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UniProtKB - P10566 (MRS3_YEAST)
Protein
Mitochondrial RNA-splicing protein MRS3
Gene
MRS3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
MRS3 suppresses a mitochondrial splice defect in the first intron of the COB gene. It may act as a carrier, exerting its suppressor activity via modulation of solute concentrations in the mitochondrion (possibly of cations).
Miscellaneous
Present with 1360 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- ferrous iron transmembrane transporter activity Source: Reactome
- iron ion transmembrane transporter activity Source: SGD
GO - Biological processi
- iron import into the mitochondrion Source: SGD
- mRNA processing Source: UniProtKB-KW
Keywordsi
Biological process | mRNA processing, Transport |
Protein family/group databases
TCDBi | 2.A.29.5.1, the mitochondrial carrier (mc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial RNA-splicing protein MRS3 |
Gene namesi | Name:MRS3 Ordered Locus Names:YJL133W ORF Names:J0675 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003669, MRS3 |
VEuPathDBi | FungiDB:YJL133W |
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial inner membrane Source: Reactome
- mitochondrion Source: SGD
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 33 – 52 | Helical; Name=1Sequence analysisAdd BLAST | 20 | |
Transmembranei | 93 – 112 | Helical; Name=2Sequence analysisAdd BLAST | 20 | |
Transmembranei | 130 – 149 | Helical; Name=3Sequence analysisAdd BLAST | 20 | |
Transmembranei | 185 – 204 | Helical; Name=4Sequence analysisAdd BLAST | 20 | |
Transmembranei | 219 – 238 | Helical; Name=5Sequence analysisAdd BLAST | 20 | |
Transmembranei | 285 – 298 | Helical; Name=6Sequence analysisAdd BLAST | 14 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000090691 | 1 – 314 | Mitochondrial RNA-splicing protein MRS3Add BLAST | 314 |
Proteomic databases
MaxQBi | P10566 |
PaxDbi | P10566 |
PRIDEi | P10566 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 33623, 48 interactors |
DIPi | DIP-8202N |
IntActi | P10566, 4 interactors |
MINTi | P10566 |
STRINGi | 4932.YJL133W |
Miscellaneous databases
RNActi | P10566, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 31 – 118 | Solcar 1Add BLAST | 88 | |
Repeati | 128 – 210 | Solcar 2Add BLAST | 83 | |
Repeati | 217 – 310 | Solcar 3Add BLAST | 94 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0760, Eukaryota |
GeneTreei | ENSGT00940000169345 |
HOGENOMi | CLU_015166_3_1_1 |
InParanoidi | P10566 |
OMAi | FTTQLTM |
Family and domain databases
Gene3Di | 1.50.40.10, 2 hits |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
i Sequence
Sequence statusi: Complete.
P10566-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVENSSSNNS TRPIPAIPMD LPDYEALPTH APLYHQLIAG AFAGIMEHSV
60 70 80 90 100
MFPIDALKTR IQSANAKSLS AKNMLSQISH ISTSEGTLAL WKGVQSVILG
110 120 130 140 150
AGPAHAVYFG TYEFCKKNLI DSSDTQTHHP FKTAISGACA TTASDALMNP
160 170 180 190 200
FDTIKQRIQL NTSASVWQTT KQIYQSEGLA AFYYSYPTTL VMNIPFAAFN
210 220 230 240 250
FVIYESSTKF LNPSNEYNPL IHCLCGSISG STCAAITTPL DCIKTVLQIR
260 270 280 290 300
GSQTVSLEIM RKADTFSKAA SAIYQVYGWK GFWRGWKPRI VANMPATAIS
310
WTAYECAKHF LMTY
Sequence cautioni
The sequence CAA39830 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X56445 Genomic DNA Translation: CAA39829.1 X56445 Genomic DNA Translation: CAA39830.1 Different initiation. X06239 Genomic DNA Translation: CAA29582.1 Sequence problems. X87371 Genomic DNA Translation: CAA60822.1 Z49408 Genomic DNA Translation: CAA89428.1 BK006943 Genomic DNA Translation: DAA08668.1 |
PIRi | S55179 |
RefSeqi | NP_012402.1, NM_001181566.1 |
Genome annotation databases
EnsemblFungii | YJL133W_mRNA; YJL133W; YJL133W |
GeneIDi | 853308 |
KEGGi | sce:YJL133W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X56445 Genomic DNA Translation: CAA39829.1 X56445 Genomic DNA Translation: CAA39830.1 Different initiation. X06239 Genomic DNA Translation: CAA29582.1 Sequence problems. X87371 Genomic DNA Translation: CAA60822.1 Z49408 Genomic DNA Translation: CAA89428.1 BK006943 Genomic DNA Translation: DAA08668.1 |
PIRi | S55179 |
RefSeqi | NP_012402.1, NM_001181566.1 |
3D structure databases
AlphaFoldDBi | P10566 |
SMRi | P10566 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 33623, 48 interactors |
DIPi | DIP-8202N |
IntActi | P10566, 4 interactors |
MINTi | P10566 |
STRINGi | 4932.YJL133W |
Protein family/group databases
TCDBi | 2.A.29.5.1, the mitochondrial carrier (mc) family |
Proteomic databases
MaxQBi | P10566 |
PaxDbi | P10566 |
PRIDEi | P10566 |
Genome annotation databases
EnsemblFungii | YJL133W_mRNA; YJL133W; YJL133W |
GeneIDi | 853308 |
KEGGi | sce:YJL133W |
Organism-specific databases
SGDi | S000003669, MRS3 |
VEuPathDBi | FungiDB:YJL133W |
Phylogenomic databases
eggNOGi | KOG0760, Eukaryota |
GeneTreei | ENSGT00940000169345 |
HOGENOMi | CLU_015166_3_1_1 |
InParanoidi | P10566 |
OMAi | FTTQLTM |
Miscellaneous databases
PROi | PR:P10566 |
RNActi | P10566, protein |
Family and domain databases
Gene3Di | 1.50.40.10, 2 hits |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | MRS3_YEAST | |
Accessioni | P10566Primary (citable) accession number: P10566 Secondary accession number(s): D6VW52 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | November 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 179 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome X
Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names - SIMILARITY comments
Index of protein domains and families