UniProtKB - P10384 (FADL_ECOLI)
Protein
Long-chain fatty acid transport protein
Gene
fadL
Organism
Escherichia coli (strain K12)
Status
Functioni
Involved in translocation of long-chain fatty acids across the outer membrane. It is a receptor for the bacteriophage T2. FadL may form a specific channel.
GO - Molecular functioni
- ligand-gated channel activity Source: EcoCyc
- long-chain fatty acid transporting porin activity Source: EcoCyc
Keywordsi
Biological process | Lipid transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10280-MONOMER MetaCyc:EG10280-MONOMER |
Protein family/group databases
TCDBi | 1.B.9.1.1, the fadl outer membrane protein (fadl) family |
Names & Taxonomyi
Protein namesi | Recommended name: Long-chain fatty acid transport proteinAlternative name(s): Outer membrane FadL protein Outer membrane flp protein |
Gene namesi | Name:fadL Synonyms:ttr Ordered Locus Names:b2344, JW2341 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Other locations
- Cell outer membrane 1 Publication; Multi-pass membrane protein 1 Publication
Other locations
- cell outer membrane Source: EcoCyc
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
Cell outer membrane, MembranePathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL3309022 |
DrugBanki | DB04233, (Hydroxyethyloxy)Tri(Ethyloxy)Octane DB04147, Dodecyldimethylamine N-oxide |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | 1 PublicationAdd BLAST | 25 | |
ChainiPRO_0000025202 | 26 – 446 | Long-chain fatty acid transport proteinAdd BLAST | 421 |
Proteomic databases
jPOSTi | P10384 |
PaxDbi | P10384 |
PRIDEi | P10384 |
Expressioni
Inductioni
By long-chain fatty acids. Expression of fadL is under the control of the FadR repressor.
Interactioni
Subunit structurei
Has been isolated from outer membrane preparation as a homodimer.
Protein-protein interaction databases
BioGRIDi | 4260536, 118 interactors |
STRINGi | 511145.b2344 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P10384 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P10384 |
Family & Domainsi
Sequence similaritiesi
Belongs to the OmpP1/FadL family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane beta strandPhylogenomic databases
eggNOGi | COG2067, Bacteria |
HOGENOMi | CLU_035981_0_0_6 |
InParanoidi | P10384 |
PhylomeDBi | P10384 |
Family and domain databases
Gene3Di | 2.40.160.60, 1 hit |
InterProi | View protein in InterPro IPR005017, OMPP1/FadL/TodX IPR042117, OMPP1/FadL/TodX_sf |
PANTHERi | PTHR35093, PTHR35093, 1 hit |
Pfami | View protein in Pfam PF03349, Toluene_X, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P10384-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQKTLFTKS ALAVAVALIS TQAWSAGFQL NEFSSSGLGR AYSGEGAIAD
60 70 80 90 100
DAGNVSRNPA LITMFDRPTF SAGAVYIDPD VNISGTSPSG RSLKADNIAP
110 120 130 140 150
TAWVPNMHFV APINDQFGWG ASITSNYGLA TEFNDTYAGG SVGGTTDLET
160 170 180 190 200
MNLNLSGAYR LNNAWSFGLG FNAVYARAKI ERFAGDLGQL VAGQIMQSPA
210 220 230 240 250
GQTQQGQALA ATANGIDSNT KIAHLNGNQW GFGWNAGILY ELDKNNRYAL
260 270 280 290 300
TYRSEVKIDF KGNYSSDLNR AFNNYGLPIP TATGGATQSG YLTLNLPEMW
310 320 330 340 350
EVSGYNRVDP QWAIHYSLAY TSWSQFQQLK ATSTSGDTLF QKHEGFKDAY
360 370 380 390 400
RIALGTTYYY DDNWTFRTGI AFDDSPVPAQ NRSISIPDQD RFWLSAGTTY
410 420 430 440
AFNKDASVDV GVSYMHGQSV KINEGPYQFE SEGKAWLFGT NFNYAF
Sequence cautioni
The sequence AAA64433 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA16205 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA68630 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 176 – 178 | ARA → RRP (PubMed:2840553).Curated | 3 | |
Sequence conflicti | 176 | A → V in AAA64433 (PubMed:1987139).Curated | 1 | |
Sequence conflicti | 286 | A → R (PubMed:1987139).Curated | 1 | |
Sequence conflicti | 286 | A → R (PubMed:2840553).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M60607 Genomic DNA Translation: AAA64433.1 Different initiation. U00096 Genomic DNA Translation: AAC75404.2 AP009048 Genomic DNA Translation: BAA16205.1 Different initiation. Y00552 Genomic DNA Translation: CAA68630.1 Different initiation. |
PIRi | F65007 |
RefSeqi | NP_416846.2, NC_000913.3 WP_001295701.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC75404; AAC75404; b2344 BAA16205; BAA16205; BAA16205 |
GeneIDi | 946820 |
KEGGi | ecj:JW2341 eco:b2344 |
PATRICi | fig|1411691.4.peg.4388 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M60607 Genomic DNA Translation: AAA64433.1 Different initiation. U00096 Genomic DNA Translation: AAC75404.2 AP009048 Genomic DNA Translation: BAA16205.1 Different initiation. Y00552 Genomic DNA Translation: CAA68630.1 Different initiation. |
PIRi | F65007 |
RefSeqi | NP_416846.2, NC_000913.3 WP_001295701.1, NZ_LN832404.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1T16 | X-ray | 2.60 | A/B | 26-446 | [»] | |
1T1L | X-ray | 2.80 | A/B | 26-446 | [»] | |
2R4L | X-ray | 3.30 | A/B/C | 26-446 | [»] | |
2R4N | X-ray | 3.20 | A/B | 26-446 | [»] | |
2R4O | X-ray | 3.60 | A/B | 26-446 | [»] | |
2R4P | X-ray | 2.90 | A/B | 26-446 | [»] | |
2R88 | X-ray | 2.60 | A/B | 26-446 | [»] | |
2R89 | X-ray | 3.40 | A/B | 31-446 | [»] | |
2R8A | X-ray | 3.00 | A/B | 36-446 | [»] | |
3DWN | X-ray | 2.50 | A/B | 26-446 | [»] | |
3PF1 | X-ray | 2.70 | A/B | 26-446 | [»] | |
3PGR | X-ray | 2.60 | A | 26-446 | [»] | |
3PGS | X-ray | 1.90 | A/B | 26-446 | [»] | |
3PGU | X-ray | 1.70 | A | 26-446 | [»] | |
SMRi | P10384 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4260536, 118 interactors |
STRINGi | 511145.b2344 |
Chemistry databases
ChEMBLi | CHEMBL3309022 |
DrugBanki | DB04233, (Hydroxyethyloxy)Tri(Ethyloxy)Octane DB04147, Dodecyldimethylamine N-oxide |
Protein family/group databases
TCDBi | 1.B.9.1.1, the fadl outer membrane protein (fadl) family |
Proteomic databases
jPOSTi | P10384 |
PaxDbi | P10384 |
PRIDEi | P10384 |
Genome annotation databases
EnsemblBacteriai | AAC75404; AAC75404; b2344 BAA16205; BAA16205; BAA16205 |
GeneIDi | 946820 |
KEGGi | ecj:JW2341 eco:b2344 |
PATRICi | fig|1411691.4.peg.4388 |
Organism-specific databases
EchoBASEi | EB0276 |
Phylogenomic databases
eggNOGi | COG2067, Bacteria |
HOGENOMi | CLU_035981_0_0_6 |
InParanoidi | P10384 |
PhylomeDBi | P10384 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10280-MONOMER MetaCyc:EG10280-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P10384 |
PROi | PR:P10384 |
Family and domain databases
Gene3Di | 2.40.160.60, 1 hit |
InterProi | View protein in InterPro IPR005017, OMPP1/FadL/TodX IPR042117, OMPP1/FadL/TodX_sf |
PANTHERi | PTHR35093, PTHR35093, 1 hit |
Pfami | View protein in Pfam PF03349, Toluene_X, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FADL_ECOLI | |
Accessioni | P10384Primary (citable) accession number: P10384 Secondary accession number(s): P77697 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | December 12, 2006 | |
Last modified: | April 7, 2021 | |
This is version 177 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families