UniProtKB - P10592 (HSP72_YEAST)
Protein
Heat shock protein SSA2
Gene
SSA2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
May play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum. A functional difference between SSA1 and SSA2 proteins is expected. SSA2 can participate in the ATP-dependent disassembly of clathrin-coated vesicles.1 Publication
Miscellaneous
Present with 364000 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- ATPase activity Source: SGD
- ATP binding Source: SGD
- heat shock protein binding Source: GO_Central
- misfolded protein binding Source: GO_Central
- protein folding chaperone Source: GO_Central
- tRNA binding Source: SGD
- unfolded protein binding Source: SGD
GO - Biological processi
- cellular response to unfolded protein Source: GO_Central
- chaperone cofactor-dependent protein refolding Source: GO_Central
- negative regulation of cell aging Source: SGD
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: SGD
- protein folding Source: SGD
- protein refolding Source: GO_Central
- SRP-dependent cotranslational protein targeting to membrane, translocation Source: SGD
- tRNA import into nucleus Source: SGD
- vesicle-mediated transport Source: GO_Central
Keywordsi
Biological process | Stress response |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-SCE-3371453, Regulation of HSF1-mediated heat shock response R-SCE-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) R-SCE-3371571, HSF1-dependent transactivation R-SCE-6798695, Neutrophil degranulation R-SCE-8856828, Clathrin-mediated endocytosis R-SCE-8876725, Protein methylation |
Names & Taxonomyi
Protein namesi | Recommended name: Heat shock protein SSA2 |
Gene namesi | Name:SSA2 Ordered Locus Names:YLL024C ORF Names:L0931 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003947, SSA2 |
VEuPathDBi | FungiDB:YLL024C |
Subcellular locationi
Cell Wall
- fungal-type cell wall Source: SGD
Cytosol
- cytosol Source: SGD
Extracellular region or secreted
- extracellular region Source: UniProtKB-KW
Mitochondrion
- mitochondrion Source: SGD
Nucleus
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: SGD
Vacuole
- fungal-type vacuole membrane Source: SGD
Other locations
Keywords - Cellular componenti
Cell wall, Cytoplasm, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000078386 | 2 – 639 | Heat shock protein SSA2Add BLAST | 638 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources1 Publication | 1 | |
Modified residuei | 20 | PhosphoserineCombined sources | 1 | |
Modified residuei | 551 | PhosphoserineBy similarity | 1 | |
Cross-linki | 556 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources | ||
Modified residuei | 603 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | P10592 |
PaxDbi | P10592 |
PRIDEi | P10592 |
2D gel databases
COMPLUYEAST-2DPAGEi | P10592 |
SWISS-2DPAGEi | P10592 |
PTM databases
CarbonylDBi | P10592 |
iPTMneti | P10592 |
Interactioni
Subunit structurei
Binds human HTN3/histatin-5, a peptide from saliva, and mediates its fungicidal activity.
Interacts with NAP1.
2 PublicationsBinary interactionsi
Hide detailsP10592
GO - Molecular functioni
- heat shock protein binding Source: GO_Central
- misfolded protein binding Source: GO_Central
- unfolded protein binding Source: SGD
Protein-protein interaction databases
BioGRIDi | 31229, 465 interactors |
ComplexPortali | CPX-1276, HMC complex CPX-1883, HAP1 transcriptional repressor complex, SSA2 variant |
DIPi | DIP-2265N |
IntActi | P10592, 972 interactors |
MINTi | P10592 |
STRINGi | 4932.YLL024C |
Miscellaneous databases
RNActi | P10592, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the heat shock protein 70 family.Curated
Phylogenomic databases
eggNOGi | KOG0101, Eukaryota |
GeneTreei | ENSGT00940000176322 |
HOGENOMi | CLU_005965_7_0_1 |
InParanoidi | P10592 |
OMAi | HIEVEYK |
Family and domain databases
Gene3Di | 1.20.1270.10, 1 hit 2.60.34.10, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR018181, Heat_shock_70_CS IPR029048, HSP70_C_sf IPR029047, HSP70_peptide-bd_sf IPR013126, Hsp_70_fam |
PANTHERi | PTHR19375, PTHR19375, 1 hit |
Pfami | View protein in Pfam PF00012, HSP70, 1 hit |
SUPFAMi | SSF100920, SSF100920, 1 hit SSF100934, SSF100934, 1 hit SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00297, HSP70_1, 1 hit PS00329, HSP70_2, 1 hit PS01036, HSP70_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P10592-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKAVGIDLG TTYSCVAHFS NDRVDIIAND QGNRTTPSFV GFTDTERLIG
60 70 80 90 100
DAAKNQAAMN PANTVFDAKR LIGRNFNDPE VQGDMKHFPF KLIDVDGKPQ
110 120 130 140 150
IQVEFKGETK NFTPEQISSM VLGKMKETAE SYLGAKVNDA VVTVPAYFND
160 170 180 190 200
SQRQATKDAG TIAGLNVLRI INEPTAAAIA YGLDKKGKEE HVLIFDLGGG
210 220 230 240 250
TFDVSLLSIE DGIFEVKATA GDTHLGGEDF DNRLVNHFIQ EFKRKNKKDL
260 270 280 290 300
STNQRALRRL RTACERAKRT LSSSAQTSVE IDSLFEGIDF YTSITRARFE
310 320 330 340 350
ELCADLFRST LDPVEKVLRD AKLDKSQVDE IVLVGGSTRI PKVQKLVTDY
360 370 380 390 400
FNGKEPNRSI NPDEAVAYGA AVQAAILTGD ESSKTQDLLL LDVAPLSLGI
410 420 430 440 450
ETAGGVMTKL IPRNSTIPTK KSEVFSTYAD NQPGVLIQVF EGERAKTKDN
460 470 480 490 500
NLLGKFELSG IPPAPRGVPQ IEVTFDVDSN GILNVSAVEK GTGKSNKITI
510 520 530 540 550
TNDKGRLSKE DIEKMVAEAE KFKEEDEKES QRIASKNQLE SIAYSLKNTI
560 570 580 590 600
SEAGDKLEQA DKDAVTKKAE ETIAWLDSNT TATKEEFDDQ LKELQEVANP
610 620 630
IMSKLYQAGG APEGAAPGGF PGGAPPAPEA EGPTVEEVD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X12927 Genomic DNA Translation: CAA31394.1 Z73129 Genomic DNA Translation: CAA97472.1 X97560 Genomic DNA Translation: CAA66167.1 BK006945 Genomic DNA Translation: DAA09296.1 |
PIRi | S20139 |
RefSeqi | NP_013076.1, NM_001181844.1 |
Genome annotation databases
EnsemblFungii | YLL024C_mRNA; YLL024C; YLL024C |
GeneIDi | 850636 |
KEGGi | sce:YLL024C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X12927 Genomic DNA Translation: CAA31394.1 Z73129 Genomic DNA Translation: CAA97472.1 X97560 Genomic DNA Translation: CAA66167.1 BK006945 Genomic DNA Translation: DAA09296.1 |
PIRi | S20139 |
RefSeqi | NP_013076.1, NM_001181844.1 |
3D structure databases
SMRi | P10592 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 31229, 465 interactors |
ComplexPortali | CPX-1276, HMC complex CPX-1883, HAP1 transcriptional repressor complex, SSA2 variant |
DIPi | DIP-2265N |
IntActi | P10592, 972 interactors |
MINTi | P10592 |
STRINGi | 4932.YLL024C |
PTM databases
CarbonylDBi | P10592 |
iPTMneti | P10592 |
2D gel databases
COMPLUYEAST-2DPAGEi | P10592 |
SWISS-2DPAGEi | P10592 |
Proteomic databases
MaxQBi | P10592 |
PaxDbi | P10592 |
PRIDEi | P10592 |
Genome annotation databases
EnsemblFungii | YLL024C_mRNA; YLL024C; YLL024C |
GeneIDi | 850636 |
KEGGi | sce:YLL024C |
Organism-specific databases
SGDi | S000003947, SSA2 |
VEuPathDBi | FungiDB:YLL024C |
Phylogenomic databases
eggNOGi | KOG0101, Eukaryota |
GeneTreei | ENSGT00940000176322 |
HOGENOMi | CLU_005965_7_0_1 |
InParanoidi | P10592 |
OMAi | HIEVEYK |
Enzyme and pathway databases
Reactomei | R-SCE-3371453, Regulation of HSF1-mediated heat shock response R-SCE-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) R-SCE-3371571, HSF1-dependent transactivation R-SCE-6798695, Neutrophil degranulation R-SCE-8856828, Clathrin-mediated endocytosis R-SCE-8876725, Protein methylation |
Miscellaneous databases
PROi | PR:P10592 |
RNActi | P10592, protein |
Family and domain databases
Gene3Di | 1.20.1270.10, 1 hit 2.60.34.10, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR018181, Heat_shock_70_CS IPR029048, HSP70_C_sf IPR029047, HSP70_peptide-bd_sf IPR013126, Hsp_70_fam |
PANTHERi | PTHR19375, PTHR19375, 1 hit |
Pfami | View protein in Pfam PF00012, HSP70, 1 hit |
SUPFAMi | SSF100920, SSF100920, 1 hit SSF100934, SSF100934, 1 hit SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00297, HSP70_1, 1 hit PS00329, HSP70_2, 1 hit PS01036, HSP70_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HSP72_YEAST | |
Accessioni | P10592Primary (citable) accession number: P10592 Secondary accession number(s): D6VXY0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 224 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XII
Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names - SIMILARITY comments
Index of protein domains and families