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Protein

Cytochrome P450 2C8

Gene

CYP2C8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).2 Publications

Caution

Alternative splicing has been shown to occur but the shorter forms are believed to be non-functional.Curated

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.1 Publication

Cofactori

Kineticsi

  1. KM=7.18 µM for paclitaxel1 Publication
  2. KM=1.35 µM for amodiaquine1 Publication
  1. Vmax=2.18 pmol/min/pmol enzyme with paclitaxel as substrate1 Publication
  2. Vmax=11.30 pmol/min/pmol enzyme with amodiaquine as substrate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei100Substrate1
Binding sitei204Substrate1
Binding sitei241Substrate1
Metal bindingi435Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.14.14.1 2681
ReactomeiR-HSA-211981 Xenobiotics
R-HSA-211999 CYP2E1 reactions
R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
R-HSA-9027307 Biosynthesis of maresin-like SPMs
SABIO-RKiP10632

Chemistry databases

SwissLipidsiSLP:000001548
SLP:000001616 [P10632-1]

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C8 (EC:1.14.14.11 Publication)
Alternative name(s):
CYPIIC8
Cytochrome P450 IIC2
Cytochrome P450 MP-12
Cytochrome P450 MP-20
Cytochrome P450 form 1
S-mephenytoin 4-hydroxylase
Gene namesi
Name:CYP2C8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000138115.13
HGNCiHGNC:2622 CYP2C8
MIMi601129 gene+phenotype
neXtProtiNX_P10632

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi1558
MIMi601129 gene+phenotype
OpenTargetsiENSG00000138115
PharmGKBiPA125

Chemistry databases

ChEMBLiCHEMBL3721
DrugBankiDB05812 Abiraterone
DB00316 Acetaminophen
DB00945 Acetylsalicylic acid
DB00918 Almotriptan
DB01424 Aminophenazone
DB01118 Amiodarone
DB00321 Amitriptyline
DB00381 Amlodipine
DB00613 Amodiaquine
DB00701 Amprenavir
DB01435 Antipyrine
DB06605 Apixaban
DB01076 Atorvastatin
DB00972 Azelastine
DB06770 Benzyl alcohol
DB05229 Beraprost
DB01393 Bezafibrate
DB00835 Brompheniramine
DB00921 Buprenorphine
DB01156 Bupropion
DB06772 Cabazitaxel
DB00201 Caffeine
DB00796 Candesartan
DB00564 Carbamazepine
DB00748 Carbinoxamine
DB00482 Celecoxib
DB00439 Cerivastatin
DB00446 Chloramphenicol
DB00608 Chloroquine
DB00169 Cholecalciferol
DB00501 Cimetidine
DB00604 Cisapride
DB00758 Clopidogrel
DB00257 Clotrimazole
DB00363 Clozapine
DB00907 Cocaine
DB01394 Colchicine
DB05219 Crisaborole
DB00531 Cyclophosphamide
DB00091 Cyclosporine
DB08912 Dabrafenib
DB00250 Dapsone
DB09183 Dasabuvir
DB00705 Delavirdine
DB01234 Dexamethasone
DB00514 Dextromethorphan
DB00647 Dextropropoxyphene
DB00829 Diazepam
DB00586 Diclofenac
DB00255 Diethylstilbestrol
DB00343 Diltiazem
DB01184 Domperidone
DB00625 Efavirenz
DB06210 Eltrombopag
DB08899 Enzalutamide
DB00530 Erlotinib
DB00783 Estradiol
DB00402 Eszopiclone
DB00977 Ethinyl Estradiol
DB00773 Etoposide
DB01023 Felodipine
DB01039 Fenofibrate
DB00544 Fluorouracil
DB01095 Fluvastatin
DB01320 Fosphenytoin
DB01241 Gemfibrozil
DB01218 Halofantrine
DB00741 Hydrocortisone
DB01050 Ibuprofen
DB09054 Idelalisib
DB01181 Ifosfamide
DB01029 Irbesartan
DB00951 Isoniazid
DB09570 Ixazomib
DB01221 Ketamine
DB06738 Ketobemidone
DB01026 Ketoconazole
DB01009 Ketoprofen
DB00448 Lansoprazole
DB01259 Lapatinib
DB08918 Levomilnacipran
DB00451 Levothyroxine
DB04725 Licofelone
DB00281 Lidocaine
DB01583 Liotrix
DB00836 Loperamide
DB01601 Lopinavir
DB00455 Loratadine
DB00678 Losartan
DB00227 Lovastatin
DB09280 Lumacaftor
DB00603 Medroxyprogesterone acetate
DB00784 Mefenamic acid
DB00814 Meloxicam
DB00532 Mephenytoin
DB00333 Methadone
DB00916 Metronidazole
DB00370 Mirtazapine
DB00764 Mometasone
DB00471 Montelukast
DB00295 Morphine
DB00688 Mycophenolate mofetil
DB01183 Naloxone
DB00788 Naproxen
DB00622 Nicardipine
DB00184 Nicotine
DB01115 Nifedipine
DB04868 Nilotinib
DB00665 Nilutamide
DB06712 Nilvadipine
DB09080 Olodaterol
DB09296 Ombitasvir
DB00338 Omeprazole
DB01062 Oxybutynin
DB01229 Paclitaxel
DB03796 Palmitic Acid
DB00617 Paramethadione
DB00715 Paroxetine
DB06589 Pazopanib
DB00738 Pentamidine
DB00850 Perphenazine
DB00780 Phenelzine
DB01174 Phenobarbital
DB00946 Phenprocoumon
DB00252 Phenytoin
DB01132 Pioglitazone
DB00554 Piroxicam
DB08860 Pitavastatin
DB08901 Ponatinib
DB00175 Pravastatin
DB00794 Primidone
DB01032 Probenecid
DB00396 Progesterone
DB01182 Propafenone
DB00818 Propofol
DB09396 Propoxyphene napsylate
DB00205 Pyrimethamine
DB04216 Quercetin
DB00908 Quinidine
DB00468 Quinine
DB01129 Rabeprazole
DB00481 Raloxifene
DB08896 Regorafenib
DB00912 Repaglinide
DB01045 Rifampicin
DB01201 Rifapentine
DB08931 Riociguat
DB00503 Ritonavir
DB00533 Rofecoxib
DB00412 Rosiglitazone
DB01698 Rutin
DB00938 Salmeterol
DB01232 Saquinavir
DB00418 Secobarbital
DB01037 Selegiline
DB11362 Selexipag
DB00641 Simvastatin
DB01261 Sitagliptin
DB00398 Sorafenib
DB00421 Spironolactone
DB09118 Stiripentol
DB00359 Sulfadiazine
DB01015 Sulfamethoxazole
DB06729 Sulfaphenazole
DB01138 Sulfinpyrazone
DB00675 Tamoxifen
DB00799 Tazarotene
DB01079 Tegaserod
DB00231 Temazepam
DB00857 Terbinafine
DB00342 Terfenadine
DB08880 Teriflunomide
DB00624 Testosterone
DB00277 Theophylline
DB00679 Thioridazine
DB00208 Ticlopidine
DB01007 Tioconazole
DB01124 Tolbutamide
DB00214 Torasemide
DB08911 Trametinib
DB00755 Tretinoin
DB00897 Triazolam
DB00347 Trimethadione
DB00440 Trimethoprim
DB00197 Troglitazone
DB01361 Troleandomycin
DB00313 Valproic Acid
DB00661 Verapamil
DB08828 Vismodegib
DB09068 Vortioxetine
DB00682 Warfarin
DB00549 Zafirlukast
DB00495 Zidovudine
DB01198 Zopiclone
GuidetoPHARMACOLOGYi1325

Polymorphism and mutation databases

BioMutaiCYP2C8
DMDMi117225

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000516991 – 490Cytochrome P450 2C8Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei100PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP10632
PeptideAtlasiP10632
PRIDEiP10632
ProteomicsDBi52621
52622 [P10632-2]

PTM databases

iPTMnetiP10632
PhosphoSitePlusiP10632

Expressioni

Inductioni

By phenobarbital.

Gene expression databases

BgeeiENSG00000138115 Expressed in 117 organ(s), highest expression level in liver
CleanExiHS_CYP2C8
ExpressionAtlasiP10632 baseline and differential
GenevisibleiP10632 HS

Organism-specific databases

HPAiHPA013547
HPA013970
HPA015066

Interactioni

Protein-protein interaction databases

BioGridi107936, 15 interactors
IntActiP10632, 10 interactors
STRINGi9606.ENSP00000360317

Chemistry databases

BindingDBiP10632

Structurei

Secondary structure

1490
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP10632
SMRiP10632
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10632

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00880000137861
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiP10632
KOiK17718
OMAiVIRSITF
OrthoDBiEOG091G0BT8
PhylomeDBiP10632
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: P10632-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPFVVLVLC LSFMLLFSLW RQSCRRRKLP PGPTPLPIIG NMLQIDVKDI
60 70 80 90 100
CKSFTNFSKV YGPVFTVYFG MNPIVVFHGY EAVKEALIDN GEEFSGRGNS
110 120 130 140 150
PISQRITKGL GIISSNGKRW KEIRRFSLTT LRNFGMGKRS IEDRVQEEAH
160 170 180 190 200
CLVEELRKTK ASPCDPTFIL GCAPCNVICS VVFQKRFDYK DQNFLTLMKR
210 220 230 240 250
FNENFRILNS PWIQVCNNFP LLIDCFPGTH NKVLKNVALT RSYIREKVKE
260 270 280 290 300
HQASLDVNNP RDFIDCFLIK MEQEKDNQKS EFNIENLVGT VADLFVAGTE
310 320 330 340 350
TTSTTLRYGL LLLLKHPEVT AKVQEEIDHV IGRHRSPCMQ DRSHMPYTDA
360 370 380 390 400
VVHEIQRYSD LVPTGVPHAV TTDTKFRNYL IPKGTTIMAL LTSVLHDDKE
410 420 430 440 450
FPNPNIFDPG HFLDKNGNFK KSDYFMPFSA GKRICAGEGL ARMELFLFLT
460 470 480 490
TILQNFNLKS VDDLKNLNTT AVTKGIVSLP PSYQICFIPV
Length:490
Mass (Da):55,825
Last modified:November 1, 1990 - v2
Checksum:iE920EB2084F477E1
GO
Isoform 2 (identifier: P10632-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MEPFVVLV → MFLQPIAK
     9-110: Missing.

Note: No experimental confirmation available.
Show »
Length:388
Mass (Da):44,358
Checksum:i0A9312FD6D4B9634
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z1F5B7Z1F5_HUMAN
Cytochrome P450 2C8
CYP2C8
420Annotation score:
G3V188G3V188_HUMAN
Cytochrome P450 2C8
CYP2C8 hCG_39487
393Annotation score:
E9PIW6E9PIW6_HUMAN
Cytochrome P450 2C8
CYP2C8
99Annotation score:
E9PLI9E9PLI9_HUMAN
Cytochrome P450 2C8
CYP2C8
83Annotation score:
A0A0D9SG51A0A0D9SG51_HUMAN
Cytochrome P450 2C8
CYP2C8
307Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54F → L no nucleotide entry (PubMed:2729895).Curated1
Sequence conflicti67V → L no nucleotide entry (PubMed:2729895).Curated1
Sequence conflicti76V → C no nucleotide entry (PubMed:2729895).Curated1
Sequence conflicti82A → S in AAH20596 (PubMed:15489334).Curated1
Sequence conflicti130T → N in AAA35739 (PubMed:3500169).Curated1
Sequence conflicti130T → N in AAA35740 (PubMed:3500169).Curated1
Sequence conflicti130T → N no nucleotide entry (PubMed:2009263).Curated1
Sequence conflicti209N → S no nucleotide entry (PubMed:2729895).Curated1
Sequence conflicti384 – 393GTTIMALLTS → SFDNKIMLAA in AAA35740 (PubMed:3500169).Curated10
Sequence conflicti386T → A in BAF85442 (PubMed:14702039).Curated1

Polymorphismi

Several alleles are found in the human population, contributing to interindividual variations in the therapeutic efficacy and toxicity of a myriad of drugs such as paclitaxel or amodiaquine. The allele shown here is CYP2C8*1 (PubMed:26427316). CYP2C8 genetic variations may be associated with adverse effects of cerivastatin including acute rhabdomyolysis [MIMi:601129].1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_012238139R → K in allele CYP2C8*3; reduces enzymatic activity with paclitaxel as substrate; decreases intrinsic clearance of paclitaxel; reduces enzymatic activity with amodiaquine as substrate. 7 PublicationsCorresponds to variant dbSNP:rs11572080EnsemblClinVar.1
Natural variantiVAR_001250154E → D1 Publication1
Natural variantiVAR_075541171G → S in allele CYP2C8*6; no effect on affinity or enzymatic activity with paclitaxel as substrate; decreases affinity for amodiaquine; reduces enzymatic activity with amodiaquine as substrate; decreases intrinsic clearance of amodiaquine. 1 PublicationCorresponds to variant dbSNP:rs142886225Ensembl.1
Natural variantiVAR_075542186R → G in allele CYP2C8*8; increases affinity for paclitaxel; reduces enzymatic activity with paclitaxel as substrate; decreases intrinsic clearance of paclitaxel; reduces enzymatic activity with amodiaquine as substrate; decreases intrinsic clearance of amodiaquine. 1 PublicationCorresponds to variant dbSNP:rs72558195Ensembl.1
Natural variantiVAR_001251193N → K1 Publication1
Natural variantiVAR_075543223I → M in allele CYP2C8*13; reduces enzymatic activity with paclitaxel as substrate; decreases intrinsic clearance of paclitaxel; reduces enzymatic activity with amodiaquine as substrate; decreases intrinsic clearance of amodiaquine. 1 Publication1
Natural variantiVAR_075544238A → P in allele CYP2C8*14; reduces enzymatic activity with paclitaxel as substrate; decreases intrinsic clearance of paclitaxel. 1 PublicationCorresponds to variant dbSNP:rs188934928Ensembl.1
Natural variantiVAR_018958244I → V1 PublicationCorresponds to variant dbSNP:rs11572102Ensembl.1
Natural variantiVAR_075545247K → R in allele CYP2C8*9; increases enzymatic activity with paclitaxel as substrate; reduces enzymatic activity with amodiaquine as substrate; decreases intrinsic clearance of amodiaquine. 1 PublicationCorresponds to variant dbSNP:rs769460274Ensembl.1
Natural variantiVAR_001252249K → R1 Publication1
Natural variantiVAR_011754264I → M in allele CYP2C8*4; reduces enzymatic activity with paclitaxel as substrate; decreases affinity for amodiaquine. 6 PublicationsCorresponds to variant dbSNP:rs1058930Ensembl.1
Natural variantiVAR_012239269I → F in allele CYP2C8*2; only found in African-Americans; increases intrinsic clearance of paclitaxel; decreases affinity for amodiaquine; increases enzymatic activity with amodiaquine as substrate. 5 PublicationsCorresponds to variant dbSNP:rs11572103Ensembl.1
Natural variantiVAR_075546383K → N in allele CYP2C8*10; reduces enzymatic activity with paclitaxel as substrate; reduces enzymatic activity with amodiaquine as substrate; decreases intrinsic clearance of amodiaquine. 1 Publication1
Natural variantiVAR_016947390L → S1 PublicationCorresponds to variant dbSNP:rs72558194Ensembl.1
Natural variantiVAR_012240399K → R in allele CYP2C8*3; reduces enzymatic activity with paclitaxel as substrate; decreases intrinsic clearance of paclitaxel; reduces enzymatic activity with amodiaquine as substrate. 7 PublicationsCorresponds to variant dbSNP:rs10509681EnsemblClinVar.1
Natural variantiVAR_001253411H → L2 Publications1
Natural variantiVAR_075547461Missing in allele CYP2C8*12; increases enzymatic activity with paclitaxel as substrate; reduces enzymatic activity with amodiaquine as substrate; decreases intrinsic clearance of amodiaquine. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0433061 – 8MEPFVVLV → MFLQPIAK in isoform 2. 1 Publication8
Alternative sequenceiVSP_0433079 – 110Missing in isoform 2. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17397 mRNA Translation: AAA35739.1
M17398 mRNA Translation: AAA35740.1
Y00498 mRNA Translation: CAA68550.1
AK292753 mRNA Translation: BAF85442.1
AK293328 mRNA Translation: BAH11492.1
AK315823 mRNA Translation: BAF98714.1
AY514490 Genomic DNA Translation: AAR89907.1
AL359672 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50018.1
BC020596 mRNA Translation: AAH20596.1
X54807 Genomic DNA Translation: CAA38578.1
M21941 mRNA Translation: AAA52160.1
M21942 mRNA Translation: AAA52161.1
X51535 mRNA Translation: CAA35915.1
CCDSiCCDS55721.1 [P10632-2]
CCDS7438.1 [P10632-1]
PIRiA29782
RefSeqiNP_000761.3, NM_000770.3 [P10632-1]
NP_001185782.1, NM_001198853.1
NP_001185783.1, NM_001198854.1 [P10632-2]
NP_001185784.1, NM_001198855.1
UniGeneiHs.709188

Genome annotation databases

EnsembliENST00000371270; ENSP00000360317; ENSG00000138115 [P10632-1]
ENST00000535898; ENSP00000445062; ENSG00000138115 [P10632-2]
GeneIDi1558
KEGGihsa:1558
UCSCiuc001kkb.4 human [P10632-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP2C8 alleles

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17397 mRNA Translation: AAA35739.1
M17398 mRNA Translation: AAA35740.1
Y00498 mRNA Translation: CAA68550.1
AK292753 mRNA Translation: BAF85442.1
AK293328 mRNA Translation: BAH11492.1
AK315823 mRNA Translation: BAF98714.1
AY514490 Genomic DNA Translation: AAR89907.1
AL359672 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50018.1
BC020596 mRNA Translation: AAH20596.1
X54807 Genomic DNA Translation: CAA38578.1
M21941 mRNA Translation: AAA52160.1
M21942 mRNA Translation: AAA52161.1
X51535 mRNA Translation: CAA35915.1
CCDSiCCDS55721.1 [P10632-2]
CCDS7438.1 [P10632-1]
PIRiA29782
RefSeqiNP_000761.3, NM_000770.3 [P10632-1]
NP_001185782.1, NM_001198853.1
NP_001185783.1, NM_001198854.1 [P10632-2]
NP_001185784.1, NM_001198855.1
UniGeneiHs.709188

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PQ2X-ray2.70A/B19-490[»]
2NNHX-ray2.60A/B28-490[»]
2NNIX-ray2.80A28-490[»]
2NNJX-ray2.28A28-490[»]
2VN0X-ray2.70A28-490[»]
ProteinModelPortaliP10632
SMRiP10632
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107936, 15 interactors
IntActiP10632, 10 interactors
STRINGi9606.ENSP00000360317

Chemistry databases

BindingDBiP10632
ChEMBLiCHEMBL3721
DrugBankiDB05812 Abiraterone
DB00316 Acetaminophen
DB00945 Acetylsalicylic acid
DB00918 Almotriptan
DB01424 Aminophenazone
DB01118 Amiodarone
DB00321 Amitriptyline
DB00381 Amlodipine
DB00613 Amodiaquine
DB00701 Amprenavir
DB01435 Antipyrine
DB06605 Apixaban
DB01076 Atorvastatin
DB00972 Azelastine
DB06770 Benzyl alcohol
DB05229 Beraprost
DB01393 Bezafibrate
DB00835 Brompheniramine
DB00921 Buprenorphine
DB01156 Bupropion
DB06772 Cabazitaxel
DB00201 Caffeine
DB00796 Candesartan
DB00564 Carbamazepine
DB00748 Carbinoxamine
DB00482 Celecoxib
DB00439 Cerivastatin
DB00446 Chloramphenicol
DB00608 Chloroquine
DB00169 Cholecalciferol
DB00501 Cimetidine
DB00604 Cisapride
DB00758 Clopidogrel
DB00257 Clotrimazole
DB00363 Clozapine
DB00907 Cocaine
DB01394 Colchicine
DB05219 Crisaborole
DB00531 Cyclophosphamide
DB00091 Cyclosporine
DB08912 Dabrafenib
DB00250 Dapsone
DB09183 Dasabuvir
DB00705 Delavirdine
DB01234 Dexamethasone
DB00514 Dextromethorphan
DB00647 Dextropropoxyphene
DB00829 Diazepam
DB00586 Diclofenac
DB00255 Diethylstilbestrol
DB00343 Diltiazem
DB01184 Domperidone
DB00625 Efavirenz
DB06210 Eltrombopag
DB08899 Enzalutamide
DB00530 Erlotinib
DB00783 Estradiol
DB00402 Eszopiclone
DB00977 Ethinyl Estradiol
DB00773 Etoposide
DB01023 Felodipine
DB01039 Fenofibrate
DB00544 Fluorouracil
DB01095 Fluvastatin
DB01320 Fosphenytoin
DB01241 Gemfibrozil
DB01218 Halofantrine
DB00741 Hydrocortisone
DB01050 Ibuprofen
DB09054 Idelalisib
DB01181 Ifosfamide
DB01029 Irbesartan
DB00951 Isoniazid
DB09570 Ixazomib
DB01221 Ketamine
DB06738 Ketobemidone
DB01026 Ketoconazole
DB01009 Ketoprofen
DB00448 Lansoprazole
DB01259 Lapatinib
DB08918 Levomilnacipran
DB00451 Levothyroxine
DB04725 Licofelone
DB00281 Lidocaine
DB01583 Liotrix
DB00836 Loperamide
DB01601 Lopinavir
DB00455 Loratadine
DB00678 Losartan
DB00227 Lovastatin
DB09280 Lumacaftor
DB00603 Medroxyprogesterone acetate
DB00784 Mefenamic acid
DB00814 Meloxicam
DB00532 Mephenytoin
DB00333 Methadone
DB00916 Metronidazole
DB00370 Mirtazapine
DB00764 Mometasone
DB00471 Montelukast
DB00295 Morphine
DB00688 Mycophenolate mofetil
DB01183 Naloxone
DB00788 Naproxen
DB00622 Nicardipine
DB00184 Nicotine
DB01115 Nifedipine
DB04868 Nilotinib
DB00665 Nilutamide
DB06712 Nilvadipine
DB09080 Olodaterol
DB09296 Ombitasvir
DB00338 Omeprazole
DB01062 Oxybutynin
DB01229 Paclitaxel
DB03796 Palmitic Acid
DB00617 Paramethadione
DB00715 Paroxetine
DB06589 Pazopanib
DB00738 Pentamidine
DB00850 Perphenazine
DB00780 Phenelzine
DB01174 Phenobarbital
DB00946 Phenprocoumon
DB00252 Phenytoin
DB01132 Pioglitazone
DB00554 Piroxicam
DB08860 Pitavastatin
DB08901 Ponatinib
DB00175 Pravastatin
DB00794 Primidone
DB01032 Probenecid
DB00396 Progesterone
DB01182 Propafenone
DB00818 Propofol
DB09396 Propoxyphene napsylate
DB00205 Pyrimethamine
DB04216 Quercetin
DB00908 Quinidine
DB00468 Quinine
DB01129 Rabeprazole
DB00481 Raloxifene
DB08896 Regorafenib
DB00912 Repaglinide
DB01045 Rifampicin
DB01201 Rifapentine
DB08931 Riociguat
DB00503 Ritonavir
DB00533 Rofecoxib
DB00412 Rosiglitazone
DB01698 Rutin
DB00938 Salmeterol
DB01232 Saquinavir
DB00418 Secobarbital
DB01037 Selegiline
DB11362 Selexipag
DB00641 Simvastatin
DB01261 Sitagliptin
DB00398 Sorafenib
DB00421 Spironolactone
DB09118 Stiripentol
DB00359 Sulfadiazine
DB01015 Sulfamethoxazole
DB06729 Sulfaphenazole
DB01138 Sulfinpyrazone
DB00675 Tamoxifen
DB00799 Tazarotene
DB01079 Tegaserod
DB00231 Temazepam
DB00857 Terbinafine
DB00342 Terfenadine
DB08880 Teriflunomide
DB00624 Testosterone
DB00277 Theophylline
DB00679 Thioridazine
DB00208 Ticlopidine
DB01007 Tioconazole
DB01124 Tolbutamide
DB00214 Torasemide
DB08911 Trametinib
DB00755 Tretinoin
DB00897 Triazolam
DB00347 Trimethadione
DB00440 Trimethoprim
DB00197 Troglitazone
DB01361 Troleandomycin
DB00313 Valproic Acid
DB00661 Verapamil
DB08828 Vismodegib
DB09068 Vortioxetine
DB00682 Warfarin
DB00549 Zafirlukast
DB00495 Zidovudine
DB01198 Zopiclone
GuidetoPHARMACOLOGYi1325
SwissLipidsiSLP:000001548
SLP:000001616 [P10632-1]

PTM databases

iPTMnetiP10632
PhosphoSitePlusiP10632

Polymorphism and mutation databases

BioMutaiCYP2C8
DMDMi117225

Proteomic databases

PaxDbiP10632
PeptideAtlasiP10632
PRIDEiP10632
ProteomicsDBi52621
52622 [P10632-2]

Protocols and materials databases

DNASUi1558
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371270; ENSP00000360317; ENSG00000138115 [P10632-1]
ENST00000535898; ENSP00000445062; ENSG00000138115 [P10632-2]
GeneIDi1558
KEGGihsa:1558
UCSCiuc001kkb.4 human [P10632-1]

Organism-specific databases

CTDi1558
DisGeNETi1558
EuPathDBiHostDB:ENSG00000138115.13
GeneCardsiCYP2C8
HGNCiHGNC:2622 CYP2C8
HPAiHPA013547
HPA013970
HPA015066
MIMi601129 gene+phenotype
neXtProtiNX_P10632
OpenTargetsiENSG00000138115
PharmGKBiPA125
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00880000137861
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiP10632
KOiK17718
OMAiVIRSITF
OrthoDBiEOG091G0BT8
PhylomeDBiP10632
TreeFamiTF352043

Enzyme and pathway databases

BRENDAi1.14.14.1 2681
ReactomeiR-HSA-211981 Xenobiotics
R-HSA-211999 CYP2E1 reactions
R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
R-HSA-9027307 Biosynthesis of maresin-like SPMs
SABIO-RKiP10632

Miscellaneous databases

ChiTaRSiCYP2C8 human
EvolutionaryTraceiP10632
GeneWikiiCYP2C8
GenomeRNAii1558
PROiPR:P10632
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138115 Expressed in 117 organ(s), highest expression level in liver
CleanExiHS_CYP2C8
ExpressionAtlasiP10632 baseline and differential
GenevisibleiP10632 HS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCP2C8_HUMAN
AccessioniPrimary (citable) accession number: P10632
Secondary accession number(s): A8K9N8
, B0AZN2, B7Z1F6, Q5VX93, Q8WWB1, Q9UCZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1990
Last modified: September 12, 2018
This is version 202 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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