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UniProtKB - P10629 (HXC6_MOUSE)
Protein
Homeobox protein Hox-C6
Gene
Hoxc6
Organism
Mus musculus (Mouse)
Status
Functioni
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 141 – 200 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- anterior/posterior pattern specification Source: MGI
- embryonic skeletal system development Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein Hox-C6Alternative name(s): Homeobox protein Hox-3.3 Homeobox protein Hox-6.1 |
Gene namesi | Name:Hoxc6 Synonyms:Hox-3.3, Hoxc-6 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96197, Hoxc6 |
VEuPathDBi | HostDB:ENSMUSG00000001661 |
Subcellular locationi
Nucleus
Cytosol
- cytosol Source: MGI
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000200175 | 1 – 235 | Homeobox protein Hox-C6Add BLAST | 235 |
Proteomic databases
MaxQBi | P10629 |
PaxDbi | P10629 |
PRIDEi | P10629 |
ProteomicsDBi | 267023 [P10629-1] 267024 [P10629-2] |
PTM databases
iPTMneti | P10629 |
PhosphoSitePlusi | P10629 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000001661, Expressed in embryonic post-anal tail and 140 other tissues |
ExpressionAtlasi | P10629, baseline and differential |
Genevisiblei | P10629, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 200388, 1 interactor |
IntActi | P10629, 1 interactor |
STRINGi | 10090.ENSMUSP00000001711 |
Miscellaneous databases
RNActi | P10629, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 200 – 235 | DisorderedSequence analysisAdd BLAST | 36 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 122 – 127 | Antp-type hexapeptide | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 218 – 235 | Basic and acidic residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the Antp homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0489, Eukaryota |
GeneTreei | ENSGT00940000159254 |
HOGENOMi | CLU_061398_1_1_1 |
InParanoidi | P10629 |
OMAi | RMNSHSE |
OrthoDBi | 1186205at2759 |
PhylomeDBi | P10629 |
TreeFami | TF316310 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001827, Homeobox_Antennapedia_CS IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00032, ANTENNAPEDIA, 1 hit PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform PRII (identifier: P10629-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNSYFTNPSL SCHLAGGQDV LPNVALNSTA YDPVRHFSTY GAAVAQNRIY
60 70 80 90 100
STPFYSPQEN VVFSSSRGPY DYGSNSFYQE KDMLSNCRQN TLGHNTQTSI
110 120 130 140 150
AQDFSSEQGR TAPQDQKASI QIYPWMQRMN SHSGVGYGAD RRRGRQIYSR
160 170 180 190 200
YQTLELEKEF HFNRYLTRRR RIEIANALCL TERQIKIWFQ NRRMKWKKES
210 220 230
NLTSTLSGGG GGATADSLGG KEEKREETEE EKQKE
Isoform PRI (identifier: P10629-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
1-82: Missing.
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 15 – 18 | AGGQ → QQRP in CAA31022 (PubMed:2901346).Curated | 4 | |
Sequence conflicti | 131 | S → N in AAA37854 (PubMed:2458223).Curated | 1 | |
Sequence conflicti | 131 | S → N in CAA34737 (PubMed:2458223).Curated | 1 | |
Sequence conflicti | 192 | R → A in AAA37854 (PubMed:2458223).Curated | 1 | |
Sequence conflicti | 192 | R → A in CAA34737 (PubMed:2458223).Curated | 1 | |
Sequence conflicti | 228 – 229 | TE → QK (PubMed:7905473).Curated | 2 | |
Sequence conflicti | 228 – 229 | TE → QK (PubMed:1684715).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002393 | 1 – 82 | Missing in isoform PRI. CuratedAdd BLAST | 82 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03074 mRNA Translation: AAA37832.1 M35986 mRNA Translation: AAA37854.1 X16511 mRNA Translation: CAA34518.1 X16510 mRNA Translation: CAA34517.1 S74185 Unassigned DNA Translation: AAB20717.1 X12504 mRNA Translation: CAA31022.1 X12504 mRNA Translation: CAA31023.1 X16838 mRNA Translation: CAA34737.1 |
CCDSi | CCDS27895.1 [P10629-1] |
PIRi | A32167 A56568 S00987, WJMSX6 |
RefSeqi | NP_034595.2, NM_010465.2 [P10629-1] XP_006520532.1, XM_006520469.2 [P10629-2] |
Genome annotation databases
Ensembli | ENSMUST00000001711; ENSMUSP00000001711; ENSMUSG00000001661 [P10629-1] |
GeneIDi | 15425 |
KEGGi | mmu:15425 |
UCSCi | uc007xxc.1, mouse [P10629-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03074 mRNA Translation: AAA37832.1 M35986 mRNA Translation: AAA37854.1 X16511 mRNA Translation: CAA34518.1 X16510 mRNA Translation: CAA34517.1 S74185 Unassigned DNA Translation: AAB20717.1 X12504 mRNA Translation: CAA31022.1 X12504 mRNA Translation: CAA31023.1 X16838 mRNA Translation: CAA34737.1 |
CCDSi | CCDS27895.1 [P10629-1] |
PIRi | A32167 A56568 S00987, WJMSX6 |
RefSeqi | NP_034595.2, NM_010465.2 [P10629-1] XP_006520532.1, XM_006520469.2 [P10629-2] |
3D structure databases
SMRi | P10629 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 200388, 1 interactor |
IntActi | P10629, 1 interactor |
STRINGi | 10090.ENSMUSP00000001711 |
PTM databases
iPTMneti | P10629 |
PhosphoSitePlusi | P10629 |
Proteomic databases
MaxQBi | P10629 |
PaxDbi | P10629 |
PRIDEi | P10629 |
ProteomicsDBi | 267023 [P10629-1] 267024 [P10629-2] |
Protocols and materials databases
Antibodypediai | 15318, 255 antibodies from 31 providers |
DNASUi | 15425 |
Genome annotation databases
Ensembli | ENSMUST00000001711; ENSMUSP00000001711; ENSMUSG00000001661 [P10629-1] |
GeneIDi | 15425 |
KEGGi | mmu:15425 |
UCSCi | uc007xxc.1, mouse [P10629-1] |
Organism-specific databases
CTDi | 3223 |
MGIi | MGI:96197, Hoxc6 |
VEuPathDBi | HostDB:ENSMUSG00000001661 |
Phylogenomic databases
eggNOGi | KOG0489, Eukaryota |
GeneTreei | ENSGT00940000159254 |
HOGENOMi | CLU_061398_1_1_1 |
InParanoidi | P10629 |
OMAi | RMNSHSE |
OrthoDBi | 1186205at2759 |
PhylomeDBi | P10629 |
TreeFami | TF316310 |
Miscellaneous databases
BioGRID-ORCSi | 15425, 2 hits in 65 CRISPR screens |
ChiTaRSi | Hoxc6, mouse |
PROi | PR:P10629 |
RNActi | P10629, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000001661, Expressed in embryonic post-anal tail and 140 other tissues |
ExpressionAtlasi | P10629, baseline and differential |
Genevisiblei | P10629, MM |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001827, Homeobox_Antennapedia_CS IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00032, ANTENNAPEDIA, 1 hit PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HXC6_MOUSE | |
Accessioni | P10629Primary (citable) accession number: P10629 Secondary accession number(s): Q61683 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1993 | |
Last modified: | February 23, 2022 | |
This is version 180 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families