TGFB3

Functionⁱ

Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.By similarity

Latency-associated peptide: Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3 (By similarity). Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3 (By similarity).By similarity

Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus (By similarity). TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3 (By similarity). Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity).By similarity

GO - Molecular functionⁱ

cytokine activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
growth factor activity Source: UniProtKB-KW
identical protein binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 18243111
protein heterodimerization activity Source: Ensembl
transforming growth factor beta binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 18243111
transforming growth factor beta receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
type III transforming growth factor beta receptor binding
Source: AgBase
Inferred from mutant phenotypeⁱ
- 8167376
type II transforming growth factor beta receptor binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 11157754
- 18243111
type I transforming growth factor beta receptor binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 18243111

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of MAPK activity Source: Ensembl
aging Source: Ensembl
cell-cell junction organization
Source: BHF-UCL
Inferred from direct assayⁱ
- 18505915
cell development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
detection of hypoxia
Source: BHF-UCL
Inferred from direct assayⁱ
- 18156205
digestive tract development Source: Ensembl
embryonic neurocranium morphogenesis Source: Ensembl
face morphogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12651933
female pregnancy Source: Ensembl
frontal suture morphogenesis Source: Ensembl
inner ear development Source: Ensembl
in utero embryonic development Source: BHF-UCL
lung alveolus development Source: BHF-UCL
mammary gland development Source: BHF-UCL
negative regulation of cell proliferation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 11158066
negative regulation of macrophage cytokine production
Source: DFLAT
Inferred from direct assayⁱ
- 20875417
negative regulation of neuron apoptotic process Source: BHF-UCL
negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
negative regulation of vascular smooth muscle cell proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- 26315405
odontogenesis
Source: BHF-UCL
Non-traceable author statementⁱ
- 18078367
ossification involved in bone remodeling
Source: BHF-UCL
Inferred from expression patternⁱ
- 17401695
platelet degranulation Source: Reactome
positive regulation of apoptotic process Source: BHF-UCL
positive regulation of bone mineralization
Source: BHF-UCL
Inferred from expression patternⁱ
- 17401695
positive regulation of cell division Source: UniProtKB-KW
positive regulation of cell proliferation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 11158066
positive regulation of collagen biosynthetic process
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 11158066
positive regulation of epithelial to mesenchymal transition
Source: BHF-UCL
Inferred from direct assayⁱ
- 18505915
- 18718461
positive regulation of filopodium assembly Source: BHF-UCL
positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
positive regulation of protein secretion
Source: BHF-UCL
Inferred from direct assayⁱ
- 18505915
positive regulation of SMAD protein signal transduction Source: BHF-UCL
positive regulation of stress fiber assembly
Source: BHF-UCL
Inferred from direct assayⁱ
- 18718461
positive regulation of tight junction disassembly
Source: BHF-UCL
Inferred from direct assayⁱ
- 18718461
positive regulation of transcription, DNA-templated
Source: BHF-UCL
Inferred from direct assayⁱ
- 18156205
positive regulation of transcription by RNA polymerase II Source: BHF-UCL
regulation of apoptotic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of cell proliferation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of MAPK cascade
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to estrogen Source: Ensembl
response to hypoxia
Source: BHF-UCL
Inferred from direct assayⁱ
- 18156205
response to laminar fluid shear stress Source: Ensembl
response to progesterone
Source: BHF-UCL
Inferred from direct assayⁱ
- 18039789
salivary gland morphogenesis
Source: BHF-UCL
Inferred from expression patternⁱ
- 18080134
secondary palate development Source: BHF-UCL
SMAD protein signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transforming growth factor beta receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 11157754
- 18718461
uterine wall breakdown
Source: BHF-UCL
Traceable author statementⁱ
- 18039789
wound healing Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Growth factor, Mitogen

Molecular function

Growth factor, Mitogen

Enzyme and pathway databases

Reactomeⁱ	R-HSA-114608 Platelet degranulation R-HSA-2129379 Molecules associated with elastic fibres R-HSA-3000178 ECM proteoglycans
SignaLinkⁱ	P10600
SIGNORⁱ	P10600

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transforming growth factor beta-3 proprotein Cleaved into the following 2 chains: Latency-associated peptide Short name: LAP Transforming growth factor beta-3 Short name: TGF-beta-3
Gene namesⁱ	Name:TGFB3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000119699.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11769 TGFB3
MIMⁱ	190230 gene
neXtProtⁱ	NX_P10600

Keywords - Cellular componentⁱ

Extracellular matrix, Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Arrhythmogenic right ventricular dysplasia, familial, 1 (ARVD1)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.

Loeys-Dietz syndrome 5 (LDS5)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of Loeys-Dietz syndrome, a syndrome with widespread systemic involvement characterized by arterial tortuosity and aneurysms, hypertelorism, and bifid uvula or cleft palate. LDS5 additional variable features include mitral valve disease, skeletal overgrowth, cervical spine instability, and clubfoot deformity. LDS5 patients do not manifest remarkable aortic or arterial tortuosity, and there is no strong evidence for early aortic dissection.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_070924	409	C → Y in LDS5; hypomorphic mutation; results in impaired TGF-beta signaling. 1 PublicationCorresponds to variant dbSNP:rs398122984EnsemblClinVar.		1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	293	Q → R: Abolishes methylation by N6AMT1. 1 Publication		1

Keywords - Diseaseⁱ

Cardiomyopathy, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7043
GeneReviewsⁱ	TGFB3
MalaCards human disease database More...MalaCardsⁱ	TGFB3
MIMⁱ	107970 phenotype 615582 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000119699
Orphanetⁱ	293899 Familial isolated arrhythmogenic ventricular dysplasia, biventricular form 293888 Familial isolated arrhythmogenic ventricular dysplasia, left dominant form 293910 Familial isolated arrhythmogenic ventricular dysplasia, right dominant form 91387 Familial thoracic aortic aneurysm and aortic dissection
PharmGKBⁱ	PA36483

Chemistry databases

ChEMBLⁱ	CHEMBL3712903

ChEMBLⁱ

CHEMBL3712903

Polymorphism and mutation databases

BioMutaⁱ	TGFB3
DMDMⁱ	135684

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 23	Sequence analysisAdd BLAST	23
ChainⁱPRO_0000033796	24 – 300	Latency-associated peptideBy similarityAdd BLAST	277
ChainⁱPRO_0000033797	301 – 412	Transforming growth factor beta-3By similarityAdd BLAST	112

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	74	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	135	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	142	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	293	N5-methylglutamine1 Publication	1
Disulfide bondⁱ	307 ↔ 316	1 Publication
Disulfide bondⁱ	315 ↔ 378	1 Publication
Disulfide bondⁱ	344 ↔ 409	1 Publication
Disulfide bondⁱ	348 ↔ 411	1 Publication
Disulfide bondⁱ	377	Interchain1 Publication

Post-translational modificationⁱ

Transforming growth factor beta-3 proprotein: The precursor proprotein is cleaved in the Golgi apparatus to form Transforming growth factor beta-3 (TGF-beta-3) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-3 inactive.By similarity

Methylated at Gln-293 by N6AMT1.1 Publication

Keywords - PTMⁱ

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Methylation

Proteomic databases

PaxDbⁱ	P10600
PeptideAtlas More...PeptideAtlasⁱ	P10600
PRIDEⁱ	P10600
ProteomicsDBⁱ	52617

PTM databases

GlyConnectⁱ	1837
iPTMnetⁱ	P10600
PhosphoSitePlusⁱ	P10600

Miscellaneous databases

PMAP-CutDBⁱ	P10600

PMAP-CutDBⁱ

P10600

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000119699 Expressed in 199 organ(s), highest expression level in left coronary artery
CleanExⁱ	HS_TGFB3
ExpressionAtlasⁱ	P10600 baseline and differential
Genevisibleⁱ	P10600 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA063582

HPAⁱ

HPA063582

Interactionⁱ

Subunit structureⁱ

Interacts with ASPN (PubMed:8819159). Latency-associated peptide: Homodimer; disulfide-linked. Latency-associated peptide: Interacts with Transforming growth factor beta-3 (TGF-beta-3) chain; interaction is non-covalent and maintains (TGF-beta-3) in a latent state (By similarity). Latency-associated peptide: Interacts with LRRC32/GARP; leading to regulate activation of TGF-beta-3 and promote epithelial fusion during palate development (By similarity). Latency-associated peptide: Interacts (via cell attachment site) with integrins, leading to release of the active TGF-beta-3 (By similarity). Transforming growth factor beta-3: Homodimer; disulfide-linked (PubMed:8819159). Transforming growth factor beta-3: Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction (By similarity).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		2	EBI-1033020,EBI-1033020
TGFBR2	P37173	8	EBI-1033020,EBI-296151

GO - Molecular functionⁱ

cytokine activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
growth factor activity Source: UniProtKB-KW
identical protein binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 18243111
protein heterodimerization activity Source: Ensembl
transforming growth factor beta binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 18243111
transforming growth factor beta receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
type III transforming growth factor beta receptor binding
Source: AgBase
Inferred from mutant phenotypeⁱ
- 8167376
type II transforming growth factor beta receptor binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 11157754
- 18243111
type I transforming growth factor beta receptor binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 18243111

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112901, 7 interactors
ComplexPortalⁱ	CPX-2544 TGF-beta-3-TGFR complex CPX-606 TGF-beta-3 complex
CORUMⁱ	P10600
Database of interacting proteins More...DIPⁱ	DIP-5937N
IntActⁱ	P10600, 7 interactors
Molecular INTeraction database More...MINTⁱ	P10600
STRINGⁱ	9606.ENSP00000238682

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	265 – 268	Combined sources	4
Helixⁱ	304 – 309	Combined sources	6
Beta strandⁱ	314 – 318	Combined sources	5
Beta strandⁱ	321 – 323	Combined sources	3
Helixⁱ	324 – 328	Combined sources	5
Beta strandⁱ	333 – 335	Combined sources	3
Beta strandⁱ	337 – 340	Combined sources	4
Beta strandⁱ	343 – 346	Combined sources	4
Turnⁱ	350 – 353	Combined sources	4
Helixⁱ	357 – 368	Combined sources	12
Helixⁱ	370 – 372	Combined sources	3
Beta strandⁱ	377 – 380	Combined sources	4
Beta strandⁱ	382 – 392	Combined sources	11
Beta strandⁱ	395 – 406	Combined sources	12
Beta strandⁱ	408 – 412	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	P10600
SMRⁱ	P10600
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P10600

EvolutionaryTraceⁱ

P10600

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	261 – 263	Cell attachment siteBy similarity		3

Sequence similaritiesⁱ

Belongs to the TGF-beta family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3900 Eukaryota ENOG410XT8Z LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143982
HOGENOMⁱ	HOG000290198
HOVERGENⁱ	HBG074115
InParanoidⁱ	P10600
KEGG Orthology (KO) More...KOⁱ	K13377
OMAⁱ	PEPSVMT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BMM
PhylomeDBⁱ	P10600
TreeFamⁱ	TF351793

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR001839 TGF-b_C IPR001111 TGF-b_propeptide IPR016319 TGF-beta IPR015615 TGF-beta-rel IPR015618 TGFB3 IPR017948 TGFb_CS
PANTHERⁱ	PTHR11848 PTHR11848, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00019 TGF_beta, 1 hit PF00688 TGFb_propeptide, 1 hit
PIRSFⁱ	PIRSF001787 TGF-beta, 1 hit
PRINTSⁱ	PR01423 TGFBETA PR01426 TGFBETA3
SMARTⁱ	View protein in SMART SM00204 TGFB, 1 hit
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS00250 TGF_BETA_1, 1 hit PS51362 TGF_BETA_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P10600-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMHLQRALV VLALLNFATV SLSLSTCTTL DFGHIKKKRV EAIRGQILSK 
        60         70         80         90        100
LRLTSPPEPT VMTHVPYQVL ALYNSTRELL EEMHGEREEG CTQENTESEY 
       110        120        130        140        150
YAKEIHKFDM IQGLAEHNEL AVCPKGITSK VFRFNVSSVE KNRTNLFRAE 
       160        170        180        190        200
FRVLRVPNPS SKRNEQRIEL FQILRPDEHI AKQRYIGGKN LPTRGTAEWL 
       210        220        230        240        250
SFDVTDTVRE WLLRRESNLG LEISIHCPCH TFQPNGDILE NIHEVMEIKF 
       260        270        280        290        300
KGVDNEDDHG RGDLGRLKKQ KDHHNPHLIL MMIPPHRLDN PGQGGQRKKR 
       310        320        330        340        350
ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY 
       360        370        380        390        400
LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ 
       410 
LSNMVVKSCK CS

Length:412

Mass (Da):47,328

Last modified:July 1, 1989 - v1

Checksum:ⁱ3CAD3548D3AEA178

GO

Isoform 2 (identifier: P10600-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
310-412: Missing.

« Hide

        10         20         30         40         50
MKMHLQRALV VLALLNFATV SLSLSTCTTL DFGHIKKKRV EAIRGQILSK 
        60         70         80         90        100
LRLTSPPEPT VMTHVPYQVL ALYNSTRELL EEMHGEREEG CTQENTESEY 
       110        120        130        140        150
YAKEIHKFDM IQGLAEHNEL AVCPKGITSK VFRFNVSSVE KNRTNLFRAE 
       160        170        180        190        200
FRVLRVPNPS SKRNEQRIEL FQILRPDEHI AKQRYIGGKN LPTRGTAEWL 
       210        220        230        240        250
SFDVTDTVRE WLLRRESNLG LEISIHCPCH TFQPNGDILE NIHEVMEIKF 
       260        270        280        290        300
KGVDNEDDHG RGDLGRLKKQ KDHHNPHLIL MMIPPHRLDN PGQGGQRKKR 

ALDTNYCFR

Note: No experimental confirmation available.

Show »

Length:309

Mass (Da):35,708

Checksum:ⁱ30F7A936E9467729

GO

Sequence cautionⁱ

The sequence CAA33024 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_016315	60	T → M1 PublicationCorresponds to variant dbSNP:rs4252315EnsemblClinVar.		1
Natural variantⁱVAR_070924	409	C → Y in LDS5; hypomorphic mutation; results in impaired TGF-beta signaling. 1 PublicationCorresponds to variant dbSNP:rs398122984EnsemblClinVar.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056285	310 – 412	Missing in isoform 2. 2 PublicationsAdd BLAST		103

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03241 mRNA Translation: AAA61161.1 X14149 mRNA Translation: CAA32362.1 X14885 X14891 Genomic DNA Translation: CAA33024.1 Different initiation. AY140241 Genomic DNA Translation: AAM96819.1 AY208161 Genomic DNA Translation: AAO13495.1 BT007287 mRNA Translation: AAP35951.1 AF107885 Genomic DNA Translation: AAC79727.1 BC018503 mRNA Translation: AAH18503.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS86415.1 [P10600-2] CCDS9846.1 [P10600-1]
PIRⁱ	A36169
NCBI Reference Sequences More...RefSeqⁱ	NP_001316867.1, NM_001329938.1 [P10600-2] NP_001316868.1, NM_001329939.1 [P10600-1] NP_003230.1, NM_003239.4 [P10600-1]
UniGeneⁱ	Hs.592317 Hs.713281 Hs.736373

Genome annotation databases

Ensemblⁱ	ENST00000238682; ENSP00000238682; ENSG00000119699 [P10600-1] ENST00000556285; ENSP00000451110; ENSG00000119699 [P10600-2]
GeneIDⁱ	7043
KEGGⁱ	hsa:7043
UCSC genome browser More...UCSCⁱ	uc001xsc.3 human [P10600-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P10600	Transforming growth factor beta		HUMAN		412	UniRef100_P10600
Transforming growth factor beta		PANTR		412
Transforming growth factor beta		PONAB		412
Transforming growth factor beta		PANPA		412
Transforming growth factor beta		NOMLE		412
+5

Protein	Similar proteins		Species	Score	Length	Source
P10600	Transforming growth factor beta-3 proprotein		RAT		412	UniRef90_P10600
Transforming growth factor beta-3 proprotein		MOUSE		410
Transforming growth factor beta		HUMAN		412
Transforming growth factor beta		PANTR		412
Transforming growth factor beta		PONAB		412
+102

Protein	Similar proteins		Species	Score	Length	Source
P10600	Transforming growth factor beta-2 proprotein	)	HUMAN		414	UniRef50_P61812
Transforming growth factor beta-2 proprotein		CHLAE		414
Transforming growth factor beta-2 proprotein		PIG		435
Transforming growth factor beta-2 proprotein	)	MOUSE		414
Transforming growth factor beta-2 proprotein		BOVIN		414
+327

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

SeattleSNPs

Wikipedia

TGF beta-3 entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03241 mRNA Translation: AAA61161.1 X14149 mRNA Translation: CAA32362.1 X14885 X14891 Genomic DNA Translation: CAA33024.1 Different initiation. AY140241 Genomic DNA Translation: AAM96819.1 AY208161 Genomic DNA Translation: AAO13495.1 BT007287 mRNA Translation: AAP35951.1 AF107885 Genomic DNA Translation: AAC79727.1 BC018503 mRNA Translation: AAH18503.1
CCDSⁱ	CCDS86415.1 [P10600-2] CCDS9846.1 [P10600-1]
PIRⁱ	A36169
RefSeqⁱ	NP_001316867.1, NM_001329938.1 [P10600-2] NP_001316868.1, NM_001329939.1 [P10600-1] NP_003230.1, NM_003239.4 [P10600-1]
UniGeneⁱ	Hs.592317 Hs.713281 Hs.736373

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1KTZ	X-ray	2.15	A	301-412	[»]
	1TGJ	X-ray	2.00	A	301-412	[»]
	1TGK	X-ray	3.30	A	301-412	[»]
	2PJY	X-ray	3.00	A	301-412	[»]
	3EO1	X-ray	3.10	C/F/I/L	301-412	[»]
	4UM9	X-ray	2.50	E/F	259-269	[»]
ProteinModelPortalⁱ	P10600
SMRⁱ	P10600
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112901, 7 interactors
ComplexPortalⁱ	CPX-2544 TGF-beta-3-TGFR complex CPX-606 TGF-beta-3 complex
CORUMⁱ	P10600
DIPⁱ	DIP-5937N
IntActⁱ	P10600, 7 interactors
MINTⁱ	P10600
STRINGⁱ	9606.ENSP00000238682

Chemistry databases

ChEMBLⁱ	CHEMBL3712903

ChEMBLⁱ

CHEMBL3712903

PTM databases

GlyConnectⁱ	1837
iPTMnetⁱ	P10600
PhosphoSitePlusⁱ	P10600

Polymorphism and mutation databases

BioMutaⁱ	TGFB3
DMDMⁱ	135684

Proteomic databases

PaxDbⁱ	P10600
PeptideAtlasⁱ	P10600
PRIDEⁱ	P10600
ProteomicsDBⁱ	52617

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7043
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000238682; ENSP00000238682; ENSG00000119699 [P10600-1] ENST00000556285; ENSP00000451110; ENSG00000119699 [P10600-2]
GeneIDⁱ	7043
KEGGⁱ	hsa:7043
UCSCⁱ	uc001xsc.3 human [P10600-1]

Organism-specific databases

CTDⁱ	7043
DisGeNETⁱ	7043
EuPathDBⁱ	HostDB:ENSG00000119699.7
GeneCardsⁱ	TGFB3
GeneReviewsⁱ	TGFB3
HGNCⁱ	HGNC:11769 TGFB3
HPAⁱ	HPA063582
MalaCardsⁱ	TGFB3
MIMⁱ	107970 phenotype 190230 gene 615582 phenotype
neXtProtⁱ	NX_P10600
OpenTargetsⁱ	ENSG00000119699
Orphanetⁱ	293899 Familial isolated arrhythmogenic ventricular dysplasia, biventricular form 293888 Familial isolated arrhythmogenic ventricular dysplasia, left dominant form 293910 Familial isolated arrhythmogenic ventricular dysplasia, right dominant form 91387 Familial thoracic aortic aneurysm and aortic dissection
PharmGKBⁱ	PA36483
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3900 Eukaryota ENOG410XT8Z LUCA
GeneTreeⁱ	ENSGT00910000143982
HOGENOMⁱ	HOG000290198
HOVERGENⁱ	HBG074115
InParanoidⁱ	P10600
KOⁱ	K13377
OMAⁱ	PEPSVMT
OrthoDBⁱ	EOG091G0BMM
PhylomeDBⁱ	P10600
TreeFamⁱ	TF351793

Enzyme and pathway databases

Reactomeⁱ	R-HSA-114608 Platelet degranulation R-HSA-2129379 Molecules associated with elastic fibres R-HSA-3000178 ECM proteoglycans
SignaLinkⁱ	P10600
SIGNORⁱ	P10600

Miscellaneous databases

ChiTaRSⁱ	TGFB3 human
EvolutionaryTraceⁱ	P10600
GeneWikiⁱ	Transforming_growth_factor,_beta_3
GenomeRNAiⁱ	7043
PMAP-CutDBⁱ	P10600
Protein Ontology More...PROⁱ	PR:P10600
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000119699 Expressed in 199 organ(s), highest expression level in left coronary artery
CleanExⁱ	HS_TGFB3
ExpressionAtlasⁱ	P10600 baseline and differential
Genevisibleⁱ	P10600 HS

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR001839 TGF-b_C IPR001111 TGF-b_propeptide IPR016319 TGF-beta IPR015615 TGF-beta-rel IPR015618 TGFB3 IPR017948 TGFb_CS
PANTHERⁱ	PTHR11848 PTHR11848, 1 hit
Pfamⁱ	View protein in Pfam PF00019 TGF_beta, 1 hit PF00688 TGFb_propeptide, 1 hit
PIRSFⁱ	PIRSF001787 TGF-beta, 1 hit
PRINTSⁱ	PR01423 TGFBETA PR01426 TGFBETA3
SMARTⁱ	View protein in SMART SM00204 TGFB, 1 hit
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS00250 TGF_BETA_1, 1 hit PS51362 TGF_BETA_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TGFB3_HUMAN
Accessionⁱ	P10600Primary (citable) accession number: P10600 Secondary accession number(s): Q8WV88
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	July 1, 1989
	Last modified:	November 7, 2018
	This is version 207 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM

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UniProtKB - P10600 (TGFB3_HUMAN)

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Transforming growth factor beta-3 proprotein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ