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Entry version 158 (07 Apr 2021)
Sequence version 2 (01 Dec 2000)
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Protein

Accessory gland-specific peptide 26Aa

Gene

Acp26Aa

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Male seminal protein which enhances ovulation in female Drosophila by stimulating the release of oocytes by the ovary following mating (PubMed:7479736, PubMed:15640356, PubMed:24101486, PubMed:10662669). Acts by increasing octopamine (OA) neuronal signaling in the female genital tract leading to the postmating relaxation of the oviduct muscles (PubMed:24101486). This activation of the OA signaling pathway is likely to indirectly contribute to the mating-dependent increase in the number of OA synaptic sites in the female reproductive tract (PubMed:24101486).4 Publications
Male seminal peptide which is able to enhance ovulation in female Drosophila.1 Publication
Male seminal peptide which is able to enhance ovulation in female Drosophila.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBehavior

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Accessory gland-specific peptide 26Aa1 Publication
Alternative name(s):
Male accessory gland secretory protein 355A1 Publication
Cleaved into the following 6 chains:
CP1-N1 Publication
CP1-C1 Publication
CP2-N1 Publication
CP2-C1 Publication
CP3-N1 Publication
CP3-C1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Acp26Aa1 PublicationImported
Synonyms:msp355a1 Publication, Mst26Aa, mst355a1 Publication, ovulin1 Publication
ORF Names:CG8982Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0002855, Acp26Aa

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi43 – 264Missing : Males have no visible phenotype and are fertile. However, mated females display a decrease in the number of oocytes released by their ovary and deposit fewer eggs on day 1 after the start of mating (ASM). No effect on the number of eggs laid by mated females on day 2 to 4 ASM. No effect on female receptibility to another mate and does not affect sperm resistance to displacement by rival ejaculates. 2 PublicationsAdd BLAST222
Mutagenesisi224 – 228YRNKY → ARNKA: Loss of homodimerization. 1 Publication5
Mutagenesisi229 – 232LTLL → ATLA: Loss of homodimerization. 1 Publication4
Mutagenesisi236 – 239SQKI → AQKA: Loss of homodimerization. 1 Publication4
Mutagenesisi243 – 246IAKV → AAKA: Loss of homodimerization. 1 Publication4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002175519 – 264Accessory gland-specific peptide 26AaAdd BLAST246
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000045107019 – 48CP1-N1 PublicationAdd BLAST30
PeptideiPRO_000045107149 – 264CP1-C1 PublicationAdd BLAST216
PeptideiPRO_000045107249 – 67CP2-N1 PublicationAdd BLAST19
PeptideiPRO_000045107368 – 264CP2-C1 PublicationAdd BLAST197
PeptideiPRO_000045107468 – 117CP3-N1 PublicationAdd BLAST50
PeptideiPRO_0000451075118 – 264CP3-C1 PublicationAdd BLAST147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi122N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylation.2 Publications
Undergoes several cleavages as it is secreted and is further processed in the recipient female (PubMed:3142802, PubMed:2257979, PubMed:7556947, PubMed:24514904, PubMed:10612039). The precursor molecule is proteolytically cleaved by the seminal metalloprotease Semp1 at Lys-48 to produce CP1-N and CP1-C (PubMed:3142802, PubMed:2257979, PubMed:7556947, PubMed:24514904).5 Publications
Cleaved at Lys-67 by Semp1 to generate CP2-N and CP2-C (PubMed:3142802, PubMed:2257979, PubMed:7556947, PubMed:24514904). Cleavage appears to take place in the mated female genital tract (PubMed:2257979, PubMed:7556947).4 Publications
Cleaved at Lys-117 by Semp1 to generate CP3-N and CP3-C (PubMed:3142802, PubMed:2257979, PubMed:7556947, PubMed:24514904). Cleavage appears to take place in the mated female genital tract (PubMed:2257979, PubMed:7556947).4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei48 – 49Cleavage; by Semp11 Publication2
Sitei67 – 68Cleavage; by Semp11 Publication2
Sitei117 – 118Cleavage; by Semp11 Publication2

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P10333

PRoteomics IDEntifications database

More...
PRIDEi
P10333

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Produced in the male accessory glands and secreted into seminal fluid (at protein level) (PubMed:2257979, PubMed:7556947, PubMed:7479736, PubMed:3142802, PubMed:10612039). Detected in the main cells and secondary cells of the accessory glands of 1 day old males (at protein level) (PubMed:2257979, PubMed:7556947, PubMed:7479736, PubMed:20138215, PubMed:24514904). In 5 day old males, confined to the secondary cells and only reappears in the main cells after mating (at protein level) (PubMed:2257979). Produced in adult males 3-4 hr after eclosion, levels increase reaching a peak at day 3-5 which is maintained until at least day 10 of adulthood (at protein level) (PubMed:2257979). In unmated male adults, levels are maintained for the first 6 days of adulthood and then gradually decrease for at least the next 8 days (PubMed:2257979). In mated females, detected in the genital tract 3 mins after the start of mating (ASM) and is secreted into the female hemolymph via the posterior vaginal wall 5 mins ASM (at protein level) (PubMed:2257979, PubMed:7556947, PubMed:10612039).7 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in response to mating.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0002855, Expressed in male reproductive gland and 12 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P10333, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

2 Publications

May form a homodimer.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
59983, 5 interactors

Database of interacting proteins

More...
DIPi
DIP-23208N

Protein interaction database and analysis system

More...
IntActi
P10333, 5 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0078786

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P10333

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 138Sufficient for promoting ovulation when expressed in females1 PublicationAdd BLAST138
Regioni219 – 264Necessary and sufficient for homodimerization2 PublicationsAdd BLAST46

Keywords - Domaini

Signal

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176795

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_1162203_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
NTYRNKY

Database of Orthologous Groups

More...
OrthoDBi
1836372at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P10333

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004315, Male_ac_gland_sc

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03082, MAGSP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P10333-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNQILLCSPI LLLLFTVASC DSEQQLDSAM HLKSDSTKSA SLKNVAPKND
60 70 80 90 100
ETQAKIAKDD VALKDAKKGD YIMDIDISDL PLDDYPINRS KSLKSSSIDL
110 120 130 140 150
NNIPFNKGLD DFPAKEKNQG SNQSALKALQ QRLLTEQNNS LLLRNHSIYL
160 170 180 190 200
MKEIEARKTD IIKVRQLNLD LELELNTVNR RLLELNGQLQ NTRKSTKPCK
210 220 230 240 250
KRSSKDSAPP AANQFQEANV RNTYRNKYLT LLKELSQKIN NEIAKVATDV
260
PTETNPSQGN LPTL
Length:264
Mass (Da):29,619
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i97377826FAE93EB6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti5L → S in strain: La28 and La106. 1
Natural varianti10I → L in strain: La120. 1
Natural varianti14L → I in strain: La14, La31, La118 and Ma24. 1
Natural varianti19S → N in strain: AF1, AF4, AF6, AF8, AF9, Au1, Au3, Au7, Au9, La3, La10, La14, La15, La25, La31, La108, Ma6, Ma11, Ma18, Ma20, Ma24, Ma35, Ma37, Ma53, Ma57, Ma74, Mo13a, Mo34a, Mo47a, NC-005, NC-007, NC-010, NFS 5.3, Ny1, Ny6, Ny8, SFS 2.2, TW2, TW3, TW6, TW9 and TW10. 1
Natural varianti24Q → K in strain: NC-005, NC-007 and NC-010. 1
Natural varianti25Q → K in strain: Au6, La25, La27, La62, La108, Ma43, Mo13a, Mo34a, NFS 5.1, NFS 5.2, NFS 5.3, NFS 6.1, NFS 7.8, Ny1, Ny2, Ny6, Ny8, SFS 1.1, SFS 1.4, SFS 2.2, SFS 3.1, SFS 3.3, SFS 3.4, TW2, TW3, TW4, TW7, TW9 and TW10. 1
Natural varianti32L → Q in strain: AF2, AF7, Au4, La3, La15, La37, La58, Ma21, Mo29b, Mo36a, Mo52B, Mo79b, NC-009, Ny3, Ny5 and TW11. 1
Natural varianti39S → G in strain: Ny2 and SFS 3.4. 1
Natural varianti40A → S in strain: Au3. 1
Natural varianti42L → V in strain: Ma18, Ma20, Ma37 and Ma53. 1
Natural varianti44N → S in strain: Au3 and Ma74. 1
Natural varianti46A → P in strain: AF1, AF3, AF4, AF5, AF6, AF8, AF9, AF10, Au1, Au2, Au4, Au6, Au7, Au8, Au10, La10, La13, La14, La25, La31, La32, La37, La46, La58, La60, La62, La105, La108, La116, La118, La125, Ma3, Ma6, Ma11, Ma20, Ma23, Ma24, Ma50, Ma56, Ma57, Ma60, Mo13a, Mo29b, Mo34a, Mo40b, Mo52B, Mo80b, NC-001, NC-004, NC-005, NC-006, NC-007, NC-008, NC-010, NFS 5.1, NFS 5.2, NFS 6.1, NFS 6.2, NFS 6.3, NFS 7.8, Ny1, Ny2, Ny4, Ny6, Ny8, SFS 1.1, SFS 1.4, SFS 2.2, SFS 3.1, SFS 3.2, SFS 3.3, SFS 3.4, TW1, TW2, TW3, TW4, TW5, TW6, TW7, TW8 and TW9. 1
Natural varianti46A → T in strain: AF2, AF7, Au3, Au5, Au9, La3, La15, La27, La36, La54, La120, Ma18, Ma21, Ma31, Ma37, Ma43, Ma53, Ma74, Mo36a, Mo79b, NC-002, NC-003, NC-009, NFS 5.4, NFS 6.4, Ny3, Ny5, Ny7, SFS 2.4, TW10 and TW11. 1
Natural varianti54A → T in strain: La116. 1
Natural varianti56I → L in strain: Au3. 1
Natural varianti65D → G in strain: AF8, Ma3 and SFS 2.3. 1
Natural varianti76D → N in strain: La116 and NC3. 1
Natural varianti79D → N in strain: Au2, Au3, Au8, La13, La32, La37, NC-004, NC-006, NC-008, Ny4, TW1, TW5 and TW8. 1
Natural varianti85Missing in strain: La108. 1
Natural varianti101N → S in strain: AF1, AF2, AF3, AF5, AF6, AF7, AF8, AF9, AF10, Au3, Au4, Au6, Au7, La3, La10, La14, La15, La27, La28, La31, La36, La37, La46, La54, La58, La60, La62, La106, La116, La118, La120, La125, Ma3, Ma6, Ma11, Ma18, Ma20, Ma21, Ma23, Ma24, Ma31, Ma35, Ma37, Ma43, Ma50, Ma53, Ma56, Ma57, Ma74, Mo40b, Mo52B, NC-001, NC-002, NC-003, NC-009, NFS 5.1, NFS 5.2, NFS 6.1, NFS 6.2, NFS 6.3, NFS 7.8, Ny2, Ny3, Ny5, Ny6, SFS 1.1, SFS 1.2, SFS 1.4, SFS 2.2, SFS 2.3, SFS 2.4, SFS 3.1, SFS 3.2, SFS 3.3, SFS 3.4, TW3, TW4, TW6, TW7, TW10 and TW11. 1
Natural varianti104P → R in strain: La62. 1
Natural varianti109L → I in strain: AF1, AF2, AF3, AF5, AF6, AF7, AF8, AF9, AF10, Au2, Au4, Au6, Au7, Au8, La3, La10, La13, La14, La15, La27, La28, La31, La32, La37, La46, La58, La60, La62, La105, La106, La116, La118, La120, La125, Ma3, Ma6, Ma11, Ma18, Ma20, Ma21, Ma23, Ma24, Ma31, Ma35, Ma37, Ma43, Ma50, Ma53, Ma56, Ma57, Ma74, Mo40b, Mo52B, Mo80b, NC-001, NC-002, NC-004, NC-006, NC-008, NC-009, NFS 5.1, NFS 5.2, NFS 6.1, NFS 6.2, NFS 6.3, NFS 6.4, NFS 7.8, Ny2, Ny3, Ny4, Ny5, SFS 1.1, SFS 1.4, SFS 2.2, SFS 2.4, SFS 3.1, SFS 3.2, SFS 3.3, SFS 3.4, TW1, TW3, TW4, TW5, TW6, TW7, TW8, TW10 and TW11. 1
Natural varianti167L → S in strain: La36, La54 and Ma20. 1
Natural varianti169L → F in strain: La3, La36, La125 and Ma20. 1
Natural varianti172E → Q in strain: Au1, Au3 and Au9. 1
Natural varianti207S → I in strain: Au5, La10, La14, La27, La31, La36, La54, La60, La62, La105, La118, La120, La125, Ma3, Ma6, Ma11, Ma21, Ma24, Ma31, Ma35, Ma43, Ma50, Ma53, Ma56, Ma57, Ma74, Mo36a, Mo37a, Mo47a, Mo79b, NC-002, NFS 5.1, NFS 5.2, NFS 6.3, NFS 7.8, Ny2, SFS 1.1, SFS 1.2, SFS 1.4, SFS 2.3, SFS 3.1 and SFS 3.4. 1
Natural varianti212A → V in strain: Ny2 and SFS 2.3. 1
Natural varianti221R → K in strain: La3, La10, La15, La27, La31, La37, La60, La120, La125, Ma6, Ma18, Ma20, Ma21, Ma35, Ma37, Ma43, Mo29b, Mo34a, Mo80b, NC-002, NC-010, NFS 5.1, NFS 5.2, NFS 5.4, NFS 6.1, NFS 6.2, NFS 6.4, NFS 7.8, Ny2, SFS 1.2, SFS 1.4, SFS 2.2, SFS 2.3, SFS 3.1, SFS 3.3 and SFS 3.4. 1
Natural varianti226N → Y in strain: TW9. 1
Natural varianti253E → D in strain: AF6, AF8, AF9, Au4, La31, La32, La60, La125, Ma6, Ma21, Ma57, TW1 and TW11. 1
Natural varianti262P → S in strain: AF5, AF10, Au5, La3, La15, La105, Mo36a, Mo37a, Mo47a, Mo79b and TW10. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y00219 Genomic DNA Translation: CAA68366.1
X70888 Genomic DNA Translation: CAA50232.1
X70889 Genomic DNA Translation: CAA50234.1
X70890 Genomic DNA Translation: CAA50236.1
X70891 Genomic DNA Translation: CAA50238.1
X70892 Genomic DNA Translation: CAA50240.1
X70893 Genomic DNA Translation: CAA50242.1
X70894 Genomic DNA Translation: CAA50244.1
X70895 Genomic DNA Translation: CAA50246.1
X70896 Genomic DNA Translation: CAA50248.1
X70897 Genomic DNA Translation: CAA50250.1
AJ231350 Genomic DNA Translation: CAB37194.1
AJ231351 Genomic DNA Translation: CAB37196.1
AJ231352 Genomic DNA Translation: CAB37198.1
AJ231353 Genomic DNA Translation: CAB37200.1
AJ231354 Genomic DNA Translation: CAB37202.1
AJ231355 Genomic DNA Translation: CAB37204.1
AJ231356 Genomic DNA Translation: CAB37206.1
AJ231357 Genomic DNA Translation: CAB37208.1
AJ231358 Genomic DNA Translation: CAB37210.1
AJ231359 Genomic DNA Translation: CAB37212.1
AJ231360 Genomic DNA Translation: CAB37214.1
AJ231361 Genomic DNA Translation: CAB37216.1
AJ231362 Genomic DNA Translation: CAB37218.1
AJ231363 Genomic DNA Translation: CAB37220.1
AJ231364 Genomic DNA Translation: CAB37222.1
AJ231365 Genomic DNA Translation: CAB37224.1
AJ231366 Genomic DNA Translation: CAB37226.1
AJ231367 Genomic DNA Translation: CAB37228.1
AJ231368 Genomic DNA Translation: CAB37230.1
AJ231369 Genomic DNA Translation: CAB37232.1
AJ231370 Genomic DNA Translation: CAB37234.1
AJ231371 Genomic DNA Translation: CAB37236.1
AJ231372 Genomic DNA Translation: CAB37238.1
AJ231373 Genomic DNA Translation: CAB37240.1
AJ231374 Genomic DNA Translation: CAB37623.1
AJ231375 Genomic DNA Translation: CAB37242.1
AJ231376 Genomic DNA Translation: CAB37244.1
AJ231377 Genomic DNA Translation: CAB37246.1
AJ231378 Genomic DNA Translation: CAB37248.1
AJ231379 Genomic DNA Translation: CAB37250.1
AJ231380 Genomic DNA Translation: CAB37252.1
AJ231381 Genomic DNA Translation: CAB37254.1
AJ231382 Genomic DNA Translation: CAB37256.1
AJ231383 Genomic DNA Translation: CAB37258.1
AJ231384 Genomic DNA Translation: CAB37260.1
AJ231385 Genomic DNA Translation: CAB37262.1
AJ231386 Genomic DNA Translation: CAB37264.1
AJ231387 Genomic DNA Translation: CAB37266.1
AJ231388 Genomic DNA Translation: CAB37268.1
AJ231389 Genomic DNA Translation: CAB37270.1
AJ231390 Genomic DNA Translation: CAB37272.1
AJ231391 Genomic DNA Translation: CAB37274.1
AJ231392 Genomic DNA Translation: CAB37276.1
AJ231393 Genomic DNA Translation: CAB37278.1
AJ231394 Genomic DNA Translation: CAB37280.1
AJ231395 Genomic DNA Translation: CAB37282.1
AJ231396 Genomic DNA Translation: CAB37284.1
AJ231397 Genomic DNA Translation: CAB37286.1
AJ231398 Genomic DNA Translation: CAB37288.1
AJ231399 Genomic DNA Translation: CAB37290.1
AJ231400 Genomic DNA Translation: CAB37292.1
AJ231401 Genomic DNA Translation: CAB37628.1
AY344246 Genomic DNA Translation: AAR04561.1
AY344247 Genomic DNA Translation: AAR04562.1
AY344248 Genomic DNA Translation: AAR04563.1
AY344249 Genomic DNA Translation: AAR04564.1
AY344250 Genomic DNA Translation: AAR04565.1
AY344251 Genomic DNA Translation: AAR04566.1
AY344252 Genomic DNA Translation: AAR04567.1
AY344253 Genomic DNA Translation: AAR04568.1
AY344254 Genomic DNA Translation: AAR04569.1
AY344255 Genomic DNA Translation: AAR04570.1
AY344256 Genomic DNA Translation: AAR04571.1
AY344257 Genomic DNA Translation: AAR04572.1
AY344258 Genomic DNA Translation: AAR04573.1
AY344259 Genomic DNA Translation: AAR04574.1
AY344260 Genomic DNA Translation: AAR04575.1
AY344261 Genomic DNA Translation: AAR04576.1
AY344262 Genomic DNA Translation: AAR04577.1
AY344263 Genomic DNA Translation: AAR04578.1
AY344264 Genomic DNA Translation: AAR04579.1
AE014134 Genomic DNA Translation: AAF52298.1
BT024423 mRNA Translation: ABC86485.1
AF052470 Genomic DNA Translation: AAC27995.1
AF052471 Genomic DNA Translation: AAC27997.1
AF052472 Genomic DNA Translation: AAC27999.1
AF052473 Genomic DNA Translation: AAC28001.1
AF052474 Genomic DNA Translation: AAC28003.1
AF052475 Genomic DNA Translation: AAC28005.1
AF052476 Genomic DNA Translation: AAC28007.1
AF052477 Genomic DNA Translation: AAC28009.1
AF052478 Genomic DNA Translation: AAC28011.1
AF052479 Genomic DNA Translation: AAC28013.1
AF052480 Genomic DNA Translation: AAC28015.1
AF052481 Genomic DNA Translation: AAC28017.1
AF053250 Genomic DNA Translation: AAC28790.1
AF053251 Genomic DNA Translation: AAC28792.1
AF053252 Genomic DNA Translation: AAC28794.1
AF053253 Genomic DNA Translation: AAC28796.1
AF053254 Genomic DNA Translation: AAC28798.1
AF053255 Genomic DNA Translation: AAC28800.1
AF053256 Genomic DNA Translation: AAC28802.1
AF053257 Genomic DNA Translation: AAC28804.1
AF053258 Genomic DNA Translation: AAC28806.1
AF053259 Genomic DNA Translation: AAC28808.1
AF053260 Genomic DNA Translation: AAC28810.1
AF053261 Genomic DNA Translation: AAC28812.1
AF053262 Genomic DNA Translation: AAC28814.1
AF053263 Genomic DNA Translation: AAC28816.1
AF053264 Genomic DNA Translation: AAC28818.1
AF053265 Genomic DNA Translation: AAC28820.1
AF053266 Genomic DNA Translation: AAC28822.1
AF053267 Genomic DNA Translation: AAC28824.1
AF053268 Genomic DNA Translation: AAC28826.1
AF053269 Genomic DNA Translation: AAC28828.1
AF053270 Genomic DNA Translation: AAC28830.1
AF053271 Genomic DNA Translation: AAC28832.1
AF053272 Genomic DNA Translation: AAC28834.1
AF053273 Genomic DNA Translation: AAC28836.1
AF053274 Genomic DNA Translation: AAC28838.1
AF053275 Genomic DNA Translation: AAC28840.1
AF053276 Genomic DNA Translation: AAC28842.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S02853

NCBI Reference Sequences

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RefSeqi
NP_476644.1, NM_057296.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0079155; FBpp0078786; FBgn0002855

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
33817

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG8982

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00219 Genomic DNA Translation: CAA68366.1
X70888 Genomic DNA Translation: CAA50232.1
X70889 Genomic DNA Translation: CAA50234.1
X70890 Genomic DNA Translation: CAA50236.1
X70891 Genomic DNA Translation: CAA50238.1
X70892 Genomic DNA Translation: CAA50240.1
X70893 Genomic DNA Translation: CAA50242.1
X70894 Genomic DNA Translation: CAA50244.1
X70895 Genomic DNA Translation: CAA50246.1
X70896 Genomic DNA Translation: CAA50248.1
X70897 Genomic DNA Translation: CAA50250.1
AJ231350 Genomic DNA Translation: CAB37194.1
AJ231351 Genomic DNA Translation: CAB37196.1
AJ231352 Genomic DNA Translation: CAB37198.1
AJ231353 Genomic DNA Translation: CAB37200.1
AJ231354 Genomic DNA Translation: CAB37202.1
AJ231355 Genomic DNA Translation: CAB37204.1
AJ231356 Genomic DNA Translation: CAB37206.1
AJ231357 Genomic DNA Translation: CAB37208.1
AJ231358 Genomic DNA Translation: CAB37210.1
AJ231359 Genomic DNA Translation: CAB37212.1
AJ231360 Genomic DNA Translation: CAB37214.1
AJ231361 Genomic DNA Translation: CAB37216.1
AJ231362 Genomic DNA Translation: CAB37218.1
AJ231363 Genomic DNA Translation: CAB37220.1
AJ231364 Genomic DNA Translation: CAB37222.1
AJ231365 Genomic DNA Translation: CAB37224.1
AJ231366 Genomic DNA Translation: CAB37226.1
AJ231367 Genomic DNA Translation: CAB37228.1
AJ231368 Genomic DNA Translation: CAB37230.1
AJ231369 Genomic DNA Translation: CAB37232.1
AJ231370 Genomic DNA Translation: CAB37234.1
AJ231371 Genomic DNA Translation: CAB37236.1
AJ231372 Genomic DNA Translation: CAB37238.1
AJ231373 Genomic DNA Translation: CAB37240.1
AJ231374 Genomic DNA Translation: CAB37623.1
AJ231375 Genomic DNA Translation: CAB37242.1
AJ231376 Genomic DNA Translation: CAB37244.1
AJ231377 Genomic DNA Translation: CAB37246.1
AJ231378 Genomic DNA Translation: CAB37248.1
AJ231379 Genomic DNA Translation: CAB37250.1
AJ231380 Genomic DNA Translation: CAB37252.1
AJ231381 Genomic DNA Translation: CAB37254.1
AJ231382 Genomic DNA Translation: CAB37256.1
AJ231383 Genomic DNA Translation: CAB37258.1
AJ231384 Genomic DNA Translation: CAB37260.1
AJ231385 Genomic DNA Translation: CAB37262.1
AJ231386 Genomic DNA Translation: CAB37264.1
AJ231387 Genomic DNA Translation: CAB37266.1
AJ231388 Genomic DNA Translation: CAB37268.1
AJ231389 Genomic DNA Translation: CAB37270.1
AJ231390 Genomic DNA Translation: CAB37272.1
AJ231391 Genomic DNA Translation: CAB37274.1
AJ231392 Genomic DNA Translation: CAB37276.1
AJ231393 Genomic DNA Translation: CAB37278.1
AJ231394 Genomic DNA Translation: CAB37280.1
AJ231395 Genomic DNA Translation: CAB37282.1
AJ231396 Genomic DNA Translation: CAB37284.1
AJ231397 Genomic DNA Translation: CAB37286.1
AJ231398 Genomic DNA Translation: CAB37288.1
AJ231399 Genomic DNA Translation: CAB37290.1
AJ231400 Genomic DNA Translation: CAB37292.1
AJ231401 Genomic DNA Translation: CAB37628.1
AY344246 Genomic DNA Translation: AAR04561.1
AY344247 Genomic DNA Translation: AAR04562.1
AY344248 Genomic DNA Translation: AAR04563.1
AY344249 Genomic DNA Translation: AAR04564.1
AY344250 Genomic DNA Translation: AAR04565.1
AY344251 Genomic DNA Translation: AAR04566.1
AY344252 Genomic DNA Translation: AAR04567.1
AY344253 Genomic DNA Translation: AAR04568.1
AY344254 Genomic DNA Translation: AAR04569.1
AY344255 Genomic DNA Translation: AAR04570.1
AY344256 Genomic DNA Translation: AAR04571.1
AY344257 Genomic DNA Translation: AAR04572.1
AY344258 Genomic DNA Translation: AAR04573.1
AY344259 Genomic DNA Translation: AAR04574.1
AY344260 Genomic DNA Translation: AAR04575.1
AY344261 Genomic DNA Translation: AAR04576.1
AY344262 Genomic DNA Translation: AAR04577.1
AY344263 Genomic DNA Translation: AAR04578.1
AY344264 Genomic DNA Translation: AAR04579.1
AE014134 Genomic DNA Translation: AAF52298.1
BT024423 mRNA Translation: ABC86485.1
AF052470 Genomic DNA Translation: AAC27995.1
AF052471 Genomic DNA Translation: AAC27997.1
AF052472 Genomic DNA Translation: AAC27999.1
AF052473 Genomic DNA Translation: AAC28001.1
AF052474 Genomic DNA Translation: AAC28003.1
AF052475 Genomic DNA Translation: AAC28005.1
AF052476 Genomic DNA Translation: AAC28007.1
AF052477 Genomic DNA Translation: AAC28009.1
AF052478 Genomic DNA Translation: AAC28011.1
AF052479 Genomic DNA Translation: AAC28013.1
AF052480 Genomic DNA Translation: AAC28015.1
AF052481 Genomic DNA Translation: AAC28017.1
AF053250 Genomic DNA Translation: AAC28790.1
AF053251 Genomic DNA Translation: AAC28792.1
AF053252 Genomic DNA Translation: AAC28794.1
AF053253 Genomic DNA Translation: AAC28796.1
AF053254 Genomic DNA Translation: AAC28798.1
AF053255 Genomic DNA Translation: AAC28800.1
AF053256 Genomic DNA Translation: AAC28802.1
AF053257 Genomic DNA Translation: AAC28804.1
AF053258 Genomic DNA Translation: AAC28806.1
AF053259 Genomic DNA Translation: AAC28808.1
AF053260 Genomic DNA Translation: AAC28810.1
AF053261 Genomic DNA Translation: AAC28812.1
AF053262 Genomic DNA Translation: AAC28814.1
AF053263 Genomic DNA Translation: AAC28816.1
AF053264 Genomic DNA Translation: AAC28818.1
AF053265 Genomic DNA Translation: AAC28820.1
AF053266 Genomic DNA Translation: AAC28822.1
AF053267 Genomic DNA Translation: AAC28824.1
AF053268 Genomic DNA Translation: AAC28826.1
AF053269 Genomic DNA Translation: AAC28828.1
AF053270 Genomic DNA Translation: AAC28830.1
AF053271 Genomic DNA Translation: AAC28832.1
AF053272 Genomic DNA Translation: AAC28834.1
AF053273 Genomic DNA Translation: AAC28836.1
AF053274 Genomic DNA Translation: AAC28838.1
AF053275 Genomic DNA Translation: AAC28840.1
AF053276 Genomic DNA Translation: AAC28842.1
PIRiS02853
RefSeqiNP_476644.1, NM_057296.2

3D structure databases

SMRiP10333
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi59983, 5 interactors
DIPiDIP-23208N
IntActiP10333, 5 interactors
STRINGi7227.FBpp0078786

Proteomic databases

PaxDbiP10333
PRIDEiP10333

Genome annotation databases

EnsemblMetazoaiFBtr0079155; FBpp0078786; FBgn0002855
GeneIDi33817
KEGGidme:Dmel_CG8982

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
33817
FlyBaseiFBgn0002855, Acp26Aa

Phylogenomic databases

GeneTreeiENSGT00940000176795
HOGENOMiCLU_1162203_0_0_1
OMAiNTYRNKY
OrthoDBi1836372at2759
PhylomeDBiP10333

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
33817, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
33817

Protein Ontology

More...
PROi
PR:P10333

Gene expression databases

BgeeiFBgn0002855, Expressed in male reproductive gland and 12 other tissues
GenevisibleiP10333, DM

Family and domain databases

InterProiView protein in InterPro
IPR004315, Male_ac_gland_sc
PfamiView protein in Pfam
PF03082, MAGSP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMS2A_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10333
Secondary accession number(s): O76297
, O76298, O76299, Q29QG7, Q6VBG2, Q6VBG3, Q6VBG4, Q6VBG7, Q6VBG8, Q6VBG9, Q6VBH0, Q6VBH1, Q6VBH5, Q6VBH7, Q6VBH8, Q6VBH9, Q95NY9, Q95PE8, Q9TVI6, Q9TVV6, Q9TVX0, Q9TW14, Q9TW58, Q9TW61, Q9TW81, Q9UB44, Q9UB45, Q9UB46, Q9UB47, Q9UB48, Q9UB49, Q9UB50, Q9UB51, Q9UB52, Q9UB53, Q9UB54, Q9UB55, Q9UB56, Q9UB57, Q9UB58, Q9UB59, Q9UB60, Q9UB61, Q9UB62, Q9UB63, Q9UB64, Q9UB65, Q9UB66, Q9UB67, Q9UB68, Q9UB69, Q9UB70, Q9UB71, Q9UB72, Q9UB73, Q9UB74, Q9UB75, Q9UB76, Q9UB77, Q9VML6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: December 1, 2000
Last modified: April 7, 2021
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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