HLA-C

Functionⁱ

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functionⁱ

peptide antigen binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
interferon-gamma-mediated signaling pathway Source: Reactome
neutrophil degranulation Source: Reactome
regulation of immune response Source: Reactome
type I interferon signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Immunity

Biological process

Immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1236974 ER-Phagosome pathway R-HSA-1236977 Endosomal/Vacuolar pathway R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-6798695 Neutrophil degranulation R-HSA-877300 Interferon gamma signaling R-HSA-909733 Interferon alpha/beta signaling R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Reactomeⁱ

R-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-6798695 Neutrophil degranulation
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: HLA class I histocompatibility antigen, Cw-7 alpha chain Alternative name(s): MHC class I antigen Cw*7
Gene namesⁱ	Name:HLA-C Synonyms:HLAC
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000204525.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4933 HLA-C
MIMⁱ	142840 gene
neXtProtⁱ	NX_P10321

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	25 – 308	ExtracellularSequence analysisAdd BLAST	284
Transmembraneⁱ	309 – 333	HelicalSequence analysisAdd BLAST	25
Topological domainⁱ	334 – 366	CytoplasmicSequence analysisAdd BLAST	33

Keywords - Cellular componentⁱ

Membrane, MHC I

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3107
MalaCards human disease database More...MalaCardsⁱ	HLA-C
Open Targets More...OpenTargetsⁱ	ENSG00000204525
PharmGKBⁱ	PA35057

Polymorphism and mutation databases

BioMutaⁱ	TET2
DMDMⁱ	84028168

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 24	Add BLAST		24
ChainⁱPRO_0000018874	25 – 366	HLA class I histocompatibility antigen, Cw-7 alpha chainAdd BLAST		342

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	110	N-linked (GlcNAc...) asparagineBy similarity	1
Disulfide bondⁱ	125 ↔ 188	PROSITE-ProRule annotation
Disulfide bondⁱ	227 ↔ 283	PROSITE-ProRule annotation

Post-translational modificationⁱ

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P10321
PaxDbⁱ	P10321
PeptideAtlas More...PeptideAtlasⁱ	P10321
PRIDEⁱ	P10321

PTM databases

GlyConnectⁱ	1363
iPTMnetⁱ	P10321
SwissPalmⁱ	P10321

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000204525 Expressed in 234 organ(s), highest expression level in mononuclear cell
CleanExⁱ	HS_HLA-C
ExpressionAtlasⁱ	P10321 baseline and differential
Genevisibleⁱ	P10321 HS

Interactionⁱ

Subunit structureⁱ

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
KIR2DL3	P43628	2	EBI-9978491,EBI-8632435

With

Entry

#Exp.

IntAct

Notes

KIR2DL3

P43628

2

EBI-9978491,EBI-8632435

Protein-protein interaction databases

BioGridⁱ	109352, 113 interactors
IntActⁱ	P10321, 10 interactors
STRINGⁱ	9606.ENSP00000365402

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	28 – 36	Combined sources	9
Turnⁱ	39 – 41	Combined sources	3
Beta strandⁱ	45 – 52	Combined sources	8
Beta strandⁱ	55 – 61	Combined sources	7
Beta strandⁱ	64 – 66	Combined sources	3
Turnⁱ	74 – 78	Combined sources	5
Helixⁱ	81 – 108	Combined sources	28
Beta strandⁱ	118 – 127	Combined sources	10
Beta strandⁱ	129 – 131	Combined sources	3
Beta strandⁱ	133 – 142	Combined sources	10
Beta strandⁱ	145 – 150	Combined sources	6
Beta strandⁱ	157 – 161	Combined sources	5
Helixⁱ	163 – 174	Combined sources	12
Helixⁱ	176 – 185	Combined sources	10
Helixⁱ	187 – 198	Combined sources	12
Helixⁱ	200 – 203	Combined sources	4
Beta strandⁱ	210 – 235	Combined sources	26
Beta strandⁱ	237 – 243	Combined sources	7
Turnⁱ	249 – 251	Combined sources	3
Beta strandⁱ	261 – 263	Combined sources	3
Beta strandⁱ	265 – 274	Combined sources	10
Helixⁱ	278 – 280	Combined sources	3
Beta strandⁱ	281 – 287	Combined sources	7
Beta strandⁱ	294 – 296	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P10321
SMRⁱ	P10321
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P10321

EvolutionaryTraceⁱ

P10321

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	209 – 297	Ig-like C1-typeAdd BLAST		89

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	25 – 114	Alpha-1Add BLAST	90
Regionⁱ	115 – 206	Alpha-2Add BLAST	92
Regionⁱ	207 – 298	Alpha-3Add BLAST	92
Regionⁱ	299 – 308	Connecting peptide	10

Sequence similaritiesⁱ

Belongs to the MHC class I family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410II5V Eukaryota ENOG4111K8F LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118960
HOVERGENⁱ	HBG016709
KEGG Orthology (KO) More...KOⁱ	K06751
PhylomeDBⁱ	P10321
TreeFamⁱ	TF336617

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.30.500.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003597 Ig_C1-set IPR011161 MHC_I-like_Ag-recog IPR037055 MHC_I-like_Ag-recog_sf IPR011162 MHC_I/II-like_Ag-recog IPR001039 MHC_I_a_a1/a2 IPR010579 MHC_I_a_C
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07654 C1-set, 1 hit PF00129 MHC_I, 1 hit PF06623 MHC_I_C, 1 hit
PRINTSⁱ	PR01638 MHCCLASSI
SMARTⁱ	View protein in SMART SM00407 IGc1, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF54452 SSF54452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 54 potential isoforms that are computationally mapped.Show all Align All

P10321-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG 
        60         70         80         90        100
YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV 
       110        120        130        140        150
SLRNLRGYYN QSEDGSHTLQ RMSGCDLGPD GRLLRGYDQS AYDGKDYIAL 
       160        170        180        190        200
NEDLRSWTAA DTAAQITQRK LEAARAAEQL RAYLEGTCVE WLRRYLENGK 
       210        220        230        240        250
ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ 
       260        270        280        290        300
DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP 
       310        320        330        340        350
SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC 
       360 
SNSAQGSDES LITCKA

Length:366

Mass (Da):40,649

Last modified:December 20, 2005 - v3

Checksum:ⁱ59C23D95FD1D0BC8

GO

Computationally mapped potential isoform sequencesⁱ

There are 54 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	P30499	1C01_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, Cw-1 alpha chain (MHC class I antigen Cw*1)	HLA-C HLAC	366	Annotation score:
	Q29963	1C06_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, Cw-6 alpha chain (MHC class I antigen Cw*6)	HLA-C HLAC	366	Annotation score:
	P30504	1C04_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, Cw-4 alpha chain (MHC class I antigen Cw*4)	HLA-C HLAC	366	Annotation score:
	P04222	1C03_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, Cw-3 alpha chain (MHC class I antigen Cw*3)	HLA-C HLAC	366	Annotation score:
	P30501	1C02_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, Cw-2 alpha chain (MHC class I antigen Cw*2)	HLA-C HLAC	366	Annotation score:
	Q95604	1C17_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, Cw-17 alpha chain (MHC class I antigen Cw*17)	HLA-C D6S204, HLA-JY3, HLAC	372	Annotation score:
	Q07000	1C15_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, Cw-15 alpha chain (MHC class I antigen Cw*15)	HLA-C HLAC	366	Annotation score:
	P30508	1C12_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, Cw-12 alpha chain (MHC class I antigen Cw*12)	HLA-C HLAC	366	Annotation score:
	Q9TNN7	1C05_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, Cw-5 alpha chain (MHC class I antigen Cw*5)	HLA-C HLAC	366	Annotation score:
	Q29960	1C16_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, Cw-16 alpha chain (MHC class I antigen Cw*16)	HLA-C HLAC	366	Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	15 – 16	GG → AA in AAA50217 (Ref. 7) Curated	2
Sequence conflictⁱ	41	R → A in AAA52665 (PubMed:3863816).Curated	1
Sequence conflictⁱ	309	M → V in AAA53259 (PubMed:2714852).Curated	1

Polymorphismⁱ

The following alleles of Cw-7 are known: Cw*07:01, Cw*07:02, Cw*07:03, Cw*07:04, Cw*07:06, Cw*07:09 and Cw*07:11. The sequence shown is that of Cw*07:02.

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_059506	10	L → I. Corresponds to variant dbSNP:rs2308527Ensembl.	1
Natural variantⁱVAR_050345	43	E → K. Corresponds to variant dbSNP:rs1050438Ensembl.	1
Natural variantⁱVAR_061450	48	S → A. Corresponds to variant dbSNP:rs707911Ensembl.	1
Natural variantⁱVAR_061451	48	S → P. Corresponds to variant dbSNP:rs707911Ensembl.	1
Natural variantⁱVAR_061452	48	S → T. Corresponds to variant dbSNP:rs707911Ensembl.	1
Natural variantⁱVAR_050346	73	A → E. Corresponds to variant dbSNP:rs1050409Ensembl.	1
Natural variantⁱVAR_050347	76	V → M. Corresponds to variant dbSNP:rs1065382Ensembl.	1
Natural variantⁱVAR_016590	90	K → N in allele Cw*07:01. Corresponds to variant dbSNP:rs28626310Ensembl.	1
Natural variantⁱVAR_050348	97	A → T. Corresponds to variant dbSNP:rs41543814Ensembl.	1
Natural variantⁱVAR_016591	101	S → N in allele Cw*07:09. Corresponds to variant dbSNP:rs2308557Ensembl.	1
Natural variantⁱVAR_016592	104	N → K in allele Cw*07:09. Corresponds to variant dbSNP:rs17408553Ensembl.	1
Natural variantⁱVAR_016593	119	L → F in allele Cw07:04 and allele Cw07:11. Corresponds to variant dbSNP:rs1071649Ensembl.	1
Natural variantⁱVAR_059507	123	S → C. Corresponds to variant dbSNP:rs1131115Ensembl.	1
Natural variantⁱVAR_059508	123	S → F. Corresponds to variant dbSNP:rs1131115Ensembl.	1
Natural variantⁱVAR_016594	123	S → Y in allele Cw*07:01. Corresponds to variant dbSNP:rs1131115Ensembl.	1
Natural variantⁱVAR_050349	137	Y → H. Corresponds to variant dbSNP:rs2308574Ensembl.	1
Natural variantⁱVAR_016595	140	S → F in allele Cw07:04 and allele Cw07:11. Corresponds to variant dbSNP:rs713032Ensembl.	1
Natural variantⁱVAR_016646	171	L → W in allele Cw*07:03. Corresponds to variant dbSNP:rs1050366Ensembl.	1
Natural variantⁱVAR_016596	180	L → D in allele Cw07:04 and allele Cw07:11; requires 2 nucleotide substitutions.	1
Natural variantⁱVAR_016647	187	T → L in allele Cw*07:03; requires 2 nucleotide substitutions.	1
Natural variantⁱVAR_016597	201	E → K in allele Cw*07:04 and allele Cw0711. Corresponds to variant dbSNP:rs1131103Ensembl.	1
Natural variantⁱVAR_061453	208	P → H. Corresponds to variant dbSNP:rs1131096Ensembl.	1
Natural variantⁱVAR_061454	208	P → R. Corresponds to variant dbSNP:rs1131096Ensembl.	1
Natural variantⁱVAR_050351	272	V → M. Corresponds to variant dbSNP:rs1050276Ensembl.	1
Natural variantⁱVAR_050352	328	V → I. Corresponds to variant dbSNP:rs1050118Ensembl.	1
Natural variantⁱVAR_050353	330	A → V. Corresponds to variant dbSNP:rs1050105Ensembl.	1
Natural variantⁱVAR_016598	331	M → K in allele Cw*07:06. Corresponds to variant dbSNP:rs41542414Ensembl.	1
Natural variantⁱVAR_050354	331	M → V. Corresponds to variant dbSNP:rs1130935Ensembl.	1
Natural variantⁱVAR_016599	348	A → V in allele Cw*07:06. Corresponds to variant dbSNP:rs41559915Ensembl.	1
Natural variantⁱVAR_061455	350	C → SCombined sourcesCorresponds to variant dbSNP:rs35708511Ensembl.	1
Natural variantⁱVAR_016600	363	T → A in allele Cw*07:11. Corresponds to variant dbSNP:rs1130838Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X83394 mRNA Translation: CAA58313.1 D38526 mRNA Translation: BAA07531.1 D49819 mRNA Translation: BAA08625.1 D49552 mRNA Translation: BAA08500.1 X97321 mRNA Translation: CAA65986.1 AJ001977 Genomic DNA Translation: CAA05125.1 Sequence problems. AJ010749 mRNA Translation: CAA09341.1 AJ293016 Genomic DNA Translation: CAC04321.1 AJ293017 Genomic DNA Translation: CAC04322.1 AJ291815 Genomic DNA Translation: CAC19191.1 U09853 mRNA Translation: AAA50217.1 AL671883 Genomic DNA No translation available. Z46810 mRNA Translation: CAA86840.1 M11886 mRNA Translation: AAA52665.1 AH006132 Genomic DNA Translation: AAC17722.1 Y18533 , Y18534, Y18535, Y18536 Genomic DNA Translation: CAB71800.1 M28207 mRNA Translation: AAA53259.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34393.1
PIRⁱ	A24512 HLHUC4 I37078 I37529 I68750
NCBI Reference Sequences More...RefSeqⁱ	NP_002108.4, NM_002117.5
UniGeneⁱ	Hs.656020 Hs.743218

Genome annotation databases

Ensemblⁱ	ENST00000376228; ENSP00000365402; ENSG00000204525
GeneIDⁱ	3107
KEGGⁱ	hsa:3107

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P10321	HLA class I antigen		HUMAN		366	UniRef100_P10321
HLA-C protein (Fragment)		HUMAN		365
MHC class I antigen (Fragment)		HUMAN		365
MHC class I antigen (Fragment)		HUMAN		365
MHC class I antigen (Fragment)		HUMAN		365
+17

Protein	Similar proteins		Species	Score	Length	Source
P10321	HLA class I antigen		HUMAN		366	UniRef90_P10321
MHC class I antigen		PANTR		366
MHC class I antigen		PANPA		366
HLA-C protein (Fragment)		HUMAN		365
MHC class I antigen (Fragment)		HUMAN		365
+1043

Protein	Similar proteins		Species	Score	Length	Source
P10321	HLA class I histocompatibility antigen, alpha chain E	)	HUMAN		358	UniRef50_P13747
Patr class I histocompatibility antigen, alpha chain G		PANTR		338
DLA class I histocompatibility antigen, A9/A9 alpha chain		CANLF		362
H-2 class I histocompatibility antigen, K-D alpha chain	)	MOUSE		368
Popy class I histocompatibility antigen, alpha chain E (Fragment)		PONPY		359
+8953

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X83394 mRNA Translation: CAA58313.1 D38526 mRNA Translation: BAA07531.1 D49819 mRNA Translation: BAA08625.1 D49552 mRNA Translation: BAA08500.1 X97321 mRNA Translation: CAA65986.1 AJ001977 Genomic DNA Translation: CAA05125.1 Sequence problems. AJ010749 mRNA Translation: CAA09341.1 AJ293016 Genomic DNA Translation: CAC04321.1 AJ293017 Genomic DNA Translation: CAC04322.1 AJ291815 Genomic DNA Translation: CAC19191.1 U09853 mRNA Translation: AAA50217.1 AL671883 Genomic DNA No translation available. Z46810 mRNA Translation: CAA86840.1 M11886 mRNA Translation: AAA52665.1 AH006132 Genomic DNA Translation: AAC17722.1 Y18533 , Y18534, Y18535, Y18536 Genomic DNA Translation: CAB71800.1 M28207 mRNA Translation: AAA53259.1
CCDSⁱ	CCDS34393.1
PIRⁱ	A24512 HLHUC4 I37078 I37529 I68750
RefSeqⁱ	NP_002108.4, NM_002117.5
UniGeneⁱ	Hs.656020 Hs.743218

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3BZF	X-ray	2.50	P/Q	3-11	[»]
	5VGE	X-ray	2.60	A	26-300	[»]
ProteinModelPortalⁱ	P10321
SMRⁱ	P10321
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109352, 113 interactors
IntActⁱ	P10321, 10 interactors
STRINGⁱ	9606.ENSP00000365402

PTM databases

GlyConnectⁱ	1363
iPTMnetⁱ	P10321
SwissPalmⁱ	P10321

Polymorphism and mutation databases

BioMutaⁱ	TET2
DMDMⁱ	84028168

Proteomic databases

EPDⁱ	P10321
PaxDbⁱ	P10321
PeptideAtlasⁱ	P10321
PRIDEⁱ	P10321

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3107
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000376228; ENSP00000365402; ENSG00000204525
GeneIDⁱ	3107
KEGGⁱ	hsa:3107

Organism-specific databases

CTDⁱ	3107
DisGeNETⁱ	3107
EuPathDBⁱ	HostDB:ENSG00000204525.15
GeneCardsⁱ	HLA-C
HGNCⁱ	HGNC:4933 HLA-C
MalaCardsⁱ	HLA-C
MIMⁱ	142840 gene
neXtProtⁱ	NX_P10321
OpenTargetsⁱ	ENSG00000204525
PharmGKBⁱ	PA35057
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410II5V Eukaryota ENOG4111K8F LUCA
GeneTreeⁱ	ENSGT00760000118960
HOVERGENⁱ	HBG016709
KOⁱ	K06751
PhylomeDBⁱ	P10321
TreeFamⁱ	TF336617

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1236974 ER-Phagosome pathway R-HSA-1236977 Endosomal/Vacuolar pathway R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-6798695 Neutrophil degranulation R-HSA-877300 Interferon gamma signaling R-HSA-909733 Interferon alpha/beta signaling R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Reactomeⁱ

R-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-6798695 Neutrophil degranulation
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Miscellaneous databases

ChiTaRSⁱ	HLA-C human
EvolutionaryTraceⁱ	P10321
GeneWikiⁱ	HLA-C
GenomeRNAiⁱ	3107
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000204525 Expressed in 234 organ(s), highest expression level in mononuclear cell
CleanExⁱ	HS_HLA-C
ExpressionAtlasⁱ	P10321 baseline and differential
Genevisibleⁱ	P10321 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.30.500.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003597 Ig_C1-set IPR011161 MHC_I-like_Ag-recog IPR037055 MHC_I-like_Ag-recog_sf IPR011162 MHC_I/II-like_Ag-recog IPR001039 MHC_I_a_a1/a2 IPR010579 MHC_I_a_C
Pfamⁱ	View protein in Pfam PF07654 C1-set, 1 hit PF00129 MHC_I, 1 hit PF06623 MHC_I_C, 1 hit
PRINTSⁱ	PR01638 MHCCLASSI
SMARTⁱ	View protein in SMART SM00407 IGc1, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF54452 SSF54452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	1C07_HUMAN
Accessionⁱ	P10321Primary (citable) accession number: P10321 Secondary accession number(s): O78061 Q9TQP9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	December 20, 2005
	Last modified:	November 7, 2018
	This is version 179 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

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Proteomes

Annotation systems

Supporting data

UniProtKB - P10321 (1C07_HUMAN)

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HLA class I histocompatibility antigen, Cw-7 alpha chain

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Endoplasmic reticulum

Endosome

Extracellular region or secreted

Golgi apparatus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ