ry - Xanthine dehydrogenase - Drosophila melanogaster (Fruit fly)

Functionⁱ

Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid (By similarity).By similarity1 Publication

Catalytic activityⁱ

H₂O
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+
NAD⁺
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xanthine
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=
H⁺
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+
NADH
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urate
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EC:
1.17.1.4
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- See the description of this EC number in ENZYME.
Source:
Rhea
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H₂O
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NAD⁺
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xanthine
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=
H⁺
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NADH
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urate
H₂O
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+
hypoxanthine
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NAD⁺
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=
H⁺
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NADH
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xanthine
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EC:
1.17.1.4
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- See the description of this EC number in ENZYME.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
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H₂O
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hypoxanthine
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NAD⁺
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=
H⁺
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NADH
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xanthine
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Cofactorⁱ

Protein has several cofactor binding sites:

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	43	Iron-sulfur 1By similarity	1
Metal bindingⁱ	48	Iron-sulfur 1By similarity	1
Metal bindingⁱ	51	Iron-sulfur 1By similarity	1
Metal bindingⁱ	73	Iron-sulfur 1By similarity	1
Metal bindingⁱ	113	Iron-sulfur 2By similarity	1
Metal bindingⁱ	116	Iron-sulfur 2By similarity	1
Metal bindingⁱ	148	Iron-sulfur 2By similarity	1
Metal bindingⁱ	150	Iron-sulfur 2By similarity	1
Binding siteⁱ	335	FADBy similarity	1
Binding siteⁱ	358	FADBy similarity	1
Binding siteⁱ	406	FAD; via amide nitrogen and carbonyl oxygenBy similarity	1
Binding siteⁱ	424	FADBy similarity	1
Metal bindingⁱ	772	MolybdenumBy similarity	1
Metal bindingⁱ	803	Molybdenum; via carbonyl oxygenBy similarity	1
Binding siteⁱ	807	SubstrateBy similarity	1
Binding siteⁱ	885	SubstrateBy similarity	1
Metal bindingⁱ	917	Molybdenum; via amide nitrogenBy similarity	1
Binding siteⁱ	919	SubstrateBy similarity	1
Metal bindingⁱ	1084	Molybdenum; via amide nitrogenBy similarity	1
Active siteⁱ	1267	Proton acceptorBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	255 – 262	FADBy similarity		8
Nucleotide bindingⁱ	345 – 349	FADBy similarity		5

GO - Molecular functionⁱ

2 iron, 2 sulfur cluster binding Source: UniProtKB
electron transfer activity Source: InterPro
FAD binding Source: InterPro
flavin adenine dinucleotide binding Source: UniProtKB
iron ion binding Source: InterPro
molybdopterin cofactor binding Source: UniProtKB
xanthine dehydrogenase activity
Source: FlyBase
Inferred from mutant phenotypeⁱ
- "Iron Sulfur and Molybdenum Cofactor Enzymes Regulate the Drosophila Life Cycle by Controlling Cell Metabolism."
  Marelja Z., Leimkuehler S., Missirlis F.
  Front. Physiol. 9:50-50(2018) [PubMed] [Europe PMC] [Abstract]
xanthine oxidase activity Source: InterPro

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	2Fe-2S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

Enzyme and pathway databases

Reactomeⁱ	R-DME-74259 Purine catabolism R-DME-964975 Vitamins B6 activation to pyridoxal phosphate

Reactomeⁱ

R-DME-74259 Purine catabolism
R-DME-964975 Vitamins B6 activation to pyridoxal phosphate

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Xanthine dehydrogenase (EC:1.17.1.4) Short name: XD Alternative name(s): Protein rosy locus
Gene namesⁱ	Name:ry Synonyms:XDH ORF Names:CG7642
Organismⁱ	Drosophila melanogaster (Fruit fly)
Taxonomic identifierⁱ	7227 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophila › Sophophora › melanogaster group › melanogaster subgroup
Proteomesⁱ	UP000000803 Componentⁱ: Chromosome 3R

Organism-specific databases

Drosophila genome database More...FlyBaseⁱ	FBgn0003308 ry

FlyBaseⁱ

FBgn0003308 ry

Keywords - Cellular componentⁱ

Peroxisome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000166079	1 – 1335	Xanthine dehydrogenaseAdd BLAST		1335

Proteomic databases

PaxDbⁱ	P10351
PRIDEⁱ	P10351

Expressionⁱ

Gene expression databases

Bgeeⁱ	FBgn0003308 Expressed in 41 organ(s), highest expression level in adult Malpighian tubule (Drosophila)
Genevisibleⁱ	P10351 DM

Interactionⁱ

Subunit structureⁱ

Homodimer.

By similarity

Protein-protein interaction databases

BioGridⁱ	66692, 7 interactors
IntActⁱ	P10351, 4 interactors
STRINGⁱ	7227.FBpp0082172

Structureⁱ

3D structure databases

SMRⁱ	P10351
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	4 – 91	2Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST		88
Domainⁱ	227 – 416	FAD-binding PCMH-typePROSITE-ProRule annotationAdd BLAST		190

Sequence similaritiesⁱ

Belongs to the xanthine dehydrogenase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0430 Eukaryota COG4630 LUCA COG4631 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00950000183114
InParanoidⁱ	P10351
KEGG Orthology (KO) More...KOⁱ	K00106
OMAⁱ	VPLMYKQ
Database of Orthologous Groups More...OrthoDBⁱ	48717at2759
PhylomeDBⁱ	P10351

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00207 fer2, 1 hit
InterProⁱ	View protein in InterPro IPR002888 2Fe-2S-bd IPR036884 2Fe-2S-bd_dom_sf IPR036010 2Fe-2S_ferredoxin-like_sf IPR001041 2Fe-2S_ferredoxin-type IPR006058 2Fe2S_fd_BS IPR000674 Ald_Oxase/Xan_DH_a/b IPR036856 Ald_Oxase/Xan_DH_a/b_sf IPR016208 Ald_Oxase/xanthine_DH IPR008274 AldOxase/xan_DH_Mopterin-bd IPR037165 AldOxase/xan_DH_Mopterin-bd_sf IPR005107 CO_DH_flav_C IPR036683 CO_DH_flav_C_dom_sf IPR016166 FAD-bd_PCMH IPR036318 FAD-bd_PCMH-like_sf IPR002346 Mopterin_DH_FAD-bd IPR022407 OxRdtase_Mopterin_BS IPR014307 Xanthine_DH_ssu
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01315 Ald_Xan_dh_C, 1 hit PF02738 Ald_Xan_dh_C2, 1 hit PF03450 CO_deh_flav_C, 1 hit PF00941 FAD_binding_5, 1 hit PF00111 Fer2, 1 hit PF01799 Fer2_2, 1 hit
PIRSFⁱ	PIRSF000127 Xanthine_DH, 1 hit
SMARTⁱ	View protein in SMART SM01008 Ald_Xan_dh_C, 1 hit SM01092 CO_deh_flav_C, 1 hit
SUPFAMⁱ	SSF47741 SSF47741, 1 hit SSF54292 SSF54292, 1 hit SSF54665 SSF54665, 1 hit SSF55447 SSF55447, 1 hit SSF56003 SSF56003, 1 hit SSF56176 SSF56176, 1 hit
TIGRFAMsⁱ	TIGR02963 xanthine_xdhA, 1 hit
PROSITEⁱ	View protein in PROSITE PS00197 2FE2S_FER_1, 1 hit PS51085 2FE2S_FER_2, 1 hit PS51387 FAD_PCMH, 1 hit PS00559 MOLYBDOPTERIN_EUK, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P10351-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MSNSVLVFFV NGKKVTEVSP DPECTLLTFL REKLRLCGTK LGCAEGGCGA 
        60         70         80         90        100
CTVMVSRLDR RANKIRHLAV NACLTPVCSM HGCAVTTVEG IGSTKTRLHP 
       110        120        130        140        150
VQERLAKAHG SQCGFCTPGI VMSMYALLRN AEQPSMRDLE VAFQGNLCRC 
       160        170        180        190        200
TGYRPILEGY KTFTKEFACG MGEKCCKVSG KGCGTDAETD DKLFERSEFQ 
       210        220        230        240        250
PLDPSQEPIF PPELQLSDAF DSQSLIFSSD RVTWYRPTNL EELLQLKAKH 
       260        270        280        290        300
PAAKLVVGNT EVGVEVKFKH FLYPHLINPT QVKELLEIKE NQDGIYFGAA 
       310        320        330        340        350
VSLMEIDALL RQRIEQLPES ETRLFQCTVD MLHYFAGKQI RNVACLGGNI 
       360        370        380        390        400
MTGSPISDMN PVLSAAGAQL EVASFVDGKL QKRSVHMGTG FFTGYRRNVI 
       410        420        430        440        450
EAHEVLLGIH FRKTTPDQYI VAFKQARRRD DDIAIVNAAI NVRFEEKSNI 
       460        470        480        490        500
VAEISMAFGG MAPTTVLAPR TSQLMVGQEW SHQLVERVAE SLCTELPLAA 
       510        520        530        540        550
SAPGGMIAYR RALVVSLFFK AYLAISLKLS KSGITSSDAL PSEERSGAET 
       560        570        580        590        600
FHTPVLKSAQ LFERVCSDQP ICDPIGRPKV HAAALKQATG EAIYTDDIPR 
       610        620        630        640        650
MDGEVYLAFV LSTKPRAKIT KLDASEALAL DGVHQFFCYK DLTEHENEVG 
       660        670        680        690        700
PVFHDEHVFA AGEVHCYGQI VGAIAADNKA LAQRAARLVK VEYEELSPVI 
       710        720        730        740        750
VTIEQAIEHK SYFPDYPRFV TKGNVEEALA QADHTFEGTC RMGGQEHFYL 
       760        770        780        790        800
ETHAALAVPR DSDELELFCS TQHPSEVQKL VAHVTALPAH RVVCRAKRLG 
       810        820        830        840        850
GGFGGKESRG ISVALPVALA AYRMGRPVRC MLDRDEDMLI TGTRHPFLFK 
       860        870        880        890        900
YKVGFTKEGL ITACDIECYN NAGWSMDLSF SVLERAMFHF ENCYRIPNVR 
       910        920        930        940        950
VGGWVCKTNL PSNTAFRGFG GPQGMYAGEH IIRDVARIVG RDVVDVMRLN 
       960        970        980        990       1000
FYKTGDYTHY HQQLEHFPIE RCLEDCLKQS RYDEKRQEIA RFNRENRWRK 
      1010       1020       1030       1040       1050
RGMAVVPTKY GIAFGVMHLN QAGSLINIYG DGSVLLSHGG VEIGQGLNTK 
      1060       1070       1080       1090       1100
MIQCAARALG IPSELIHISE TATDKVPNTS PTAASVGSDL NGMAVLDACE 
      1110       1120       1130       1140       1150
KLNKRLAPIK EALPGGTWKE WINKAYFDRV SLSATGFYAM PGIGYHPETN 
      1160       1170       1180       1190       1200
PNARTYSYYT NGVGVTVVEI DCLTGDHQVL STDIVMDIGS SLNPAIDIGQ 
      1210       1220       1230       1240       1250
IEGAFMQGYG LFTLEELMYS PQGMLYSRGP GMYKLPGFAD IPGEFNVSLL 
      1260       1270       1280       1290       1300
TGAPNPRAVY SSKAVGEPPL FIGSSAFFAI KEAIAAARED QGLSGDFPLE 
      1310       1320       1330 
APSTSARIRI ACQDKFTELL EIPEPGSFTP WNIVP

Length:1,335

Mass (Da):146,927

Last modified:June 20, 2003 - v2

Checksum:ⁱ230368EA59B30AD8

GO

Sequence cautionⁱ

The sequence AAM11042 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	106	A → P in CAA68409 (Ref. 1) Curated	1
Sequence conflictⁱ	106	A → P no nucleotide entry (PubMed:3036645).Curated	1
Sequence conflictⁱ	316	Q → L in CAA68409 (Ref. 1) Curated	1
Sequence conflictⁱ	316	Q → L no nucleotide entry (PubMed:3036646).Curated	1
Sequence conflictⁱ	542	S → P in CAA68409 (Ref. 1) Curated	1
Sequence conflictⁱ	542	S → P no nucleotide entry (PubMed:3036646).Curated	1
Sequence conflictⁱ	709	H → L in CAA68409 (Ref. 1) Curated	1
Sequence conflictⁱ	709	H → L no nucleotide entry (PubMed:3036646).Curated	1
Sequence conflictⁱ	730	A → S in CAA68409 (Ref. 1) Curated	1
Sequence conflictⁱ	730	A → S no nucleotide entry (PubMed:3036646).Curated	1
Sequence conflictⁱ	988	E → D in CAA68409 (Ref. 1) Curated	1
Sequence conflictⁱ	988	E → D no nucleotide entry (PubMed:3036646).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y00308 Genomic DNA Translation: CAA68409.1 AE014297 Genomic DNA Translation: AAF54895.1 BT015293 mRNA Translation: AAT94522.1 AY094689 mRNA Translation: AAM11042.1 Different initiation.
PIRⁱ	S07245
NCBI Reference Sequences More...RefSeqⁱ	NP_524337.1, NM_079613.3

Genome annotation databases

EnsemblMetazoaⁱ	FBtr0082704; FBpp0082172; FBgn0003308
GeneIDⁱ	41605
KEGGⁱ	dme:Dmel_CG7642

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P10351	GM24078		DROSE		1335	UniRef90_P10351
Xanthine dehydrogenase		DROER		1335
Ry		DROYA		1335
Xanthine dehydrogenase (Fragment)		Drosophila mimetica		1322
Xanthine dehydrogenase (Fragment)		DROOR		1321
+9

Protein	Similar proteins		Species	Score	Length	Source
P10351	Xanthine dehydrogenase		CALVI		1353	UniRef50_P10351
Xanthine dehydrogenase		DROSU		1344
Xanthine dehydrogenase		DROPS		1343
GM24078		DROSE		1335
Ry		DROYA		1335
+105

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y00308 Genomic DNA Translation: CAA68409.1 AE014297 Genomic DNA Translation: AAF54895.1 BT015293 mRNA Translation: AAT94522.1 AY094689 mRNA Translation: AAM11042.1 Different initiation.
PIRⁱ	S07245
RefSeqⁱ	NP_524337.1, NM_079613.3

3D structure databases

SMRⁱ	P10351
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	66692, 7 interactors
IntActⁱ	P10351, 4 interactors
STRINGⁱ	7227.FBpp0082172

Proteomic databases

PaxDbⁱ	P10351
PRIDEⁱ	P10351

Genome annotation databases

EnsemblMetazoaⁱ	FBtr0082704; FBpp0082172; FBgn0003308
GeneIDⁱ	41605
KEGGⁱ	dme:Dmel_CG7642

Organism-specific databases

CTDⁱ	41605
FlyBaseⁱ	FBgn0003308 ry

Phylogenomic databases

eggNOGⁱ	KOG0430 Eukaryota COG4630 LUCA COG4631 LUCA
GeneTreeⁱ	ENSGT00950000183114
InParanoidⁱ	P10351
KOⁱ	K00106
OMAⁱ	VPLMYKQ
OrthoDBⁱ	48717at2759
PhylomeDBⁱ	P10351

Enzyme and pathway databases

Reactomeⁱ	R-DME-74259 Purine catabolism R-DME-964975 Vitamins B6 activation to pyridoxal phosphate

Reactomeⁱ

R-DME-74259 Purine catabolism
R-DME-964975 Vitamins B6 activation to pyridoxal phosphate

Miscellaneous databases

GenomeRNAiⁱ	41605
Protein Ontology More...PROⁱ	PR:P10351

Gene expression databases

Bgeeⁱ	FBgn0003308 Expressed in 41 organ(s), highest expression level in adult Malpighian tubule (Drosophila)
Genevisibleⁱ	P10351 DM

Family and domain databases

CDDⁱ	cd00207 fer2, 1 hit
InterProⁱ	View protein in InterPro IPR002888 2Fe-2S-bd IPR036884 2Fe-2S-bd_dom_sf IPR036010 2Fe-2S_ferredoxin-like_sf IPR001041 2Fe-2S_ferredoxin-type IPR006058 2Fe2S_fd_BS IPR000674 Ald_Oxase/Xan_DH_a/b IPR036856 Ald_Oxase/Xan_DH_a/b_sf IPR016208 Ald_Oxase/xanthine_DH IPR008274 AldOxase/xan_DH_Mopterin-bd IPR037165 AldOxase/xan_DH_Mopterin-bd_sf IPR005107 CO_DH_flav_C IPR036683 CO_DH_flav_C_dom_sf IPR016166 FAD-bd_PCMH IPR036318 FAD-bd_PCMH-like_sf IPR002346 Mopterin_DH_FAD-bd IPR022407 OxRdtase_Mopterin_BS IPR014307 Xanthine_DH_ssu
Pfamⁱ	View protein in Pfam PF01315 Ald_Xan_dh_C, 1 hit PF02738 Ald_Xan_dh_C2, 1 hit PF03450 CO_deh_flav_C, 1 hit PF00941 FAD_binding_5, 1 hit PF00111 Fer2, 1 hit PF01799 Fer2_2, 1 hit
PIRSFⁱ	PIRSF000127 Xanthine_DH, 1 hit
SMARTⁱ	View protein in SMART SM01008 Ald_Xan_dh_C, 1 hit SM01092 CO_deh_flav_C, 1 hit
SUPFAMⁱ	SSF47741 SSF47741, 1 hit SSF54292 SSF54292, 1 hit SSF54665 SSF54665, 1 hit SSF55447 SSF55447, 1 hit SSF56003 SSF56003, 1 hit SSF56176 SSF56176, 1 hit
TIGRFAMsⁱ	TIGR02963 xanthine_xdhA, 1 hit
PROSITEⁱ	View protein in PROSITE PS00197 2FE2S_FER_1, 1 hit PS51085 2FE2S_FER_2, 1 hit PS51387 FAD_PCMH, 1 hit PS00559 MOLYBDOPTERIN_EUK, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	XDH_DROME
Accessionⁱ	P10351Primary (citable) accession number: P10351 Secondary accession number(s): Q6AWF5, Q8SXC4, Q9VFZ9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	June 20, 2003
	Last modified:	July 3, 2019
	This is version 184 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Drosophila annotation project

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Xanthine dehydrogenase

ry

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

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Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Peroxisome

Cytosol

Peroxisome

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ