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Protein

Cytochrome P450 2C8

Gene

CYP2C8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).2 Publications

Caution

Alternative splicing has been shown to occur but the shorter forms are believed to be non-functional.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=7.18 µM for paclitaxel1 Publication
  2. KM=1.35 µM for amodiaquine1 Publication
  1. Vmax=2.18 pmol/min/pmol enzyme with paclitaxel as substrate1 Publication
  2. Vmax=11.30 pmol/min/pmol enzyme with amodiaquine as substrate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei100Substrate1
Binding sitei204Substrate1
Binding sitei241Substrate1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi435Iron (heme axial ligand)1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
1.14.14.1 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-211981 Xenobiotics
R-HSA-211999 CYP2E1 reactions
R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
R-HSA-9027307 Biosynthesis of maresin-like SPMs

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P10632

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001548
SLP:000001616 [P10632-1]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome P450 2C8 (EC:1.14.14.11 Publication)
Alternative name(s):
CYPIIC8
Cytochrome P450 IIC2
Cytochrome P450 MP-12
Cytochrome P450 MP-20
Cytochrome P450 form 1
S-mephenytoin 4-hydroxylase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYP2C8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000138115.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2622 CYP2C8

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601129 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P10632

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1558
MIMi618018 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000138115

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA125

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3721

Drug and drug target database

More...
DrugBanki
DB05812 Abiraterone
DB00316 Acetaminophen
DB00945 Acetylsalicylic acid
DB00918 Almotriptan
DB01424 Aminophenazone
DB01118 Amiodarone
DB00321 Amitriptyline
DB00381 Amlodipine
DB00613 Amodiaquine
DB00701 Amprenavir
DB01435 Antipyrine
DB06605 Apixaban
DB01076 Atorvastatin
DB00972 Azelastine
DB06770 Benzyl alcohol
DB05229 Beraprost
DB01393 Bezafibrate
DB00835 Brompheniramine
DB00921 Buprenorphine
DB01156 Bupropion
DB06772 Cabazitaxel
DB00201 Caffeine
DB00796 Candesartan
DB00564 Carbamazepine
DB00748 Carbinoxamine
DB00482 Celecoxib
DB00439 Cerivastatin
DB00446 Chloramphenicol
DB00608 Chloroquine
DB00169 Cholecalciferol
DB00501 Cimetidine
DB00604 Cisapride
DB00758 Clopidogrel
DB00257 Clotrimazole
DB00363 Clozapine
DB00907 Cocaine
DB01394 Colchicine
DB05219 Crisaborole
DB00531 Cyclophosphamide
DB00091 Cyclosporine
DB08912 Dabrafenib
DB00250 Dapsone
DB09183 Dasabuvir
DB00705 Delavirdine
DB01234 Dexamethasone
DB00514 Dextromethorphan
DB00647 Dextropropoxyphene
DB00829 Diazepam
DB00586 Diclofenac
DB00255 Diethylstilbestrol
DB00343 Diltiazem
DB01184 Domperidone
DB00625 Efavirenz
DB06210 Eltrombopag
DB08899 Enzalutamide
DB00530 Erlotinib
DB00783 Estradiol
DB00402 Eszopiclone
DB00977 Ethinyl Estradiol
DB00773 Etoposide
DB01023 Felodipine
DB01039 Fenofibrate
DB00544 Fluorouracil
DB01095 Fluvastatin
DB01320 Fosphenytoin
DB01241 Gemfibrozil
DB01218 Halofantrine
DB00741 Hydrocortisone
DB01050 Ibuprofen
DB09054 Idelalisib
DB01181 Ifosfamide
DB01029 Irbesartan
DB00951 Isoniazid
DB09570 Ixazomib
DB01221 Ketamine
DB06738 Ketobemidone
DB01026 Ketoconazole
DB01009 Ketoprofen
DB00448 Lansoprazole
DB01259 Lapatinib
DB08918 Levomilnacipran
DB00451 Levothyroxine
DB04725 Licofelone
DB00281 Lidocaine
DB01583 Liotrix
DB00836 Loperamide
DB01601 Lopinavir
DB00455 Loratadine
DB00678 Losartan
DB00227 Lovastatin
DB09280 Lumacaftor
DB00603 Medroxyprogesterone acetate
DB00784 Mefenamic acid
DB00814 Meloxicam
DB00532 Mephenytoin
DB00333 Methadone
DB00916 Metronidazole
DB00370 Mirtazapine
DB00764 Mometasone
DB00471 Montelukast
DB00295 Morphine
DB00688 Mycophenolate mofetil
DB01183 Naloxone
DB00788 Naproxen
DB00622 Nicardipine
DB00184 Nicotine
DB01115 Nifedipine
DB04868 Nilotinib
DB00665 Nilutamide
DB06712 Nilvadipine
DB09080 Olodaterol
DB09296 Ombitasvir
DB00338 Omeprazole
DB01062 Oxybutynin
DB01229 Paclitaxel
DB03796 Palmitic Acid
DB00617 Paramethadione
DB00715 Paroxetine
DB06589 Pazopanib
DB00738 Pentamidine
DB00850 Perphenazine
DB00780 Phenelzine
DB01174 Phenobarbital
DB00946 Phenprocoumon
DB00252 Phenytoin
DB01132 Pioglitazone
DB00554 Piroxicam
DB08860 Pitavastatin
DB08901 Ponatinib
DB00175 Pravastatin
DB00794 Primidone
DB01032 Probenecid
DB00396 Progesterone
DB01182 Propafenone
DB00818 Propofol
DB09396 Propoxyphene napsylate
DB00205 Pyrimethamine
DB04216 Quercetin
DB00908 Quinidine
DB00468 Quinine
DB01129 Rabeprazole
DB00481 Raloxifene
DB08896 Regorafenib
DB00912 Repaglinide
DB01045 Rifampicin
DB01201 Rifapentine
DB08931 Riociguat
DB00503 Ritonavir
DB00533 Rofecoxib
DB00412 Rosiglitazone
DB01698 Rutin
DB00938 Salmeterol
DB01232 Saquinavir
DB00418 Secobarbital
DB01037 Selegiline
DB11362 Selexipag
DB00641 Simvastatin
DB01261 Sitagliptin
DB00398 Sorafenib
DB00421 Spironolactone
DB09118 Stiripentol
DB00359 Sulfadiazine
DB01015 Sulfamethoxazole
DB06729 Sulfaphenazole
DB01138 Sulfinpyrazone
DB00675 Tamoxifen
DB00799 Tazarotene
DB01079 Tegaserod
DB00231 Temazepam
DB00857 Terbinafine
DB00342 Terfenadine
DB08880 Teriflunomide
DB00624 Testosterone
DB00277 Theophylline
DB00679 Thioridazine
DB00208 Ticlopidine
DB01007 Tioconazole
DB01124 Tolbutamide
DB00214 Torasemide
DB08911 Trametinib
DB00755 Tretinoin
DB00897 Triazolam
DB00347 Trimethadione
DB00440 Trimethoprim
DB00197 Troglitazone
DB01361 Troleandomycin
DB00313 Valproic Acid
DB00661 Verapamil
DB08828 Vismodegib
DB09068 Vortioxetine
DB00682 Warfarin
DB00549 Zafirlukast
DB00495 Zidovudine
DB01198 Zopiclone

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1325

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CYP2C8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
117225

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000516991 – 490Cytochrome P450 2C8Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei100PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P10632

PeptideAtlas

More...
PeptideAtlasi
P10632

PRoteomics IDEntifications database

More...
PRIDEi
P10632

ProteomicsDB human proteome resource

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ProteomicsDBi
52621
52622 [P10632-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P10632

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P10632

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By phenobarbital.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000138115 Expressed in 117 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_CYP2C8

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P10632 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P10632 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA013547
HPA013970
HPA015066

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107936, 15 interactors

Protein interaction database and analysis system

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IntActi
P10632, 10 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000360317

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P10632

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1490
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P10632

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P10632

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P10632

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0156 Eukaryota
COG2124 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163696

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000036992

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG015789

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P10632

KEGG Orthology (KO)

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KOi
K17718

Identification of Orthologs from Complete Genome Data

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OMAi
AEDCKVN

Database of Orthologous Groups

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OrthoDBi
EOG091G0BT8

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P10632

TreeFam database of animal gene trees

More...
TreeFami
TF352043

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.630.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00067 p450, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00463 EP450I
PR00385 P450

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48264 SSF48264, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P10632-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPFVVLVLC LSFMLLFSLW RQSCRRRKLP PGPTPLPIIG NMLQIDVKDI
60 70 80 90 100
CKSFTNFSKV YGPVFTVYFG MNPIVVFHGY EAVKEALIDN GEEFSGRGNS
110 120 130 140 150
PISQRITKGL GIISSNGKRW KEIRRFSLTT LRNFGMGKRS IEDRVQEEAH
160 170 180 190 200
CLVEELRKTK ASPCDPTFIL GCAPCNVICS VVFQKRFDYK DQNFLTLMKR
210 220 230 240 250
FNENFRILNS PWIQVCNNFP LLIDCFPGTH NKVLKNVALT RSYIREKVKE
260 270 280 290 300
HQASLDVNNP RDFIDCFLIK MEQEKDNQKS EFNIENLVGT VADLFVAGTE
310 320 330 340 350
TTSTTLRYGL LLLLKHPEVT AKVQEEIDHV IGRHRSPCMQ DRSHMPYTDA
360 370 380 390 400
VVHEIQRYSD LVPTGVPHAV TTDTKFRNYL IPKGTTIMAL LTSVLHDDKE
410 420 430 440 450
FPNPNIFDPG HFLDKNGNFK KSDYFMPFSA GKRICAGEGL ARMELFLFLT
460 470 480 490
TILQNFNLKS VDDLKNLNTT AVTKGIVSLP PSYQICFIPV
Length:490
Mass (Da):55,825
Last modified:November 1, 1990 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE920EB2084F477E1
GO
Isoform 2 (identifier: P10632-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MEPFVVLV → MFLQPIAK
     9-110: Missing.

Note: No experimental confirmation available.
Show »
Length:388
Mass (Da):44,358
Checksum:i0A9312FD6D4B9634
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z1F5B7Z1F5_HUMAN
Cytochrome P450 2C8
CYP2C8
420Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V188G3V188_HUMAN
Cytochrome P450 2C8
CYP2C8 hCG_39487
393Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIW6E9PIW6_HUMAN
Cytochrome P450 2C8
CYP2C8
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLI9E9PLI9_HUMAN
Cytochrome P450 2C8
CYP2C8
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SG51A0A0D9SG51_HUMAN
Cytochrome P450 2C8
CYP2C8
307Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti54F → L no nucleotide entry (PubMed:2729895).Curated1
Sequence conflicti67V → L no nucleotide entry (PubMed:2729895).Curated1
Sequence conflicti76V → C no nucleotide entry (PubMed:2729895).Curated1
Sequence conflicti82A → S in AAH20596 (PubMed:15489334).Curated1
Sequence conflicti130T → N in AAA35739 (PubMed:3500169).Curated1
Sequence conflicti130T → N in AAA35740 (PubMed:3500169).Curated1
Sequence conflicti130T → N no nucleotide entry (PubMed:2009263).Curated1
Sequence conflicti209N → S no nucleotide entry (PubMed:2729895).Curated1
Sequence conflicti384 – 393GTTIMALLTS → SFDNKIMLAA in AAA35740 (PubMed:3500169).Curated10
Sequence conflicti386T → A in BAF85442 (PubMed:14702039).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Several alleles are found in the human population, contributing to interindividual variations in the therapeutic efficacy and toxicity of a myriad of drugs such as paclitaxel or amodiaquine. The allele shown here is CYP2C8*1 (PubMed:26427316). CYP2C8 genetic variations are associated with altered drug metabolism and adverse drug effects including acute rhabdomyolysis after cerivastatin use [MIMi:618018].2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_012238139R → K in allele CYP2C8*3; reduces enzymatic activity with paclitaxel as substrate; decreases intrinsic clearance of paclitaxel; reduces enzymatic activity with amodiaquine as substrate. 7 PublicationsCorresponds to variant dbSNP:rs11572080EnsemblClinVar.1
Natural variantiVAR_001250154E → D1 Publication1
Natural variantiVAR_075541171G → S in allele CYP2C8*6; no effect on affinity or enzymatic activity with paclitaxel as substrate; decreases affinity for amodiaquine; reduces enzymatic activity with amodiaquine as substrate; decreases intrinsic clearance of amodiaquine. 1 PublicationCorresponds to variant dbSNP:rs142886225Ensembl.1
Natural variantiVAR_075542186R → G in allele CYP2C8*8; increases affinity for paclitaxel; reduces enzymatic activity with paclitaxel as substrate; decreases intrinsic clearance of paclitaxel; reduces enzymatic activity with amodiaquine as substrate; decreases intrinsic clearance of amodiaquine. 1 PublicationCorresponds to variant dbSNP:rs72558195Ensembl.1
Natural variantiVAR_001251193N → K1 Publication1
Natural variantiVAR_075543223I → M in allele CYP2C8*13; reduces enzymatic activity with paclitaxel as substrate; decreases intrinsic clearance of paclitaxel; reduces enzymatic activity with amodiaquine as substrate; decreases intrinsic clearance of amodiaquine. 1 Publication1
Natural variantiVAR_075544238A → P in allele CYP2C8*14; reduces enzymatic activity with paclitaxel as substrate; decreases intrinsic clearance of paclitaxel. 1 PublicationCorresponds to variant dbSNP:rs188934928Ensembl.1
Natural variantiVAR_018958244I → V1 PublicationCorresponds to variant dbSNP:rs11572102Ensembl.1
Natural variantiVAR_075545247K → R in allele CYP2C8*9; increases enzymatic activity with paclitaxel as substrate; reduces enzymatic activity with amodiaquine as substrate; decreases intrinsic clearance of amodiaquine. 1 PublicationCorresponds to variant dbSNP:rs769460274Ensembl.1
Natural variantiVAR_001252249K → R1 Publication1
Natural variantiVAR_011754264I → M in allele CYP2C8*4; reduces enzymatic activity with paclitaxel as substrate; decreases affinity for amodiaquine. 6 PublicationsCorresponds to variant dbSNP:rs1058930Ensembl.1
Natural variantiVAR_012239269I → F in allele CYP2C8*2; only found in African-Americans; increases intrinsic clearance of paclitaxel; decreases affinity for amodiaquine; increases enzymatic activity with amodiaquine as substrate. 5 PublicationsCorresponds to variant dbSNP:rs11572103Ensembl.1
Natural variantiVAR_075546383K → N in allele CYP2C8*10; reduces enzymatic activity with paclitaxel as substrate; reduces enzymatic activity with amodiaquine as substrate; decreases intrinsic clearance of amodiaquine. 1 Publication1
Natural variantiVAR_016947390L → S1 PublicationCorresponds to variant dbSNP:rs72558194Ensembl.1
Natural variantiVAR_012240399K → R in allele CYP2C8*3; reduces enzymatic activity with paclitaxel as substrate; decreases intrinsic clearance of paclitaxel; reduces enzymatic activity with amodiaquine as substrate. 7 PublicationsCorresponds to variant dbSNP:rs10509681EnsemblClinVar.1
Natural variantiVAR_001253411H → L2 Publications1
Natural variantiVAR_075547461Missing in allele CYP2C8*12; increases enzymatic activity with paclitaxel as substrate; reduces enzymatic activity with amodiaquine as substrate; decreases intrinsic clearance of amodiaquine. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0433061 – 8MEPFVVLV → MFLQPIAK in isoform 2. 1 Publication8
Alternative sequenceiVSP_0433079 – 110Missing in isoform 2. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M17397 mRNA Translation: AAA35739.1
M17398 mRNA Translation: AAA35740.1
Y00498 mRNA Translation: CAA68550.1
AK292753 mRNA Translation: BAF85442.1
AK293328 mRNA Translation: BAH11492.1
AK315823 mRNA Translation: BAF98714.1
AY514490 Genomic DNA Translation: AAR89907.1
AL359672 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50018.1
BC020596 mRNA Translation: AAH20596.1
X54807 Genomic DNA Translation: CAA38578.1
M21941 mRNA Translation: AAA52160.1
M21942 mRNA Translation: AAA52161.1
X51535 mRNA Translation: CAA35915.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55721.1 [P10632-2]
CCDS7438.1 [P10632-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A29782

NCBI Reference Sequences

More...
RefSeqi
NP_000761.3, NM_000770.3 [P10632-1]
NP_001185782.1, NM_001198853.1
NP_001185783.1, NM_001198854.1 [P10632-2]
NP_001185784.1, NM_001198855.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.709188

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000371270; ENSP00000360317; ENSG00000138115 [P10632-1]
ENST00000535898; ENSP00000445062; ENSG00000138115 [P10632-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1558

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1558

UCSC genome browser

More...
UCSCi
uc001kkb.4 human [P10632-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP2C8 alleles

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17397 mRNA Translation: AAA35739.1
M17398 mRNA Translation: AAA35740.1
Y00498 mRNA Translation: CAA68550.1
AK292753 mRNA Translation: BAF85442.1
AK293328 mRNA Translation: BAH11492.1
AK315823 mRNA Translation: BAF98714.1
AY514490 Genomic DNA Translation: AAR89907.1
AL359672 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50018.1
BC020596 mRNA Translation: AAH20596.1
X54807 Genomic DNA Translation: CAA38578.1
M21941 mRNA Translation: AAA52160.1
M21942 mRNA Translation: AAA52161.1
X51535 mRNA Translation: CAA35915.1
CCDSiCCDS55721.1 [P10632-2]
CCDS7438.1 [P10632-1]
PIRiA29782
RefSeqiNP_000761.3, NM_000770.3 [P10632-1]
NP_001185782.1, NM_001198853.1
NP_001185783.1, NM_001198854.1 [P10632-2]
NP_001185784.1, NM_001198855.1
UniGeneiHs.709188

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PQ2X-ray2.70A/B19-490[»]
2NNHX-ray2.60A/B28-490[»]
2NNIX-ray2.80A28-490[»]
2NNJX-ray2.28A28-490[»]
2VN0X-ray2.70A28-490[»]
ProteinModelPortaliP10632
SMRiP10632
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107936, 15 interactors
IntActiP10632, 10 interactors
STRINGi9606.ENSP00000360317

Chemistry databases

BindingDBiP10632
ChEMBLiCHEMBL3721
DrugBankiDB05812 Abiraterone
DB00316 Acetaminophen
DB00945 Acetylsalicylic acid
DB00918 Almotriptan
DB01424 Aminophenazone
DB01118 Amiodarone
DB00321 Amitriptyline
DB00381 Amlodipine
DB00613 Amodiaquine
DB00701 Amprenavir
DB01435 Antipyrine
DB06605 Apixaban
DB01076 Atorvastatin
DB00972 Azelastine
DB06770 Benzyl alcohol
DB05229 Beraprost
DB01393 Bezafibrate
DB00835 Brompheniramine
DB00921 Buprenorphine
DB01156 Bupropion
DB06772 Cabazitaxel
DB00201 Caffeine
DB00796 Candesartan
DB00564 Carbamazepine
DB00748 Carbinoxamine
DB00482 Celecoxib
DB00439 Cerivastatin
DB00446 Chloramphenicol
DB00608 Chloroquine
DB00169 Cholecalciferol
DB00501 Cimetidine
DB00604 Cisapride
DB00758 Clopidogrel
DB00257 Clotrimazole
DB00363 Clozapine
DB00907 Cocaine
DB01394 Colchicine
DB05219 Crisaborole
DB00531 Cyclophosphamide
DB00091 Cyclosporine
DB08912 Dabrafenib
DB00250 Dapsone
DB09183 Dasabuvir
DB00705 Delavirdine
DB01234 Dexamethasone
DB00514 Dextromethorphan
DB00647 Dextropropoxyphene
DB00829 Diazepam
DB00586 Diclofenac
DB00255 Diethylstilbestrol
DB00343 Diltiazem
DB01184 Domperidone
DB00625 Efavirenz
DB06210 Eltrombopag
DB08899 Enzalutamide
DB00530 Erlotinib
DB00783 Estradiol
DB00402 Eszopiclone
DB00977 Ethinyl Estradiol
DB00773 Etoposide
DB01023 Felodipine
DB01039 Fenofibrate
DB00544 Fluorouracil
DB01095 Fluvastatin
DB01320 Fosphenytoin
DB01241 Gemfibrozil
DB01218 Halofantrine
DB00741 Hydrocortisone
DB01050 Ibuprofen
DB09054 Idelalisib
DB01181 Ifosfamide
DB01029 Irbesartan
DB00951 Isoniazid
DB09570 Ixazomib
DB01221 Ketamine
DB06738 Ketobemidone
DB01026 Ketoconazole
DB01009 Ketoprofen
DB00448 Lansoprazole
DB01259 Lapatinib
DB08918 Levomilnacipran
DB00451 Levothyroxine
DB04725 Licofelone
DB00281 Lidocaine
DB01583 Liotrix
DB00836 Loperamide
DB01601 Lopinavir
DB00455 Loratadine
DB00678 Losartan
DB00227 Lovastatin
DB09280 Lumacaftor
DB00603 Medroxyprogesterone acetate
DB00784 Mefenamic acid
DB00814 Meloxicam
DB00532 Mephenytoin
DB00333 Methadone
DB00916 Metronidazole
DB00370 Mirtazapine
DB00764 Mometasone
DB00471 Montelukast
DB00295 Morphine
DB00688 Mycophenolate mofetil
DB01183 Naloxone
DB00788 Naproxen
DB00622 Nicardipine
DB00184 Nicotine
DB01115 Nifedipine
DB04868 Nilotinib
DB00665 Nilutamide
DB06712 Nilvadipine
DB09080 Olodaterol
DB09296 Ombitasvir
DB00338 Omeprazole
DB01062 Oxybutynin
DB01229 Paclitaxel
DB03796 Palmitic Acid
DB00617 Paramethadione
DB00715 Paroxetine
DB06589 Pazopanib
DB00738 Pentamidine
DB00850 Perphenazine
DB00780 Phenelzine
DB01174 Phenobarbital
DB00946 Phenprocoumon
DB00252 Phenytoin
DB01132 Pioglitazone
DB00554 Piroxicam
DB08860 Pitavastatin
DB08901 Ponatinib
DB00175 Pravastatin
DB00794 Primidone
DB01032 Probenecid
DB00396 Progesterone
DB01182 Propafenone
DB00818 Propofol
DB09396 Propoxyphene napsylate
DB00205 Pyrimethamine
DB04216 Quercetin
DB00908 Quinidine
DB00468 Quinine
DB01129 Rabeprazole
DB00481 Raloxifene
DB08896 Regorafenib
DB00912 Repaglinide
DB01045 Rifampicin
DB01201 Rifapentine
DB08931 Riociguat
DB00503 Ritonavir
DB00533 Rofecoxib
DB00412 Rosiglitazone
DB01698 Rutin
DB00938 Salmeterol
DB01232 Saquinavir
DB00418 Secobarbital
DB01037 Selegiline
DB11362 Selexipag
DB00641 Simvastatin
DB01261 Sitagliptin
DB00398 Sorafenib
DB00421 Spironolactone
DB09118 Stiripentol
DB00359 Sulfadiazine
DB01015 Sulfamethoxazole
DB06729 Sulfaphenazole
DB01138 Sulfinpyrazone
DB00675 Tamoxifen
DB00799 Tazarotene
DB01079 Tegaserod
DB00231 Temazepam
DB00857 Terbinafine
DB00342 Terfenadine
DB08880 Teriflunomide
DB00624 Testosterone
DB00277 Theophylline
DB00679 Thioridazine
DB00208 Ticlopidine
DB01007 Tioconazole
DB01124 Tolbutamide
DB00214 Torasemide
DB08911 Trametinib
DB00755 Tretinoin
DB00897 Triazolam
DB00347 Trimethadione
DB00440 Trimethoprim
DB00197 Troglitazone
DB01361 Troleandomycin
DB00313 Valproic Acid
DB00661 Verapamil
DB08828 Vismodegib
DB09068 Vortioxetine
DB00682 Warfarin
DB00549 Zafirlukast
DB00495 Zidovudine
DB01198 Zopiclone
GuidetoPHARMACOLOGYi1325
SwissLipidsiSLP:000001548
SLP:000001616 [P10632-1]

PTM databases

iPTMnetiP10632
PhosphoSitePlusiP10632

Polymorphism and mutation databases

BioMutaiCYP2C8
DMDMi117225

Proteomic databases

PaxDbiP10632
PeptideAtlasiP10632
PRIDEiP10632
ProteomicsDBi52621
52622 [P10632-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1558
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371270; ENSP00000360317; ENSG00000138115 [P10632-1]
ENST00000535898; ENSP00000445062; ENSG00000138115 [P10632-2]
GeneIDi1558
KEGGihsa:1558
UCSCiuc001kkb.4 human [P10632-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1558
DisGeNETi1558
EuPathDBiHostDB:ENSG00000138115.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CYP2C8
HGNCiHGNC:2622 CYP2C8
HPAiHPA013547
HPA013970
HPA015066
MIMi601129 gene
618018 phenotype
neXtProtiNX_P10632
OpenTargetsiENSG00000138115
PharmGKBiPA125

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00940000163696
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiP10632
KOiK17718
OMAiAEDCKVN
OrthoDBiEOG091G0BT8
PhylomeDBiP10632
TreeFamiTF352043

Enzyme and pathway databases

BRENDAi1.14.14.1 2681
ReactomeiR-HSA-211981 Xenobiotics
R-HSA-211999 CYP2E1 reactions
R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
R-HSA-9027307 Biosynthesis of maresin-like SPMs
SABIO-RKiP10632

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CYP2C8 human
EvolutionaryTraceiP10632

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CYP2C8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1558

Protein Ontology

More...
PROi
PR:P10632

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138115 Expressed in 117 organ(s), highest expression level in liver
CleanExiHS_CYP2C8
ExpressionAtlasiP10632 baseline and differential
GenevisibleiP10632 HS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP2C8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10632
Secondary accession number(s): A8K9N8
, B0AZN2, B7Z1F6, Q5VX93, Q8WWB1, Q9UCZ9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1990
Last modified: December 5, 2018
This is version 204 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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