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Entry version 211 (03 Jul 2019)
Sequence version 1 (01 Jul 1989)
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Protein

Osteopontin

Gene

SPP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.
Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine
Biological processBiomineralization, Cell adhesion
LigandSialic acid

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-186797 Signaling by PDGF
R-HSA-216083 Integrin cell surface interactions
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8949275 RUNX3 Regulates Immune Response and Cell Migration
R-HSA-8957275 Post-translational protein phosphorylation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P10451

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Osteopontin
Alternative name(s):
Bone sialoprotein 1
Nephropontin
Secreted phosphoprotein 1
Short name:
SPP-1
Urinary stone protein
Uropontin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPP1
Synonyms:BNSP, OPN
ORF Names:PSEC0156
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11255 SPP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
166490 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P10451

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6696

MalaCards human disease database

More...
MalaCardsi
SPP1

Open Targets

More...
OpenTargetsi
ENSG00000118785

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
93552 Pediatric systemic lupus erythematosus
536 Systemic lupus erythematosus

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36085

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1741309

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
129260

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002032117 – 314OsteopontinAdd BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei24Phosphoserine1 Publication1
Modified residuei26Phosphoserine; by FAM20C2 Publications1
Modified residuei27Phosphoserine; by FAM20C2 Publications1
Modified residuei62Phosphoserine; by FAM20C2 Publications1
Modified residuei63Phosphoserine; by FAM20C2 Publications1
Modified residuei66Phosphothreonine1 Publication1
Modified residuei76Phosphoserine1 Publication1
Modified residuei78PhosphoserineBy similarity1
Modified residuei81PhosphoserineCombined sources1 Publication1
Modified residuei99Phosphoserine1 Publication1
Modified residuei102Phosphoserine1 Publication1
Modified residuei105Phosphoserine1 Publication1
Modified residuei108Phosphoserine1 Publication1
Modified residuei117Phosphoserine1 Publication1
Modified residuei120Phosphoserine1 Publication1
Modified residuei123Phosphoserine1 Publication1
Modified residuei126Phosphoserine1 Publication1
Modified residuei129Phosphoserine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi134O-linked (GalNAc...) threonine1 Publication1
Glycosylationi138O-linked (GalNAc...) threonine1 Publication1
Glycosylationi143O-linked (GalNAc...) threonine1 Publication1
Glycosylationi147O-linked (GalNAc...) threonine1 Publication1
Glycosylationi152O-linked (GalNAc...) threonine1 Publication1
Modified residuei185Phosphothreonine1 Publication1
Modified residuei190Phosphothreonine; by FAM20C1 Publication1
Modified residuei191Phosphoserine; by FAM20C2 Publications1
Modified residuei195Phosphoserine; by FAM20C2 Publications1
Modified residuei215Phosphoserine; by FAM20C2 Publications1
Modified residuei219Phosphoserine; by FAM20CCombined sources2 Publications1
Modified residuei224Phosphoserine; by FAM20CCombined sources2 Publications1
Modified residuei225Phosphotyrosine1 Publication1
Modified residuei228Phosphoserine; by FAM20C2 Publications1
Modified residuei234Phosphoserine; by FAM20CCombined sources2 Publications1
Modified residuei237Phosphothreonine; by FAM20C1 Publication1
Modified residuei239Phosphoserine; by FAM20C1 Publication1
Modified residuei243Phosphoserine; by FAM20C1 Publication1
Modified residuei254Phosphoserine; by FAM20CCombined sources2 Publications1
Modified residuei258Phosphoserine; by FAM20C1 Publication1
Modified residuei263Phosphoserine; by FAM20C2 Publications1
Modified residuei267Phosphoserine; by FAM20C2 Publications1
Modified residuei270Phosphoserine; by FAM20C1 Publication1
Modified residuei275Phosphoserine; by FAM20C2 Publications1
Modified residuei280Phosphoserine; by FAM20C2 Publications1
Modified residuei291Phosphoserine; by FAM20C1 Publication1
Modified residuei303Phosphoserine; by FAM20C2 Publications1
Modified residuei308Phosphoserine; by FAM20C2 Publications1
Modified residuei310Phosphoserine; by FAM20C2 Publications1
Modified residuei311Phosphoserine; by FAM20C1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Extensively phosphorylated by FAM20C in the extracellular medium at multiple sites within the S-x-E/pS motif.3 Publications
O-glycosylated. Isoform 5 is GalNAc O-glycosylated at Thr-59 or Ser-62.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P10451

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P10451

PeptideAtlas

More...
PeptideAtlasi
P10451

PRoteomics IDEntifications database

More...
PRIDEi
P10451

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52605
52606 [P10451-2]
52607 [P10451-3]
52608 [P10451-4]
52609 [P10451-5]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
474

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P10451

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P10451

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P10451

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P10451

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Bone. Found in plasma.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000118785 Expressed in 216 organ(s), highest expression level in amniotic fluid

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P10451 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P10451 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002212
HPA027540
HPA027541

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Ligand for integrin alpha-V/beta-3.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112574, 83 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P10451

Database of interacting proteins

More...
DIPi
DIP-49933N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P10451

Protein interaction database and analysis system

More...
IntActi
P10451, 21 interactors

Molecular INTeraction database

More...
MINTi
P10451

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000378517

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1314
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P10451

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi159 – 161Cell attachment site3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the osteopontin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IVP1 Eukaryota
ENOG41116B5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002509

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000059656

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P10451

KEGG Orthology (KO)

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KOi
K06250

Identification of Orthologs from Complete Genome Data

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OMAi
DHSVETH

Database of Orthologous Groups

More...
OrthoDBi
811995at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P10451

TreeFam database of animal gene trees

More...
TreeFami
TF350201

Family and domain databases

Database of protein disorder

More...
DisProti
DP00214

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002038 Osteopontin
IPR019841 Osteopontin_CS

The PANTHER Classification System

More...
PANTHERi
PTHR10607 PTHR10607, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00865 Osteopontin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00216 OSTEOPONTIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00017 OSTEO, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00884 OSTEOPONTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform A (identifier: P10451-1) [UniParc]FASTAAdd to basket
Also known as: OPN-a, OP1B

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRIAVICFCL LGITCAIPVK QADSGSSEEK QLYNKYPDAV ATWLNPDPSQ
60 70 80 90 100
KQNLLAPQNA VSSEETNDFK QETLPSKSNE SHDHMDDMDD EDDDDHVDSQ
110 120 130 140 150
DSIDSNDSDD VDDTDDSHQS DESHHSDESD ELVTDFPTDL PATEVFTPVV
160 170 180 190 200
PTVDTYDGRG DSVVYGLRSK SKKFRRPDIQ YPDATDEDIT SHMESEELNG
210 220 230 240 250
AYKAIPVAQD LNAPSDWDSR GKDSYETSQL DDQSAETHSH KQSRLYKRKA
260 270 280 290 300
NDESNEHSDV IDSQELSKVS REFHSHEFHS HEDMLVVDPK SKEEDKHLKF
310
RISHELDSAS SEVN
Length:314
Mass (Da):35,423
Last modified:July 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4996429EC4752B86
GO
Isoform B (identifier: P10451-2) [UniParc]FASTAAdd to basket
Also known as: OPN-b, OP1A

The sequence of this isoform differs from the canonical sequence as follows:
     58-71: Missing.

Show »
Length:300
Mass (Da):33,844
Checksum:iE844D1466BD20E64
GO
Isoform C (identifier: P10451-3) [UniParc]FASTAAdd to basket
Also known as: OPN-c

The sequence of this isoform differs from the canonical sequence as follows:
     31-57: Missing.

Show »
Length:287
Mass (Da):32,355
Checksum:iAF604D4E223BA02F
GO
Isoform D (identifier: P10451-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-116: Missing.

Show »
Length:292
Mass (Da):33,017
Checksum:iE93E418982C3AD60
GO
Isoform 5 (identifier: P10451-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-72: Missing.

Note: No experimental confirmation available.
Show »
Length:300
Mass (Da):33,843
Checksum:iB844D7EBDD096CBF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R9C5D6R9C5_HUMAN
Osteopontin
SPP1
241Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti188D → H in BAA05949 (PubMed:7837791).Curated1
Sequence conflicti188D → H in BAA05950 (PubMed:7837791).Curated1
Sequence conflicti188D → H in BAA05951 (PubMed:7837791).Curated1
Sequence conflicti237T → A in BAA05949 (PubMed:7837791).Curated1
Sequence conflicti237T → A in BAA05950 (PubMed:7837791).Curated1
Sequence conflicti237T → A in BAA05951 (PubMed:7837791).Curated1
Sequence conflicti275 – 278SHEF → GNSL (PubMed:1974876).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050432224S → N. Corresponds to variant dbSNP:rs7435825Ensembl.1
Natural variantiVAR_014717301R → H. Corresponds to variant dbSNP:rs4660Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00377731 – 57Missing in isoform C. 4 PublicationsAdd BLAST27
Alternative sequenceiVSP_00377858 – 71Missing in isoform B. 4 PublicationsAdd BLAST14
Alternative sequenceiVSP_04369559 – 72Missing in isoform 5. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_01163995 – 116Missing in isoform D. 1 PublicationAdd BLAST22

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X13694 mRNA Translation: CAA31984.1
J04765 mRNA Translation: AAA59974.1
M83248 mRNA Translation: AAA17675.1
U20758 Genomic DNA Translation: AAA86886.1
D14813 Genomic DNA Translation: BAA03554.1
D28759 mRNA Translation: BAA05949.1
D28760 mRNA Translation: BAA05950.1
D28761 mRNA Translation: BAA05951.1
AF052124 mRNA Translation: AAC28619.1
AK290104 mRNA Translation: BAF82793.1
JF412667 mRNA Translation: AEA49031.1
AK075463 mRNA Translation: BAC11635.1
AK290090 mRNA Translation: BAF82779.1
AK296035 mRNA Translation: BAG58801.1
AK315461 mRNA Translation: BAG37848.1
DQ839491 mRNA Translation: ABI63352.1
DQ846871 mRNA Translation: ABI63358.1
AC131944 Genomic DNA Translation: AAY41035.1
CH471057 Genomic DNA Translation: EAX06004.1
CH471057 Genomic DNA Translation: EAX06005.1
CH471057 Genomic DNA Translation: EAX06006.1
BC007016 mRNA Translation: AAH07016.1
BC017387 mRNA Translation: AAH17387.1
BC022844 mRNA Translation: AAH22844.1
BC093033 mRNA Translation: AAH93033.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34027.1 [P10451-3]
CCDS3626.1 [P10451-5]
CCDS43250.1 [P10451-1]

Protein sequence database of the Protein Information Resource

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PIRi
S50028 S09575

NCBI Reference Sequences

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RefSeqi
NP_000573.1, NM_000582.2 [P10451-5]
NP_001035147.1, NM_001040058.1 [P10451-1]
NP_001035149.1, NM_001040060.1 [P10451-3]
NP_001238758.1, NM_001251829.1
NP_001238759.1, NM_001251830.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000237623; ENSP00000237623; ENSG00000118785 [P10451-5]
ENST00000360804; ENSP00000354042; ENSG00000118785 [P10451-3]
ENST00000395080; ENSP00000378517; ENSG00000118785 [P10451-1]
ENST00000614857; ENSP00000477824; ENSG00000118785 [P10451-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6696

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6696

UCSC genome browser

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UCSCi
uc003hra.4 human [P10451-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Wikipedia

Osteopontin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13694 mRNA Translation: CAA31984.1
J04765 mRNA Translation: AAA59974.1
M83248 mRNA Translation: AAA17675.1
U20758 Genomic DNA Translation: AAA86886.1
D14813 Genomic DNA Translation: BAA03554.1
D28759 mRNA Translation: BAA05949.1
D28760 mRNA Translation: BAA05950.1
D28761 mRNA Translation: BAA05951.1
AF052124 mRNA Translation: AAC28619.1
AK290104 mRNA Translation: BAF82793.1
JF412667 mRNA Translation: AEA49031.1
AK075463 mRNA Translation: BAC11635.1
AK290090 mRNA Translation: BAF82779.1
AK296035 mRNA Translation: BAG58801.1
AK315461 mRNA Translation: BAG37848.1
DQ839491 mRNA Translation: ABI63352.1
DQ846871 mRNA Translation: ABI63358.1
AC131944 Genomic DNA Translation: AAY41035.1
CH471057 Genomic DNA Translation: EAX06004.1
CH471057 Genomic DNA Translation: EAX06005.1
CH471057 Genomic DNA Translation: EAX06006.1
BC007016 mRNA Translation: AAH07016.1
BC017387 mRNA Translation: AAH17387.1
BC022844 mRNA Translation: AAH22844.1
BC093033 mRNA Translation: AAH93033.1
CCDSiCCDS34027.1 [P10451-3]
CCDS3626.1 [P10451-5]
CCDS43250.1 [P10451-1]
PIRiS50028 S09575
RefSeqiNP_000573.1, NM_000582.2 [P10451-5]
NP_001035147.1, NM_001040058.1 [P10451-1]
NP_001035149.1, NM_001040060.1 [P10451-3]
NP_001238758.1, NM_001251829.1
NP_001238759.1, NM_001251830.1

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CXDX-ray2.80P40-51[»]
3DSFX-ray2.80P40-51[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGridi112574, 83 interactors
CORUMiP10451
DIPiDIP-49933N
ELMiP10451
IntActiP10451, 21 interactors
MINTiP10451
STRINGi9606.ENSP00000378517

Chemistry databases

ChEMBLiCHEMBL1741309

PTM databases

GlyConnecti474
iPTMnetiP10451
PhosphoSitePlusiP10451
UniCarbKBiP10451

Polymorphism and mutation databases

BioMutaiSPP1
DMDMi129260

Proteomic databases

jPOSTiP10451
PaxDbiP10451
PeptideAtlasiP10451
PRIDEiP10451
ProteomicsDBi52605
52606 [P10451-2]
52607 [P10451-3]
52608 [P10451-4]
52609 [P10451-5]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
P10451

The DNASU plasmid repository

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DNASUi
6696
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000237623; ENSP00000237623; ENSG00000118785 [P10451-5]
ENST00000360804; ENSP00000354042; ENSG00000118785 [P10451-3]
ENST00000395080; ENSP00000378517; ENSG00000118785 [P10451-1]
ENST00000614857; ENSP00000477824; ENSG00000118785 [P10451-4]
GeneIDi6696
KEGGihsa:6696
UCSCiuc003hra.4 human [P10451-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6696
DisGeNETi6696

GeneCards: human genes, protein and diseases

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GeneCardsi
SPP1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0004361
HGNCiHGNC:11255 SPP1
HPAiCAB002212
HPA027540
HPA027541
MalaCardsiSPP1
MIMi166490 gene
neXtProtiNX_P10451
OpenTargetsiENSG00000118785
Orphaneti93552 Pediatric systemic lupus erythematosus
536 Systemic lupus erythematosus
PharmGKBiPA36085

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IVP1 Eukaryota
ENOG41116B5 LUCA
GeneTreeiENSGT00390000002509
HOGENOMiHOG000059656
InParanoidiP10451
KOiK06250
OMAiDHSVETH
OrthoDBi811995at2759
PhylomeDBiP10451
TreeFamiTF350201

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix
R-HSA-186797 Signaling by PDGF
R-HSA-216083 Integrin cell surface interactions
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8949275 RUNX3 Regulates Immune Response and Cell Migration
R-HSA-8957275 Post-translational protein phosphorylation
SIGNORiP10451

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SPP1 human
EvolutionaryTraceiP10451

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Osteopontin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6696
PMAP-CutDBiP10451

Protein Ontology

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PROi
PR:P10451

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000118785 Expressed in 216 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiP10451 baseline and differential
GenevisibleiP10451 HS

Family and domain databases

DisProtiDP00214
InterProiView protein in InterPro
IPR002038 Osteopontin
IPR019841 Osteopontin_CS
PANTHERiPTHR10607 PTHR10607, 2 hits
PfamiView protein in Pfam
PF00865 Osteopontin, 1 hit
PRINTSiPR00216 OSTEOPONTIN
SMARTiView protein in SMART
SM00017 OSTEO, 1 hit
PROSITEiView protein in PROSITE
PS00884 OSTEOPONTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOSTP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10451
Secondary accession number(s): B2RDA1
, Q15681, Q15682, Q15683, Q4W597, Q567T5, Q8NBK2, Q96IZ1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 3, 2019
This is version 211 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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