UniProtKB - P10600 (TGFB3_HUMAN)
Transforming growth factor beta-3 proprotein
TGFB3
Functioni
GO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- identical protein binding Source: BHF-UCL
- protein-containing complex binding Source: Ensembl
- transforming growth factor beta binding Source: BHF-UCL
- type III transforming growth factor beta receptor binding Source: AgBase
- type II transforming growth factor beta receptor binding Source: BHF-UCL
- type I transforming growth factor beta receptor binding Source: BHF-UCL
GO - Biological processi
- activation of MAPK activity Source: Ensembl
- aging Source: Ensembl
- BMP signaling pathway Source: GO_Central
- cell-cell junction organization Source: BHF-UCL
- detection of hypoxia Source: BHF-UCL
- digestive tract development Source: Ensembl
- embryonic neurocranium morphogenesis Source: Ensembl
- face morphogenesis Source: BHF-UCL
- female pregnancy Source: Ensembl
- frontal suture morphogenesis Source: Ensembl
- inner ear development Source: Ensembl
- in utero embryonic development Source: BHF-UCL
- lung alveolus development Source: BHF-UCL
- mammary gland development Source: BHF-UCL
- negative regulation of cell population proliferation Source: BHF-UCL
- negative regulation of macrophage cytokine production Source: DFLAT
- negative regulation of neuron apoptotic process Source: BHF-UCL
- negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
- negative regulation of vascular associated smooth muscle cell proliferation Source: BHF-UCL
- odontogenesis Source: BHF-UCL
- ossification involved in bone remodeling Source: BHF-UCL
- platelet degranulation Source: Reactome
- positive regulation of apoptotic process Source: BHF-UCL
- positive regulation of bone mineralization Source: BHF-UCL
- positive regulation of cell division Source: UniProtKB-KW
- positive regulation of cell population proliferation Source: BHF-UCL
- positive regulation of collagen biosynthetic process Source: BHF-UCL
- positive regulation of epithelial to mesenchymal transition Source: BHF-UCL
- positive regulation of filopodium assembly Source: BHF-UCL
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
- positive regulation of protein secretion Source: BHF-UCL
- positive regulation of SMAD protein signal transduction Source: BHF-UCL
- positive regulation of stress fiber assembly Source: BHF-UCL
- positive regulation of tight junction disassembly Source: BHF-UCL
- positive regulation of transcription, DNA-templated Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- regulation of cell population proliferation Source: GO_Central
- response to estrogen Source: Ensembl
- response to hypoxia Source: BHF-UCL
- response to laminar fluid shear stress Source: Ensembl
- response to progesterone Source: BHF-UCL
- salivary gland morphogenesis Source: BHF-UCL
- secondary palate development Source: BHF-UCL
- SMAD protein signal transduction Source: GO_Central
- transforming growth factor beta receptor signaling pathway Source: BHF-UCL
- uterine wall breakdown Source: BHF-UCL
- wound healing Source: Ensembl
Keywordsi
Molecular function | Growth factor, Mitogen |
Enzyme and pathway databases
PathwayCommonsi | P10600 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-2129379, Molecules associated with elastic fibres R-HSA-3000178, ECM proteoglycans |
SignaLinki | P10600 |
SIGNORi | P10600 |
Names & Taxonomyi
Protein namesi | Recommended name: Transforming growth factor beta-3 proproteinCleaved into the following 2 chains: |
Gene namesi | Name:TGFB3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000119699.7 |
HGNCi | HGNC:11769, TGFB3 |
MIMi | 190230, gene |
neXtProti | NX_P10600 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Nucleus
- nucleus Source: Ensembl
Plasma Membrane
- plasma membrane Source: BHF-UCL
- T-tubule Source: Ensembl
Other locations
- cell surface Source: Ensembl
- intracellular membrane-bounded organelle Source: HPA
- neuronal cell body Source: Ensembl
- platelet alpha granule lumen Source: Reactome
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Involvement in diseasei
Arrhythmogenic right ventricular dysplasia, familial, 1 (ARVD1)1 Publication
Loeys-Dietz syndrome 5 (LDS5)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_070924 | 409 | C → Y in LDS5; hypomorphic mutation; results in impaired TGF-beta signaling. 1 PublicationCorresponds to variant dbSNP:rs398122984EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 293 | Q → R: Abolishes methylation by N6AMT1. 1 Publication | 1 |
Keywords - Diseasei
Cardiomyopathy, Disease mutationOrganism-specific databases
DisGeNETi | 7043 |
GeneReviewsi | TGFB3 |
MalaCardsi | TGFB3 |
MIMi | 107970, phenotype 615582, phenotype |
OpenTargetsi | ENSG00000119699 |
Orphaneti | 293899, Familial isolated arrhythmogenic ventricular dysplasia, biventricular form 293888, Familial isolated arrhythmogenic ventricular dysplasia, left dominant form 293910, Familial isolated arrhythmogenic ventricular dysplasia, right dominant form 91387, Familial thoracic aortic aneurysm and aortic dissection |
PharmGKBi | PA36483 |
Miscellaneous databases
Pharosi | P10600, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3712903 |
DrugBanki | DB03316, 1,4-Dioxane |
Polymorphism and mutation databases
BioMutai | TGFB3 |
DMDMi | 135684 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000033796 | 24 – 300 | Latency-associated peptideBy similarityAdd BLAST | 277 | |
ChainiPRO_0000033797 | 301 – 412 | Transforming growth factor beta-3By similarityAdd BLAST | 112 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 74 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 135 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 142 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 293 | N5-methylglutamine1 Publication | 1 | |
Disulfide bondi | 307 ↔ 316 | 1 Publication | ||
Disulfide bondi | 315 ↔ 378 | 1 Publication | ||
Disulfide bondi | 344 ↔ 409 | 1 Publication | ||
Disulfide bondi | 348 ↔ 411 | 1 Publication | ||
Disulfide bondi | 377 | Interchain1 Publication |
Post-translational modificationi
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, MethylationProteomic databases
jPOSTi | P10600 |
MassIVEi | P10600 |
PaxDbi | P10600 |
PeptideAtlasi | P10600 |
PRIDEi | P10600 |
ProteomicsDBi | 52617 [P10600-1] 74762 |
PTM databases
GlyConnecti | 1837, 3 N-Linked glycans (1 site) |
GlyGeni | P10600, 3 sites |
iPTMneti | P10600 |
PhosphoSitePlusi | P10600 |
Expressioni
Gene expression databases
Bgeei | ENSG00000119699, Expressed in left coronary artery and 214 other tissues |
ExpressionAtlasi | P10600, baseline and differential |
Genevisiblei | P10600, HS |
Organism-specific databases
HPAi | ENSG00000119699, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with ASPN (PubMed:8819159). Latency-associated peptide: Homodimer; disulfide-linked. Latency-associated peptide:
Interacts with Transforming growth factor beta-3 (TGF-beta-3) chain; interaction is non-covalent and maintains (TGF-beta-3) in a latent state (By similarity). Latency-associated peptide:
Interacts with LRRC32/GARP; leading to regulate activation of TGF-beta-3 and promote epithelial fusion during palate development (By similarity). Latency-associated peptide:
Interacts (via cell attachment site) with integrins, leading to release of the active TGF-beta-3 (By similarity). Transforming growth factor beta-3: Homodimer; disulfide-linked (PubMed:8819159). Transforming growth factor beta-3:
Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction (By similarity).
By similarity1 PublicationBinary interactionsi
Hide detailsP10600
With | #Exp. | IntAct |
---|---|---|
itself | 2 | EBI-1033020,EBI-1033020 |
TGFBR2 [P37173] | 8 | EBI-1033020,EBI-296151 |
GO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- identical protein binding Source: BHF-UCL
- transforming growth factor beta binding Source: BHF-UCL
- type III transforming growth factor beta receptor binding Source: AgBase
- type II transforming growth factor beta receptor binding Source: BHF-UCL
- type I transforming growth factor beta receptor binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 112901, 7 interactors |
ComplexPortali | CPX-2544, TGF-beta-3-TGFR complex CPX-606, TGF-beta-3 complex |
CORUMi | P10600 |
DIPi | DIP-5937N |
IntActi | P10600, 9 interactors |
MINTi | P10600 |
STRINGi | 9606.ENSP00000238682 |
Miscellaneous databases
RNActi | P10600, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P10600 |
SMRi | P10600 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P10600 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 261 – 263 | Cell attachment siteBy similarity | 3 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000155747 |
HOGENOMi | CLU_039840_0_0_1 |
InParanoidi | P10600 |
OMAi | CVTMTLS |
PhylomeDBi | P10600 |
TreeFami | TF351793 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
IDEALi | IID00355 |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR015618, TGFB3 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01426, TGFBETA3 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKMHLQRALV VLALLNFATV SLSLSTCTTL DFGHIKKKRV EAIRGQILSK
60 70 80 90 100
LRLTSPPEPT VMTHVPYQVL ALYNSTRELL EEMHGEREEG CTQENTESEY
110 120 130 140 150
YAKEIHKFDM IQGLAEHNEL AVCPKGITSK VFRFNVSSVE KNRTNLFRAE
160 170 180 190 200
FRVLRVPNPS SKRNEQRIEL FQILRPDEHI AKQRYIGGKN LPTRGTAEWL
210 220 230 240 250
SFDVTDTVRE WLLRRESNLG LEISIHCPCH TFQPNGDILE NIHEVMEIKF
260 270 280 290 300
KGVDNEDDHG RGDLGRLKKQ KDHHNPHLIL MMIPPHRLDN PGQGGQRKKR
310 320 330 340 350
ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY
360 370 380 390 400
LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ
410
LSNMVVKSCK CS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A6Q8PGK5 | A0A6Q8PGK5_HUMAN | Transforming growth factor beta-3 p... | TGFB3 | 106 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_016315 | 60 | T → M1 PublicationCorresponds to variant dbSNP:rs4252315EnsemblClinVar. | 1 | |
Natural variantiVAR_070924 | 409 | C → Y in LDS5; hypomorphic mutation; results in impaired TGF-beta signaling. 1 PublicationCorresponds to variant dbSNP:rs398122984EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056285 | 310 – 412 | Missing in isoform 2. 2 PublicationsAdd BLAST | 103 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03241 mRNA Translation: AAA61161.1 X14149 mRNA Translation: CAA32362.1 X14885 , X14886, X14887, X14888, X14889, X14890, X14891 Genomic DNA Translation: CAA33024.1 Different initiation. AY140241 Genomic DNA Translation: AAM96819.1 AY208161 Genomic DNA Translation: AAO13495.1 BT007287 mRNA Translation: AAP35951.1 AF107885 Genomic DNA Translation: AAC79727.1 BC018503 mRNA Translation: AAH18503.1 |
CCDSi | CCDS86415.1 [P10600-2] CCDS9846.1 [P10600-1] |
PIRi | A36169 |
RefSeqi | NP_001316867.1, NM_001329938.1 [P10600-2] NP_001316868.1, NM_001329939.1 [P10600-1] NP_003230.1, NM_003239.4 [P10600-1] |
Genome annotation databases
Ensembli | ENST00000238682; ENSP00000238682; ENSG00000119699 [P10600-1] ENST00000556285; ENSP00000451110; ENSG00000119699 [P10600-2] |
GeneIDi | 7043 |
KEGGi | hsa:7043 |
UCSCi | uc001xsc.3, human [P10600-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
SeattleSNPs |
Wikipedia TGF beta-3 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03241 mRNA Translation: AAA61161.1 X14149 mRNA Translation: CAA32362.1 X14885 , X14886, X14887, X14888, X14889, X14890, X14891 Genomic DNA Translation: CAA33024.1 Different initiation. AY140241 Genomic DNA Translation: AAM96819.1 AY208161 Genomic DNA Translation: AAO13495.1 BT007287 mRNA Translation: AAP35951.1 AF107885 Genomic DNA Translation: AAC79727.1 BC018503 mRNA Translation: AAH18503.1 |
CCDSi | CCDS86415.1 [P10600-2] CCDS9846.1 [P10600-1] |
PIRi | A36169 |
RefSeqi | NP_001316867.1, NM_001329938.1 [P10600-2] NP_001316868.1, NM_001329939.1 [P10600-1] NP_003230.1, NM_003239.4 [P10600-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1KTZ | X-ray | 2.15 | A | 301-412 | [»] | |
1TGJ | X-ray | 2.00 | A | 301-412 | [»] | |
1TGK | X-ray | 3.30 | A | 301-412 | [»] | |
2PJY | X-ray | 3.00 | A | 301-412 | [»] | |
3EO1 | X-ray | 3.10 | C/F/I/L | 301-412 | [»] | |
4UM9 | X-ray | 2.50 | E/F | 259-269 | [»] | |
BMRBi | P10600 | |||||
SMRi | P10600 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112901, 7 interactors |
ComplexPortali | CPX-2544, TGF-beta-3-TGFR complex CPX-606, TGF-beta-3 complex |
CORUMi | P10600 |
DIPi | DIP-5937N |
IntActi | P10600, 9 interactors |
MINTi | P10600 |
STRINGi | 9606.ENSP00000238682 |
Chemistry databases
ChEMBLi | CHEMBL3712903 |
DrugBanki | DB03316, 1,4-Dioxane |
PTM databases
GlyConnecti | 1837, 3 N-Linked glycans (1 site) |
GlyGeni | P10600, 3 sites |
iPTMneti | P10600 |
PhosphoSitePlusi | P10600 |
Polymorphism and mutation databases
BioMutai | TGFB3 |
DMDMi | 135684 |
Proteomic databases
jPOSTi | P10600 |
MassIVEi | P10600 |
PaxDbi | P10600 |
PeptideAtlasi | P10600 |
PRIDEi | P10600 |
ProteomicsDBi | 52617 [P10600-1] 74762 |
Protocols and materials databases
ABCDi | P10600, 1 sequenced antibody |
Antibodypediai | 4331, 459 antibodies |
DNASUi | 7043 |
Genome annotation databases
Ensembli | ENST00000238682; ENSP00000238682; ENSG00000119699 [P10600-1] ENST00000556285; ENSP00000451110; ENSG00000119699 [P10600-2] |
GeneIDi | 7043 |
KEGGi | hsa:7043 |
UCSCi | uc001xsc.3, human [P10600-1] |
Organism-specific databases
CTDi | 7043 |
DisGeNETi | 7043 |
EuPathDBi | HostDB:ENSG00000119699.7 |
GeneCardsi | TGFB3 |
GeneReviewsi | TGFB3 |
HGNCi | HGNC:11769, TGFB3 |
HPAi | ENSG00000119699, Low tissue specificity |
MalaCardsi | TGFB3 |
MIMi | 107970, phenotype 190230, gene 615582, phenotype |
neXtProti | NX_P10600 |
OpenTargetsi | ENSG00000119699 |
Orphaneti | 293899, Familial isolated arrhythmogenic ventricular dysplasia, biventricular form 293888, Familial isolated arrhythmogenic ventricular dysplasia, left dominant form 293910, Familial isolated arrhythmogenic ventricular dysplasia, right dominant form 91387, Familial thoracic aortic aneurysm and aortic dissection |
PharmGKBi | PA36483 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000155747 |
HOGENOMi | CLU_039840_0_0_1 |
InParanoidi | P10600 |
OMAi | CVTMTLS |
PhylomeDBi | P10600 |
TreeFami | TF351793 |
Enzyme and pathway databases
PathwayCommonsi | P10600 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-2129379, Molecules associated with elastic fibres R-HSA-3000178, ECM proteoglycans |
SignaLinki | P10600 |
SIGNORi | P10600 |
Miscellaneous databases
BioGRID-ORCSi | 7043, 4 hits in 853 CRISPR screens |
ChiTaRSi | TGFB3, human |
EvolutionaryTracei | P10600 |
GeneWikii | Transforming_growth_factor,_beta_3 |
GenomeRNAii | 7043 |
Pharosi | P10600, Tbio |
PROi | PR:P10600 |
RNActi | P10600, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000119699, Expressed in left coronary artery and 214 other tissues |
ExpressionAtlasi | P10600, baseline and differential |
Genevisiblei | P10600, HS |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
IDEALi | IID00355 |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR015618, TGFB3 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01426, TGFBETA3 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TGFB3_HUMAN | |
Accessioni | P10600Primary (citable) accession number: P10600 Secondary accession number(s): Q8WV88 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | December 2, 2020 | |
This is version 222 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations