Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein Hox-D4

Gene

Hoxd4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi152 – 211HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • skeletal system development Source: GO_Central
  • stem cell differentiation Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D4
Alternative name(s):
Homeobox protein Hox-4.2
Homeobox protein Hox-5.1
Gene namesi
Name:Hoxd4
Synonyms:Hox-4.2, Hoxd-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96208 Hoxd4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002111 – 250Homeobox protein Hox-D4Add BLAST250

Proteomic databases

MaxQBiP10628
PaxDbiP10628
PRIDEiP10628

PTM databases

PhosphoSitePlusiP10628

Expressioni

Gene expression databases

BgeeiENSMUSG00000101174 Expressed in 132 organ(s), highest expression level in head
GenevisibleiP10628 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200397, 3 interactors
STRINGi10090.ENSMUSP00000047949

Structurei

3D structure databases

ProteinModelPortaliP10628
SMRiP10628
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi131 – 136Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi220 – 229Ser-rich10

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231179
HOVERGENiHBG016849
InParanoidiP10628
KOiK09304
OMAiPDFGEQT
OrthoDBiEOG091G09XD
PhylomeDBiP10628
TreeFamiTF352857

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P10628-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMSSYMVNS KYVDPKFPPC EEYLQGGYLG EQGADYYGSG AQGADFQPSG
60 70 80 90 100
LYPRPDFGEQ PFGGGGPGPG SALPARGHGQ EPSGPGSHYG APGERCPAPP
110 120 130 140 150
PAPLPGARAC SQPTGPKQPP PGTALKQPAV VYPWMKKVHV NSVNPNYTGG
160 170 180 190 200
EPKRSRTAYT RQQVLELEKE FHFNRYLTRR RRIEIAHTLC LSERQIKIWF
210 220 230 240 250
QNRRMKWKKD HKLPNTKGRS SSSSSCSSSA APGQHLQPMA KDHHTDLTTL
Length:250
Mass (Da):27,371
Last modified:September 5, 2006 - v3
Checksum:i2B20A00BAD1B8757
GO

Sequence cautioni

The sequence AAA20072 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95R → P (PubMed:2898782).Curated1
Sequence conflicti95R → P (PubMed:9360992).Curated1
Sequence conflicti143V → A in AAA20072 (PubMed:2898782).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03770 mRNA Translation: AAA20072.1 Different initiation.
U77364 Genomic DNA Translation: AAB41222.1
AK135479 mRNA Translation: BAE22547.1
AL928644 Genomic DNA Translation: CAM20533.1
M87804 Genomic DNA Translation: AAA37851.1
CCDSiCCDS16145.1
PIRiA36170
E42694
RefSeqiNP_034599.2, NM_010469.2
UniGeneiMm.482194

Genome annotation databases

EnsembliENSMUST00000047904; ENSMUSP00000047949; ENSMUSG00000115956
ENSMUST00000111980; ENSMUSP00000107611; ENSMUSG00000101174
GeneIDi15436
KEGGimmu:15436
UCSCiuc008kef.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03770 mRNA Translation: AAA20072.1 Different initiation.
U77364 Genomic DNA Translation: AAB41222.1
AK135479 mRNA Translation: BAE22547.1
AL928644 Genomic DNA Translation: CAM20533.1
M87804 Genomic DNA Translation: AAA37851.1
CCDSiCCDS16145.1
PIRiA36170
E42694
RefSeqiNP_034599.2, NM_010469.2
UniGeneiMm.482194

3D structure databases

ProteinModelPortaliP10628
SMRiP10628
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200397, 3 interactors
STRINGi10090.ENSMUSP00000047949

PTM databases

PhosphoSitePlusiP10628

Proteomic databases

MaxQBiP10628
PaxDbiP10628
PRIDEiP10628

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047904; ENSMUSP00000047949; ENSMUSG00000115956
ENSMUST00000111980; ENSMUSP00000107611; ENSMUSG00000101174
GeneIDi15436
KEGGimmu:15436
UCSCiuc008kef.1 mouse

Organism-specific databases

CTDi3233
MGIiMGI:96208 Hoxd4

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231179
HOVERGENiHBG016849
InParanoidiP10628
KOiK09304
OMAiPDFGEQT
OrthoDBiEOG091G09XD
PhylomeDBiP10628
TreeFamiTF352857

Miscellaneous databases

PROiPR:P10628
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000101174 Expressed in 132 organ(s), highest expression level in head
GenevisibleiP10628 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXD4_MOUSE
AccessioniPrimary (citable) accession number: P10628
Secondary accession number(s): A2ASN3, P97451, Q3UXL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: September 5, 2006
Last modified: November 7, 2018
This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again