UniProtKB - P10415 (BCL2_HUMAN)
Apoptosis regulator Bcl-2
BCL2
Functioni
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells (PubMed:1508712, PubMed:8183370).
Regulates cell death by controlling the mitochondrial membrane permeability (PubMed:11368354).
Appears to function in a feedback loop system with caspases (PubMed:11368354).
Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (PubMed:11368354).
Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function (PubMed:18570871, PubMed:21358617, PubMed:20889974).
May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
1 Publication6 PublicationsGO - Molecular functioni
- BH3 domain binding Source: UniProtKB
- channel activity Source: BHF-UCL
- channel inhibitor activity Source: BHF-UCL
- DNA-binding transcription factor binding Source: ARUK-UCL
- identical protein binding Source: UniProtKB
- protease binding Source: UniProtKB
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: GO_Central
- protein phosphatase 2A binding Source: Ensembl
- sequence-specific DNA binding Source: MGI
- ubiquitin protein ligase binding Source: UniProtKB
GO - Biological processi
- actin filament organization Source: Ensembl
- apoptotic process Source: MGI
- axonogenesis Source: Ensembl
- axon regeneration Source: Ensembl
- B cell homeostasis Source: Ensembl
- B cell lineage commitment Source: Ensembl
- B cell proliferation Source: MGI
- B cell receptor signaling pathway Source: UniProtKB
- behavioral fear response Source: Ensembl
- branching involved in ureteric bud morphogenesis Source: Ensembl
- CD8-positive, alpha-beta T cell lineage commitment Source: Ensembl
- cell aging Source: Ensembl
- cell-cell adhesion Source: Ensembl
- cellular response to DNA damage stimulus Source: UniProtKB
- cellular response to glucose starvation Source: Ensembl
- cellular response to hypoxia Source: Ensembl
- cellular response to organic substance Source: Ensembl
- cochlear nucleus development Source: Ensembl
- defense response to virus Source: UniProtKB
- digestive tract morphogenesis Source: Ensembl
- ear development Source: Ensembl
- endoplasmic reticulum calcium ion homeostasis Source: UniProtKB
- extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
- extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
- female pregnancy Source: UniProtKB
- focal adhesion assembly Source: Ensembl
- gland morphogenesis Source: Ensembl
- glomerulus development Source: Ensembl
- hair follicle morphogenesis Source: Ensembl
- homeostasis of number of cells within a tissue Source: Ensembl
- humoral immune response Source: UniProtKB
- intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: MGI
- intrinsic apoptotic signaling pathway in response to oxidative stress Source: Ensembl
- lymphoid progenitor cell differentiation Source: Ensembl
- male gonad development Source: Ensembl
- melanin metabolic process Source: Ensembl
- melanocyte differentiation Source: Ensembl
- mesenchymal cell development Source: Ensembl
- metanephros development Source: Ensembl
- negative regulation of anoikis Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of apoptotic signaling pathway Source: UniProtKB
- negative regulation of autophagy Source: UniProtKB
- negative regulation of calcium ion transport into cytosol Source: Ensembl
- negative regulation of cell growth Source: Ensembl
- negative regulation of cell migration Source: Ensembl
- negative regulation of cellular pH reduction Source: UniProtKB
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
- negative regulation of G1/S transition of mitotic cell cycle Source: Ensembl
- negative regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: BHF-UCL
- negative regulation of mitochondrial depolarization Source: UniProtKB
- negative regulation of myeloid cell apoptotic process Source: Ensembl
- negative regulation of neuron apoptotic process Source: MGI
- negative regulation of ossification Source: Ensembl
- negative regulation of osteoblast proliferation Source: Ensembl
- negative regulation of reactive oxygen species metabolic process Source: Ensembl
- negative regulation of retinal cell programmed cell death Source: Ensembl
- neuron apoptotic process Source: HGNC-UCL
- oocyte development Source: Ensembl
- organ growth Source: Ensembl
- ossification Source: Ensembl
- ovarian follicle development Source: Ensembl
- peptidyl-serine phosphorylation Source: Ensembl
- peptidyl-threonine phosphorylation Source: Ensembl
- pigment granule organization Source: Ensembl
- positive regulation of B cell proliferation Source: UniProtKB
- positive regulation of catalytic activity Source: Ensembl
- positive regulation of cell growth Source: MGI
- positive regulation of cell population proliferation Source: ARUK-UCL
- positive regulation of melanocyte differentiation Source: Ensembl
- positive regulation of multicellular organism growth Source: Ensembl
- positive regulation of neuron maturation Source: Ensembl
- positive regulation of peptidyl-serine phosphorylation Source: Ensembl
- positive regulation of skeletal muscle fiber development Source: Ensembl
- positive regulation of smooth muscle cell migration Source: Ensembl
- post-embryonic development Source: Ensembl
- protein dephosphorylation Source: Ensembl
- protein polyubiquitination Source: MGI
- reactive oxygen species metabolic process Source: Ensembl
- regulation of calcium ion transport Source: MGI
- regulation of cell-matrix adhesion Source: Ensembl
- regulation of gene expression Source: Ensembl
- regulation of glycoprotein biosynthetic process Source: Ensembl
- regulation of mitochondrial membrane permeability Source: HGNC-UCL
- regulation of mitochondrial membrane potential Source: HGNC-UCL
- regulation of nitrogen utilization Source: Ensembl
- regulation of protein localization Source: Ensembl
- regulation of protein stability Source: Ensembl
- regulation of transmembrane transporter activity Source: BHF-UCL
- regulation of viral genome replication Source: Ensembl
- release of cytochrome c from mitochondria Source: HGNC-UCL
- renal system process Source: Ensembl
- response to cytokine Source: MGI
- response to gamma radiation Source: Ensembl
- response to glucocorticoid Source: Ensembl
- response to hydrogen peroxide Source: Ensembl
- response to iron ion Source: UniProtKB
- response to ischemia Source: Ensembl
- response to nicotine Source: UniProtKB
- response to radiation Source: UniProtKB
- response to toxic substance Source: HGNC-UCL
- response to UV-B Source: Ensembl
- response to xenobiotic stimulus Source: MGI
- spleen development Source: Ensembl
- T cell differentiation in thymus Source: Ensembl
- T cell homeostasis Source: Ensembl
- thymus development Source: Ensembl
Keywordsi
Biological process | Apoptosis |
Enzyme and pathway databases
PathwayCommonsi | P10415 |
Reactomei | R-HSA-111447, Activation of BAD and translocation to mitochondria R-HSA-111453, BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-844455, The NLRP1 inflammasome R-HSA-9018519, Estrogen-dependent gene expression R-HSA-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling |
SignaLinki | P10415 |
SIGNORi | P10415 |
Protein family/group databases
TCDBi | 1.A.21.1.10, the bcl-2 (bcl-2) family |
Names & Taxonomyi
Protein namesi | Recommended name: Apoptosis regulator Bcl-2 |
Gene namesi | Name:BCL2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:990, BCL2 |
MIMi | 151430, gene+phenotype |
neXtProti | NX_P10415 |
VEuPathDBi | HostDB:ENSG00000171791 |
Subcellular locationi
Nucleus
- Nucleus membrane 1 Publication; Single-pass membrane protein Sequence analysis
Mitochondrion
- Mitochondrion outer membrane 2 Publications; Single-pass membrane protein Sequence analysis
Cytoplasm and Cytosol
- Cytoplasm By similarity
Endoplasmic reticulum
- Endoplasmic reticulum membrane 2 Publications; Single-pass membrane protein Sequence analysis
Cytosol
- cytosol Source: Ensembl
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum membrane Source: UniProtKB
Mitochondrion
- mitochondrial outer membrane Source: UniProtKB
- mitochondrion Source: UniProtKB
Nucleus
- nuclear membrane Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: MGI
Other locations
- cytoplasm Source: UniProtKB
- membrane Source: MGI
- myelin sheath Source: Ensembl
- pore complex Source: BHF-UCL
- protein-containing complex Source: CAFA
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 212 – 233 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane, NucleusPathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 34 | D → A: Abolishes cleavage by caspase-3. 1 Publication | 1 | |
Mutagenesisi | 64 | D → A: No effect on cleavage by caspase-3. 1 Publication | 1 | |
Mutagenesisi | 138 – 141 | FRDG → AAAA: Loss of BAX-binding and of anti-apoptotic activity. 1 Publication | 4 | |
Mutagenesisi | 144 | W → A: Loss of BAX-binding and of anti-apoptotic activity; when associated with A-145 and A146. 1 Publication | 1 | |
Mutagenesisi | 145 | G → A: Loss of BAX-binding and of anti-apoptotic activity. No effect on NLRP1-induced IL1B release, nor on homodimerization. Loss of BAX-binding and of anti-apoptotic activity; when associated with A-145 and A146. 2 Publications | 1 | |
Mutagenesisi | 145 | G → E: Loss of BAX-binding and of anti-apoptotic activity. No effect on homodimerization. 2 Publications | 1 | |
Mutagenesisi | 146 | R → A: Loss of BAX-binding and of anti-apoptotic activity; when associated with A-144 and A145. 1 Publication | 1 | |
Mutagenesisi | 188 | W → A: Loss of BAX-binding and of anti-apoptotic activity. No effect on homodimerization. 1 Publication | 1 | |
Mutagenesisi | 190 | Q → L: Partial loss of BAX-binding and 50% decrease in anti-apoptotic activity; when associated with A-191 and A-192. No effect on homodimerization; when associated with L-190 and A-191. 1 Publication | 1 | |
Mutagenesisi | 191 | D → A: No effect on BAX-binding, nor on anti-apoptotic activity. Partial loss of BAX-binding and 50% decrease in anti-apoptotic activity; when associated with L-190 and A-192. No effect on homodimerization; when associated with L-190 and A-191. 1 Publication | 1 | |
Mutagenesisi | 192 | N → A: Partial loss of BAX-binding and 50% decrease in anti-apoptotic activity; when associated with L-190 and A-191. No effect on homodimerization; when associated with L-190 and A-191. 1 Publication | 1 | |
Mutagenesisi | 194 – 197 | Missing : Loss of BAX-binding and of anti-apoptotic activity. May also affect protein stability. 1 Publication | 4 | |
Mutagenesisi | 200 | E → A: Partial loss of BAX-binding and 50% decrease in anti-apoptotic activity. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, Proto-oncogeneOrganism-specific databases
DisGeNETi | 596 |
MalaCardsi | BCL2 |
MIMi | 151430, gene+phenotype |
OpenTargetsi | ENSG00000171791 |
Orphaneti | 545, Follicular lymphoma 480541, High grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement 98839, Intravascular large B-cell lymphoma |
PharmGKBi | PA25302 |
Miscellaneous databases
Pharosi | P10415, Tclin |
Chemistry databases
ChEMBLi | CHEMBL4860 |
DrugBanki | DB06307, Apoptone DB09213, Dexibuprofen DB01248, Docetaxel DB08871, Eribulin DB06756, Glycine betaine DB01050, Ibuprofen DB09401, Isosorbide DB12340, Navitoclax DB12191, Obatoclax DB01229, Paclitaxel DB05297, Paclitaxel docosahexaenoic acid DB01367, Rasagiline DB11581, Venetoclax |
DrugCentrali | P10415 |
GuidetoPHARMACOLOGYi | 2844 |
Genetic variation databases
BioMutai | BCL2 |
DMDMi | 231632 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000143048 | 1 – 239 | Apoptosis regulator Bcl-2Add BLAST | 239 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 69 | Phosphothreonine; by MAPK81 Publication | 1 | |
Modified residuei | 70 | Phosphoserine; by MAPK8 and PKC1 Publication | 1 | |
Modified residuei | 87 | Phosphoserine; by MAPK81 Publication | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 34 – 35 | Cleavage; by caspase-3 | 2 |
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P10415 |
jPOSTi | P10415 |
MassIVEi | P10415 |
MaxQBi | P10415 |
PaxDbi | P10415 |
PeptideAtlasi | P10415 |
PRIDEi | P10415 |
ProteomicsDBi | 10203 52603 [P10415-1] 52604 [P10415-2] |
PTM databases
iPTMneti | P10415 |
PhosphoSitePlusi | P10415 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000171791, Expressed in thyroid gland and 239 other tissues |
ExpressionAtlasi | P10415, baseline and differential |
Genevisiblei | P10415, HS |
Organism-specific databases
HPAi | ENSG00000171791, Low tissue specificity |
Interactioni
Subunit structurei
Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization with BAX requires intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity (PubMed:8183370, PubMed:25609812).
Part of a complex composed of SEPTIN4 isoform ARTS, XIAP and BCL2, within the complex interacts (via BH3 domain) with SEPTIN4 isoform ARTS and XIAP, SEPTIN4 isoform ARTS acts as a scaffold protein and stabilizes the complex (PubMed:29020630).
Interacts with EI24 (By similarity).
Also interacts with APAF1, BBC3, BCL2L1, BNIPL, MRPL41 and TP53BP2. Binding to FKBP8 seems to target BCL2 to the mitochondria and probably interferes with the binding of BCL2 to its targets.
Interacts with BAG1 in an ATP-dependent manner.
Interacts with RAF1 (the 'Ser-338' and 'Ser-339' phosphorylated form).
Interacts (via the BH4 domain) with EGLN3; the interaction prevents the formation of the BAX-BCL2 complex and inhibits the anti-apoptotic activity of BCL2.
Interacts with G0S2; this interaction also prevents the formation of the anti-apoptotic BAX-BCL2 complex.
Interacts with RTL10/BOP.
Interacts with the SCF(FBXO10) complex.
Interacts (via the loop between motifs BH4 and BH3) with NLRP1 (via LRR repeats), but not with NLRP2, NLRP3, NLRP4, PYCARD, nor MEFV (PubMed:17418785).
Interacts with GIMAP3/IAN4, GIMAP4/IAN1 and GIMAP5/IAN5 (By similarity).
Interacts with BCAP31 (PubMed:31206022).
Interacts with IRF3; the interaction is inhibited by Sendai virus infection (PubMed:25609812).
Interacts with BECN1; thereby inhibiting autophagy in non-starvation conditions (PubMed:18570871, PubMed:21358617).
Interacts with AMBRA1; thereby inhibiting autophagy (PubMed:21358617).
By similarity20 PublicationsBinary interactionsi
P10415
Isoform Alpha [P10415-1]
With | #Exp. | IntAct |
---|---|---|
LRRK2 [Q5S007] | 2 | EBI-4370304,EBI-5323863 |
PMAIP1 [Q13794] | 3 | EBI-4370304,EBI-707392 |
GO - Molecular functioni
- BH3 domain binding Source: UniProtKB
- DNA-binding transcription factor binding Source: ARUK-UCL
- identical protein binding Source: UniProtKB
- protease binding Source: UniProtKB
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: GO_Central
- protein phosphatase 2A binding Source: Ensembl
- ubiquitin protein ligase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107068, 132 interactors |
ComplexPortali | CPX-1981, BCL-2 dimer CPX-1982, BAD:BCL-2 complex CPX-1984, BID:BCL-2 complex CPX-1986, PUMA:BCL-2 complex CPX-1990, BIM:BCL-2 complex |
CORUMi | P10415 |
DIPi | DIP-1043N |
ELMi | P10415 |
IntActi | P10415, 54 interactors |
MINTi | P10415 |
STRINGi | 9606.ENSP00000381185 |
Chemistry databases
BindingDBi | P10415 |
Miscellaneous databases
RNActi | P10415, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P10415 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P10415 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 39 – 85 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 92 – 107 | Required for interaction with SEPTIN4 isoform ARTS. Required XIAP-mediated ubiquitination and apoptosis1 PublicationAdd BLAST | 16 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 10 – 30 | BH4PROSITE-ProRule annotationAdd BLAST | 21 | |
Motifi | 93 – 107 | BH3Sequence analysisAdd BLAST | 15 | |
Motifi | 136 – 155 | BH1Sequence analysisAdd BLAST | 20 | |
Motifi | 187 – 202 | BH2Sequence analysisAdd BLAST | 16 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4728, Eukaryota |
GeneTreei | ENSGT01020000230347 |
HOGENOMi | CLU_085401_0_0_1 |
InParanoidi | P10415 |
OMAi | QRGYDWA |
OrthoDBi | 80538at2759 |
PhylomeDBi | P10415 |
TreeFami | TF315834 |
Family and domain databases
CDDi | cd06845, Bcl-2_like, 1 hit |
DisProti | DP00297 |
Gene3Di | 1.10.437.10, 1 hit |
InterProi | View protein in InterPro IPR013278, Apop_reg_Bcl2 IPR036834, Bcl-2-like_sf IPR026298, Bcl-2_fam IPR002475, Bcl2-like IPR004725, Bcl2/BclX IPR020717, Bcl2_BH1_motif_CS IPR020726, Bcl2_BH2_motif_CS IPR020728, Bcl2_BH3_motif_CS IPR003093, Bcl2_BH4 IPR020731, Bcl2_BH4_motif_CS |
PANTHERi | PTHR11256, PTHR11256, 1 hit PTHR11256:SF11, PTHR11256:SF11, 1 hit |
Pfami | View protein in Pfam PF00452, Bcl-2, 1 hit PF02180, BH4, 1 hit |
PRINTSi | PR01863, APOPREGBCL2 PR01862, BCL2FAMILY |
SMARTi | View protein in SMART SM00337, BCL, 1 hit SM00265, BH4, 1 hit |
SUPFAMi | SSF56854, SSF56854, 1 hit |
TIGRFAMsi | TIGR00865, bcl-2, 1 hit |
PROSITEi | View protein in PROSITE PS50062, BCL2_FAMILY, 1 hit PS01080, BH1, 1 hit PS01258, BH2, 1 hit PS01259, BH3, 1 hit PS01260, BH4_1, 1 hit PS50063, BH4_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAHAGRTGYD NREIVMKYIH YKLSQRGYEW DAGDVGAAPP GAAPAPGIFS
60 70 80 90 100
SQPGHTPHPA ASRDPVARTS PLQTPAAPGA AAGPALSPVP PVVHLTLRQA
110 120 130 140 150
GDDFSRRYRR DFAEMSSQLH LTPFTARGRF ATVVEELFRD GVNWGRIVAF
160 170 180 190 200
FEFGGVMCVE SVNREMSPLV DNIALWMTEY LNRHLHTWIQ DNGGWDAFVE
210 220 230
LYGPSMRPLF DFSWLSLKTL LSLALVGACI TLGAYLGHK
The sequence of this isoform differs from the canonical sequence as follows:
196-239: DAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK → VGALGDVSLG
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A7I2V3S7 | A0A7I2V3S7_HUMAN | Apoptosis regulator Bcl-2 | BCL2 | 198 | Annotation score: | ||
A0A7I2V5Q7 | A0A7I2V5Q7_HUMAN | Apoptosis regulator Bcl-2 | BCL2 | 268 | Annotation score: | ||
A0A7I2V4W1 | A0A7I2V4W1_HUMAN | Apoptosis regulator Bcl-2 | BCL2 | 46 | Annotation score: | ||
A0A7I2V5Q9 | A0A7I2V5Q9_HUMAN | Apoptosis regulator Bcl-2 | BCL2 | 52 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 48 | I → F in CAA29778 (PubMed:2834197).Curated | 1 | ||
Sequence conflicti | 59 | P → T in AAA35591 (PubMed:2875799).Curated | 1 | ||
Sequence conflicti | 96 | T → A in AAD14111 (PubMed:1339299).Curated | 1 | ||
Sequence conflicti | 110 | R → G in AAD14111 (PubMed:1339299).Curated | 1 | ||
Sequence conflicti | 117 | S → R in AAA35591 (PubMed:2875799).Curated | 1 | ||
Sequence conflicti | 129 | R → C in CAA29778 (PubMed:2834197).Curated | 1 | ||
Isoform Beta (identifier: P10415-2) | |||||
Sequence conflicti | 199 | L → S in AAA51814 (PubMed:3523487).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_000827 | 7 | T → S2 Publications | 1 | |
Natural variantiVAR_014716 | 43 | A → T1 PublicationCorresponds to variant dbSNP:rs1800477Ensembl. | 1 | |
Natural variantiVAR_000828 | 59 | P → S in non-Hodgkin lymphoma; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_000829 | 93 | V → I in non-Hodgkin lymphoma; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000512 | 196 – 239 | DAFVE…YLGHK → VGALGDVSLG in isoform Beta. 1 PublicationAdd BLAST | 44 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M13994 mRNA Translation: AAA51813.1 Sequence problems. M13995 mRNA Translation: AAA51814.1 Sequence problems. M14745 mRNA Translation: AAA35591.1 X06487 mRNA Translation: CAA29778.1 AY220759 Genomic DNA Translation: AAO26045.1 AC021803 Genomic DNA No translation available. AC022726 Genomic DNA No translation available. CH471096 Genomic DNA Translation: EAW63137.1 BC027258 mRNA Translation: AAH27258.1 S72602 Genomic DNA Translation: AAD14111.1 Sequence problems. |
CCDSi | CCDS11981.1 [P10415-1] CCDS45882.1 [P10415-2] |
PIRi | B29409, TVHUB1 C37332, TVHUA1 |
RefSeqi | NP_000624.2, NM_000633.2 [P10415-1] NP_000648.2, NM_000657.2 [P10415-2] |
Genome annotation databases
Ensembli | ENST00000333681; ENSP00000329623; ENSG00000171791 ENST00000398117; ENSP00000381185; ENSG00000171791 ENST00000589955; ENSP00000466417; ENSG00000171791 [P10415-2] ENST00000678349; ENSP00000504190; ENSG00000171791 [P10415-2] |
GeneIDi | 596 |
KEGGi | hsa:596 |
MANE-Selecti | ENST00000333681.5; ENSP00000329623.3; NM_000633.3; NP_000624.2 |
UCSCi | uc002lit.2, human [P10415-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
NIEHS-SNPs |
Wikipedia Bcl-2 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M13994 mRNA Translation: AAA51813.1 Sequence problems. M13995 mRNA Translation: AAA51814.1 Sequence problems. M14745 mRNA Translation: AAA35591.1 X06487 mRNA Translation: CAA29778.1 AY220759 Genomic DNA Translation: AAO26045.1 AC021803 Genomic DNA No translation available. AC022726 Genomic DNA No translation available. CH471096 Genomic DNA Translation: EAW63137.1 BC027258 mRNA Translation: AAH27258.1 S72602 Genomic DNA Translation: AAD14111.1 Sequence problems. |
CCDSi | CCDS11981.1 [P10415-1] CCDS45882.1 [P10415-2] |
PIRi | B29409, TVHUB1 C37332, TVHUA1 |
RefSeqi | NP_000624.2, NM_000633.2 [P10415-1] NP_000648.2, NM_000657.2 [P10415-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1G5M | NMR | - | A | 1-34 | [»] | |
A | 92-207 | [»] | ||||
1GJH | NMR | - | A | 1-34 | [»] | |
A | 92-207 | [»] | ||||
1YSW | NMR | - | A | 3-33 | [»] | |
A | 92-206 | [»] | ||||
2O21 | NMR | - | A | 3-34 | [»] | |
A | 92-207 | [»] | ||||
2O22 | NMR | - | A | 3-34 | [»] | |
A | 92-207 | [»] | ||||
2O2F | NMR | - | A | 8-31 | [»] | |
A | 92-204 | [»] | ||||
2W3L | X-ray | 2.10 | A/B | 92-206 | [»] | |
2XA0 | X-ray | 2.70 | A/B | 1-207 | [»] | |
4AQ3 | X-ray | 2.40 | A/B/C/D/E/F | 1-33 | [»] | |
A/B/C/D/E/F | 92-207 | [»] | ||||
4IEH | X-ray | 2.10 | A | 1-34 | [»] | |
A | 92-207 | [»] | ||||
4LVT | X-ray | 2.05 | A/B | 1-34 | [»] | |
A/B | 92-207 | [»] | ||||
4LXD | X-ray | 1.90 | A | 1-34 | [»] | |
A | 92-207 | [»] | ||||
4MAN | X-ray | 2.07 | A/B | 1-34 | [»] | |
A/B | 92-207 | [»] | ||||
5AGW | X-ray | 2.69 | A/B | 1-34 | [»] | |
A/B | 92-207 | [»] | ||||
5AGX | X-ray | 2.24 | A/B | 1-34 | [»] | |
A/B | 92-207 | [»] | ||||
5FCG | X-ray | 2.10 | A | 1-207 | [»] | |
5JSN | X-ray | 2.10 | A/C | 1-207 | [»] | |
5VAU | X-ray | 1.75 | A/B/C/D | 1-207 | [»] | |
5VAX | X-ray | 2.00 | A/B/C/D | 1-207 | [»] | |
5VAY | X-ray | 1.80 | A/B/C/D | 1-34 | [»] | |
A/B/C/D | 66-207 | [»] | ||||
6GL8 | X-ray | 1.40 | A | 9-206 | [»] | |
6IWB | X-ray | 2.50 | B/D | 1-34 | [»] | |
B/D | 92-207 | [»] | ||||
6O0K | X-ray | 1.62 | A | 1-34 | [»] | |
A | 66-207 | [»] | ||||
6O0L | X-ray | 2.20 | A/C | 1-34 | [»] | |
A/C | 66-207 | [»] | ||||
6O0M | X-ray | 1.75 | A | 1-34 | [»] | |
A | 66-207 | [»] | ||||
6O0O | X-ray | 2.00 | A/C | 1-34 | [»] | |
A/C | 66-207 | [»] | ||||
6O0P | X-ray | 1.80 | A | 1-34 | [»] | |
A | 66-207 | [»] | ||||
7LHB | X-ray | 2.07 | A/B/C | 1-207 | [»] | |
SMRi | P10415 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107068, 132 interactors |
ComplexPortali | CPX-1981, BCL-2 dimer CPX-1982, BAD:BCL-2 complex CPX-1984, BID:BCL-2 complex CPX-1986, PUMA:BCL-2 complex CPX-1990, BIM:BCL-2 complex |
CORUMi | P10415 |
DIPi | DIP-1043N |
ELMi | P10415 |
IntActi | P10415, 54 interactors |
MINTi | P10415 |
STRINGi | 9606.ENSP00000381185 |
Chemistry databases
BindingDBi | P10415 |
ChEMBLi | CHEMBL4860 |
DrugBanki | DB06307, Apoptone DB09213, Dexibuprofen DB01248, Docetaxel DB08871, Eribulin DB06756, Glycine betaine DB01050, Ibuprofen DB09401, Isosorbide DB12340, Navitoclax DB12191, Obatoclax DB01229, Paclitaxel DB05297, Paclitaxel docosahexaenoic acid DB01367, Rasagiline DB11581, Venetoclax |
DrugCentrali | P10415 |
GuidetoPHARMACOLOGYi | 2844 |
Protein family/group databases
TCDBi | 1.A.21.1.10, the bcl-2 (bcl-2) family |
PTM databases
iPTMneti | P10415 |
PhosphoSitePlusi | P10415 |
Genetic variation databases
BioMutai | BCL2 |
DMDMi | 231632 |
Proteomic databases
EPDi | P10415 |
jPOSTi | P10415 |
MassIVEi | P10415 |
MaxQBi | P10415 |
PaxDbi | P10415 |
PeptideAtlasi | P10415 |
PRIDEi | P10415 |
ProteomicsDBi | 10203 52603 [P10415-1] 52604 [P10415-2] |
Protocols and materials databases
ABCDi | P10415, 1 sequenced antibody |
Antibodypediai | 3491, 3851 antibodies from 58 providers |
DNASUi | 596 |
Genome annotation databases
Ensembli | ENST00000333681; ENSP00000329623; ENSG00000171791 ENST00000398117; ENSP00000381185; ENSG00000171791 ENST00000589955; ENSP00000466417; ENSG00000171791 [P10415-2] ENST00000678349; ENSP00000504190; ENSG00000171791 [P10415-2] |
GeneIDi | 596 |
KEGGi | hsa:596 |
MANE-Selecti | ENST00000333681.5; ENSP00000329623.3; NM_000633.3; NP_000624.2 |
UCSCi | uc002lit.2, human [P10415-1] |
Organism-specific databases
CTDi | 596 |
DisGeNETi | 596 |
GeneCardsi | BCL2 |
HGNCi | HGNC:990, BCL2 |
HPAi | ENSG00000171791, Low tissue specificity |
MalaCardsi | BCL2 |
MIMi | 151430, gene+phenotype |
neXtProti | NX_P10415 |
OpenTargetsi | ENSG00000171791 |
Orphaneti | 545, Follicular lymphoma 480541, High grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement 98839, Intravascular large B-cell lymphoma |
PharmGKBi | PA25302 |
VEuPathDBi | HostDB:ENSG00000171791 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4728, Eukaryota |
GeneTreei | ENSGT01020000230347 |
HOGENOMi | CLU_085401_0_0_1 |
InParanoidi | P10415 |
OMAi | QRGYDWA |
OrthoDBi | 80538at2759 |
PhylomeDBi | P10415 |
TreeFami | TF315834 |
Enzyme and pathway databases
PathwayCommonsi | P10415 |
Reactomei | R-HSA-111447, Activation of BAD and translocation to mitochondria R-HSA-111453, BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-844455, The NLRP1 inflammasome R-HSA-9018519, Estrogen-dependent gene expression R-HSA-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling |
SignaLinki | P10415 |
SIGNORi | P10415 |
Miscellaneous databases
BioGRID-ORCSi | 596, 57 hits in 1047 CRISPR screens |
ChiTaRSi | BCL2, human |
EvolutionaryTracei | P10415 |
GeneWikii | Bcl-2 |
GenomeRNAii | 596 |
Pharosi | P10415, Tclin |
PROi | PR:P10415 |
RNActi | P10415, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171791, Expressed in thyroid gland and 239 other tissues |
ExpressionAtlasi | P10415, baseline and differential |
Genevisiblei | P10415, HS |
Family and domain databases
CDDi | cd06845, Bcl-2_like, 1 hit |
DisProti | DP00297 |
Gene3Di | 1.10.437.10, 1 hit |
InterProi | View protein in InterPro IPR013278, Apop_reg_Bcl2 IPR036834, Bcl-2-like_sf IPR026298, Bcl-2_fam IPR002475, Bcl2-like IPR004725, Bcl2/BclX IPR020717, Bcl2_BH1_motif_CS IPR020726, Bcl2_BH2_motif_CS IPR020728, Bcl2_BH3_motif_CS IPR003093, Bcl2_BH4 IPR020731, Bcl2_BH4_motif_CS |
PANTHERi | PTHR11256, PTHR11256, 1 hit PTHR11256:SF11, PTHR11256:SF11, 1 hit |
Pfami | View protein in Pfam PF00452, Bcl-2, 1 hit PF02180, BH4, 1 hit |
PRINTSi | PR01863, APOPREGBCL2 PR01862, BCL2FAMILY |
SMARTi | View protein in SMART SM00337, BCL, 1 hit SM00265, BH4, 1 hit |
SUPFAMi | SSF56854, SSF56854, 1 hit |
TIGRFAMsi | TIGR00865, bcl-2, 1 hit |
PROSITEi | View protein in PROSITE PS50062, BCL2_FAMILY, 1 hit PS01080, BH1, 1 hit PS01258, BH2, 1 hit PS01259, BH3, 1 hit PS01260, BH4_1, 1 hit PS50063, BH4_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BCL2_HUMAN | |
Accessioni | P10415Primary (citable) accession number: P10415 Secondary accession number(s): C9JHD5 Q16197 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | April 1, 1993 | |
Last modified: | February 23, 2022 | |
This is version 258 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families