Cellular tumor antigen p53

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: UniProtKB
• chromatin binding Source: GO_Central
• copper ion binding Source: UniProtKB
• damaged DNA binding Source: GO_Central
• DNA binding Source: UniProtKB
• DNA-binding transcription factor activity Source: GO_Central
• double-stranded DNA binding Source: GO_Central
• MDM2/MDM4 family protein binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 23941874
• p53 binding Source: GO_Central
• promoter-specific chromatin binding Source: UniProtKB
• protein C-terminus binding Source: RGDInferred from physical interactionⁱ
  • 11278372
• RNA polymerase II distal enhancer sequence-specific DNA binding Source: UniProtKB
• RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: UniProtKB
• sequence-specific DNA binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 15632413
• transcription cofactor binding Source: RGDInferred from physical interactionⁱ
  • 21792911
• ubiquitin protein ligase binding Source: RGDInferred from physical interactionⁱ
  • 16330492

GO - Biological processⁱ

• aging Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • 18037131
• cell aging Source: UniProtKB
• cellular response to DNA damage stimulus Source: UniProtKB
• cellular response to heat Source: RGDInferred from expression patternⁱ
  • 11295070
• cellular response to organonitrogen compound Source: RGDInferred from expression patternⁱ
  • 11502571
• cellular response to reactive oxygen species Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 24817286
• cellular response to UV Source: GO_Central
• circadian behavior Source: UniProtKB
• DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: GO_Central
• DNA strand renaturation Source: UniProtKB
• entrainment of circadian clock by photoperiod Source: UniProtKB
• intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: GO_Central
• mitotic G1 DNA damage checkpoint Source: GO_Central
• multicellular organism development Source: UniProtKB
• negative regulation of cell growth Source: UniProtKB
• negative regulation of DNA biosynthetic process Source: RGDInferred from mutant phenotypeⁱ
  • 11502571
• negative regulation of smooth muscle cell proliferation Source: RGDInferred from mutant phenotypeⁱ
  • 17659301
• negative regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • 8389468
• negative regulation of transcription by RNA polymerase II Source: GO_Central
• nucleotide-excision repair Source: UniProtKB
• oligodendrocyte apoptotic process Source: UniProtKB
• positive regulation of apoptotic process Source: RGDInferred from mutant phenotypeⁱ
  • 16688778
• positive regulation of cell cycle Source: RGDInferred from mutant phenotypeⁱ
  • 18026139
• positive regulation of gene expression Source: ARUK-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 23164821
• positive regulation of histone deacetylation Source: GO_Central
• positive regulation of leukocyte migration Source: RGDInferred from mutant phenotypeⁱ
  • 18317410
• positive regulation of neuron apoptotic process Source: GO_Central
• positive regulation of release of cytochrome c from mitochondria Source: UniProtKB
• positive regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • 11278372
• protein tetramerization Source: InterPro
• regulation of hydrogen peroxide-induced cell death Source: UniProtKBInferred from mutant phenotypeⁱ
  • 17998337
• regulation of intracellular pH Source: RGDInferred from mutant phenotypeⁱ
  • 16688778
• regulation of transcription by RNA polymerase II Source: RGD <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 11502571
• response to amino acid Source: RGDInferred from expression patternⁱ
  • 17542038
• response to caffeine Source: RGDInferred from expression patternⁱ
  • 16544096
• response to cytokine Source: RGDInferred from expression patternⁱ
  • 17651018
• response to drug Source: RGDInferred from expression patternⁱ
  • 18336558
• response to ethanol Source: RGDInferred from expression patternⁱ
  • 20961644
• response to gamma radiation Source: GO_Central
• response to hyperoxia Source: RGDInferred from expression patternⁱ
  • 18337831
• response to inorganic substance Source: RGDInferred from expression patternⁱ
  • 18335527
• response to metal ion Source: RGDInferred from expression patternⁱ
  • 17466256
• response to organic cyclic compound Source: RGDInferred from expression patternⁱ
  • 18093815
• response to organonitrogen compound Source: RGDInferred from expression patternⁱ
  • 18311796
• response to oxidative stress Source: RGDInferred from expression patternⁱ
  • 17600529
• response to retinoic acid Source: RGDInferred from expression patternⁱ
  • 17962954
• response to UV Source: RGDInferred from expression patternⁱ
  • 17724205
• response to UV-B Source: RGDInferred from expression patternⁱ
  • 22559303
• response to vitamin B3 Source: RGDInferred from expression patternⁱ
  • 17516866
• response to X-ray Source: RGDInferred from expression patternⁱ
  • 17699727
• transcription, DNA-templated Source: UniProtKB-KW
• wound healing Source: RGDInferred from expression patternⁱ
  • 18337831

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Keywords - Diseaseⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Sites

GO - Molecular functionⁱ

• MDM2/MDM4 family protein binding Source: RGDInferred from physical interactionⁱ
  • 23941874
• p53 binding Source: GO_Central
• protein C-terminus binding Source: RGDInferred from physical interactionⁱ
  • 11278372
• transcription cofactor binding Source: RGDInferred from physical interactionⁱ
  • 21792911
• ubiquitin protein ligase binding Source: RGDInferred from physical interactionⁱ
  • 16330492

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>computationally mapped.ⁱShow all

        10         20         30         40         50
MEDSQSDMSI ELPLSQETFS CLWKLLPPDD ILPTTATGSP NSMEDLFLPQ 
        60         70         80         90        100
DVAELLEGPE EALQVSAPAA QEPGTEAPAP VAPASATPWP LSSSVPSQKT 
       110        120        130        140        150
YQGNYGFHLG FLQSGTAKSV MCTYSISLNK LFCQLAKTCP VQLWVTSTPP 
       160        170        180        190        200
PGTRVRAMAI YKKSQHMTEV VRRCPHHERC SDGDGLAPPQ HLIRVEGNPY 
       210        220        230        240        250
AEYLDDRQTF RHSVVVPYEP PEVGSDYTTI HYKYMCNSSC MGGMNRRPIL 
       260        270        280        290        300
TIITLEDSSG NLLGRDSFEV RVCACPGRDR RTEEENFRKK EEHCPELPPG 
       310        320        330        340        350
SAKRALPTST SSSPQQKKKP LDGEYFTLKI RGRERFEMFR ELNEALELKD 
       360        370        380        390 
ARAAEESGDS RAHSSYPKTK KGQSTSRHKK PMIKKVGPDS D          

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ