UniProtKB - P10588 (NR2F6_HUMAN)
Protein
Nuclear receptor subfamily 2 group F member 6
Gene
NR2F6
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4+ T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).4 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 53 – 128 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 76 | |
Zinc fingeri | 56 – 76 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 92 – 116 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
- nuclear receptor activity Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: UniProtKB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- zinc ion binding Source: InterPro
GO - Biological processi
- anatomical structure development Source: GO_Central
- cell differentiation Source: GO_Central
- detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
- entrainment of circadian clock by photoperiod Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- neuron development Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
- transcription initiation from RNA polymerase II promoter Source: Reactome
Keywordsi
Molecular function | DNA-binding, Receptor, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P10588 |
Reactomei | R-HSA-383280, Nuclear Receptor transcription pathway |
SignaLinki | P10588 |
SIGNORi | P10588 |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear receptor subfamily 2 group F member 6Alternative name(s): V-erbA-related protein 2 Short name: EAR-2 |
Gene namesi | Name:NR2F6 Synonyms:EAR2, ERBAL2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000160113.5 |
HGNCi | HGNC:7977, NR2F6 |
MIMi | 132880, gene |
neXtProti | NX_P10588 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation2 Publications
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 74 – 78 | EGCKS → GSCKV: Loss of DNA (TRE) binding. Reduces the corepressor activity towards THRB. 1 Publication | 5 |
Organism-specific databases
DisGeNETi | 2063 |
OpenTargetsi | ENSG00000160113 |
PharmGKBi | PA31760 |
Miscellaneous databases
Pharosi | P10588, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1961791 |
Polymorphism and mutation databases
BioMutai | NR2F6 |
DMDMi | 23503053 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053613 | 1 – 404 | Nuclear receptor subfamily 2 group F member 6Add BLAST | 404 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 34 | PhosphoserineBy similarity | 1 | |
Modified residuei | 40 | PhosphoserineCombined sources | 1 | |
Modified residuei | 83 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P10588 |
jPOSTi | P10588 |
MassIVEi | P10588 |
MaxQBi | P10588 |
PaxDbi | P10588 |
PeptideAtlasi | P10588 |
PRIDEi | P10588 |
ProteomicsDBi | 52614 |
PTM databases
iPTMneti | P10588 |
PhosphoSitePlusi | P10588 |
Expressioni
Tissue specificityi
Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas.1 Publication
Inductioni
Inhibited by gonadotropin in granulosa cells.1 Publication
Gene expression databases
Bgeei | ENSG00000160113, Expressed in vagina and 235 other tissues |
ExpressionAtlasi | P10588, baseline and differential |
Genevisiblei | P10588, HS |
Organism-specific databases
HPAi | ENSG00000160113, Low tissue specificity |
Interactioni
Subunit structurei
Binds DNA as dimer; homodimer and heterodimer with NR2F2 and probably NR2F1 (By similarity).
Interacts with THRB.
By similarity2 PublicationsBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 108375, 28 interactors |
IntActi | P10588, 24 interactors |
MINTi | P10588 |
STRINGi | 9606.ENSP00000291442 |
Miscellaneous databases
RNActi | P10588, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 165 – 393 | NR LBDPROSITE-ProRule annotationAdd BLAST | 229 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 327 – 404 | Important for dimerizationBy similarityAdd BLAST | 78 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 56 – 76 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 92 – 116 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000160748 |
HOGENOMi | CLU_007368_20_1_1 |
InParanoidi | P10588 |
OMAi | NWPYAAG |
OrthoDBi | 666130at2759 |
PhylomeDBi | P10588 |
TreeFami | TF352097 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P10588-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAMVTGGWGG PGGDTNGVDK AGGYPRAAED DSASPPGAAS DAEPGDEERP
60 70 80 90 100
GLQVDCVVCG DKSSGKHYGV FTCEGCKSFF KRSIRRNLSY TCRSNRDCQI
110 120 130 140 150
DQHHRNQCQY CRLKKCFRVG MRKEAVQRGR IPHSLPGAVA ASSGSPPGSA
160 170 180 190 200
LAAVASGGDL FPGQPVSELI AQLLRAEPYP AAAGRFGAGG GAAGAVLGID
210 220 230 240 250
NVCELAARLL FSTVEWARHA PFFPELPVAD QVALLRLSWS ELFVLNAAQA
260 270 280 290 300
ALPLHTAPLL AAAGLHAAPM AAERAVAFMD QVRAFQEQVD KLGRLQVDSA
310 320 330 340 350
EYGCLKAIAL FTPDACGLSD PAHVESLQEK AQVALTEYVR AQYPSQPQRF
360 370 380 390 400
GRLLLRLPAL RAVPASLISQ LFFMRLVGKT PIETLIRDML LSGSTFNWPY
GSGQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM0R175 | M0R175_HUMAN | Nuclear receptor subfamily 2 group ... | NR2F6 | 125 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 83 | S → T in CAA31282 (PubMed:2905047).Curated | 1 | |
Sequence conflicti | 220 – 221 | AP → G in CAA31282 (PubMed:2905047).Curated | 2 | |
Sequence conflicti | 237 | L → M in CAA31282 (PubMed:2905047).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X12794 Genomic DNA Translation: CAA31282.1 AK314961 mRNA Translation: BAG37465.1 CH471106 Genomic DNA Translation: EAW84580.1 BC002669 mRNA Translation: AAH02669.3 BC063018 mRNA Translation: AAH63018.2 BC084544 mRNA Translation: AAH84544.2 |
CCDSi | CCDS12352.1 |
PIRi | S02709 |
RefSeqi | NP_005225.2, NM_005234.3 |
Genome annotation databases
Ensembli | ENST00000291442; ENSP00000291442; ENSG00000160113 |
GeneIDi | 2063 |
KEGGi | hsa:2063 |
UCSCi | uc002nfq.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X12794 Genomic DNA Translation: CAA31282.1 AK314961 mRNA Translation: BAG37465.1 CH471106 Genomic DNA Translation: EAW84580.1 BC002669 mRNA Translation: AAH02669.3 BC063018 mRNA Translation: AAH63018.2 BC084544 mRNA Translation: AAH84544.2 |
CCDSi | CCDS12352.1 |
PIRi | S02709 |
RefSeqi | NP_005225.2, NM_005234.3 |
3D structure databases
SMRi | P10588 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 108375, 28 interactors |
IntActi | P10588, 24 interactors |
MINTi | P10588 |
STRINGi | 9606.ENSP00000291442 |
Chemistry databases
ChEMBLi | CHEMBL1961791 |
PTM databases
iPTMneti | P10588 |
PhosphoSitePlusi | P10588 |
Polymorphism and mutation databases
BioMutai | NR2F6 |
DMDMi | 23503053 |
Proteomic databases
EPDi | P10588 |
jPOSTi | P10588 |
MassIVEi | P10588 |
MaxQBi | P10588 |
PaxDbi | P10588 |
PeptideAtlasi | P10588 |
PRIDEi | P10588 |
ProteomicsDBi | 52614 |
Protocols and materials databases
Antibodypediai | 14278, 368 antibodies |
Genome annotation databases
Ensembli | ENST00000291442; ENSP00000291442; ENSG00000160113 |
GeneIDi | 2063 |
KEGGi | hsa:2063 |
UCSCi | uc002nfq.4, human |
Organism-specific databases
CTDi | 2063 |
DisGeNETi | 2063 |
EuPathDBi | HostDB:ENSG00000160113.5 |
GeneCardsi | NR2F6 |
HGNCi | HGNC:7977, NR2F6 |
HPAi | ENSG00000160113, Low tissue specificity |
MIMi | 132880, gene |
neXtProti | NX_P10588 |
OpenTargetsi | ENSG00000160113 |
PharmGKBi | PA31760 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000160748 |
HOGENOMi | CLU_007368_20_1_1 |
InParanoidi | P10588 |
OMAi | NWPYAAG |
OrthoDBi | 666130at2759 |
PhylomeDBi | P10588 |
TreeFami | TF352097 |
Enzyme and pathway databases
PathwayCommonsi | P10588 |
Reactomei | R-HSA-383280, Nuclear Receptor transcription pathway |
SignaLinki | P10588 |
SIGNORi | P10588 |
Miscellaneous databases
BioGRID-ORCSi | 2063, 7 hits in 867 CRISPR screens |
ChiTaRSi | NR2F6, human |
GeneWikii | V-erbA-related_gene |
GenomeRNAii | 2063 |
Pharosi | P10588, Tbio |
PROi | PR:P10588 |
RNActi | P10588, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000160113, Expressed in vagina and 235 other tissues |
ExpressionAtlasi | P10588, baseline and differential |
Genevisiblei | P10588, HS |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NR2F6_HUMAN | |
Accessioni | P10588Primary (citable) accession number: P10588 Secondary accession number(s): B2RC68 Q9BUE8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | September 19, 2002 | |
Last modified: | December 2, 2020 | |
This is version 209 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM