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Entry version 223 (08 May 2019)
Sequence version 2 (16 Apr 2002)
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Protein

Lysosomal protective protein

Gene

CTSA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation EC:3.4.16.5

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1781
Active sitei400By similarity1
Active sitei4571

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
3.4.16.5 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1660662 Glycosphingolipid metabolism
R-HSA-2132295 MHC class II antigen presentation
R-HSA-4085001 Sialic acid metabolism
R-HSA-4341670 Defective NEU1 causes sialidosis
R-HSA-6798695 Neutrophil degranulation

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P10619

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P10619

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

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ESTHERi
human-CTSA Carboxypeptidase_S10

MEROPS protease database

More...
MEROPSi
S10.002

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysosomal protective protein (EC:3.4.16.5)
Alternative name(s):
Carboxypeptidase C
Carboxypeptidase L
Cathepsin A
Protective protein cathepsin A
Short name:
PPCA
Protective protein for beta-galactosidase
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CTSA
Synonyms:PPGB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9251 CTSA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613111 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P10619

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Galactosialidosis (GSL)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA lysosomal storage disease associated with a combined deficiency of beta-galactosidase and neuraminidase, secondary to a defect in cathepsin A. All patients have clinical manifestations typical of a lysosomal disorder, such as coarse facies, cherry red spots, vertebral changes, foam cells in the bone marrow, and vacuolated lymphocytes. Three phenotypic subtypes are recognized. The early infantile form is associated with fetal hydrops, edema, ascites, visceromegaly, skeletal dysplasia, and early death. The late infantile type is characterized by hepatosplenomegaly, growth retardation, cardiac involvement, and a normal or mildly affected mental state. The juvenile/adult form is characterized by myoclonus, ataxia, angiokeratoma, mental retardation, neurologic deterioration, absence of visceromegaly, and long survival.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00138549Q → R in GSL. 1 PublicationCorresponds to variant dbSNP:rs137854541Ensembl.1
Natural variantiVAR_06301851S → Y in GSL. 1 PublicationCorresponds to variant dbSNP:rs538562022Ensembl.1
Natural variantiVAR_00138665W → R in GSL. 1 PublicationCorresponds to variant dbSNP:rs28934603Ensembl.1
Natural variantiVAR_00138790S → L in GSL. 1 PublicationCorresponds to variant dbSNP:rs137854542Ensembl.1
Natural variantiVAR_063019132V → M in GSL. 1 PublicationCorresponds to variant dbSNP:rs137854545Ensembl.1
Natural variantiVAR_063020236L → P in GSL. 1 PublicationCorresponds to variant dbSNP:rs137854546EnsemblClinVar.1
Natural variantiVAR_001388249Y → N in GSL; small amount of activity. 2 PublicationsCorresponds to variant dbSNP:rs137854544Ensembl.1
Natural variantiVAR_001389395Y → C in GSL; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs137854543Ensembl.1
Natural variantiVAR_063021406M → T in GSL. 1 PublicationCorresponds to variant dbSNP:rs137854548Ensembl.1
Natural variantiVAR_063022439G → S in GSL. 1 PublicationCorresponds to variant dbSNP:rs137854547Ensembl.1
Natural variantiVAR_001390440F → V in GSL. 2 PublicationsCorresponds to variant dbSNP:rs137854540Ensembl.1
Natural variantiVAR_063023453K → E in GSL. 1 PublicationCorresponds to variant dbSNP:rs137854549Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi178S → A: Inactivates the enzyme. 1 Publication1
Mutagenesisi457H → Q: Inactivates the enzyme. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
5476

MalaCards human disease database

More...
MalaCardsi
CTSA
MIMi256540 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000064601

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
351 Galactosialidosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33572

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL6115

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1581

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CTSA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20178316

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Combined sources2 PublicationsAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000427429 – 480Lysosomal protective proteinAdd BLAST452
ChainiPRO_000000427529 – 326Lysosomal protective protein 32 kDa chainAdd BLAST298
ChainiPRO_0000004276327 – 480Lysosomal protective protein 20 kDa chainAdd BLAST154

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi88 ↔ 362
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi145N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi240 ↔ 256
Disulfide bondi241 ↔ 246
Disulfide bondi281 ↔ 331
Glycosylationi333N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P10619

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P10619

MaxQB - The MaxQuant DataBase

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MaxQBi
P10619

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P10619

PeptideAtlas

More...
PeptideAtlasi
P10619

PRoteomics IDEntifications database

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PRIDEi
P10619

ProteomicsDB human proteome resource

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ProteomicsDBi
52619

Consortium for Top Down Proteomics

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TopDownProteomicsi
P10619-1 [P10619-1]
P10619-2 [P10619-2]

2D gel databases

USC-OGP 2-DE database

More...
OGPi
P10619

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1477

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P10619

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P10619

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P10619

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000064601 Expressed in 230 organ(s), highest expression level in right adrenal gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P10619 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P10619 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB024930
HPA031068

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of a 32 kDa chain and a 20 kDa chain; disulfide-linked.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111472, 41 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P10619

Protein interaction database and analysis system

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IntActi
P10619, 15 interactors

Molecular INTeraction database

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MINTi
P10619

STRING: functional protein association networks

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STRINGi
9606.ENSP00000361562

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P10619

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1480
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P10619

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P10619

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1282 Eukaryota
COG2939 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00880000138014

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P10619

KEGG Orthology (KO)

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KOi
K13289

Database of Orthologous Groups

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OrthoDBi
607679at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P10619

TreeFam database of animal gene trees

More...
TreeFami
TF323769

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR033124 Ser_caboxypep_his_AS
IPR018202 Ser_caboxypep_ser_AS

The PANTHER Classification System

More...
PANTHERi
PTHR11802 PTHR11802, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00450 Peptidase_S10, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00724 CRBOXYPTASEC

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474 SSF53474, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00560 CARBOXYPEPT_SER_HIS, 1 hit
PS00131 CARBOXYPEPT_SER_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P10619-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIRAAPPPLF LLLLLLLLLV SWASRGEAAP DQDEIQRLPG LAKQPSFRQY
60 70 80 90 100
SGYLKGSGSK HLHYWFVESQ KDPENSPVVL WLNGGPGCSS LDGLLTEHGP
110 120 130 140 150
FLVQPDGVTL EYNPYSWNLI ANVLYLESPA GVGFSYSDDK FYATNDTEVA
160 170 180 190 200
QSNFEALQDF FRLFPEYKNN KLFLTGESYA GIYIPTLAVL VMQDPSMNLQ
210 220 230 240 250
GLAVGNGLSS YEQNDNSLVY FAYYHGLLGN RLWSSLQTHC CSQNKCNFYD
260 270 280 290 300
NKDLECVTNL QEVARIVGNS GLNIYNLYAP CAGGVPSHFR YEKDTVVVQD
310 320 330 340 350
LGNIFTRLPL KRMWHQALLR SGDKVRMDPP CTNTTAASTY LNNPYVRKAL
360 370 380 390 400
NIPEQLPQWD MCNFLVNLQY RRLYRSMNSQ YLKLLSSQKY QILLYNGDVD
410 420 430 440 450
MACNFMGDEW FVDSLNQKME VQRRPWLVKY GDSGEQIAGF VKEFSHIAFL
460 470 480
TIKGAGHMVP TDKPLAAFTM FSRFLNKQPY
Length:480
Mass (Da):54,466
Last modified:April 16, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i46B737DEE775C508
GO
Isoform 2 (identifier: P10619-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     102-118: Missing.

Note: Gene prediction based on EST data.
Show »
Length:463
Mass (Da):52,489
Checksum:i7342A76945E40684
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R8A1X6R8A1_HUMAN
Carboxypeptidase
CTSA
498Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6R5C5X6R5C5_HUMAN
Carboxypeptidase
CTSA
481Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQU6U3KQU6_HUMAN
Carboxypeptidase
CTSA
231Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JZH0Q5JZH0_HUMAN
Carboxypeptidase
CTSA
202Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQ41U3KQ41_HUMAN
Lysosomal protective protein
CTSA
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQF1U3KQF1_HUMAN
Lysosomal protective protein
CTSA
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti19Missing in AAH00597 (PubMed:15489334).Curated1
Sequence conflicti56G → S in AAA36476 (PubMed:3136930).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00138549Q → R in GSL. 1 PublicationCorresponds to variant dbSNP:rs137854541Ensembl.1
Natural variantiVAR_06301851S → Y in GSL. 1 PublicationCorresponds to variant dbSNP:rs538562022Ensembl.1
Natural variantiVAR_00138665W → R in GSL. 1 PublicationCorresponds to variant dbSNP:rs28934603Ensembl.1
Natural variantiVAR_00138790S → L in GSL. 1 PublicationCorresponds to variant dbSNP:rs137854542Ensembl.1
Natural variantiVAR_063019132V → M in GSL. 1 PublicationCorresponds to variant dbSNP:rs137854545Ensembl.1
Natural variantiVAR_063020236L → P in GSL. 1 PublicationCorresponds to variant dbSNP:rs137854546EnsemblClinVar.1
Natural variantiVAR_001388249Y → N in GSL; small amount of activity. 2 PublicationsCorresponds to variant dbSNP:rs137854544Ensembl.1
Natural variantiVAR_001389395Y → C in GSL; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs137854543Ensembl.1
Natural variantiVAR_063021406M → T in GSL. 1 PublicationCorresponds to variant dbSNP:rs137854548Ensembl.1
Natural variantiVAR_063022439G → S in GSL. 1 PublicationCorresponds to variant dbSNP:rs137854547Ensembl.1
Natural variantiVAR_001390440F → V in GSL. 2 PublicationsCorresponds to variant dbSNP:rs137854540Ensembl.1
Natural variantiVAR_063023453K → E in GSL. 1 PublicationCorresponds to variant dbSNP:rs137854549Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054832102 – 118Missing in isoform 2. CuratedAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M22960 mRNA Translation: AAA36476.1
AK312898 mRNA Translation: BAG35745.1
AL008726 Genomic DNA No translation available.
BC000597 mRNA Translation: AAH00597.1
BC093009 mRNA Translation: AAH93009.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS46609.1 [P10619-1]

Protein sequence database of the Protein Information Resource

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PIRi
A31589

NCBI Reference Sequences

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RefSeqi
NP_000299.2, NM_000308.3
NP_001121167.1, NM_001127695.2 [P10619-1]
NP_001161066.1, NM_001167594.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000191018; ENSP00000191018; ENSG00000064601 [P10619-1]
ENST00000372459; ENSP00000361537; ENSG00000064601 [P10619-1]
ENST00000646241; ENSP00000493613; ENSG00000064601 [P10619-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5476

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5476

UCSC genome browser

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UCSCi
uc002xqj.5 human [P10619-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22960 mRNA Translation: AAA36476.1
AK312898 mRNA Translation: BAG35745.1
AL008726 Genomic DNA No translation available.
BC000597 mRNA Translation: AAH00597.1
BC093009 mRNA Translation: AAH93009.1
CCDSiCCDS46609.1 [P10619-1]
PIRiA31589
RefSeqiNP_000299.2, NM_000308.3
NP_001121167.1, NM_001127695.2 [P10619-1]
NP_001161066.1, NM_001167594.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IVYX-ray2.20A/B29-480[»]
3BP4X-ray1.85C2-10[»]
3BP7X-ray1.80C2-10[»]
3BXNX-ray1.86C2-10[»]
4AZ0X-ray2.17A29-326[»]
B327-480[»]
4AZ3X-ray2.04A29-326[»]
B327-480[»]
4CI9X-ray1.58A29-480[»]
4CIAX-ray1.98A29-480[»]
4CIBX-ray1.89A29-480[»]
4MWSX-ray2.80A/B29-480[»]
4MWTX-ray3.85A/B29-480[»]
SMRiP10619
ModBaseiSearch...

Protein-protein interaction databases

BioGridi111472, 41 interactors
CORUMiP10619
IntActiP10619, 15 interactors
MINTiP10619
STRINGi9606.ENSP00000361562

Chemistry databases

BindingDBiP10619
ChEMBLiCHEMBL6115
GuidetoPHARMACOLOGYi1581

Protein family/group databases

ESTHERihuman-CTSA Carboxypeptidase_S10
MEROPSiS10.002

PTM databases

GlyConnecti1477
iPTMnetiP10619
PhosphoSitePlusiP10619
SwissPalmiP10619

Polymorphism and mutation databases

BioMutaiCTSA
DMDMi20178316

2D gel databases

OGPiP10619

Proteomic databases

EPDiP10619
jPOSTiP10619
MaxQBiP10619
PaxDbiP10619
PeptideAtlasiP10619
PRIDEiP10619
ProteomicsDBi52619
TopDownProteomicsiP10619-1 [P10619-1]
P10619-2 [P10619-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5476
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000191018; ENSP00000191018; ENSG00000064601 [P10619-1]
ENST00000372459; ENSP00000361537; ENSG00000064601 [P10619-1]
ENST00000646241; ENSP00000493613; ENSG00000064601 [P10619-1]
GeneIDi5476
KEGGihsa:5476
UCSCiuc002xqj.5 human [P10619-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5476
DisGeNETi5476

GeneCards: human genes, protein and diseases

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GeneCardsi
CTSA
HGNCiHGNC:9251 CTSA
HPAiCAB024930
HPA031068
MalaCardsiCTSA
MIMi256540 phenotype
613111 gene
neXtProtiNX_P10619
OpenTargetsiENSG00000064601
Orphaneti351 Galactosialidosis
PharmGKBiPA33572

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
GeneTreeiENSGT00880000138014
InParanoidiP10619
KOiK13289
OrthoDBi607679at2759
PhylomeDBiP10619
TreeFamiTF323769

Enzyme and pathway databases

BRENDAi3.4.16.5 2681
ReactomeiR-HSA-1660662 Glycosphingolipid metabolism
R-HSA-2132295 MHC class II antigen presentation
R-HSA-4085001 Sialic acid metabolism
R-HSA-4341670 Defective NEU1 causes sialidosis
R-HSA-6798695 Neutrophil degranulation
SABIO-RKiP10619
SignaLinkiP10619

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CTSA human
EvolutionaryTraceiP10619

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Cathepsin_A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5476

Protein Ontology

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PROi
PR:P10619

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000064601 Expressed in 230 organ(s), highest expression level in right adrenal gland
ExpressionAtlasiP10619 baseline and differential
GenevisibleiP10619 HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR033124 Ser_caboxypep_his_AS
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00560 CARBOXYPEPT_SER_HIS, 1 hit
PS00131 CARBOXYPEPT_SER_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPGB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10619
Secondary accession number(s): B2R798
, Q561W6, Q5JZH1, Q96KJ2, Q9BR08, Q9BW68
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 16, 2002
Last modified: May 8, 2019
This is version 223 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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