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Protein

Heat shock protein SSA1

Gene

SSA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum. A functional difference between SSA1 and SSA2 proteins is expected. SSA1 can participate in the ATP-dependent disassembly of clathrin-coated vesicles.1 Publication

Miscellaneous

Present with 269000 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • ATPase activity Source: SGD
  • ATP binding Source: UniProtKB-KW
  • tRNA binding Source: SGD
  • unfolded protein binding Source: SGD

GO - Biological processi

Keywordsi

Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-28819-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein SSA1
Alternative name(s):
Heat shock protein YG100
Gene namesi
Name:SSA1
Ordered Locus Names:YAL005C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAL005C
SGDiS000000004 SSA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell wall, Cytoplasm, Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5186

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000783852 – 642Heat shock protein SSA1Add BLAST641

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei62PhosphoserineCombined sources1
Modified residuei551PhosphoserineCombined sources1
Cross-linki556Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei603PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP10591
PaxDbiP10591
PRIDEiP10591

2D gel databases

COMPLUYEAST-2DPAGEiP10591
SWISS-2DPAGEiP10591

PTM databases

CarbonylDBiP10591
iPTMnetiP10591

Interactioni

Subunit structurei

Binds human HTN3/histatin-5, a peptide from saliva, and mediates its fungicidal activity. Interacts with polyadenylate-binding protein PAB1 and Hsp70 chaperone SSA1 on translating ribosomes. Interacts with NAP1.3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi31786, 793 interactors
ComplexPortaliCPX-1276 HMC complex
CPX-1882 HAP1 transcriptional repressor complex - variant 1
DIPiDIP-2253N
IntActiP10591, 583 interactors
MINTiP10591
STRINGi4932.YAL005C

Structurei

3D structure databases

ProteinModelPortaliP10591
SMRiP10591
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10591

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

GeneTreeiENSGT00920000149212
HOGENOMiHOG000228135
InParanoidiP10591
KOiK03283
OMAiAYTKNQD
OrthoDBiEOG092C1VPN

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10591-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKAVGIDLG TTYSCVAHFA NDRVDIIAND QGNRTTPSFV AFTDTERLIG
60 70 80 90 100
DAAKNQAAMN PSNTVFDAKR LIGRNFNDPE VQADMKHFPF KLIDVDGKPQ
110 120 130 140 150
IQVEFKGETK NFTPEQISSM VLGKMKETAE SYLGAKVNDA VVTVPAYFND
160 170 180 190 200
SQRQATKDAG TIAGLNVLRI INEPTAAAIA YGLDKKGKEE HVLIFDLGGG
210 220 230 240 250
TFDVSLLSIE DGIFEVKATA GDTHLGGEDF DNRLVNHFIQ EFKRKNKKDL
260 270 280 290 300
STNQRALRRL RTACERAKRT LSSSAQTSVE IDSLFEGIDF YTSITRARFE
310 320 330 340 350
ELCADLFRST LDPVEKVLRD AKLDKSQVDE IVLVGGSTRI PKVQKLVTDY
360 370 380 390 400
FNGKEPNRSI NPDEAVAYGA AVQAAILTGD ESSKTQDLLL LDVAPLSLGI
410 420 430 440 450
ETAGGVMTKL IPRNSTIPTK KSEIFSTYAD NQPGVLIQVF EGERAKTKDN
460 470 480 490 500
NLLGKFELSG IPPAPRGVPQ IEVTFDVDSN GILNVSAVEK GTGKSNKITI
510 520 530 540 550
TNDKGRLSKE DIEKMVAEAE KFKEEDEKES QRIASKNQLE SIAYSLKNTI
560 570 580 590 600
SEAGDKLEQA DKDTVTKKAE ETISWLDSNT TASKEEFDDK LKELQDIANP
610 620 630 640
IMSKLYQAGG APGGAAGGAP GGFPGGAPPA PEAEGPTVEE VD
Length:642
Mass (Da):69,657
Last modified:January 23, 2007 - v4
Checksum:i249D8A3BC42527CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti208S → F in AAC04952 (PubMed:7941740).Curated1
Sequence conflicti418P → S in AAC04952 (PubMed:7941740).Curated1
Sequence conflicti422S → F in AAC04952 (PubMed:7941740).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12926 Genomic DNA Translation: CAA31393.1
L22015 Genomic DNA Translation: AAC04952.1
BK006935 Genomic DNA Translation: DAA06982.1
PIRiS43449 HHBYA1
RefSeqiNP_009396.2, NM_001178151.1

Genome annotation databases

EnsemblFungiiYAL005C; YAL005C; YAL005C
GeneIDi851259
KEGGisce:YAL005C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12926 Genomic DNA Translation: CAA31393.1
L22015 Genomic DNA Translation: AAC04952.1
BK006935 Genomic DNA Translation: DAA06982.1
PIRiS43449 HHBYA1
RefSeqiNP_009396.2, NM_001178151.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LCAX-ray2.19Q631-642[»]
5LYNX-ray2.00C/D636-642[»]
ProteinModelPortaliP10591
SMRiP10591
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31786, 793 interactors
ComplexPortaliCPX-1276 HMC complex
CPX-1882 HAP1 transcriptional repressor complex - variant 1
DIPiDIP-2253N
IntActiP10591, 583 interactors
MINTiP10591
STRINGi4932.YAL005C

Chemistry databases

ChEMBLiCHEMBL5186

PTM databases

CarbonylDBiP10591
iPTMnetiP10591

2D gel databases

COMPLUYEAST-2DPAGEiP10591
SWISS-2DPAGEiP10591

Proteomic databases

MaxQBiP10591
PaxDbiP10591
PRIDEiP10591

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYAL005C; YAL005C; YAL005C
GeneIDi851259
KEGGisce:YAL005C

Organism-specific databases

EuPathDBiFungiDB:YAL005C
SGDiS000000004 SSA1

Phylogenomic databases

GeneTreeiENSGT00920000149212
HOGENOMiHOG000228135
InParanoidiP10591
KOiK03283
OMAiAYTKNQD
OrthoDBiEOG092C1VPN

Enzyme and pathway databases

BioCyciYEAST:G3O-28819-MONOMER

Miscellaneous databases

EvolutionaryTraceiP10591
PROiPR:P10591

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHSP71_YEAST
AccessioniPrimary (citable) accession number: P10591
Secondary accession number(s): D6VPL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 206 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names
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Main funding by: National Institutes of Health

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