UniProtKB - P10384 (FADL_ECOLI)

BLAST

>sp|P10384|FADL_ECOLI Long-chain fatty acid transport protein OS=Escherichia coli (strain K12) OX=83333 GN=fadL PE=1 SV=5
MSQKTLFTKSALAVAVALISTQAWSAGFQLNEFSSSGLGRAYSGEGAIADDAGNVSRNPA
LITMFDRPTFSAGAVYIDPDVNISGTSPSGRSLKADNIAPTAWVPNMHFVAPINDQFGWG
ASITSNYGLATEFNDTYAGGSVGGTTDLETMNLNLSGAYRLNNAWSFGLGFNAVYARAKI
ERFAGDLGQLVAGQIMQSPAGQTQQGQALAATANGIDSNTKIAHLNGNQWGFGWNAGILY
ELDKNNRYALTYRSEVKIDFKGNYSSDLNRAFNNYGLPIPTATGGATQSGYLTLNLPEMW
EVSGYNRVDPQWAIHYSLAYTSWSQFQQLKATSTSGDTLFQKHEGFKDAYRIALGTTYYY
DDNWTFRTGIAFDDSPVPAQNRSISIPDQDRFWLSAGTTYAFNKDASVDVGVSYMHGQSV
KINEGPYQFESEGKAWLFGTNFNYAF

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History
Entry version 160 (18 Jul 2018)
Sequence version 5 (12 Dec 2006)
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Protein

Long-chain fatty acid transport protein

Gene

fadL

Organism

Escherichia coli (strain K12)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Involved in translocation of long-chain fatty acids across the outer membrane. It is a receptor for the bacteriophage T2. FadL may form a specific channel.

GO - Molecular functionⁱ

ligand-gated channel activity
Source: EcoCyc
Inferred from direct assayⁱ
- 24970895
long-chain fatty acid transporting porin activity
Source: EcoCyc
Inferred from direct assayⁱ
- 15178802

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Lipid transport, Transport

Biological process

Lipid transport, Transport

Enzyme and pathway databases

BioCycⁱ	EcoCyc:EG10280-MONOMER MetaCyc:EG10280-MONOMER

BioCycⁱ

EcoCyc:EG10280-MONOMER
MetaCyc:EG10280-MONOMER

Protein family/group databases

TCDBⁱ	1.B.9.1.1 the fadl outer membrane protein (fadl) family

TCDBⁱ

1.B.9.1.1 the fadl outer membrane protein (fadl) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Long-chain fatty acid transport protein Alternative name(s): Outer membrane FadL protein Outer membrane flp protein
Gene namesⁱ	Name:fadL Synonyms:ttr Ordered Locus Names:b2344, JW2341
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG10280 fadL

EcoGeneⁱ

EG10280 fadL

Subcellular locationⁱ

Cell outer membrane
1 Publication
Manual assertion based on experiment inⁱ
- Ref.6
  "Protein complexes of the Escherichia coli cell envelope."
  Stenberg F., Chovanec P., Maslen S.L., Robinson C.V., Ilag L., von Heijne G., Daley D.O.
  J. Biol. Chem. 280:34409-34419(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: DIMERIZATION, SUBCELLULAR LOCATION.
; Multi-pass membrane protein
1 Publication
Manual assertion based on experiment inⁱ
- Ref.6
  "Protein complexes of the Escherichia coli cell envelope."
  Stenberg F., Chovanec P., Maslen S.L., Robinson C.V., Ilag L., von Heijne G., Daley D.O.
  J. Biol. Chem. 280:34409-34419(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: DIMERIZATION, SUBCELLULAR LOCATION.

GO - Cellular componentⁱ

cell outer membrane
Source: EcoCyc
Inferred from direct assayⁱ
- 3027089
- 3286621
integral component of membrane Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell outer membrane, Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL3309022
Drug and drug target database More...DrugBankⁱ	DB04233 (Hydroxyethyloxy)Tri(Ethyloxy)Octane DB04147 Lauryl Dimethylamine-N-Oxide

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 25	1 PublicationAdd BLAST		25
ChainⁱPRO_0000025202	26 – 446	Long-chain fatty acid transport proteinAdd BLAST		421

Proteomic databases

EPDⁱ	P10384
PaxDbⁱ	P10384
PRIDEⁱ	P10384

Expressionⁱ

Inductionⁱ

By long-chain fatty acids. Expression of fadL is under the control of the FadR repressor.

Interactionⁱ

Subunit structureⁱ

Has been isolated from outer membrane preparation as a homodimer.

Protein-protein interaction databases

BioGridⁱ	4260536, 118 interactors
STRINGⁱ	316385.ECDH10B_2507

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	35 – 39	Combined sources	5
Turnⁱ	40 – 42	Combined sources	3
Turnⁱ	45 – 47	Combined sources	3
Helixⁱ	52 – 56	Combined sources	5
Helixⁱ	59 – 64	Combined sources	6
Beta strandⁱ	69 – 84	Combined sources	16
Beta strandⁱ	90 – 92	Combined sources	3
Beta strandⁱ	95 – 97	Combined sources	3
Beta strandⁱ	102 – 112	Combined sources	11
Beta strandⁱ	114 – 124	Combined sources	11
Beta strandⁱ	127 – 132	Combined sources	6
Turnⁱ	138 – 142	Combined sources	5
Beta strandⁱ	144 – 160	Combined sources	17
Beta strandⁱ	162 – 183	Combined sources	22
Helixⁱ	187 – 197	Combined sources	11
Helixⁱ	199 – 202	Combined sources	4
Helixⁱ	204 – 214	Combined sources	11
Beta strandⁱ	221 – 243	Combined sources	23
Beta strandⁱ	246 – 253	Combined sources	8
Beta strandⁱ	256 – 260	Combined sources	5
Beta strandⁱ	263 – 265	Combined sources	3
Turnⁱ	272 – 276	Combined sources	5
Beta strandⁱ	291 – 296	Combined sources	6
Beta strandⁱ	298 – 309	Combined sources	12
Beta strandⁱ	312 – 325	Combined sources	14
Beta strandⁱ	329 – 334	Combined sources	6
Beta strandⁱ	337 – 342	Combined sources	6
Beta strandⁱ	347 – 359	Combined sources	13
Beta strandⁱ	361 – 374	Combined sources	14
Helixⁱ	379 – 381	Combined sources	3
Beta strandⁱ	384 – 386	Combined sources	3
Beta strandⁱ	391 – 417	Combined sources	27
Beta strandⁱ	420 – 424	Combined sources	5
Beta strandⁱ	427 – 446	Combined sources	20

Show more details

3D structure databases

ProteinModelPortalⁱ	P10384
SMRⁱ	P10384
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P10384

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the OmpP1/FadL family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGⁱ	ENOG4105CKF Bacteria COG2067 LUCA
HOGENOMⁱ	HOG000277333
InParanoidⁱ	P10384
KEGG Orthology (KO) More...KOⁱ	K06076
OMAⁱ	YKVNKEW
PhylomeDBⁱ	P10384

Family and domain databases

InterProⁱ	View protein in InterPro IPR005017 OMPP1/FadL/TodX
PANTHERⁱ	PTHR35093 PTHR35093, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03349 Toluene_X, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P10384-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSQKTLFTKS ALAVAVALIS TQAWSAGFQL NEFSSSGLGR AYSGEGAIAD 
        60         70         80         90        100
DAGNVSRNPA LITMFDRPTF SAGAVYIDPD VNISGTSPSG RSLKADNIAP 
       110        120        130        140        150
TAWVPNMHFV APINDQFGWG ASITSNYGLA TEFNDTYAGG SVGGTTDLET 
       160        170        180        190        200
MNLNLSGAYR LNNAWSFGLG FNAVYARAKI ERFAGDLGQL VAGQIMQSPA 
       210        220        230        240        250
GQTQQGQALA ATANGIDSNT KIAHLNGNQW GFGWNAGILY ELDKNNRYAL 
       260        270        280        290        300
TYRSEVKIDF KGNYSSDLNR AFNNYGLPIP TATGGATQSG YLTLNLPEMW 
       310        320        330        340        350
EVSGYNRVDP QWAIHYSLAY TSWSQFQQLK ATSTSGDTLF QKHEGFKDAY 
       360        370        380        390        400
RIALGTTYYY DDNWTFRTGI AFDDSPVPAQ NRSISIPDQD RFWLSAGTTY 
       410        420        430        440 
AFNKDASVDV GVSYMHGQSV KINEGPYQFE SEGKAWLFGT NFNYAF

Length:446

Mass (Da):48,542

Last modified:December 12, 2006 - v5

Checksum:ⁱ9B50C55D82CDB085

Sequence cautionⁱ

The sequence AAA64433 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAA16205 differs from that shown. Reason: Erroneous initiation.Curated

The sequence CAA68630 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	176 – 178	ARA → RRP (PubMed:2840553).Curated	3
Sequence conflictⁱ	176	A → V in AAA64433 (PubMed:1987139).Curated	1
Sequence conflictⁱ	286	A → R (PubMed:1987139).Curated	1
Sequence conflictⁱ	286	A → R (PubMed:2840553).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M60607 Genomic DNA Translation: AAA64433.1 Different initiation. U00096 Genomic DNA Translation: AAC75404.2 AP009048 Genomic DNA Translation: BAA16205.1 Different initiation. Y00552 Genomic DNA Translation: CAA68630.1 Different initiation.
PIRⁱ	F65007
NCBI Reference Sequences More...RefSeqⁱ	NP_416846.2, NC_000913.3 WP_001295701.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC75404; AAC75404; b2344 BAA16205; BAA16205; BAA16205
GeneIDⁱ	946820
KEGGⁱ	ecj:JW2341 eco:b2344
PATRICⁱ	fig\|1411691.4.peg.4388

Protein	Similar proteins		Species	Score	Length	Source
P10384	Long-chain fatty acid transport protein		ECOH1		448	UniRef100_P10384
Long-chain fatty acid transport protein (Outer membrane fadLprotein) (Outer membrane flp protein)		Escherichia coli H420		448
Long-chain fatty acid transport protein (Outer membrane fadLprotein) (Outer membrane flp protein)		Escherichia coli H736		448
Long-chain fatty acid transport protein		Klebsiella pneumoniae IS22		446
Long-chain fatty acid outer membrane transporter		ECOLX		446
+22

Protein	Similar proteins		Species	Score	Length	Source
P10384	Long-chain fatty acid transport protein		SHIFL		446	UniRef90_P10384
Long-chain fatty acid transport protein		ECO57		446
Long-chain fatty acid transport protein		SALTY		435
Long-chain fatty acid transport protein		SALTI		435
Long-chain fatty acid transport protein		ECOH1		448
+688

Protein	Similar proteins		Species	Score	Length	Source
P10384	Long-chain fatty acid transport protein		ECO57		446	UniRef50_P10384
Long-chain fatty acid transport protein		SHIFL		446
Long-chain fatty acid transport protein		SALTI		435
Long-chain fatty acid transport protein		SALTY		435
Long-chain fatty acid transport protein		ECOL6		446
+1763

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M60607 Genomic DNA Translation: AAA64433.1 Different initiation. U00096 Genomic DNA Translation: AAC75404.2 AP009048 Genomic DNA Translation: BAA16205.1 Different initiation. Y00552 Genomic DNA Translation: CAA68630.1 Different initiation.
PIRⁱ	F65007
RefSeqⁱ	NP_416846.2, NC_000913.3 WP_001295701.1, NZ_LN832404.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1T16	X-ray	2.60	A/B	26-446	[»]
	1T1L	X-ray	2.80	A/B	26-446	[»]
	2R4L	X-ray	3.30	A/B/C	26-446	[»]
	2R4N	X-ray	3.20	A/B	26-446	[»]
	2R4O	X-ray	3.60	A/B	26-446	[»]
	2R4P	X-ray	2.90	A/B	26-446	[»]
	2R88	X-ray	2.60	A/B	26-446	[»]
	2R89	X-ray	3.40	A/B	31-446	[»]
	2R8A	X-ray	3.00	A/B	36-446	[»]
	3DWN	X-ray	2.50	A/B	26-446	[»]
	3PF1	X-ray	2.70	A/B	26-446	[»]
	3PGR	X-ray	2.60	A	26-446	[»]
	3PGS	X-ray	1.90	A/B	26-446	[»]
	3PGU	X-ray	1.70	A	26-446	[»]
ProteinModelPortalⁱ	P10384
SMRⁱ	P10384
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4260536, 118 interactors
STRINGⁱ	316385.ECDH10B_2507

Chemistry databases

ChEMBLⁱ	CHEMBL3309022
DrugBankⁱ	DB04233 (Hydroxyethyloxy)Tri(Ethyloxy)Octane DB04147 Lauryl Dimethylamine-N-Oxide

Protein family/group databases

TCDBⁱ	1.B.9.1.1 the fadl outer membrane protein (fadl) family

TCDBⁱ

1.B.9.1.1 the fadl outer membrane protein (fadl) family

Proteomic databases

EPDⁱ	P10384
PaxDbⁱ	P10384
PRIDEⁱ	P10384

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC75404; AAC75404; b2344 BAA16205; BAA16205; BAA16205
GeneIDⁱ	946820
KEGGⁱ	ecj:JW2341 eco:b2344
PATRICⁱ	fig\|1411691.4.peg.4388

Organism-specific databases

EchoBASEⁱ	EB0276
EcoGeneⁱ	EG10280 fadL

Phylogenomic databases

eggNOGⁱ	ENOG4105CKF Bacteria COG2067 LUCA
HOGENOMⁱ	HOG000277333
InParanoidⁱ	P10384
KOⁱ	K06076
OMAⁱ	YKVNKEW
PhylomeDBⁱ	P10384

Enzyme and pathway databases

BioCycⁱ	EcoCyc:EG10280-MONOMER MetaCyc:EG10280-MONOMER

BioCycⁱ

EcoCyc:EG10280-MONOMER
MetaCyc:EG10280-MONOMER

Miscellaneous databases

EvolutionaryTraceⁱ	P10384
Protein Ontology More...PROⁱ	PR:P10384

Family and domain databases

InterProⁱ	View protein in InterPro IPR005017 OMPP1/FadL/TodX
PANTHERⁱ	PTHR35093 PTHR35093, 1 hit
Pfamⁱ	View protein in Pfam PF03349 Toluene_X, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FADL_ECOLI
Accessionⁱ	P10384Primary (citable) accession number: P10384 Secondary accession number(s): P77697
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	December 12, 2006
	Last modified:	July 18, 2018
	This is version 160 of the entry and version 5 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P10384 (FADL_ECOLI)

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Long-chain fatty acid transport protein

fadL

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ