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Protein

Cytochrome c oxidase subunit 5B, mitochondrial

Gene

COX5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi91ZincPROSITE-ProRule annotation1
Metal bindingi93ZincPROSITE-ProRule annotation1
Metal bindingi113ZincPROSITE-ProRule annotation1
Metal bindingi116ZincPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytochrome-c oxidase activity Source: ProtInc
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-611105 Respiratory electron transport

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P10606

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.D.4.11.1 the proton-translocating cytochrome oxidase (cox) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome c oxidase subunit 5B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide Vb
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COX5B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000135940.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2269 COX5B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
123866 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P10606

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1329

Open Targets

More...
OpenTargetsi
ENSG00000135940

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26786

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB02659 Cholic Acid
DB04464 N-Formylmethionine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
COX5B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20141332

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 31MitochondrionCombined sources1 PublicationAdd BLAST31
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000610932 – 129Cytochrome c oxidase subunit 5B, mitochondrialAdd BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei68N6-acetyllysineBy similarity1
Modified residuei86N6-acetyllysineBy similarity1
Modified residuei121N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P10606

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P10606

PeptideAtlas

More...
PeptideAtlasi
P10606

PRoteomics IDEntifications database

More...
PRIDEi
P10606

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52618

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P10606

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P10606

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P10606

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P10606

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135940 Expressed in 239 organ(s), highest expression level in myocardium

CleanEx database of gene expression profiles

More...
CleanExi
HS_COX5B

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P10606 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA034517

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107722, 43 interactors

Protein interaction database and analysis system

More...
IntActi
P10606, 57 interactors

Molecular INTeraction database

More...
MINTi
P10606

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000258424

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P10606

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P10606

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3352 Eukaryota
ENOG4111XEM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011010

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000184129

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051089

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P10606

KEGG Orthology (KO)

More...
KOi
K02265

Identification of Orthologs from Complete Genome Data

More...
OMAi
DMRVFKR

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0S9L

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P10606

TreeFam database of animal gene trees

More...
TreeFami
TF105063

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00924 Cyt_c_Oxidase_Vb, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.11.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002124 Cyt_c_oxidase_su5b
IPR036972 Cyt_c_oxidase_su5b_sf
IPR020893 Cyt_c_oxidase_su5b_Zn_BS

The PANTHER Classification System

More...
PANTHERi
PTHR10122 PTHR10122, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01215 COX5B, 1 hit

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD007270 Cyt_c_oxidase_su5b, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00848 COX5B_1, 1 hit
PS51359 COX5B_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P10606-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASRLLRGAG TLAAQALRAR GPSGAAAMRS MASGGGVPTD EEQATGLERE
60 70 80 90 100
IMLAAKKGLD PYNVLAPKGA SGTREDPNLV PSISNKRIVG CICEEDNTSV
110 120
VWFWLHKGEA QRCPRCGAHY KLVPQQLAH
Length:129
Mass (Da):13,696
Last modified:April 3, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i877BF4CD334AC931
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti36 – 37GV → TR in AAB19185 (PubMed:8806766).Curated2
Sequence conflicti109E → Q in AAA52061 (PubMed:2840351).Curated1
Sequence conflicti109E → Q in AAA52060 (PubMed:2840351).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M19961 mRNA Translation: AAA52061.1
M59250 Genomic DNA Translation: AAA52060.1
BT006742 mRNA Translation: AAP35388.1
AC017099 Genomic DNA Translation: AAY24279.1
BC006229 mRNA Translation: AAH06229.1
U41284 Genomic DNA Translation: AAB19185.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2032.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JT0324 OTHU5B

NCBI Reference Sequences

More...
RefSeqi
NP_001853.2, NM_001862.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.1342

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000258424; ENSP00000258424; ENSG00000135940

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1329

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1329

UCSC genome browser

More...
UCSCi
uc002sya.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19961 mRNA Translation: AAA52061.1
M59250 Genomic DNA Translation: AAA52060.1
BT006742 mRNA Translation: AAP35388.1
AC017099 Genomic DNA Translation: AAY24279.1
BC006229 mRNA Translation: AAH06229.1
U41284 Genomic DNA Translation: AAB19185.1
CCDSiCCDS2032.1
PIRiJT0324 OTHU5B
RefSeqiNP_001853.2, NM_001862.2
UniGeneiHs.1342

3D structure databases

ProteinModelPortaliP10606
SMRiP10606
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107722, 43 interactors
IntActiP10606, 57 interactors
MINTiP10606
STRINGi9606.ENSP00000258424

Chemistry databases

DrugBankiDB02659 Cholic Acid
DB04464 N-Formylmethionine

Protein family/group databases

TCDBi3.D.4.11.1 the proton-translocating cytochrome oxidase (cox) superfamily

PTM databases

iPTMnetiP10606
PhosphoSitePlusiP10606

Polymorphism and mutation databases

BioMutaiCOX5B
DMDMi20141332

2D gel databases

SWISS-2DPAGEiP10606

Proteomic databases

EPDiP10606
PaxDbiP10606
PeptideAtlasiP10606
PRIDEiP10606
ProteomicsDBi52618
TopDownProteomicsiP10606

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1329
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258424; ENSP00000258424; ENSG00000135940
GeneIDi1329
KEGGihsa:1329
UCSCiuc002sya.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1329
DisGeNETi1329
EuPathDBiHostDB:ENSG00000135940.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
COX5B
HGNCiHGNC:2269 COX5B
HPAiHPA034517
MIMi123866 gene
neXtProtiNX_P10606
OpenTargetsiENSG00000135940
PharmGKBiPA26786

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3352 Eukaryota
ENOG4111XEM LUCA
GeneTreeiENSGT00390000011010
HOGENOMiHOG000184129
HOVERGENiHBG051089
InParanoidiP10606
KOiK02265
OMAiDMRVFKR
OrthoDBiEOG091G0S9L
PhylomeDBiP10606
TreeFamiTF105063

Enzyme and pathway databases

ReactomeiR-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-611105 Respiratory electron transport
SIGNORiP10606

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
COX5B human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
COX5B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1329

Protein Ontology

More...
PROi
PR:P10606

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000135940 Expressed in 239 organ(s), highest expression level in myocardium
CleanExiHS_COX5B
GenevisibleiP10606 HS

Family and domain databases

CDDicd00924 Cyt_c_Oxidase_Vb, 1 hit
Gene3Di2.60.11.10, 1 hit
InterProiView protein in InterPro
IPR002124 Cyt_c_oxidase_su5b
IPR036972 Cyt_c_oxidase_su5b_sf
IPR020893 Cyt_c_oxidase_su5b_Zn_BS
PANTHERiPTHR10122 PTHR10122, 1 hit
PfamiView protein in Pfam
PF01215 COX5B, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007270 Cyt_c_oxidase_su5b, 1 hit
PROSITEiView protein in PROSITE
PS00848 COX5B_1, 1 hit
PS51359 COX5B_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOX5B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10606
Secondary accession number(s): Q53YB7, Q96J18, Q99610
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 3, 2002
Last modified: December 5, 2018
This is version 188 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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