UniProtKB - P10635 (CP2D6_HUMAN)

>sp|P10635|CP2D6_HUMAN Cytochrome P450 2D6 OS=Homo sapiens OX=9606 GN=CYP2D6 PE=1 SV=2
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR

Entry version 208 (05 Jun 2019)
Sequence version 2 (20 Dec 2005)
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Protein

Cytochrome P450 2D6

Gene

CYP2D6

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.1 Publication

Catalytic activityⁱ

an alkane
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
O₂
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See the description of this molecule in ChEBI.
+
reduced [NADPH—hemoprotein reductase]
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Search chemical reactions in Rhea for this molecule.
=
a primary alcohol
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H₂O
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
oxidized [NADPH—hemoprotein reductase]
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Search chemical reactions in Rhea for this molecule.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.8
  "Cholesterol 25-hydroxylation activity of CYP3A."
  Honda A., Miyazaki T., Ikegami T., Iwamoto J., Maeda T., Hirayama T., Saito Y., Teramoto T., Matsuzaki Y.
  J. Lipid Res. 52:1509-1516(2011) [PubMed] [Europe PMC] [Abstract]
  Cited for: CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
EC:
1.14.14.1
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.8
  "Cholesterol 25-hydroxylation activity of CYP3A."
  Honda A., Miyazaki T., Ikegami T., Iwamoto J., Maeda T., Hirayama T., Saito Y., Teramoto T., Matsuzaki Y.
  J. Lipid Res. 52:1509-1516(2011) [PubMed] [Europe PMC] [Abstract]
  Cited for: CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
an alkane
zoom
+
O₂
+
reduced [NADPH—hemoprotein reductase]
FMNH₂
=
a primary alcohol
zoom
+
H⁺
+
H₂O
+
oxidized [NADPH—hemoprotein reductase]
FMN

Cofactorⁱ

heme

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	301	SubstrateCurated		1
Metal bindingⁱ	443	Iron (heme axial ligand)		1

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Monooxygenase, Oxidoreductase
Biological process	Lipid metabolism, Steroid metabolism, Sterol metabolism
Ligand	Heme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAⁱ	1.14.14.1 2681 1.14.99.38 2681
Reactomeⁱ	R-HSA-211935 Fatty acids R-HSA-211958 Miscellaneous substrates R-HSA-211981 Xenobiotics R-HSA-211999 CYP2E1 reactions R-HSA-9027307 Biosynthesis of maresin-like SPMs
SABIO-RKⁱ	P10635

Chemistry databases

SwissLipidsⁱ	SLP:000001204

SwissLipidsⁱ

SLP:000001204

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytochrome P450 2D6 (EC:1.14.14.11 Publication) Alternative name(s): CYPIID6 Cholesterol 25-hydroxylase1 Publication Cytochrome P450-DB1 Debrisoquine 4-hydroxylase
Gene namesⁱ	Name:CYP2D6 Synonyms:CYP2DL1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2625 CYP2D6
MIMⁱ	124030 gene
neXtProtⁱ	NX_P10635

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1565
MalaCards human disease database More...MalaCardsⁱ	CYP2D6
MIMⁱ	608902 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000100197
Orphanetⁱ	413667 Antidepressant or antipsychotic toxicity or dose selection 240867 Codeine toxicity 240947 Resistance to tamoxifene
PharmGKBⁱ	PA128

Chemistry databases

ChEMBLⁱ	CHEMBL289
Drug and drug target database More...DrugBankⁱ	DB01562 1-(2-Phenylethyl)-4-phenyl-4-acetoxypiperidine DB01472 4-Methoxyamphetamine DB05812 Abiraterone DB01193 Acebutolol DB00316 Acetaminophen DB03128 Acetylcholine DB01426 Ajmaline DB00918 Almotriptan DB06203 Alogliptin DB00866 Alprenolol DB01424 Aminophenazone DB01118 Amiodarone DB00321 Amitriptyline DB00381 Amlodipine DB00613 Amodiaquine DB00543 Amoxapine DB00182 Amphetamine DB00701 Amprenavir DB00276 Amsacrine DB01435 Antipyrine DB01429 Aprindine DB01274 Arformoterol DB01238 Aripiprazole DB06697 Artemether DB06216 Asenapine DB00637 Astemizole DB00289 Atomoxetine DB01076 Atorvastatin DB00972 Azelastine DB00245 Benzatropine DB06770 Benzyl alcohol DB01244 Bepridil DB00195 Betaxolol DB01128 Bicalutamide DB04889 Bicifadine DB00810 Biperiden DB00612 Bisoprolol DB00188 Bortezomib DB09128 Brexpiprazole DB00835 Brompheniramine DB06726 Bufuralol DB00297 Bupivacaine DB00921 Buprenorphine DB01156 Bupropion DB00490 Buspirone DB00201 Caffeine DB01197 Captopril DB00748 Carbinoxamine DB06016 Cariprazine DB00521 Carteolol DB01136 Carvedilol DB00482 Celecoxib DB00567 Cephalexin DB00439 Cerivastatin DB00185 Cevimeline DB00475 Chlordiazepoxide DB00608 Chloroquine DB01114 Chlorphenamine DB00477 Chlorpromazine DB00356 Chlorzoxazone DB00169 Cholecalciferol DB01410 Ciclesonide DB01166 Cilostazol DB00501 Cimetidine DB01012 Cinacalcet DB00568 Cinnarizine DB00604 Cisapride DB00215 Citalopram DB00283 Clemastine DB04920 Clevidipine DB00349 Clobazam DB01242 Clomipramine DB00575 Clonidine DB00257 Clotrimazole DB00363 Clozapine DB09065 Cobicistat DB00907 Cocaine DB00318 Codeine DB00924 Cyclobenzaprine DB00531 Cyclophosphamide DB00091 Cyclosporine DB04839 Cyproterone acetate DB06292 Dapagliflozin DB00496 Darifenacin DB09183 Dasabuvir DB04840 Debrisoquin DB00705 Delavirdine DB06512 Deramciclane DB01151 Desipramine DB00967 Desloratadine DB01234 Dexamethasone DB09555 Dexchlorpheniramine maleate DB01191 Dexfenfluramine DB00633 Dexmedetomidine DB06701 Dexmethylphenidate DB01576 Dextroamphetamine DB00514 Dextromethorphan DB00647 Dextropropoxyphene DB01551 Dihydrocodeine DB00343 Diltiazem DB01093 Dimethyl sulfoxide DB01075 Diphenhydramine DB00822 Disulfiram DB00757 Dolasetron DB01184 Domperidone DB00843 Donepezil DB00988 Dopamine DB00590 Doxazosin DB01142 Doxepin DB00997 Doxorubicin DB04855 Dronedarone DB00476 Duloxetine DB00625 Efavirenz DB00216 Eletriptan DB09039 Eliglustat DB01228 Encainide DB06735 Enclomiphene DB00494 Entacapone DB08899 Enzalutamide DB00751 Epinastine DB00530 Erlotinib DB01175 Escitalopram DB06678 Esmirtazapine DB01466 Ethylmorphine DB01628 Etoricoxib DB01023 Felodipine DB00574 Fenfluramine DB06702 Fesoterodine DB00950 Fexofenadine DB08868 Fingolimod DB01195 Flecainide DB04841 Flunarizine DB00472 Fluoxetine DB00623 Fluphenazine DB01095 Fluvastatin DB00176 Fluvoxamine DB00983 Formoterol DB00674 Galantamine DB00317 Gefitinib DB01437 Glutethimide DB08909 Glycerol Phenylbutyrate DB00889 Granisetron DB01218 Halofantrine DB00502 Haloperidol DB01159 Halothane DB05381 Histamine DB00956 Hydrocodone DB00327 Hydromorphone DB01611 Hydroxychloroquine DB01005 Hydroxyurea DB00557 Hydroxyzine DB09053 Ibrutinib DB01177 Idarubicin DB04946 Iloperidone DB00619 Imatinib DB00458 Imipramine DB00224 Indinavir DB00332 Ipratropium bromide DB01029 Irbesartan DB00951 Isoniazid DB01167 Itraconazole DB09570 Ixazomib DB01026 Ketoconazole DB00598 Labetalol DB00448 Lansoprazole DB00528 Lercanidipine DB01235 Levodopa DB08918 Levomilnacipran DB13139 Levosalbutamol DB00281 Lidocaine DB00589 Lisuride DB01206 Lomustine DB00836 Loperamide DB01601 Lopinavir DB00455 Loratadine DB04871 Lorcaserin DB00227 Lovastatin DB06708 Lumefantrine DB00934 Maprotiline DB00358 Mefloquine DB00532 Mephenytoin DB06691 Mepyramine DB01071 Mequitazine DB00933 Mesoridazine DB00333 Methadone DB01577 Methamphetamine DB00703 Methazolamide DB00763 Methimazole DB01403 Methotrimeprazine DB00553 Methoxsalen DB01028 Methoxyflurane DB09543 Methyl salicylate DB06800 Methylnaltrexone DB00422 Methylphenidate DB01107 Methyprylon DB01233 Metoclopramide DB00264 Metoprolol DB00379 Mexiletine DB06148 Mianserin DB01388 Mibefradil DB01110 Miconazole DB00211 Midodrine DB00834 Mifepristone DB00805 Minaprine DB08893 Mirabegron DB00370 Mirtazapine DB01171 Moclobemide DB00295 Morphine DB09049 Naloxegol DB00731 Nateglinide DB04861 Nebivolol DB01149 Nefazodone DB00220 Nelfinavir DB09048 Netupitant DB00238 Nevirapine DB00627 Niacin DB00622 Nicardipine DB00699 Nicergoline DB02701 Nicotinamide DB00184 Nicotine DB01115 Nifedipine DB04868 Nilotinib DB00336 Nitrofural DB00540 Nortriptyline DB00334 Olanzapine DB00338 Omeprazole DB00904 Ondansetron DB04938 Ospemifene DB01096 Oxamniquine DB01580 Oxprenolol DB01062 Oxybutynin DB00497 Oxycodone DB06412 Oxymetholone DB01192 Oxymorphone DB01267 Paliperidone DB00377 Palonosetron DB06603 Panobinostat DB00715 Paroxetine DB06589 Pazopanib DB00022 Peginterferon alfa-2b DB00738 Pentamidine DB01186 Pergolide DB01074 Perhexiline DB00850 Perphenazine DB00454 Pethidine DB03783 Phenacetin DB00914 Phenformin DB00191 Phentermine DB01100 Pimozide DB00960 Pindolol DB01132 Pioglitazone DB00592 Piperazine DB01621 Pipotiazine DB08901 Ponatinib DB00175 Pravastatin DB01058 Praziquantel DB01087 Primaquine DB01035 Procainamide DB00433 Prochlorperazine DB00396 Progesterone DB01131 Proguanil DB00420 Promazine DB01069 Promethazine DB01182 Propafenone DB00818 Propofol DB09396 Propoxyphene napsylate DB00571 Propranolol DB00344 Protriptyline DB00852 Pseudoephedrine DB00205 Pyrimethamine DB01224 Quetiapine DB00908 Quinidine DB00468 Quinine DB01129 Rabeprazole DB00863 Ranitidine DB00243 Ranolazine DB00234 Reboxetine DB00409 Remoxipride DB01201 Rifapentine DB00734 Risperidone DB00503 Ritonavir DB00989 Rivastigmine DB09291 Rolapitant DB00268 Ropinirole DB00296 Ropivacaine DB00412 Rosiglitazone DB05271 Rotigotine DB12332 Rucaparib DB01698 Rutin DB01232 Saquinavir DB01037 Selegiline DB06144 Sertindole DB01104 Sertraline DB00203 Sildenafil DB00641 Simvastatin DB06819 Sodium phenylbutyrate DB00398 Sorafenib DB06727 Sparteine DB09118 Stiripentol DB06820 Sulconazole DB00259 Sulfanilamide DB06729 Sulfaphenazole DB00675 Tamoxifen DB00706 Tamsulosin DB06204 Tapentadol DB01079 Tegaserod DB00976 Telithromycin DB06287 Temsirolimus DB00857 Terbinafine DB00342 Terfenadine DB04905 Tesmilifene DB04844 Tetrabenazine DB00277 Theophylline DB00679 Thioridazine DB01623 Thiothixene DB08816 Ticagrelor DB00208 Ticlopidine DB00373 Timolol DB01007 Tioconazole DB01409 Tiotropium DB00932 Tipranavir DB01036 Tolterodine DB05109 Trabectedin DB00193 Tramadol DB00752 Tranylcypromine DB00656 Trazodone DB00726 Trimipramine DB00792 Tripelennamine DB00427 Triprolidine DB00209 Trospium DB09076 Umeclidinium DB08881 Vemurafenib DB00285 Venlafaxine DB00661 Verapamil DB06684 Vilazodone DB00570 Vinblastine DB00361 Vinorelbine DB09068 Vortioxetine DB01392 Yohimbine DB00549 Zafirlukast DB00943 Zalcitabine DB00246 Ziprasidone DB00425 Zolpidem DB01624 Zuclopenthixol
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1329

Polymorphism and mutation databases

BioMutaⁱ	CYP2D6
DMDMⁱ	84028191

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051731	1 – 497	Cytochrome P450 2D6Add BLAST		497

Proteomic databases

EPDⁱ	P10635
PaxDbⁱ	P10635
PeptideAtlas More...PeptideAtlasⁱ	P10635
PRIDEⁱ	P10635
ProteomicsDBⁱ	52623

PTM databases

iPTMnetⁱ	P10635
PhosphoSitePlusⁱ	P10635

Expressionⁱ

Inductionⁱ

By pregnancy.

Gene expression databases

Bgeeⁱ	ENSG00000100197 Expressed in 89 organ(s), highest expression level in liver
ExpressionAtlasⁱ	P10635 baseline and differential
Genevisibleⁱ	P10635 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA045223

HPAⁱ

HPA045223

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	107940, 4 interactors
STRINGⁱ	9606.ENSP00000353820

Chemistry databases

BindingDBⁱ

P10635

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	41 – 43	Combined sources	3
Helixⁱ	46 – 48	Combined sources	3
Beta strandⁱ	51 – 53	Combined sources	3
Helixⁱ	54 – 65	Combined sources	12
Beta strandⁱ	67 – 73	Combined sources	7
Beta strandⁱ	76 – 81	Combined sources	6
Helixⁱ	83 – 91	Combined sources	9
Turnⁱ	92 – 94	Combined sources	3
Helixⁱ	95 – 97	Combined sources	3
Helixⁱ	105 – 110	Combined sources	6
Beta strandⁱ	119 – 121	Combined sources	3
Helixⁱ	126 – 141	Combined sources	16
Beta strandⁱ	145 – 147	Combined sources	3
Helixⁱ	148 – 165	Combined sources	18
Turnⁱ	166 – 169	Combined sources	4
Helixⁱ	175 – 191	Combined sources	17
Helixⁱ	200 – 214	Combined sources	15
Helixⁱ	219 – 226	Combined sources	8
Helixⁱ	228 – 232	Combined sources	5
Helixⁱ	234 – 240	Combined sources	7
Helixⁱ	242 – 261	Combined sources	20
Helixⁱ	271 – 281	Combined sources	11
Turnⁱ	282 – 284	Combined sources	3
Helixⁱ	292 – 323	Combined sources	32
Helixⁱ	325 – 338	Combined sources	14
Beta strandⁱ	341 – 343	Combined sources	3
Helixⁱ	347 – 350	Combined sources	4
Helixⁱ	354 – 367	Combined sources	14
Beta strandⁱ	370 – 372	Combined sources	3
Beta strandⁱ	382 – 384	Combined sources	3
Beta strandⁱ	387 – 389	Combined sources	3
Beta strandⁱ	394 – 397	Combined sources	4
Helixⁱ	399 – 403	Combined sources	5
Turnⁱ	406 – 408	Combined sources	3
Beta strandⁱ	409 – 411	Combined sources	3
Helixⁱ	417 – 420	Combined sources	4
Helixⁱ	439 – 441	Combined sources	3
Helixⁱ	446 – 463	Combined sources	18
Beta strandⁱ	464 – 467	Combined sources	4
Beta strandⁱ	470 – 472	Combined sources	3
Beta strandⁱ	479 – 487	Combined sources	9
Beta strandⁱ	492 – 496	Combined sources	5

Show more details

3D structure databases

SMRⁱ	P10635
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P10635

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0156 Eukaryota COG2124 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000153331
InParanoidⁱ	P10635
KEGG Orthology (KO) More...KOⁱ	K17712
OMAⁱ	QYLSFGC
Database of Orthologous Groups More...OrthoDBⁱ	702827at2759
PhylomeDBⁱ	P10635
TreeFamⁱ	TF352043

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR008069 Cyt_P450_E_grp-I_CYP2D-like IPR036396 Cyt_P450_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00463 EP450I PR01686 EP450ICYP2D PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P10635-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLEALVPLA VIVAIFLLLV DLMHRRQRWA ARYPPGPLPL PGLGNLLHVD 
        60         70         80         90        100
FQNTPYCFDQ LRRRFGDVFS LQLAWTPVVV LNGLAAVREA LVTHGEDTAD 
       110        120        130        140        150
RPPVPITQIL GFGPRSQGVF LARYGPAWRE QRRFSVSTLR NLGLGKKSLE 
       160        170        180        190        200
QWVTEEAACL CAAFANHSGR PFRPNGLLDK AVSNVIASLT CGRRFEYDDP 
       210        220        230        240        250
RFLRLLDLAQ EGLKEESGFL REVLNAVPVL LHIPALAGKV LRFQKAFLTQ 
       260        270        280        290        300
LDELLTEHRM TWDPAQPPRD LTEAFLAEME KAKGNPESSF NDENLRIVVA 
       310        320        330        340        350
DLFSAGMVTT STTLAWGLLL MILHPDVQRR VQQEIDDVIG QVRRPEMGDQ 
       360        370        380        390        400
AHMPYTTAVI HEVQRFGDIV PLGVTHMTSR DIEVQGFRIP KGTTLITNLS 
       410        420        430        440        450
SVLKDEAVWE KPFRFHPEHF LDAQGHFVKP EAFLPFSAGR RACLGEPLAR 
       460        470        480        490 
MELFLFFTSL LQHFSFSVPT GQPRPSHHGV FAFLVSPSPY ELCAVPR

Length:497

Mass (Da):55,769

Last modified:December 20, 2005 - v2

Checksum:ⁱ542B1D505DF3CDAC

Isoform 2 (identifier: P10635-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
118-168: Missing.

« Hide

        10         20         30         40         50
MGLEALVPLA VIVAIFLLLV DLMHRRQRWA ARYPPGPLPL PGLGNLLHVD 
        60         70         80         90        100
FQNTPYCFDQ LRRRFGDVFS LQLAWTPVVV LNGLAAVREA LVTHGEDTAD 
       110        120        130        140        150
RPPVPITQIL GFGPRSQGRP FRPNGLLDKA VSNVIASLTC GRRFEYDDPR 
       160        170        180        190        200
FLRLLDLAQE GLKEESGFLR EVLNAVPVLL HIPALAGKVL RFQKAFLTQL 
       210        220        230        240        250
DELLTEHRMT WDPAQPPRDL TEAFLAEMEK AKGNPESSFN DENLRIVVAD 
       260        270        280        290        300
LFSAGMVTTS TTLAWGLLLM ILHPDVQRRV QQEIDDVIGQ VRRPEMGDQA 
       310        320        330        340        350
HMPYTTAVIH EVQRFGDIVP LGVTHMTSRD IEVQGFRIPK GTTLITNLSS 
       360        370        380        390        400
VLKDEAVWEK PFRFHPEHFL DAQGHFVKPE AFLPFSAGRR ACLGEPLARM 
       410        420        430        440 
ELFLFFTSLL QHFSFSVPTG QPRPSHHGVF AFLVSPSPYE LCAVPR

Note: No experimental confirmation available.

Show »

Length:446

Mass (Da):50,061

Checksum:ⁱD1FB49C5A4B10965

Computationally mapped potential isoform sequencesⁱ

There are 10 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q6NWU0	Q6NWU0_HUMAN	Cytochrome P450 2D6 Cytochrome P450 2D6, EC 1.14.14.1 (Cytochrome P450 2D6 variant) (Cytochrome P450, family 2, subfamily D, polypeptide 6)	CYP2D6	497	Annotation score:
Q38LG0	Q38LG0_HUMAN	CYP2D6 CYP2D6 (Cytochrome P450 2D6, EC 1.14.14.1)	CYP2D6	497	Annotation score:
A0A1B0GV74	A0A1B0GV74_HUMAN	Cytochrome P450 2D6 Cytochrome P450 2D6	CYP2D6	446	Annotation score:
A0A0G2JLK7	A0A0G2JLK7_HUMAN	Cytochrome P450 2D6 Cytochrome P450 2D6	CYP2D6	446	Annotation score:
C1ID54	C1ID54_HUMAN	Cytochrome P450 2D6 Cytochrome P450 2D6	CYP2D6	497	Annotation score:
A0A1B0GUD8	A0A1B0GUD8_HUMAN	Cytochrome P450 2D6 Cytochrome P450 2D6	CYP2D6	180	Annotation score:
E7ENE7	E7ENE7_HUMAN	Cytochrome P450 2D6 Cytochrome P450 2D6	CYP2D6	494	Annotation score:
A0A1B0GU72	A0A1B0GU72_HUMAN	Cytochrome P450 2D6 Cytochrome P450 2D6	CYP2D6	494	Annotation score:
A0A0G2JSD7	A0A0G2JSD7_HUMAN	Cytochrome P450 2D6 Cytochrome P450 2D6	CYP2D6	494	Annotation score:
H7BY38	H7BY38_HUMAN	Cytochrome P450 2D6 Cytochrome P450 2D6	CYP2D6	180	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	374	V → M in AAA52153 (PubMed:3410476).Curated		1
Sequence conflictⁱ	374	V → M in CAA30807 (PubMed:3123997).Curated		1

Polymorphismⁱ

Genetic variations in CYP2D6 are the cause of poor drug metabolism CYP2D6-related [MIMⁱ:608902]. The CYP2D6 gene is highly polymorphic. CYP2D6 activity ranges widely within a population comprising ultrarapid (UM), extensive (EM), intermediate (IM) and poor (PM) metabolizer phenotypes. UM and PM are those most at risk for treatment failure or dose-dependent drug toxicity, respectively. Of the Caucasian populations of Europe and North America, 5%-10% are of the PM phenotype and are unable to metabolize the antihypersensitive drug debrisoquine and numerous other drugs. Different alleles are known, including CYP2D6*1 (PubMed:15768052), CYP2D6*2 (PubMed:25469868), CYP2D6*6B/6C (PubMed:7868129), CYP2D6*7 also known CYP2D6E (PubMed:7845481), CYP2D6*9 also known CYP2D6C (PubMed:1844820), CYP2D6*10 also known CYP2D6J (PubMed:8287064, PubMed:25469868), CYP2D6*12 (PubMed:8655150), CYP2D6*14 (PubMed:10064570), CYP2D6*17 also known CYP2D6Z (PubMed:8971426), CYP2D6*41B (PubMed:15768052), CYP2D6*45A (PubMed:15768052), CYP2D6*45B (PubMed:15768052), CYP2D6*46 (PubMed:15768052), CYP2D6*87 (PubMed:25469868), CYP2D6*88 (PubMed:25469868), CYP2D6*89 (PubMed:25469868), CYP2D6*90 (PubMed:25469868), CYP2D6*91 (PubMed:25469868), CYP2D6*93 (PubMed:25469868), C CYP2D6*94 (PubMed:25469868), CYP2D6*97 (PubMed:25469868) and CYP2D6*98 (PubMed:25469868). Isozymes CYP2D6.45 (Lys-155, Cys-296 and Thr-486) and CYP2D6.46 (His-26, Lys-155, Cys-296 and Thr-486) are functional (PubMed:15768052). The sequence shown is that of isozyme CYP2D6.1 corresponding to allele CYP2D6*1.9 Publications

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_072764	5	A → V in allele CYP2D6*87. 1 PublicationCorresponds to variant dbSNP:rs773790593Ensembl.	1
Natural variantⁱVAR_008366	11	V → M in allele CYP2D6*35. 1 PublicationCorresponds to variant dbSNP:rs769258Ensembl.	1
Natural variantⁱVAR_072765	25	R → Q1 PublicationCorresponds to variant dbSNP:rs138417770Ensembl.	1
Natural variantⁱVAR_008367	26	R → H in allele CYP2D621 and allele CYP2D646. 3 PublicationsCorresponds to variant dbSNP:rs28371696Ensembl.	1
Natural variantⁱVAR_008368	28	R → C in allele CYP2D6*22. Corresponds to variant dbSNP:rs138100349Ensembl.	1
Natural variantⁱVAR_008336	34	P → S in allele CYP2D610 and allele CYP2D614; poor debrisquone metabolism. 3 PublicationsCorresponds to variant dbSNP:rs1065852EnsemblClinVar.	1
Natural variantⁱVAR_001256	42	G → R in allele CYP2D6*12; impaired metabolism of sparteine. 1 PublicationCorresponds to variant dbSNP:rs5030862Ensembl.	1
Natural variantⁱVAR_008369	85	A → V in allele CYP2D6*23. Corresponds to variant dbSNP:rs267608310Ensembl.	1
Natural variantⁱVAR_024720	91	L → M1 PublicationCorresponds to variant dbSNP:rs28371703Ensembl.	1
Natural variantⁱVAR_024721	94	H → R1 PublicationCorresponds to variant dbSNP:rs28371704Ensembl.	1
Natural variantⁱVAR_072766	104	V → A in allele CYP2D6*88. 1 PublicationCorresponds to variant dbSNP:rs76187628Ensembl.	1
Natural variantⁱVAR_008337	107	T → I in allele CYP2D6*17; poor debrisquone metabolism. 2 PublicationsCorresponds to variant dbSNP:rs28371706Ensembl.	1
Natural variantⁱVAR_024722	120	F → I1 PublicationCorresponds to variant dbSNP:rs1135822Ensembl.	1
Natural variantⁱVAR_072767	142	L → S in allele CYP2D6*89; >90% decrease of monooxygenase activity towards dextromethorphan and bufuralol. 1 PublicationCorresponds to variant dbSNP:rs375135093Ensembl.	1
Natural variantⁱVAR_072768	147	K → R in allele CYP2D6*90. 1 PublicationCorresponds to variant dbSNP:rs569229126Ensembl.	1
Natural variantⁱVAR_024723	155	E → K in allele CYP2D645A, allele CYP2D645B and allele CYP2D6*46. 2 PublicationsCorresponds to variant dbSNP:rs28371710Ensembl.	1
Natural variantⁱVAR_072769	161	C → S in allele CYP2D6*91. 1 Publication	1
Natural variantⁱVAR_072770	164	F → L1 Publication	1
Natural variantⁱVAR_008338	169	G → R in allele CYP2D6*14; poor debrisquone metabolism. 1 PublicationCorresponds to variant dbSNP:rs5030865Ensembl.	1
Natural variantⁱVAR_008339	212	G → E in allele CYP2D66B and allele CYP2D66C. 1 PublicationCorresponds to variant dbSNP:rs5030866Ensembl.	1
Natural variantⁱVAR_072771	215	E → K >90% decrease of monooxygenase activity towards dextromethorphan and bufuralol. 1 PublicationCorresponds to variant dbSNP:rs567606867Ensembl.	1
Natural variantⁱVAR_072772	219	F → S1 PublicationCorresponds to variant dbSNP:rs371793722Ensembl.	1
Natural variantⁱVAR_045679	231	L → P. Corresponds to variant dbSNP:rs17002853Ensembl.	1
Natural variantⁱVAR_008370	237	A → S in allele CYP2D6*33. 1 PublicationCorresponds to variant dbSNP:rs28371717EnsemblClinVar.	1
Natural variantⁱVAR_072773	249	T → P in allele CYP2D6*93; >90% decrease of monooxygenase activity towards dextromethorphan and bufuralol. 1 Publication	1
Natural variantⁱVAR_008347	281	Missing in allele CYP2D6*9. 1 Publication	1
Natural variantⁱVAR_008340	296	R → C in allele CYP2D62, allele CYP2D612, allele CYP2D614, allele CYP2D617, allele CYP2D645A, allele CYP2D645B and allele CYP2D6*46; slightly decrease of monooxygenase activity towards bufuralol. 5 PublicationsCorresponds to variant dbSNP:rs16947EnsemblClinVar.	1
Natural variantⁱVAR_008371	297	I → L in allele CYP2D6*24. Corresponds to variant dbSNP:rs949717872Ensembl.	1
Natural variantⁱVAR_045680	300	A → G. Corresponds to variant dbSNP:rs1058170Ensembl.	1
Natural variantⁱVAR_014633	311	S → L. Corresponds to variant dbSNP:rs1800754Ensembl.	1
Natural variantⁱVAR_008348	324	H → P in allele CYP2D6*7; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs5030867Ensembl.	1
Natural variantⁱVAR_072774	327	V → M1 Publication	1
Natural variantⁱVAR_059150	329	R → L. Corresponds to variant dbSNP:rs3915951Ensembl.	1
Natural variantⁱVAR_072775	336	D → N1 PublicationCorresponds to variant dbSNP:rs745746329Ensembl.	1
Natural variantⁱVAR_072776	337	D → G in allele CYP2D6*94. 1 PublicationCorresponds to variant dbSNP:rs748712690Ensembl.	1
Natural variantⁱVAR_072777	342	V → M1 PublicationCorresponds to variant dbSNP:rs750996195Ensembl.	1
Natural variantⁱVAR_008372	343	R → G in allele CYP2D6*25. Corresponds to variant dbSNP:rs267608295Ensembl.	1
Natural variantⁱVAR_072778	344	R → Q1 PublicationCorresponds to variant dbSNP:rs76088846Ensembl.	1
Natural variantⁱVAR_045681	365	R → H. Corresponds to variant dbSNP:rs1058172Ensembl.	1
Natural variantⁱVAR_008373	369	I → T in allele CYP2D6*26.	1
Natural variantⁱVAR_059151	373	G → S. Corresponds to variant dbSNP:rs61737946Ensembl.	1
Natural variantⁱVAR_008374	410	E → K in allele CYP2D6*27. Corresponds to variant dbSNP:rs769157652Ensembl.	1
Natural variantⁱVAR_024724	418	E → K1 PublicationCorresponds to variant dbSNP:rs28371733Ensembl.	1
Natural variantⁱVAR_072779	440	R → C >90% decrease of monooxygenase activity towards dextromethorphan and bufuralol. 1 PublicationCorresponds to variant dbSNP:rs777560972Ensembl.	1
Natural variantⁱVAR_072780	457	F → L in allele CYP2D6*97. 1 Publication	1
Natural variantⁱVAR_072781	463	H → D in allele CYP2D6*98. 1 Publication	1
Natural variantⁱVAR_024725	469	P → A1 PublicationCorresponds to variant dbSNP:rs1135833Ensembl.	1
Natural variantⁱVAR_024726	478	H → Y1 PublicationCorresponds to variant dbSNP:rs28371735Ensembl.	1
Natural variantⁱVAR_008341	486	S → T in allele CYP2D62, allele CYP2D610, allele CYP2D612, allele CYP2D614, allele CYP2D617, allele CYP2D645A, allele CYP2D645B and allele CYP2D646; impaired metabolism of sparteine. 6 PublicationsCorresponds to variant dbSNP:rs1135840EnsemblClinVar.	1
Natural variantⁱVAR_072782	497	R → C1 PublicationCorresponds to variant dbSNP:rs370580423Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_044486	118 – 168	Missing in isoform 2. 1 PublicationAdd BLAST		51

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M20403 mRNA Translation: AAA52153.1 X08006 mRNA Translation: CAA30807.1 M33388 Genomic DNA Translation: AAA53500.1 AY545216 Genomic DNA Translation: AAS55001.1 DQ282144 Genomic DNA Translation: ABB77895.1 DQ282145 Genomic DNA Translation: ABB77896.1 DQ282146 Genomic DNA Translation: ABB77897.1 DQ282151 Genomic DNA Translation: ABB77899.1 DQ282154 Genomic DNA Translation: ABB77902.1 DQ282155 Genomic DNA Translation: ABB77903.1 BX247885 Genomic DNA No translation available. BC066877 mRNA Translation: AAH66877.1 BC075023 mRNA Translation: AAH75023.1 BC075024 mRNA Translation: AAH75024.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33657.1 [P10635-2] CCDS46721.1 [P10635-1]
PIRⁱ	S01199 O4HUD1
NCBI Reference Sequences More...RefSeqⁱ	NP_000097.3, NM_000106.5 [P10635-1] NP_001020332.2, NM_001025161.2 [P10635-2]

Genome annotation databases

Ensemblⁱ	ENST00000359033; ENSP00000351927; ENSG00000100197 [P10635-2] ENST00000612990; ENSP00000483677; ENSG00000275211 ENST00000645361; ENSP00000496150; ENSG00000100197 [P10635-1]
GeneIDⁱ	1565
KEGGⁱ	hsa:1565
UCSC genome browser More...UCSCⁱ	uc003bce.4 human [P10635-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P10635	Cytochrome P450 2D6		HUMAN		497	UniRef100_P10635

Protein	Similar proteins		Species	Score	Length	Source
P10635	Putative cytochrome P450 2D7		HUMAN		515	UniRef90_P10635
Cytochrome P450 2D6		PANTR		497
Cytochrome P450 CYP2D42		MACMU		497
CYP2D7 isoform 1		PONAB		497
Cytochrome P450, family 2, subfamily D, polypeptide 6 (Fragment)		MACFA		106
+55
P10635-2	Cytochrome P450 2D6		HUMAN		446	UniRef90_P10635-2
Uncharacterized protein		SAIBB		446
Uncharacterized protein		MACMU		446
Cytochrome P450 2D19		CALJA		446
Uncharacterized protein		COLAP		446
+22

Protein	Similar proteins		Species	Score	Length	Source
P10635	Putative cytochrome P450 2D7		HUMAN		515	UniRef50_P10635
Cytochrome P450 2D6		PANTR		497
Cytochrome P450 2D4		RAT		500
Cytochrome P450 2D19		CALJA		497
Cytochrome P450 2D17		MACFA		497
+616
P10635-2	Uncharacterized protein		MACMU		446	UniRef50_P10635-2
Uncharacterized protein		PAPAN		446
CYP2D6 isoform 3		PANTR		446
Uncharacterized protein		SAIBB		446
Uncharacterized protein		NOMLE		446
+92

Cross-referencesⁱ

Web resourcesⁱ

Cytochrome P450 Allele Nomenclature Committee

CYP2D6 alleles

Wikipedia

CYP2D6 entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M20403 mRNA Translation: AAA52153.1 X08006 mRNA Translation: CAA30807.1 M33388 Genomic DNA Translation: AAA53500.1 AY545216 Genomic DNA Translation: AAS55001.1 DQ282144 Genomic DNA Translation: ABB77895.1 DQ282145 Genomic DNA Translation: ABB77896.1 DQ282146 Genomic DNA Translation: ABB77897.1 DQ282151 Genomic DNA Translation: ABB77899.1 DQ282154 Genomic DNA Translation: ABB77902.1 DQ282155 Genomic DNA Translation: ABB77903.1 BX247885 Genomic DNA No translation available. BC066877 mRNA Translation: AAH66877.1 BC075023 mRNA Translation: AAH75023.1 BC075024 mRNA Translation: AAH75024.1
CCDSⁱ	CCDS33657.1 [P10635-2] CCDS46721.1 [P10635-1]
PIRⁱ	S01199 O4HUD1
RefSeqⁱ	NP_000097.3, NM_000106.5 [P10635-1] NP_001020332.2, NM_001025161.2 [P10635-2]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2F9Q	X-ray	3.00	A/B/C/D	34-497	[»]
	3QM4	X-ray	2.85	A/B	34-497	[»]
	3TBG	X-ray	2.10	A/B/C/D	34-497	[»]
	3TDA	X-ray	2.67	A/B/C/D	34-497	[»]
	4WNT	X-ray	2.60	A/B	34-497	[»]
	4WNU	X-ray	2.26	A/B/C/D	34-497	[»]
	4WNV	X-ray	2.35	A/B/C/D	48-497	[»]
	4WNW	X-ray	3.30	A/B	34-497	[»]
	4XRY	X-ray	2.50	A/B/C/D	34-497	[»]
	4XRZ	X-ray	2.40	A/B/C/D	34-497	[»]
	5TFT	X-ray	2.71	A/B/C/D	34-497	[»]
	5TFU	X-ray	2.75	A/B/C/D	34-497	[»]
	6CSB	X-ray	2.39	A/B/C/D	34-497	[»]
	6CSD	X-ray	2.39	A/B	34-497	[»]
SMRⁱ	P10635
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107940, 4 interactors
STRINGⁱ	9606.ENSP00000353820

Chemistry databases

BindingDBⁱ	P10635
ChEMBLⁱ	CHEMBL289
DrugBankⁱ	DB01562 1-(2-Phenylethyl)-4-phenyl-4-acetoxypiperidine DB01472 4-Methoxyamphetamine DB05812 Abiraterone DB01193 Acebutolol DB00316 Acetaminophen DB03128 Acetylcholine DB01426 Ajmaline DB00918 Almotriptan DB06203 Alogliptin DB00866 Alprenolol DB01424 Aminophenazone DB01118 Amiodarone DB00321 Amitriptyline DB00381 Amlodipine DB00613 Amodiaquine DB00543 Amoxapine DB00182 Amphetamine DB00701 Amprenavir DB00276 Amsacrine DB01435 Antipyrine DB01429 Aprindine DB01274 Arformoterol DB01238 Aripiprazole DB06697 Artemether DB06216 Asenapine DB00637 Astemizole DB00289 Atomoxetine DB01076 Atorvastatin DB00972 Azelastine DB00245 Benzatropine DB06770 Benzyl alcohol DB01244 Bepridil DB00195 Betaxolol DB01128 Bicalutamide DB04889 Bicifadine DB00810 Biperiden DB00612 Bisoprolol DB00188 Bortezomib DB09128 Brexpiprazole DB00835 Brompheniramine DB06726 Bufuralol DB00297 Bupivacaine DB00921 Buprenorphine DB01156 Bupropion DB00490 Buspirone DB00201 Caffeine DB01197 Captopril DB00748 Carbinoxamine DB06016 Cariprazine DB00521 Carteolol DB01136 Carvedilol DB00482 Celecoxib DB00567 Cephalexin DB00439 Cerivastatin DB00185 Cevimeline DB00475 Chlordiazepoxide DB00608 Chloroquine DB01114 Chlorphenamine DB00477 Chlorpromazine DB00356 Chlorzoxazone DB00169 Cholecalciferol DB01410 Ciclesonide DB01166 Cilostazol DB00501 Cimetidine DB01012 Cinacalcet DB00568 Cinnarizine DB00604 Cisapride DB00215 Citalopram DB00283 Clemastine DB04920 Clevidipine DB00349 Clobazam DB01242 Clomipramine DB00575 Clonidine DB00257 Clotrimazole DB00363 Clozapine DB09065 Cobicistat DB00907 Cocaine DB00318 Codeine DB00924 Cyclobenzaprine DB00531 Cyclophosphamide DB00091 Cyclosporine DB04839 Cyproterone acetate DB06292 Dapagliflozin DB00496 Darifenacin DB09183 Dasabuvir DB04840 Debrisoquin DB00705 Delavirdine DB06512 Deramciclane DB01151 Desipramine DB00967 Desloratadine DB01234 Dexamethasone DB09555 Dexchlorpheniramine maleate DB01191 Dexfenfluramine DB00633 Dexmedetomidine DB06701 Dexmethylphenidate DB01576 Dextroamphetamine DB00514 Dextromethorphan DB00647 Dextropropoxyphene DB01551 Dihydrocodeine DB00343 Diltiazem DB01093 Dimethyl sulfoxide DB01075 Diphenhydramine DB00822 Disulfiram DB00757 Dolasetron DB01184 Domperidone DB00843 Donepezil DB00988 Dopamine DB00590 Doxazosin DB01142 Doxepin DB00997 Doxorubicin DB04855 Dronedarone DB00476 Duloxetine DB00625 Efavirenz DB00216 Eletriptan DB09039 Eliglustat DB01228 Encainide DB06735 Enclomiphene DB00494 Entacapone DB08899 Enzalutamide DB00751 Epinastine DB00530 Erlotinib DB01175 Escitalopram DB06678 Esmirtazapine DB01466 Ethylmorphine DB01628 Etoricoxib DB01023 Felodipine DB00574 Fenfluramine DB06702 Fesoterodine DB00950 Fexofenadine DB08868 Fingolimod DB01195 Flecainide DB04841 Flunarizine DB00472 Fluoxetine DB00623 Fluphenazine DB01095 Fluvastatin DB00176 Fluvoxamine DB00983 Formoterol DB00674 Galantamine DB00317 Gefitinib DB01437 Glutethimide DB08909 Glycerol Phenylbutyrate DB00889 Granisetron DB01218 Halofantrine DB00502 Haloperidol DB01159 Halothane DB05381 Histamine DB00956 Hydrocodone DB00327 Hydromorphone DB01611 Hydroxychloroquine DB01005 Hydroxyurea DB00557 Hydroxyzine DB09053 Ibrutinib DB01177 Idarubicin DB04946 Iloperidone DB00619 Imatinib DB00458 Imipramine DB00224 Indinavir DB00332 Ipratropium bromide DB01029 Irbesartan DB00951 Isoniazid DB01167 Itraconazole DB09570 Ixazomib DB01026 Ketoconazole DB00598 Labetalol DB00448 Lansoprazole DB00528 Lercanidipine DB01235 Levodopa DB08918 Levomilnacipran DB13139 Levosalbutamol DB00281 Lidocaine DB00589 Lisuride DB01206 Lomustine DB00836 Loperamide DB01601 Lopinavir DB00455 Loratadine DB04871 Lorcaserin DB00227 Lovastatin DB06708 Lumefantrine DB00934 Maprotiline DB00358 Mefloquine DB00532 Mephenytoin DB06691 Mepyramine DB01071 Mequitazine DB00933 Mesoridazine DB00333 Methadone DB01577 Methamphetamine DB00703 Methazolamide DB00763 Methimazole DB01403 Methotrimeprazine DB00553 Methoxsalen DB01028 Methoxyflurane DB09543 Methyl salicylate DB06800 Methylnaltrexone DB00422 Methylphenidate DB01107 Methyprylon DB01233 Metoclopramide DB00264 Metoprolol DB00379 Mexiletine DB06148 Mianserin DB01388 Mibefradil DB01110 Miconazole DB00211 Midodrine DB00834 Mifepristone DB00805 Minaprine DB08893 Mirabegron DB00370 Mirtazapine DB01171 Moclobemide DB00295 Morphine DB09049 Naloxegol DB00731 Nateglinide DB04861 Nebivolol DB01149 Nefazodone DB00220 Nelfinavir DB09048 Netupitant DB00238 Nevirapine DB00627 Niacin DB00622 Nicardipine DB00699 Nicergoline DB02701 Nicotinamide DB00184 Nicotine DB01115 Nifedipine DB04868 Nilotinib DB00336 Nitrofural DB00540 Nortriptyline DB00334 Olanzapine DB00338 Omeprazole DB00904 Ondansetron DB04938 Ospemifene DB01096 Oxamniquine DB01580 Oxprenolol DB01062 Oxybutynin DB00497 Oxycodone DB06412 Oxymetholone DB01192 Oxymorphone DB01267 Paliperidone DB00377 Palonosetron DB06603 Panobinostat DB00715 Paroxetine DB06589 Pazopanib DB00022 Peginterferon alfa-2b DB00738 Pentamidine DB01186 Pergolide DB01074 Perhexiline DB00850 Perphenazine DB00454 Pethidine DB03783 Phenacetin DB00914 Phenformin DB00191 Phentermine DB01100 Pimozide DB00960 Pindolol DB01132 Pioglitazone DB00592 Piperazine DB01621 Pipotiazine DB08901 Ponatinib DB00175 Pravastatin DB01058 Praziquantel DB01087 Primaquine DB01035 Procainamide DB00433 Prochlorperazine DB00396 Progesterone DB01131 Proguanil DB00420 Promazine DB01069 Promethazine DB01182 Propafenone DB00818 Propofol DB09396 Propoxyphene napsylate DB00571 Propranolol DB00344 Protriptyline DB00852 Pseudoephedrine DB00205 Pyrimethamine DB01224 Quetiapine DB00908 Quinidine DB00468 Quinine DB01129 Rabeprazole DB00863 Ranitidine DB00243 Ranolazine DB00234 Reboxetine DB00409 Remoxipride DB01201 Rifapentine DB00734 Risperidone DB00503 Ritonavir DB00989 Rivastigmine DB09291 Rolapitant DB00268 Ropinirole DB00296 Ropivacaine DB00412 Rosiglitazone DB05271 Rotigotine DB12332 Rucaparib DB01698 Rutin DB01232 Saquinavir DB01037 Selegiline DB06144 Sertindole DB01104 Sertraline DB00203 Sildenafil DB00641 Simvastatin DB06819 Sodium phenylbutyrate DB00398 Sorafenib DB06727 Sparteine DB09118 Stiripentol DB06820 Sulconazole DB00259 Sulfanilamide DB06729 Sulfaphenazole DB00675 Tamoxifen DB00706 Tamsulosin DB06204 Tapentadol DB01079 Tegaserod DB00976 Telithromycin DB06287 Temsirolimus DB00857 Terbinafine DB00342 Terfenadine DB04905 Tesmilifene DB04844 Tetrabenazine DB00277 Theophylline DB00679 Thioridazine DB01623 Thiothixene DB08816 Ticagrelor DB00208 Ticlopidine DB00373 Timolol DB01007 Tioconazole DB01409 Tiotropium DB00932 Tipranavir DB01036 Tolterodine DB05109 Trabectedin DB00193 Tramadol DB00752 Tranylcypromine DB00656 Trazodone DB00726 Trimipramine DB00792 Tripelennamine DB00427 Triprolidine DB00209 Trospium DB09076 Umeclidinium DB08881 Vemurafenib DB00285 Venlafaxine DB00661 Verapamil DB06684 Vilazodone DB00570 Vinblastine DB00361 Vinorelbine DB09068 Vortioxetine DB01392 Yohimbine DB00549 Zafirlukast DB00943 Zalcitabine DB00246 Ziprasidone DB00425 Zolpidem DB01624 Zuclopenthixol
GuidetoPHARMACOLOGYⁱ	1329
SwissLipidsⁱ	SLP:000001204

PTM databases

iPTMnetⁱ	P10635
PhosphoSitePlusⁱ	P10635

Polymorphism and mutation databases

BioMutaⁱ	CYP2D6
DMDMⁱ	84028191

Proteomic databases

EPDⁱ	P10635
PaxDbⁱ	P10635
PeptideAtlasⁱ	P10635
PRIDEⁱ	P10635
ProteomicsDBⁱ	52623

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1565
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000359033; ENSP00000351927; ENSG00000100197 [P10635-2] ENST00000612990; ENSP00000483677; ENSG00000275211 ENST00000645361; ENSP00000496150; ENSG00000100197 [P10635-1]
GeneIDⁱ	1565
KEGGⁱ	hsa:1565
UCSCⁱ	uc003bce.4 human [P10635-1]

Organism-specific databases

CTDⁱ	1565
DisGeNETⁱ	1565
GeneCardsⁱ	CYP2D6
HGNCⁱ	HGNC:2625 CYP2D6
HPAⁱ	HPA045223
MalaCardsⁱ	CYP2D6
MIMⁱ	124030 gene 608902 phenotype
neXtProtⁱ	NX_P10635
OpenTargetsⁱ	ENSG00000100197
Orphanetⁱ	413667 Antidepressant or antipsychotic toxicity or dose selection 240867 Codeine toxicity 240947 Resistance to tamoxifene
PharmGKBⁱ	PA128
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0156 Eukaryota COG2124 LUCA
GeneTreeⁱ	ENSGT00940000153331
InParanoidⁱ	P10635
KOⁱ	K17712
OMAⁱ	QYLSFGC
OrthoDBⁱ	702827at2759
PhylomeDBⁱ	P10635
TreeFamⁱ	TF352043

Enzyme and pathway databases

BRENDAⁱ	1.14.14.1 2681 1.14.99.38 2681
Reactomeⁱ	R-HSA-211935 Fatty acids R-HSA-211958 Miscellaneous substrates R-HSA-211981 Xenobiotics R-HSA-211999 CYP2E1 reactions R-HSA-9027307 Biosynthesis of maresin-like SPMs
SABIO-RKⁱ	P10635

Miscellaneous databases

EvolutionaryTraceⁱ	P10635
GeneWikiⁱ	CYP2D6
GenomeRNAiⁱ	1565
Protein Ontology More...PROⁱ	PR:P10635
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000100197 Expressed in 89 organ(s), highest expression level in liver
ExpressionAtlasⁱ	P10635 baseline and differential
Genevisibleⁱ	P10635 HS

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR008069 Cyt_P450_E_grp-I_CYP2D-like IPR036396 Cyt_P450_sf
Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00463 EP450I PR01686 EP450ICYP2D PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CP2D6_HUMAN
Accessionⁱ	P10635Primary (citable) accession number: P10635 Secondary accession number(s): Q16752 , Q2XND6, Q2XND7, Q2XNE0, Q6B012, Q6NXU8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	December 20, 2005
	Last modified:	June 5, 2019
	This is version 208 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P10635 (CP2D6_HUMAN)

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Cytochrome P450 2D6

CYP2D6

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ