NR2F1

Functionⁱ

Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG.2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	83 – 158	Nuclear receptorPROSITE-ProRule annotationAdd BLAST	76
Zinc fingerⁱ	86 – 106	NR C4-typePROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	122 – 146	NR C4-typePROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- Ref.6
  "Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor."
  Zhang Y., Dufau M.L.
  J. Biol. Chem. 275:2763-2770(2000) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION.
DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- Ref.6
  "Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor."
  Zhang Y., Dufau M.L.
  J. Biol. Chem. 275:2763-2770(2000) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION.
nuclear receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
retinoic acid-responsive element binding Source: Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- Ref.6
  "Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor."
  Zhang Y., Dufau M.L.
  J. Biol. Chem. 275:2763-2770(2000) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION.
sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- Ref.6
  "Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor."
  Zhang Y., Dufau M.L.
  J. Biol. Chem. 275:2763-2770(2000) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION.
sequence-specific double-stranded DNA binding
Source: ARUK-UCL
Inferred from direct assayⁱ
- "Impact of cytosine methylation on DNA binding specificities of human transcription factors."
  Yin Y., Morgunova E., Jolma A., Kaasinen E., Sahu B., Khund-Sayeed S., Das P.K., Kivioja T., Dave K., Zhong F., Nitta K.R., Taipale M., Popov A., Ginno P.A., Domcke S., Yan J., Schubeler D., Vinson C., Taipale J.
  Science 356:0-0(2017) [PubMed] [Europe PMC] [Abstract]
zinc ion binding Source: InterPro

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Receptor, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

PathwayCommonsⁱ	P10589
Reactomeⁱ	R-HSA-383280, Nuclear Receptor transcription pathway
SignaLinkⁱ	P10589
SIGNORⁱ	P10589

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: COUP transcription factor 1 Short name: COUP-TF1 Alternative name(s): COUP transcription factor I Short name: COUP-TF I Nuclear receptor subfamily 2 group F member 1 V-erbA-related protein 3 Short name: EAR-3
Gene namesⁱ	Name:NR2F1 Synonyms:EAR3, ERBAL3, TFCOUP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7975, NR2F1
MIMⁱ	132890, gene
neXtProtⁱ	NX_P10589
VEuPathDBⁱ	HostDB:ENSG00000175745.11

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Bosch-Boonstra-Schaaf optic atrophy syndrome (BBSOAS)1 Publication

The disease is caused by variants affecting the gene represented in this entry.

Disease descriptionAn autosomal dominant disorder characterized by optic atrophy associated with developmental delay and intellectual disability. Most patients also have evidence of cerebral visual impairment.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_071319	112	R → K in BBSOAS; decreases transcriptional activity. 1 PublicationCorresponds to variant dbSNP:rs587777277EnsemblClinVar.	1
Natural variantⁱVAR_071320	113	S → R in BBSOAS; decreases transcriptional activity. 1 PublicationCorresponds to variant dbSNP:rs587777275EnsemblClinVar.	1
Natural variantⁱVAR_071321	115	R → P in BBSOAS; decreases transcriptional activity. 1 PublicationCorresponds to variant dbSNP:rs587777274EnsemblClinVar.	1
Natural variantⁱVAR_071322	252	L → P in BBSOAS; decreases transcriptional activity. 1 PublicationCorresponds to variant dbSNP:rs587777276EnsemblClinVar.	1

Keywords - Diseaseⁱ

Disease variant

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7025
MalaCards human disease database More...MalaCardsⁱ	NR2F1
MIMⁱ	615722, phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000175745
Orphanetⁱ	401777, Optic atrophy-intellectual disability syndrome
PharmGKBⁱ	PA31758

Miscellaneous databases

Pharosⁱ	P10589, Tbio

Pharosⁱ

P10589, Tbio

Chemistry databases

ChEMBLⁱ	CHEMBL1961789
Drug and drug target database More...DrugBankⁱ	DB06732, beta-Naphthoflavone

Genetic variation databases

BioMutaⁱ	NR2F1
DMDMⁱ	116959

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053602	1 – 423	COUP transcription factor 1Add BLAST		423

Proteomic databases

EPDⁱ	P10589
jPOSTⁱ	P10589
MassIVEⁱ	P10589
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P10589
PaxDbⁱ	P10589
PeptideAtlas More...PeptideAtlasⁱ	P10589
PRIDEⁱ	P10589
ProteomicsDBⁱ	52615

PTM databases

iPTMnetⁱ	P10589
PhosphoSitePlusⁱ	P10589

Expressionⁱ

Inductionⁱ

Inhibited by gonadotropin in granulosa cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000175745, Expressed in metanephros and 231 other tissues
ExpressionAtlasⁱ	P10589, baseline and differential
Genevisibleⁱ	P10589, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000175745, Low tissue specificity

HPAⁱ

ENSG00000175745, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Binds DNA as dimer; homodimer and probable heterodimer with NR2F6 (PubMed:11682620).

Interacts with GTF2B; this interaction is direct (PubMed:1517211).

Interacts with COPS2 (PubMed:10207062).

3 Publications

Protein-protein interaction databases

BioGRIDⁱ	112883, 38 interactors
Database of interacting proteins More...DIPⁱ	DIP-622N
IntActⁱ	P10589, 11 interactors
Molecular INTeraction database More...MINTⁱ	P10589
STRINGⁱ	9606.ENSP00000325819

Chemistry databases

BindingDBⁱ

P10589

Miscellaneous databases

RNActⁱ	P10589, protein

RNActⁱ

P10589, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	87 – 89	Combined sources	3
Beta strandⁱ	95 – 97	Combined sources	3
Helixⁱ	104 – 114	Combined sources	11
Turnⁱ	115 – 117	Combined sources	3
Beta strandⁱ	132 – 136	Combined sources	5
Helixⁱ	140 – 149	Combined sources	10
Helixⁱ	153 – 156	Combined sources	4

Show more details

3D structure databases

SMRⁱ	P10589
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P10589

EvolutionaryTraceⁱ

P10589

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	184 – 410	NR LBDPROSITE-ProRule annotationAdd BLAST		227

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	32 – 36	Poly-Gly		5

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR2 subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	86 – 106	NR C4-typePROSITE-ProRule annotationAdd BLAST		21
Zinc fingerⁱ	122 – 146	NR C4-typePROSITE-ProRule annotationAdd BLAST		25

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3575, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000157876
InParanoidⁱ	P10589
OMAⁱ	HHVIKED
Database of Orthologous Groups More...OrthoDBⁱ	666130at2759
PhylomeDBⁱ	P10589
TreeFamⁱ	TF352097

Family and domain databases

Gene3Dⁱ	1.10.565.10, 1 hit 3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit
PRINTSⁱ	PR00398, STRDHORMONER PR00047, STROIDFINGER
SMARTⁱ	View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508, SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P10589-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAMVVSSWRD PQDDVAGGNP GGPNPAAQAA RGGGGGAGEQ QQQAGSGAPH 
        60         70         80         90        100
TPQTPGQPGA PATPGTAGDK GQGPPGSGQS QQHIECVVCG DKSSGKHYGQ 
       110        120        130        140        150
FTCEGCKSFF KRSVRRNLTY TCRANRNCPI DQHHRNQCQY CRLKKCLKVG 
       160        170        180        190        200
MRREAVQRGR MPPTQPNPGQ YALTNGDPLN GHCYLSGYIS LLLRAEPYPT 
       210        220        230        240        250
SRYGSQCMQP NNIMGIENIC ELAARLLFSA VEWARNIPFF PDLQITDQVS 
       260        270        280        290        300
LLRLTWSELF VLNAAQCSMP LHVAPLLAAA GLHASPMSAD RVVAFMDHIR 
       310        320        330        340        350
IFQEQVEKLK ALHVDSAEYS CLKAIVLFTS DACGLSDAAH IESLQEKSQC 
       360        370        380        390        400
ALEEYVRSQY PNQPSRFGKL LLRLPSLRTV SSSVIEQLFF VRLVGKTPIE 
       410        420 
TLIRDMLLSG SSFNWPYMSI QCS

Length:423

Mass (Da):46,156

Last modified:July 1, 1989 - v1

Checksum:ⁱ6EE634BE96242731

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F1DAL9	F1DAL9_HUMAN	COUP transcription factor 1 COUP transcription factor 1 (Ovalbumin upstream promoter-transcription factor I)	NR2F1	398	Annotation score:
F1DAL7	F1DAL7_HUMAN	COUP transcription factor 1 COUP transcription factor 1 (Ovalbumin upstream promoter-transcription factor I)	NR2F1	372	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_078708	110	Missing Probable disease-associated variant found in a patient with early infantile epileptic encephalopathy. 1 Publication	1
Natural variantⁱVAR_071319	112	R → K in BBSOAS; decreases transcriptional activity. 1 PublicationCorresponds to variant dbSNP:rs587777277EnsemblClinVar.	1
Natural variantⁱVAR_071320	113	S → R in BBSOAS; decreases transcriptional activity. 1 PublicationCorresponds to variant dbSNP:rs587777275EnsemblClinVar.	1
Natural variantⁱVAR_071321	115	R → P in BBSOAS; decreases transcriptional activity. 1 PublicationCorresponds to variant dbSNP:rs587777274EnsemblClinVar.	1
Natural variantⁱVAR_071322	252	L → P in BBSOAS; decreases transcriptional activity. 1 PublicationCorresponds to variant dbSNP:rs587777276EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X16155 mRNA Translation: CAA34277.1 X12795 Genomic DNA Translation: CAA31283.1 BC004154 mRNA Translation: AAH04154.1 BC017493 mRNA Translation: AAH17493.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4068.1
PIRⁱ	S02710
NCBI Reference Sequences More...RefSeqⁱ	NP_005645.1, NM_005654.5

Genome annotation databases

Ensemblⁱ	ENST00000327111; ENSP00000325819; ENSG00000175745
GeneIDⁱ	7025
KEGGⁱ	hsa:7025
UCSC genome browser More...UCSCⁱ	uc003kkj.4, human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P10589	COUP transcription factor 1		MACMU		423	UniRef100_P10589
Uncharacterized protein		CEBIM		423
Nuclear receptor subfamily 2 group F member 1		CALJA		423
NR2F1 isoform 1		PONAB		423
Nuclear receptor subfamily 2 group F member 1		PANTR		423
+8

Protein	Similar proteins		Species	Score	Length	Source
P10589	COUP transcription factor 1		MOUSE		422	UniRef90_P10589
COUP transcription factor 1		MACMU		423
Uncharacterized protein		CEBIM		423
Nuclear receptor subfamily 2 group F member 1		CALJA		423
NR2F1 isoform 1		PONAB		423
+44

Protein	Similar proteins		Species	Score	Length	Source
P10589	COUP transcription factor 2	)	HUMAN		414	UniRef50_P24468
COUP transcription factor 2		MOUSE		414
COUP transcription factor 2		BOVIN		414
Nuclear receptor subfamily 2 group F member 1-A		DANRE		411
Nuclear receptor subfamily 2 group F member 2		PANTR		414
+576

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X16155 mRNA Translation: CAA34277.1 X12795 Genomic DNA Translation: CAA31283.1 BC004154 mRNA Translation: AAH04154.1 BC017493 mRNA Translation: AAH17493.1
CCDSⁱ	CCDS4068.1
PIRⁱ	S02710
RefSeqⁱ	NP_005645.1, NM_005654.5

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2EBL	NMR	-	A	84-159	[»]
SMRⁱ	P10589
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	112883, 38 interactors
DIPⁱ	DIP-622N
IntActⁱ	P10589, 11 interactors
MINTⁱ	P10589
STRINGⁱ	9606.ENSP00000325819

Chemistry databases

BindingDBⁱ	P10589
ChEMBLⁱ	CHEMBL1961789
DrugBankⁱ	DB06732, beta-Naphthoflavone

PTM databases

iPTMnetⁱ	P10589
PhosphoSitePlusⁱ	P10589

Genetic variation databases

BioMutaⁱ	NR2F1
DMDMⁱ	116959

Proteomic databases

EPDⁱ	P10589
jPOSTⁱ	P10589
MassIVEⁱ	P10589
MaxQBⁱ	P10589
PaxDbⁱ	P10589
PeptideAtlasⁱ	P10589
PRIDEⁱ	P10589
ProteomicsDBⁱ	52615

Protocols and materials databases

Antibodypediaⁱ	24914, 268 antibodies
The DNASU plasmid repository More...DNASUⁱ	7025

Genome annotation databases

Ensemblⁱ	ENST00000327111; ENSP00000325819; ENSG00000175745
GeneIDⁱ	7025
KEGGⁱ	hsa:7025
UCSCⁱ	uc003kkj.4, human

Organism-specific databases

CTDⁱ	7025
DisGeNETⁱ	7025
GeneCardsⁱ	NR2F1
HGNCⁱ	HGNC:7975, NR2F1
HPAⁱ	ENSG00000175745, Low tissue specificity
MalaCardsⁱ	NR2F1
MIMⁱ	132890, gene 615722, phenotype
neXtProtⁱ	NX_P10589
OpenTargetsⁱ	ENSG00000175745
Orphanetⁱ	401777, Optic atrophy-intellectual disability syndrome
PharmGKBⁱ	PA31758
VEuPathDBⁱ	HostDB:ENSG00000175745.11
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3575, Eukaryota
GeneTreeⁱ	ENSGT00940000157876
InParanoidⁱ	P10589
OMAⁱ	HHVIKED
OrthoDBⁱ	666130at2759
PhylomeDBⁱ	P10589
TreeFamⁱ	TF352097

Enzyme and pathway databases

PathwayCommonsⁱ	P10589
Reactomeⁱ	R-HSA-383280, Nuclear Receptor transcription pathway
SignaLinkⁱ	P10589
SIGNORⁱ	P10589

Miscellaneous databases

BioGRID-ORCSⁱ	7025, 8 hits in 1011 CRISPR screens
ChiTaRSⁱ	NR2F1, human
EvolutionaryTraceⁱ	P10589
GeneWikiⁱ	COUP-TFI
GenomeRNAiⁱ	7025
Pharosⁱ	P10589, Tbio
Protein Ontology More...PROⁱ	PR:P10589
RNActⁱ	P10589, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000175745, Expressed in metanephros and 231 other tissues
ExpressionAtlasⁱ	P10589, baseline and differential
Genevisibleⁱ	P10589, HS

Family and domain databases

Gene3Dⁱ	1.10.565.10, 1 hit 3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit
PRINTSⁱ	PR00398, STRDHORMONER PR00047, STROIDFINGER
SMARTⁱ	View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508, SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	COT1_HUMAN
Accessionⁱ	P10589Primary (citable) accession number: P10589
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	July 1, 1989
	Last modified:	April 7, 2021
	This is version 212 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing, Reference proteome

Documents

Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P10589 (COT1_HUMAN)

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COUP transcription factor 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ