Hoxc6

Functionⁱ

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	141 – 200	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II distal enhancer sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Homeobox protein Hox-C6 Alternative name(s): Homeobox protein Hox-3.3 Homeobox protein Hox-6.1
Gene namesⁱ	Name:Hoxc6 Synonyms:Hox-3.3, Hoxc-6
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 15

Organism-specific databases

MGIⁱ	MGI:96197 Hoxc6

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000200175	1 – 235	Homeobox protein Hox-C6Add BLAST		235

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P10629
PaxDbⁱ	P10629
PRIDEⁱ	P10629

PTM databases

iPTMnetⁱ	P10629
PhosphoSitePlusⁱ	P10629

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000001661 Expressed in 103 organ(s), highest expression level in mesonephros
CleanExⁱ	MM_HOXC6
ExpressionAtlasⁱ	P10629 baseline and differential
Genevisibleⁱ	P10629 MM

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	200388, 1 interactor
STRINGⁱ	10090.ENSMUSP00000001711

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P10629
SMRⁱ	P10629
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	122 – 127	Antp-type hexapeptide		6

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	221 – 235	Glu/Lys-richAdd BLAST		15

Sequence similaritiesⁱ

Belongs to the Antp homeobox family.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0489 Eukaryota ENOG410ZTBY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143983
HOGENOMⁱ	HOG000231181
HOVERGENⁱ	HBG016849
InParanoidⁱ	P10629
KEGG Orthology (KO) More...KOⁱ	K09306
OMAⁱ	RMNSHSE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09XD
PhylomeDBⁱ	P10629
TreeFamⁱ	TF316310

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR001827 Homeobox_Antennapedia_CS IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00032 ANTENNAPEDIA, 1 hit PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform PRII (identifier: P10629-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSYFTNPSL SCHLAGGQDV LPNVALNSTA YDPVRHFSTY GAAVAQNRIY 
        60         70         80         90        100
STPFYSPQEN VVFSSSRGPY DYGSNSFYQE KDMLSNCRQN TLGHNTQTSI 
       110        120        130        140        150
AQDFSSEQGR TAPQDQKASI QIYPWMQRMN SHSGVGYGAD RRRGRQIYSR 
       160        170        180        190        200
YQTLELEKEF HFNRYLTRRR RIEIANALCL TERQIKIWFQ NRRMKWKKES 
       210        220        230 
NLTSTLSGGG GGATADSLGG KEEKREETEE EKQKE

Length:235

Mass (Da):26,915

Last modified:July 1, 1993 - v2

Checksum:ⁱBD695C7347CB71C0

GO

Isoform PRI (identifier: P10629-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-82: Missing.

« Hide

        10         20         30         40         50
MLSNCRQNTL GHNTQTSIAQ DFSSEQGRTA PQDQKASIQI YPWMQRMNSH 
        60         70         80         90        100
SGVGYGADRR RGRQIYSRYQ TLELEKEFHF NRYLTRRRRI EIANALCLTE 
       110        120        130        140        150
RQIKIWFQNR RMKWKKESNL TSTLSGGGGG ATADSLGGKE EKREETEEEK 

QKE

Show »

Length:153

Mass (Da):17,834

Checksum:ⁱ291E2439914263AE

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	15 – 18	AGGQ → QQRP in CAA31022 (PubMed:2901346).Curated	4
Sequence conflictⁱ	131	S → N in AAA37854 (PubMed:2458223).Curated	1
Sequence conflictⁱ	131	S → N in CAA34737 (PubMed:2458223).Curated	1
Sequence conflictⁱ	192	R → A in AAA37854 (PubMed:2458223).Curated	1
Sequence conflictⁱ	192	R → A in CAA34737 (PubMed:2458223).Curated	1
Sequence conflictⁱ	228 – 229	TE → QK (PubMed:7905473).Curated	2
Sequence conflictⁱ	228 – 229	TE → QK (PubMed:1684715).Curated	2

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_002393	1 – 82	Missing in isoform PRI. CuratedAdd BLAST		82

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03074 mRNA Translation: AAA37832.1 M35986 mRNA Translation: AAA37854.1 X16511 mRNA Translation: CAA34518.1 X16510 mRNA Translation: CAA34517.1 S74185 Unassigned DNA Translation: AAB20717.1 X12504 mRNA Translation: CAA31022.1 X12504 mRNA Translation: CAA31023.1 X16838 mRNA Translation: CAA34737.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27895.1 [P10629-1]
PIRⁱ	A32167 A56568 S00987 WJMSX6
NCBI Reference Sequences More...RefSeqⁱ	NP_034595.2, NM_010465.2 [P10629-1] XP_006520532.1, XM_006520469.2 [P10629-2]
UniGeneⁱ	Mm.4444

Genome annotation databases

Ensemblⁱ	ENSMUST00000001711; ENSMUSP00000001711; ENSMUSG00000001661 [P10629-1]
GeneIDⁱ	15425
KEGGⁱ	mmu:15425
UCSC genome browser More...UCSCⁱ	uc007xxc.1 mouse [P10629-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P10629	Homeobox protein Hox-C6		HUMAN		235	UniRef100_P09630
HOXC6 isoform 1		PANTR		235
Homeobox C6		MACFA		235
Homeobox C6		SAIBB		235
Uncharacterized protein		CALJA		235
+29

Protein	Similar proteins		Species	Score	Length	Source
P10629	Homeobox protein Hox-C6		HUMAN		235	UniRef90_P09630
Homeobox protein Hox-C6		SHEEP		153
HOXC6 isoform 1		PANTR		235
Homeobox C6		MACFA		235
Homeobox C6		SAIBB		235
+159

Protein	Similar proteins		Species	Score	Length	Source
P10629	Homeobox protein Hox-C8		MOUSE		242	UniRef50_P09025
Homeobox protein Hox-C8		CHICK		242
Homeobox protein Hox-C8		HUMAN		242
Homeobox protein Hox-C6		SHEEP		153
HOXC8 isoform 1		PANTR		242
+343

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03074 mRNA Translation: AAA37832.1 M35986 mRNA Translation: AAA37854.1 X16511 mRNA Translation: CAA34518.1 X16510 mRNA Translation: CAA34517.1 S74185 Unassigned DNA Translation: AAB20717.1 X12504 mRNA Translation: CAA31022.1 X12504 mRNA Translation: CAA31023.1 X16838 mRNA Translation: CAA34737.1
CCDSⁱ	CCDS27895.1 [P10629-1]
PIRⁱ	A32167 A56568 S00987 WJMSX6
RefSeqⁱ	NP_034595.2, NM_010465.2 [P10629-1] XP_006520532.1, XM_006520469.2 [P10629-2]
UniGeneⁱ	Mm.4444

3D structure databases

ProteinModelPortalⁱ	P10629
SMRⁱ	P10629
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	200388, 1 interactor
STRINGⁱ	10090.ENSMUSP00000001711

PTM databases

iPTMnetⁱ	P10629
PhosphoSitePlusⁱ	P10629

Proteomic databases

MaxQBⁱ	P10629
PaxDbⁱ	P10629
PRIDEⁱ	P10629

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000001711; ENSMUSP00000001711; ENSMUSG00000001661 [P10629-1]
GeneIDⁱ	15425
KEGGⁱ	mmu:15425
UCSCⁱ	uc007xxc.1 mouse [P10629-1]

Organism-specific databases

CTDⁱ	3223
MGIⁱ	MGI:96197 Hoxc6

Phylogenomic databases

eggNOGⁱ	KOG0489 Eukaryota ENOG410ZTBY LUCA
GeneTreeⁱ	ENSGT00910000143983
HOGENOMⁱ	HOG000231181
HOVERGENⁱ	HBG016849
InParanoidⁱ	P10629
KOⁱ	K09306
OMAⁱ	RMNSHSE
OrthoDBⁱ	EOG091G09XD
PhylomeDBⁱ	P10629
TreeFamⁱ	TF316310

Miscellaneous databases

ChiTaRSⁱ	Hoxc6 mouse
Protein Ontology More...PROⁱ	PR:P10629
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000001661 Expressed in 103 organ(s), highest expression level in mesonephros
CleanExⁱ	MM_HOXC6
ExpressionAtlasⁱ	P10629 baseline and differential
Genevisibleⁱ	P10629 MM

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR001827 Homeobox_Antennapedia_CS IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00032 ANTENNAPEDIA, 1 hit PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HXC6_MOUSE
Accessionⁱ	P10629Primary (citable) accession number: P10629 Secondary accession number(s): Q61683
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	July 1, 1993
	Last modified:	November 7, 2018
	This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P10629 (HXC6_MOUSE)

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Homeobox protein Hox-C6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ