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Protein

Mitochondrial RNA-splicing protein MRS3

Gene

MRS3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

MRS3 suppresses a mitochondrial splice defect in the first intron of the COB gene. It may act as a carrier, exerting its suppressor activity via modulation of solute concentrations in the mitochondrion (possibly of cations).

Miscellaneous

Present with 1360 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • ferrous iron transmembrane transporter activity Source: Reactome
  • iron ion transmembrane transporter activity Source: SGD

GO - Biological processi

  • iron import into the mitochondrion Source: SGD
  • iron ion homeostasis Source: GO_Central
  • mitochondrial transport Source: GO_Central
  • mRNA processing Source: UniProtKB-KW
  • RNA splicing Source: SGD

Keywordsi

Biological processmRNA processing, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31582-MONOMER

Protein family/group databases

TCDBi2.A.29.5.1 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial RNA-splicing protein MRS3
Gene namesi
Name:MRS3
Ordered Locus Names:YJL133W
ORF Names:J0675
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL133W
SGDiS000003669 MRS3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 52Helical; Name=1Sequence analysisAdd BLAST20
Transmembranei93 – 112Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei130 – 149Helical; Name=3Sequence analysisAdd BLAST20
Transmembranei185 – 204Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei219 – 238Helical; Name=5Sequence analysisAdd BLAST20
Transmembranei285 – 298Helical; Name=6Sequence analysisAdd BLAST14

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906911 – 314Mitochondrial RNA-splicing protein MRS3Add BLAST314

Proteomic databases

MaxQBiP10566
PaxDbiP10566
PRIDEiP10566

Interactioni

Protein-protein interaction databases

BioGridi33623, 48 interactors
DIPiDIP-8202N
IntActiP10566, 4 interactors
MINTiP10566
STRINGi4932.YJL133W

Structurei

3D structure databases

ProteinModelPortaliP10566
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati31 – 118Solcar 1Add BLAST88
Repeati128 – 210Solcar 2Add BLAST83
Repeati217 – 310Solcar 3Add BLAST94

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074721
HOGENOMiHOG000038810
InParanoidiP10566
KOiK15113
OMAiEHAVMFP
OrthoDBiEOG092C3EFS

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

P10566-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVENSSSNNS TRPIPAIPMD LPDYEALPTH APLYHQLIAG AFAGIMEHSV
60 70 80 90 100
MFPIDALKTR IQSANAKSLS AKNMLSQISH ISTSEGTLAL WKGVQSVILG
110 120 130 140 150
AGPAHAVYFG TYEFCKKNLI DSSDTQTHHP FKTAISGACA TTASDALMNP
160 170 180 190 200
FDTIKQRIQL NTSASVWQTT KQIYQSEGLA AFYYSYPTTL VMNIPFAAFN
210 220 230 240 250
FVIYESSTKF LNPSNEYNPL IHCLCGSISG STCAAITTPL DCIKTVLQIR
260 270 280 290 300
GSQTVSLEIM RKADTFSKAA SAIYQVYGWK GFWRGWKPRI VANMPATAIS
310
WTAYECAKHF LMTY
Length:314
Mass (Da):34,502
Last modified:November 1, 1995 - v4
Checksum:i861145CE6E4EF321
GO

Sequence cautioni

The sequence CAA39830 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56445 Genomic DNA Translation: CAA39829.1
X56445 Genomic DNA Translation: CAA39830.1 Different initiation.
X06239 Genomic DNA Translation: CAA29582.1 Sequence problems.
X87371 Genomic DNA Translation: CAA60822.1
Z49408 Genomic DNA Translation: CAA89428.1
BK006943 Genomic DNA Translation: DAA08668.1
PIRiS55179
RefSeqiNP_012402.1, NM_001181566.1

Genome annotation databases

EnsemblFungiiYJL133W; YJL133W; YJL133W
GeneIDi853308
KEGGisce:YJL133W

Similar proteinsi

Entry informationi

Entry nameiMRS3_YEAST
AccessioniPrimary (citable) accession number: P10566
Secondary accession number(s): D6VW52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 161 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

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