494 | Annotation score: | ||
H7BY38 | H7BY38_HUMAN | Cytochrome P450 2D6 | CYP2D6 | 180 | Annotation score: | ||
A0A1B0GU72 | A0A1B0GU72_HUMAN | Cytochrome P450 2D6 | CYP2D6 | 494 | Annotation score: | ||
A0A0G2JSD7 | A0A0G2JSD7_HUMAN | Cytochrome P450 2D6 | CYP2D6 | 494 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 374 | V → M in AAA52153 (PubMed:3410476).Curated | 1 | |
Sequence conflicti | 374 | V → M in CAA30807 (PubMed:3123997).Curated | 1 |
Polymorphismi
Genetic variations in CYP2D6 are the cause of poor drug metabolism CYP2D6-related [MIMi:608902]. The CYP2D6 gene is highly polymorphic. CYP2D6 activity ranges widely within a population comprising ultrarapid (UM), extensive (EM), intermediate (IM) and poor (PM) metabolizer phenotypes. UM and PM are those most at risk for treatment failure or dose-dependent drug toxicity, respectively. Of the Caucasian populations of Europe and North America, 5%-10% are of the PM phenotype and are unable to metabolize the antihypersensitive drug debrisoquine and numerous other drugs. Different alleles are known, including CYP2D6*1 (PubMed:15768052), CYP2D6*2 (PubMed:25469868), CYP2D6*6B/6C (PubMed:7868129), CYP2D6*7 also known CYP2D6E (PubMed:7845481), CYP2D6*9 also known CYP2D6C (PubMed:1844820), CYP2D6*10 also known CYP2D6J (PubMed:8287064, PubMed:25469868), CYP2D6*12 (PubMed:8655150), CYP2D6*14 (PubMed:10064570), CYP2D6*17 also known CYP2D6Z (PubMed:8971426), CYP2D6*41B (PubMed:15768052), CYP2D6*45A (PubMed:15768052), CYP2D6*45B (PubMed:15768052), CYP2D6*46 (PubMed:15768052), CYP2D6*87 (PubMed:25469868), CYP2D6*88 (PubMed:25469868), CYP2D6*89 (PubMed:25469868), CYP2D6*90 (PubMed:25469868), CYP2D6*91 (PubMed:25469868), CYP2D6*93 (PubMed:25469868), C CYP2D6*94 (PubMed:25469868), CYP2D6*97 (PubMed:25469868) and CYP2D6*98 (PubMed:25469868). Isozymes CYP2D6.45 (Lys-155, Cys-296 and Thr-486) and CYP2D6.46 (His-26, Lys-155, Cys-296 and Thr-486) are functional (PubMed:15768052). The sequence shown is that of isozyme CYP2D6.1 corresponding to allele CYP2D6*1.9 Publications
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_072764 | 5 | A → V in allele CYP2D6*87. 1 PublicationCorresponds to variant dbSNP:rs773790593Ensembl. | 1 | |
Natural variantiVAR_008366 | 11 | V → M in allele CYP2D6*35. 1 PublicationCorresponds to variant dbSNP:rs769258EnsemblClinVar. | 1 | |
Natural variantiVAR_072765 | 25 | R → Q1 PublicationCorresponds to variant dbSNP:rs138417770Ensembl. | 1 | |
Natural variantiVAR_008367 | 26 | R → H in allele CYP2D6*21 and allele CYP2D6*46. 3 PublicationsCorresponds to variant dbSNP:rs28371696Ensembl. | 1 | |
Natural variantiVAR_008368 | 28 | R → C in allele CYP2D6*22. Corresponds to variant dbSNP:rs138100349Ensembl. | 1 | |
Natural variantiVAR_008336 | 34 | P → S in allele CYP2D6*10 and allele CYP2D6*14; poor debrisquone metabolism. 3 PublicationsCorresponds to variant dbSNP:rs1065852Ensembl. | 1 | |
Natural variantiVAR_001256 | 42 | G → R in allele CYP2D6*12; impaired metabolism of sparteine. 1 PublicationCorresponds to variant dbSNP:rs5030862EnsemblClinVar. | 1 | |
Natural variantiVAR_008369 | 85 | A → V in allele CYP2D6*23. Corresponds to variant dbSNP:rs267608310Ensembl. | 1 | |
Natural variantiVAR_024720 | 91 | L → M1 PublicationCorresponds to variant dbSNP:rs28371703EnsemblClinVar. | 1 | |
Natural variantiVAR_024721 | 94 | H → R1 PublicationCorresponds to variant dbSNP:rs28371704EnsemblClinVar. | 1 | |
Natural variantiVAR_072766 | 104 | V → A in allele CYP2D6*88. 1 PublicationCorresponds to variant dbSNP:rs76187628Ensembl. | 1 | |
Natural variantiVAR_008337 | 107 | T → I in allele CYP2D6*17; poor debrisquone metabolism. 2 PublicationsCorresponds to variant dbSNP:rs28371706Ensembl. | 1 | |
Natural variantiVAR_024722 | 120 | F → I1 PublicationCorresponds to variant dbSNP:rs1135822Ensembl. | 1 | |
Natural variantiVAR_072767 | 142 | L → S in allele CYP2D6*89; >90% decrease of monooxygenase activity towards dextromethorphan and bufuralol. 1 PublicationCorresponds to variant dbSNP:rs375135093EnsemblClinVar. | 1 | |
Natural variantiVAR_072768 | 147 | K → R in allele CYP2D6*90. 1 PublicationCorresponds to variant dbSNP:rs569229126Ensembl. | 1 | |
Natural variantiVAR_024723 | 155 | E → K in allele CYP2D6*45A, allele CYP2D6*45B and allele CYP2D6*46. 2 PublicationsCorresponds to variant dbSNP:rs28371710Ensembl. | 1 | |
Natural variantiVAR_072769 | 161 | C → S in allele CYP2D6*91. 1 Publication | 1 | |
Natural variantiVAR_072770 | 164 | F → L1 Publication | 1 | |
Natural variantiVAR_008338 | 169 | G → R in allele CYP2D6*14; poor debrisquone metabolism. 1 PublicationCorresponds to variant dbSNP:rs5030865EnsemblClinVar. | 1 | |
Natural variantiVAR_008339 | 212 | G → E in allele CYP2D6*6B and allele CYP2D6*6C. 1 PublicationCorresponds to variant dbSNP:rs5030866Ensembl. | 1 | |
Natural variantiVAR_072771 | 215 | E → K >90% decrease of monooxygenase activity towards dextromethorphan and bufuralol. 1 PublicationCorresponds to variant dbSNP:rs567606867Ensembl. | 1 | |
Natural variantiVAR_072772 | 219 | F → S1 PublicationCorresponds to variant dbSNP:rs371793722Ensembl. | 1 | |
Natural variantiVAR_045679 | 231 | L → P. Corresponds to variant dbSNP:rs17002853EnsemblClinVar. | 1 | |
Natural variantiVAR_008370 | 237 | A → S in allele CYP2D6*33. 1 PublicationCorresponds to variant dbSNP:rs28371717EnsemblClinVar. | 1 | |
Natural variantiVAR_072773 | 249 | T → P in allele CYP2D6*93; >90% decrease of monooxygenase activity towards dextromethorphan and bufuralol. 1 Publication | 1 | |
Natural variantiVAR_008347 | 281 | Missing in allele CYP2D6*9. 1 Publication | 1 | |
Natural variantiVAR_008340 | 296 | R → C in allele CYP2D6*2, allele CYP2D6*12, allele CYP2D6*14, allele CYP2D6*17, allele CYP2D6*45A, allele CYP2D6*45B and allele CYP2D6*46; significantly reduced monooxygenase activity toward anandamide; slight decrease of monooxygenase activity towards bufuralol. 6 PublicationsCorresponds to variant dbSNP:rs16947EnsemblClinVar. | 1 | |
Natural variantiVAR_008371 | 297 | I → L in allele CYP2D6*24. Corresponds to variant dbSNP:rs949717872Ensembl. | 1 | |
Natural variantiVAR_045680 | 300 | A → G. Corresponds to variant dbSNP:rs1058170Ensembl. | 1 | |
Natural variantiVAR_014633 | 311 | S → L. Corresponds to variant dbSNP:rs1800754Ensembl. | 1 | |
Natural variantiVAR_008348 | 324 | H → P in allele CYP2D6*7; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs5030867EnsemblClinVar. | 1 | |
Natural variantiVAR_072774 | 327 | V → M1 Publication | 1 | |
Natural variantiVAR_059150 | 329 | R → L. Corresponds to variant dbSNP:rs3915951Ensembl. | 1 | |
Natural variantiVAR_072775 | 336 | D → N1 PublicationCorresponds to variant dbSNP:rs745746329Ensembl. | 1 | |
Natural variantiVAR_072776 | 337 | D → G in allele CYP2D6*94. 1 PublicationCorresponds to variant dbSNP:rs748712690Ensembl. | 1 | |
Natural variantiVAR_072777 | 342 | V → M1 PublicationCorresponds to variant dbSNP:rs750996195Ensembl. | 1 | |
Natural variantiVAR_008372 | 343 | R → G in allele CYP2D6*25. Corresponds to variant dbSNP:rs267608295Ensembl. | 1 | |
Natural variantiVAR_072778 | 344 | R → Q1 PublicationCorresponds to variant dbSNP:rs76088846Ensembl. | 1 | |
Natural variantiVAR_045681 | 365 | R → H. Corresponds to variant dbSNP:rs1058172EnsemblClinVar. | 1 | |
Natural variantiVAR_008373 | 369 | I → T in allele CYP2D6*26. | 1 | |
Natural variantiVAR_059151 | 373 | G → S. Corresponds to variant dbSNP:rs61737946EnsemblClinVar. | 1 | |
Natural variantiVAR_008374 | 410 | E → K in allele CYP2D6*27. Corresponds to variant dbSNP:rs769157652Ensembl. | 1 | |
Natural variantiVAR_024724 | 418 | E → K1 PublicationCorresponds to variant dbSNP:rs28371733Ensembl. | 1 | |
Natural variantiVAR_072779 | 440 | R → C >90% decrease of monooxygenase activity towards dextromethorphan and bufuralol. 1 PublicationCorresponds to variant dbSNP:rs777560972Ensembl. | 1 | |
Natural variantiVAR_072780 | 457 | F → L in allele CYP2D6*97. 1 Publication | 1 | |
Natural variantiVAR_072781 | 463 | H → D in allele CYP2D6*98. 1 Publication | 1 | |
Natural variantiVAR_024725 | 469 | P → A1 PublicationCorresponds to variant dbSNP:rs1135833Ensembl. | 1 | |
Natural variantiVAR_024726 | 478 | H → Y1 PublicationCorresponds to variant dbSNP:rs28371735Ensembl. | 1 | |
Natural variantiVAR_008341 | 486 | S → T in allele CYP2D6*2, allele CYP2D6*10, allele CYP2D6*12, allele CYP2D6*14, allele CYP2D6*17, allele CYP2D6*45A, allele CYP2D6*45B and allele CYP2D6*46; impaired metabolism of sparteine. 6 PublicationsCorresponds to variant dbSNP:rs1135840EnsemblClinVar. | 1 | |
Natural variantiVAR_072782 | 497 | R → C1 PublicationCorresponds to variant dbSNP:rs370580423Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044486 | 118 – 168 | Missing in isoform 2. 1 PublicationAdd BLAST | 51 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M20403 mRNA Translation: AAA52153.1 X08006 mRNA Translation: CAA30807.1 M33388 Genomic DNA Translation: AAA53500.1 AY545216 Genomic DNA Translation: AAS55001.1 DQ282144 Genomic DNA Translation: ABB77895.1 DQ282145 Genomic DNA Translation: ABB77896.1 DQ282146 Genomic DNA Translation: ABB77897.1 DQ282151 Genomic DNA Translation: ABB77899.1 DQ282154 Genomic DNA Translation: ABB77902.1 DQ282155 Genomic DNA Translation: ABB77903.1 BX247885 Genomic DNA No translation available. BC066877 mRNA Translation: AAH66877.1 BC075023 mRNA Translation: AAH75023.1 BC075024 mRNA Translation: AAH75024.1 |
CCDSi | CCDS33657.1 [P10635-2] CCDS46721.1 [P10635-1] |
PIRi | S01199, O4HUD1 |
RefSeqi | NP_000097.3, NM_000106.5 [P10635-1] NP_001020332.2, NM_001025161.2 [P10635-2] |
Genome annotation databases
Ensembli | ENST00000359033; ENSP00000351927; ENSG00000100197 [P10635-2] ENST00000612990; ENSP00000483677; ENSG00000275211 ENST00000645361; ENSP00000496150; ENSG00000100197 [P10635-1] |
GeneIDi | 1565 |
KEGGi | hsa:1565 |
UCSCi | uc003bce.4, human [P10635-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Cytochrome P450 Allele Nomenclature Committee CYP2D6 alleles |
Wikipedia CYP2D6 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M20403 mRNA Translation: AAA52153.1 X08006 mRNA Translation: CAA30807.1 M33388 Genomic DNA Translation: AAA53500.1 AY545216 Genomic DNA Translation: AAS55001.1 DQ282144 Genomic DNA Translation: ABB77895.1 DQ282145 Genomic DNA Translation: ABB77896.1 DQ282146 Genomic DNA Translation: ABB77897.1 DQ282151 Genomic DNA Translation: ABB77899.1 DQ282154 Genomic DNA Translation: ABB77902.1 DQ282155 Genomic DNA Translation: ABB77903.1 BX247885 Genomic DNA No translation available. BC066877 mRNA Translation: AAH66877.1 BC075023 mRNA Translation: AAH75023.1 BC075024 mRNA Translation: AAH75024.1 |
CCDSi | CCDS33657.1 [P10635-2] CCDS46721.1 [P10635-1] |
PIRi | S01199, O4HUD1 |
RefSeqi | NP_000097.3, NM_000106.5 [P10635-1] NP_001020332.2, NM_001025161.2 [P10635-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2F9Q | X-ray | 3.00 | A/B/C/D | 34-497 | [»] | |
3QM4 | X-ray | 2.85 | A/B | 34-497 | [»] | |
3TBG | X-ray | 2.10 | A/B/C/D | 34-497 | [»] | |
3TDA | X-ray | 2.67 | A/B/C/D | 34-497 | [»] | |
4WNT | X-ray | 2.60 | A/B | 34-497 | [»] | |
4WNU | X-ray | 2.26 | A/B/C/D | 34-497 | [»] | |
4WNV | X-ray | 2.35 | A/B/C/D | 48-497 | [»] | |
4WNW | X-ray | 3.30 | A/B | 34-497 | [»] | |
4XRY | X-ray | 2.50 | A/B/C/D | 34-497 | [»] | |
4XRZ | X-ray | 2.40 | A/B/C/D | 34-497 | [»] | |
5TFT | X-ray | 2.71 | A/B/C/D | 34-497 | [»] | |
5TFU | X-ray | 2.75 | A/B/C/D | 34-497 | [»] | |
6CSB | X-ray | 2.39 | A/B/C/D | 34-497 | [»] | |
6CSD | X-ray | 2.39 | A/B | 34-497 | [»] | |
BMRBi | P10635 | |||||
SMRi | P10635 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107940, 4 interactors |
STRINGi | 9606.ENSP00000353820 |
Chemistry databases
BindingDBi | P10635 |
ChEMBLi | CHEMBL289 |
DrugBanki | DB01562, 1-(2-Phenylethyl)-4-phenyl-4-acetoxypiperidine DB01472, 4-Methoxyamphetamine DB14010, 5-methoxy-N,N-dimethyltryptamine DB12001, Abemaciclib DB05812, Abiraterone DB01193, Acebutolol DB00316, Acetaminophen DB00918, Almotriptan DB06203, Alogliptin DB00866, Alprenolol DB01424, Aminophenazone DB01118, Amiodarone DB00321, Amitriptyline DB00381, Amlodipine DB00613, Amodiaquine DB00543, Amoxapine DB00182, Amphetamine DB00701, Amprenavir DB11785, Anisodamine DB01435, Antipyrine DB01429, Aprindine DB01274, Arformoterol DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB09204, Arotinolol DB11638, Artenimol DB06216, Asenapine DB00637, Astemizole DB11586, Asunaprevir DB00335, Atenolol DB00289, Atomoxetine DB01076, Atorvastatin DB00972, Azelastine DB04957, Azimilide DB09013, Befunolol DB06770, Benzyl alcohol DB01244, Bepridil DB00195, Betaxolol DB01295, Bevantolol DB01128, Bicalutamide DB04889, Bicifadine DB00810, Biperiden DB13975, Black cohosh DB08807, Bopindolol DB00188, Bortezomib DB09128, Brexpiprazole DB12752, Bucindolol DB06726, Bufuralol DB00297, Bupivacaine DB08808, Bupranolol DB00921, Buprenorphine DB01156, Bupropion DB00490, Buspirone DB09173, Butyrfentanyl DB00201, Caffeine DB09061, Cannabidiol DB06016, Cariprazine DB00521, Carteolol DB01136, Carvedilol DB00482, Celecoxib DB04846, Celiprolol DB00439, Cerivastatin DB00185, Cevimeline DB00608, Chloroquine DB01114, Chlorpheniramine DB00477, Chlorpromazine DB00356, Chlorzoxazone DB01410, Ciclesonide DB01166, Cilostazol DB00501, Cimetidine DB01012, Cinacalcet DB00568, Cinnarizine DB00604, Cisapride DB00215, Citalopram DB00283, Clemastine DB04920, Clevidipine DB14025, Clinafloxacin DB00349, Clobazam DB00845, Clofazimine DB01242, Clomipramine DB00575, Clonidine DB13508, Cloranolol DB00257, Clotrimazole DB00363, Clozapine DB09065, Cobicistat DB00907, Cocaine DB00318, Codeine DB11672, Curcumin DB14635, Curcumin sulfate DB00924, Cyclobenzaprine DB00091, Cyclosporine DB11963, Dacomitinib DB06292, Dapagliflozin DB04884, Dapoxetine DB00496, Darifenacin DB01264, Darunavir DB09183, Dasabuvir DB04840, Debrisoquine DB00705, Delavirdine DB06512, Deramciclane DB01151, Desipramine DB06700, Desvenlafaxine DB12161, Deutetrabenazine DB13679, Dexchlorpheniramine DB09555, Dexchlorpheniramine maleate DB01191, Dexfenfluramine DB00633, Dexmedetomidine DB01576, Dextroamphetamine DB00514, Dextromethorphan DB00647, Dextropropoxyphene DB11994, Diacerein DB01551, Dihydrocodeine DB00343, Diltiazem DB01093, Dimethyl sulfoxide DB01075, Diphenhydramine DB00757, Dolasetron DB01184, Domperidone DB00843, Donepezil DB09167, Dosulepin DB00590, Doxazosin DB01142, Doxepin DB00997, Doxorubicin DB04855, Dronedarone DB00476, Duloxetine DB00625, Efavirenz DB11979, Elagolix DB00216, Eletriptan DB15444, Elexacaftor DB09039, Eliglustat DB13874, Enasidenib DB01228, Encainide DB06735, Enclomiphene DB11718, Encorafenib DB00494, Entacapone DB13757, Epanolol DB00751, Epinastine DB00530, Erlotinib DB13443, Esatenolol DB01175, Escitalopram DB06678, Esmirtazapine DB00187, Esmolol DB01466, Ethylmorphine DB01628, Etoricoxib DB01590, Everolimus DB12500, Fedratinib DB01023, Felodipine DB00574, Fenfluramine DB06702, Fesoterodine DB01195, Flecainide DB04841, Flunarizine DB00472, Fluoxetine DB00623, Fluphenazine DB01095, Fluvastatin DB00176, Fluvoxamine DB00983, Formoterol DB02703, Fusidic acid DB00674, Galantamine DB00317, Gefitinib DB08909, Glycerol phenylbutyrate DB01218, Halofantrine DB00502, Haloperidol DB00956, Hydrocodone DB01611, Hydroxychloroquine DB01005, Hydroxyurea DB00557, Hydroxyzine DB09053, Ibrutinib DB01177, Idarubicin DB04946, Iloperidone DB00619, Imatinib DB00458, Imipramine DB08952, Indenolol DB00224, Indinavir DB06370, Indisulam DB13293, Ipecac DB04818, Iproniazid DB11633, Isavuconazole DB00951, Isoniazid DB11757, Istradefylline DB09570, Ixazomib DB01026, Ketoconazole DB00598, Labetalol DB12212, Landiolol DB00448, Lansoprazole DB11732, Lasmiditan DB09078, Lenvatinib DB00528, Lercanidipine DB12070, Letermovir DB09351, Levobetaxolol DB01210, Levobunolol DB08918, Levomilnacipran DB13139, Levosalbutamol DB00281, Lidocaine DB01255, Lisdexamfetamine DB04948, Lofexidine DB01206, Lomustine DB00836, Loperamide DB01601, Lopinavir DB00455, Loratadine DB04871, Lorcaserin DB09195, Lorpiprazole DB06708, Lumefantrine DB04829, Lysergic acid diethylamide DB09238, Manidipine DB00934, Maprotiline DB00737, Meclizine DB14009, Medical Cannabis DB09224, Melperone DB00454, Meperidine DB00532, Mephenytoin DB13530, Mepindolol DB06691, Mepyramine DB01071, Mequitazine DB00933, Mesoridazine DB01577, Metamfetamine DB00333, Methadone DB00763, Methimazole DB01403, Methotrimeprazine DB01028, Methoxyflurane DB09241, Methylene blue DB01214, Metipranolol DB01233, Metoclopramide DB00264, Metoprolol DB00379, Mexiletine DB06148, Mianserin DB01388, Mibefradil DB01110, Miconazole DB00211, Midodrine DB01454, Midomafetamine DB06595, Midostaurin DB00834, Mifepristone DB00805, Minaprine DB08893, Mirabegron DB00370, Mirtazapine DB12523, Mizolastine DB01171, Moclobemide DB14011, Nabiximols DB09049, Naloxegol DB00731, Nateglinide DB04861, Nebivolol DB01149, Nefazodone DB00220, Nelfinavir DB09048, Netupitant DB00238, Nevirapine DB00627, Niacin DB00622, Nicardipine DB00699, Nicergoline DB02701, Nicotinamide DB00184, Nicotine DB01115, Nifedipine DB04868, Nilotinib DB00540, Nortriptyline DB00334, Olanzapine DB00338, Omeprazole DB00904, Ondansetron DB11130, Opium DB04911, Oritavancin DB01173, Orphenadrine DB11837, Osilodrostat DB04938, Ospemifene DB01096, Oxamniquine DB01580, Oxprenolol DB01062, Oxybutynin DB00497, Oxycodone DB06412, Oxymetholone DB01192, Oxymorphone DB01267, Paliperidone DB00377, Palonosetron DB06603, Panobinostat DB00715, Paroxetine DB06589, Pazopanib DB00022, Peginterferon alfa-2b DB01359, Penbutolol DB00738, Pentamidine DB01074, Perhexiline DB08922, Perospirone DB00850, Perphenazine DB03783, Phenacetin DB00780, Phenelzine DB00914, Phenformin DB06819, Phenylbutyric acid DB00252, Phenytoin DB01100, Pimozide DB00960, Pindolol DB00592, Piperazine DB01621, Pipotiazine DB11642, Pitolisant DB08901, Ponatinib DB01297, Practolol DB01087, Primaquine DB01035, Procainamide DB00433, Prochlorperazine DB00396, Progesterone DB01131, Proguanil DB00420, Promazine DB01069, Promethazine DB09288, Propacetamol DB01182, Propafenone DB00571, Propranolol DB01224, Quetiapine DB00908, Quinidine DB00468, Quinine DB01129, Rabeprazole DB00863, Ranitidine DB00243, Ranolazine DB00234, Reboxetine DB14761, Remdesivir DB00409, Remoxipride DB06506, Repinotan DB11855, Revefenacin DB13174, Rhein DB08864, Rilpivirine DB14840, Ripretinib DB00734, Risperidone DB12693, Ritanserin DB00503, Ritonavir DB09291, Rolapitant DB00412, Rosiglitazone DB05271, Rotigotine DB12332, Rucaparib DB11614, Rupatadine DB06654, Safinamide DB01232, Saquinavir DB01037, Selegiline DB06144, Sertindole DB01104, Sertraline DB00203, Sildenafil DB00641, Simvastatin DB01591, Solifenacin DB00398, Sorafenib DB00489, Sotalol DB06727, Sparteine DB01323, St. John's Wort DB09118, Stiripentol DB06820, Sulconazole DB00259, Sulfanilamide DB06729, Sulfaphenazole DB06608, Tafenoquine DB11770, Talinolol DB00675, Tamoxifen DB00706, Tamsulosin DB06204, Tapentadol DB01079, Tegaserod DB06287, Temsirolimus DB00857, Terbinafine DB00342, Terfenadine DB13775, Tertatolol DB04905, Tesmilifene DB04844, Tetrabenazine DB00277, Theophylline DB00679, Thioridazine DB01623, Thiothixene DB00208, Ticlopidine DB00373, Timolol DB01409, Tiotropium DB00932, Tipranavir DB01036, Tolterodine DB05109, Trabectedin DB00193, Tramadol DB00752, Tranylcypromine DB00656, Trazodone DB12245, Triclabendazole DB00726, Trimipramine DB00792, Tripelennamine DB00209, Trospium DB15328, Ubrogepant DB09076, Umeclidinium DB13609, Umifenovir DB15091, Upadacitinib DB11915, Valbenazine DB08881, Vemurafenib DB00285, Venlafaxine DB00661, Verapamil DB06217, Vernakalant DB06684, Vilazodone DB00570, Vinblastine DB00361, Vinorelbine DB09068, Vortioxetine DB01392, Yohimbine DB00425, Zolpidem DB01624, Zuclopenthixol |
DrugCentrali | P10635 |
GuidetoPHARMACOLOGYi | 1329 |
SwissLipidsi | SLP:000001204 |
PTM databases
iPTMneti | P10635 |
PhosphoSitePlusi | P10635 |
Polymorphism and mutation databases
BioMutai | CYP2D6 |
DMDMi | 84028191 |
Proteomic databases
jPOSTi | P10635 |
MassIVEi | P10635 |
PaxDbi | P10635 |
PeptideAtlasi | P10635 |
PRIDEi | P10635 |
ProteomicsDBi | 52623 [P10635-1] 66778 |
Protocols and materials databases
Antibodypediai | 13178, 597 antibodies |
DNASUi | 1565 |
Genome annotation databases
Ensembli | ENST00000359033; ENSP00000351927; ENSG00000100197 [P10635-2] ENST00000612990; ENSP00000483677; ENSG00000275211 ENST00000645361; ENSP00000496150; ENSG00000100197 [P10635-1] |
GeneIDi | 1565 |
KEGGi | hsa:1565 |
UCSCi | uc003bce.4, human [P10635-1] |
Organism-specific databases
CTDi | 1565 |
DisGeNETi | 1565 |
EuPathDBi | HostDB:ENSG00000100197.20 |
GeneCardsi | CYP2D6 |
HGNCi | HGNC:2625, CYP2D6 |
HPAi | ENSG00000100197, Tissue enriched (liver) |
MalaCardsi | CYP2D6 |
MIMi | 124030, gene 608902, phenotype |
neXtProti | NX_P10635 |
OpenTargetsi | ENSG00000100197 |
Orphaneti | 413667, Antidepressant or antipsychotic toxicity or dose selection 240867, Codeine toxicity 240947, Resistance to tamoxifene |
PharmGKBi | PA128 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0156, Eukaryota |
GeneTreei | ENSGT00940000153331 |
HOGENOMi | CLU_001570_22_3_1 |
InParanoidi | P10635 |
OMAi | GGIWPVD |
PhylomeDBi | P10635 |
TreeFami | TF352043 |
Enzyme and pathway databases
UniPathwayi | UPA00199 UPA00296 UPA00912 |
BRENDAi | 1.14.14.1, 2681 1.14.99.38, 2681 |
PathwayCommonsi | P10635 |
Reactomei | R-HSA-211935, Fatty acids R-HSA-211958, Miscellaneous substrates R-HSA-211981, Xenobiotics R-HSA-211999, CYP2E1 reactions R-HSA-9027307, Biosynthesis of maresin-like SPMs |
SABIO-RKi | P10635 |
Miscellaneous databases
BioGRID-ORCSi | 1565, 5 hits in 841 CRISPR screens |
EvolutionaryTracei | P10635 |
GeneWikii | CYP2D6 |
GenomeRNAii | 1565 |
Pharosi | P10635, Tclin |
PROi | PR:P10635 |
RNActi | P10635, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100197, Expressed in right lobe of liver and 111 other tissues |
ExpressionAtlasi | P10635, baseline and differential |
Genevisiblei | P10635, HS |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR008069, Cyt_P450_E_grp-I_CYP2D-like IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR01686, EP450ICYP2D PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CP2D6_HUMAN | |
Accessioni | P10635Primary (citable) accession number: P10635 Secondary accession number(s): Q16752 Q6NXU8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | December 20, 2005 | |
Last modified: | December 2, 2020 | |
This is version 219 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations