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Protein

Long-chain fatty acid transport protein

Gene

fadL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in translocation of long-chain fatty acids across the outer membrane. It is a receptor for the bacteriophage T2. FadL may form a specific channel.

GO - Molecular functioni

Keywordsi

Biological processLipid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG10280-MONOMER
MetaCyc:EG10280-MONOMER

Protein family/group databases

TCDBi1.B.9.1.1 the fadl outer membrane protein (fadl) family

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain fatty acid transport protein
Alternative name(s):
Outer membrane FadL protein
Outer membrane flp protein
Gene namesi
Name:fadL
Synonyms:ttr
Ordered Locus Names:b2344, JW2341
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10280 fadL

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3309022
DrugBankiDB04233 (Hydroxyethyloxy)Tri(Ethyloxy)Octane
DB04147 Lauryl Dimethylamine-N-Oxide

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000002520226 – 446Long-chain fatty acid transport proteinAdd BLAST421

Proteomic databases

EPDiP10384
PaxDbiP10384
PRIDEiP10384

Expressioni

Inductioni

By long-chain fatty acids. Expression of fadL is under the control of the FadR repressor.

Interactioni

Subunit structurei

Has been isolated from outer membrane preparation as a homodimer.

Protein-protein interaction databases

BioGridi4260536, 118 interactors
STRINGi316385.ECDH10B_2507

Structurei

Secondary structure

1446
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP10384
SMRiP10384
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10384

Family & Domainsi

Sequence similaritiesi

Belongs to the OmpP1/FadL family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105CKF Bacteria
COG2067 LUCA
HOGENOMiHOG000277333
InParanoidiP10384
KOiK06076
OMAiYKVNKEW
PhylomeDBiP10384

Family and domain databases

InterProiView protein in InterPro
IPR005017 OMPP1/FadL/TodX
PANTHERiPTHR35093 PTHR35093, 1 hit
PfamiView protein in Pfam
PF03349 Toluene_X, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10384-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQKTLFTKS ALAVAVALIS TQAWSAGFQL NEFSSSGLGR AYSGEGAIAD
60 70 80 90 100
DAGNVSRNPA LITMFDRPTF SAGAVYIDPD VNISGTSPSG RSLKADNIAP
110 120 130 140 150
TAWVPNMHFV APINDQFGWG ASITSNYGLA TEFNDTYAGG SVGGTTDLET
160 170 180 190 200
MNLNLSGAYR LNNAWSFGLG FNAVYARAKI ERFAGDLGQL VAGQIMQSPA
210 220 230 240 250
GQTQQGQALA ATANGIDSNT KIAHLNGNQW GFGWNAGILY ELDKNNRYAL
260 270 280 290 300
TYRSEVKIDF KGNYSSDLNR AFNNYGLPIP TATGGATQSG YLTLNLPEMW
310 320 330 340 350
EVSGYNRVDP QWAIHYSLAY TSWSQFQQLK ATSTSGDTLF QKHEGFKDAY
360 370 380 390 400
RIALGTTYYY DDNWTFRTGI AFDDSPVPAQ NRSISIPDQD RFWLSAGTTY
410 420 430 440
AFNKDASVDV GVSYMHGQSV KINEGPYQFE SEGKAWLFGT NFNYAF
Length:446
Mass (Da):48,542
Last modified:December 12, 2006 - v5
Checksum:i9B50C55D82CDB085
GO

Sequence cautioni

The sequence AAA64433 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA16205 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA68630 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176 – 178ARA → RRP (PubMed:2840553).Curated3
Sequence conflicti176A → V in AAA64433 (PubMed:1987139).Curated1
Sequence conflicti286A → R (PubMed:1987139).Curated1
Sequence conflicti286A → R (PubMed:2840553).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60607 Genomic DNA Translation: AAA64433.1 Different initiation.
U00096 Genomic DNA Translation: AAC75404.2
AP009048 Genomic DNA Translation: BAA16205.1 Different initiation.
Y00552 Genomic DNA Translation: CAA68630.1 Different initiation.
PIRiF65007
RefSeqiNP_416846.2, NC_000913.3
WP_001295701.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75404; AAC75404; b2344
BAA16205; BAA16205; BAA16205
GeneIDi946820
KEGGiecj:JW2341
eco:b2344
PATRICifig|1411691.4.peg.4388

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60607 Genomic DNA Translation: AAA64433.1 Different initiation.
U00096 Genomic DNA Translation: AAC75404.2
AP009048 Genomic DNA Translation: BAA16205.1 Different initiation.
Y00552 Genomic DNA Translation: CAA68630.1 Different initiation.
PIRiF65007
RefSeqiNP_416846.2, NC_000913.3
WP_001295701.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1T16X-ray2.60A/B26-446[»]
1T1LX-ray2.80A/B26-446[»]
2R4LX-ray3.30A/B/C26-446[»]
2R4NX-ray3.20A/B26-446[»]
2R4OX-ray3.60A/B26-446[»]
2R4PX-ray2.90A/B26-446[»]
2R88X-ray2.60A/B26-446[»]
2R89X-ray3.40A/B31-446[»]
2R8AX-ray3.00A/B36-446[»]
3DWNX-ray2.50A/B26-446[»]
3PF1X-ray2.70A/B26-446[»]
3PGRX-ray2.60A26-446[»]
3PGSX-ray1.90A/B26-446[»]
3PGUX-ray1.70A26-446[»]
ProteinModelPortaliP10384
SMRiP10384
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260536, 118 interactors
STRINGi316385.ECDH10B_2507

Chemistry databases

ChEMBLiCHEMBL3309022
DrugBankiDB04233 (Hydroxyethyloxy)Tri(Ethyloxy)Octane
DB04147 Lauryl Dimethylamine-N-Oxide

Protein family/group databases

TCDBi1.B.9.1.1 the fadl outer membrane protein (fadl) family

Proteomic databases

EPDiP10384
PaxDbiP10384
PRIDEiP10384

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75404; AAC75404; b2344
BAA16205; BAA16205; BAA16205
GeneIDi946820
KEGGiecj:JW2341
eco:b2344
PATRICifig|1411691.4.peg.4388

Organism-specific databases

EchoBASEiEB0276
EcoGeneiEG10280 fadL

Phylogenomic databases

eggNOGiENOG4105CKF Bacteria
COG2067 LUCA
HOGENOMiHOG000277333
InParanoidiP10384
KOiK06076
OMAiYKVNKEW
PhylomeDBiP10384

Enzyme and pathway databases

BioCyciEcoCyc:EG10280-MONOMER
MetaCyc:EG10280-MONOMER

Miscellaneous databases

EvolutionaryTraceiP10384
PROiPR:P10384

Family and domain databases

InterProiView protein in InterPro
IPR005017 OMPP1/FadL/TodX
PANTHERiPTHR35093 PTHR35093, 1 hit
PfamiView protein in Pfam
PF03349 Toluene_X, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFADL_ECOLI
AccessioniPrimary (citable) accession number: P10384
Secondary accession number(s): P77697
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: December 12, 2006
Last modified: July 18, 2018
This is version 160 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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