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Protein

Beta-casein

Gene

Csn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Important role in determination of the surface properties of the casein micelles.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMilk protein

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-casein
Gene namesi
Name:Csn2
Synonyms:Csnb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:88541 Csn2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15By similarityAdd BLAST15
ChainiPRO_000000447716 – 231Beta-caseinAdd BLAST216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23PhosphoserineBy similarity1
Modified residuei26PhosphothreonineBy similarity1
Modified residuei28PhosphoserineBy similarity1
Modified residuei30PhosphoserineBy similarity1
Modified residuei31PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP10598
PeptideAtlasiP10598
PRIDEiP10598

PTM databases

PhosphoSitePlusiP10598

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Gene expression databases

BgeeiENSMUSG00000063157 Expressed in 36 organ(s), highest expression level in white adipose tissue
CleanExiMM_CSN2
ExpressionAtlasiP10598 baseline and differential
GenevisibleiP10598 MM

Interactioni

Protein-protein interaction databases

BioGridi198938, 2 interactors
STRINGi10090.ENSMUSP00000080976

Structurei

3D structure databases

ProteinModelPortaliP10598
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-casein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYJE Eukaryota
ENOG411197Z LUCA
GeneTreeiENSGT00390000001890
HOVERGENiHBG004973
InParanoidiP10598
KOiK17107
OMAiEIMEVPK
OrthoDBiEOG091G0XI8
PhylomeDBiP10598
TreeFamiTF336929

Family and domain databases

InterProiView protein in InterPro
IPR001588 Casein
IPR016345 Casein_beta
IPR031305 Casein_CS
PANTHERiPTHR11500 PTHR11500, 1 hit
PfamiView protein in Pfam
PF00363 Casein, 1 hit
PIRSFiPIRSF002372 Beta-casein, 1 hit
PROSITEiView protein in PROSITE
PS00306 CASEIN_ALPHA_BETA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P10598-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVFILACLV ALALARETTF TVSSETDSIS SEESVEHINE QKLQKVNLMG
60 70 80 90 100
QLQAEDVLQA KVHSSIQSQP QAFPYAQAQT ISCNPVPQNI QPIAQPPVVP
110 120 130 140 150
SLGPVISPEL ESFLKAKATI LPKHKQMPLL NSETVLRLIN SQIPSLASLA
160 170 180 190 200
NLHLPQSLVQ LLAQVVQAFP QTHLVSSQTQ LSLPQSKVLY FLQQVAPFLP
210 220 230
QDMSVQDLLQ YLELLNPTVQ FPATPQHSVS V
Length:231
Mass (Da):25,337
Last modified:July 1, 1989 - v1
Checksum:i7DD7DFF0766A9422
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BGL0Q8BGL0_MOUSE
Beta-casein
Csn2 Csnb
230Annotation score:
A0A0G2JF04A0A0G2JF04_MOUSE
Beta-casein
Csn2
215Annotation score:
A0A0G2JE86A0A0G2JE86_MOUSE
Beta-casein
Csn2
223Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3V → T in AAH19189 (PubMed:15489334).Curated1
Sequence conflicti41Missing in BAB32374 (PubMed:16141072).Curated1
Sequence conflicti41Missing in BAB32375 (PubMed:16141072).Curated1
Sequence conflicti41Missing in AAH19114 (PubMed:15489334).Curated1
Sequence conflicti41Missing in AAH19189 (PubMed:15489334).Curated1
Sequence conflicti145S → C in BAB32374 (PubMed:16141072).Curated1
Sequence conflicti156Q → R in AAH13332 (PubMed:15489334).Curated1
Sequence conflicti165 – 166VV → GG in BAB32375 (PubMed:16141072).Curated2
Sequence conflicti192L → V in BAB32374 (PubMed:16141072).Curated1
Sequence conflicti218T → P in BAB32374 (PubMed:16141072).Curated1
Sequence conflicti218T → P in BAB32375 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04490 mRNA Translation: CAA28178.1
X13484 Genomic DNA Translation: CAA31840.1
AK021324 mRNA Translation: BAB32374.1
AK021328 mRNA Translation: BAB32375.1
AK052803 mRNA Translation: BAC35152.1
AK052805 mRNA Translation: BAC35153.1
AK085694 mRNA Translation: BAC39508.1
AK085729 mRNA Translation: BAC39522.1
AK142616 mRNA Translation: BAE25131.1
AK142620 mRNA Translation: BAE25133.1
AK142635 mRNA Translation: BAE25141.1
AK164747 mRNA Translation: BAE37898.1
AK164791 mRNA Translation: BAE37917.1
AK164792 mRNA Translation: BAE37918.1
AK164793 mRNA Translation: BAE37919.1
AK164794 mRNA Translation: BAE37920.1
BC013332 mRNA Translation: AAH13332.1
BC019114 mRNA Translation: AAH19114.1
BC019189 mRNA Translation: AAH19189.1
BC021153 mRNA Translation: AAH21153.1
CCDSiCCDS39131.1
PIRiJU0061
RefSeqiNP_001272949.1, NM_001286020.1
NP_001272950.1, NM_001286021.1
NP_001272952.1, NM_001286023.1
NP_034102.1, NM_009972.2
UniGeneiMm.268737

Genome annotation databases

EnsembliENSMUST00000197422; ENSMUSP00000143341; ENSMUSG00000063157
ENSMUST00000199624; ENSMUSP00000143409; ENSMUSG00000063157
GeneIDi12991
KEGGimmu:12991
UCSCiuc008xyu.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04490 mRNA Translation: CAA28178.1
X13484 Genomic DNA Translation: CAA31840.1
AK021324 mRNA Translation: BAB32374.1
AK021328 mRNA Translation: BAB32375.1
AK052803 mRNA Translation: BAC35152.1
AK052805 mRNA Translation: BAC35153.1
AK085694 mRNA Translation: BAC39508.1
AK085729 mRNA Translation: BAC39522.1
AK142616 mRNA Translation: BAE25131.1
AK142620 mRNA Translation: BAE25133.1
AK142635 mRNA Translation: BAE25141.1
AK164747 mRNA Translation: BAE37898.1
AK164791 mRNA Translation: BAE37917.1
AK164792 mRNA Translation: BAE37918.1
AK164793 mRNA Translation: BAE37919.1
AK164794 mRNA Translation: BAE37920.1
BC013332 mRNA Translation: AAH13332.1
BC019114 mRNA Translation: AAH19114.1
BC019189 mRNA Translation: AAH19189.1
BC021153 mRNA Translation: AAH21153.1
CCDSiCCDS39131.1
PIRiJU0061
RefSeqiNP_001272949.1, NM_001286020.1
NP_001272950.1, NM_001286021.1
NP_001272952.1, NM_001286023.1
NP_034102.1, NM_009972.2
UniGeneiMm.268737

3D structure databases

ProteinModelPortaliP10598
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198938, 2 interactors
STRINGi10090.ENSMUSP00000080976

PTM databases

PhosphoSitePlusiP10598

Proteomic databases

PaxDbiP10598
PeptideAtlasiP10598
PRIDEiP10598

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000197422; ENSMUSP00000143341; ENSMUSG00000063157
ENSMUST00000199624; ENSMUSP00000143409; ENSMUSG00000063157
GeneIDi12991
KEGGimmu:12991
UCSCiuc008xyu.2 mouse

Organism-specific databases

CTDi1447
MGIiMGI:88541 Csn2

Phylogenomic databases

eggNOGiENOG410IYJE Eukaryota
ENOG411197Z LUCA
GeneTreeiENSGT00390000001890
HOVERGENiHBG004973
InParanoidiP10598
KOiK17107
OMAiEIMEVPK
OrthoDBiEOG091G0XI8
PhylomeDBiP10598
TreeFamiTF336929

Miscellaneous databases

ChiTaRSiCsn2 mouse
PROiPR:P10598
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063157 Expressed in 36 organ(s), highest expression level in white adipose tissue
CleanExiMM_CSN2
ExpressionAtlasiP10598 baseline and differential
GenevisibleiP10598 MM

Family and domain databases

InterProiView protein in InterPro
IPR001588 Casein
IPR016345 Casein_beta
IPR031305 Casein_CS
PANTHERiPTHR11500 PTHR11500, 1 hit
PfamiView protein in Pfam
PF00363 Casein, 1 hit
PIRSFiPIRSF002372 Beta-casein, 1 hit
PROSITEiView protein in PROSITE
PS00306 CASEIN_ALPHA_BETA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCASB_MOUSE
AccessioniPrimary (citable) accession number: P10598
Secondary accession number(s): Q543D9
, Q8VCT6, Q8VCU8, Q91VI5, Q922Y5, Q9D1U6, Q9D1U7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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