RRAS

Functionⁱ

Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267).2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	36 – 44	GTP	9
Nucleotide bindingⁱ	83 – 87	GTPBy similarity	5
Nucleotide bindingⁱ	142 – 145	GTP	4
Nucleotide bindingⁱ	172 – 174	GTP	3

GO - Molecular functionⁱ

GDP binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16773572
GTPase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16773572
GTP binding Source: UniProtKB-KW
protein-containing complex binding
Source: MGI
Inferred from direct assayⁱ
- 23209302

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

face morphogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24705357
leukocyte differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24705357
negative regulation of cell migration Source: Ensembl
positive regulation of angiogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21393242
Ras protein signal transduction
Source: ProtInc
Traceable author statementⁱ
- 3098437
regulation of ERK1 and ERK2 cascade
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24705357
regulation of protein kinase B signaling
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24705357

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	GTP-binding, Nucleotide-binding

Ligand

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-416550 Sema4D mediated inhibition of cell attachment and migration R-HSA-442742 CREB phosphorylation through the activation of Ras
SignaLinkⁱ	P10301
SIGNORⁱ	P10301

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-related protein R-Ras Alternative name(s): p23
Gene namesⁱ	Name:RRAS
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000126458.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10447 RRAS
MIMⁱ	165090 gene
neXtProtⁱ	NX_P10301

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	38	G → V: No effect on interaction with OSBPL3. 1 Publication		1
Mutagenesisⁱ	43	S → N: No effect on interaction with OSBPL3. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6237
MalaCards human disease database More...MalaCardsⁱ	RRAS
Open Targets More...OpenTargetsⁱ	ENSG00000126458
PharmGKBⁱ	PA34861

Polymorphism and mutation databases

BioMutaⁱ	RRAS
DMDMⁱ	133486

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000082650	1 – 215	Ras-related protein R-RasAdd BLAST		215
PropeptideⁱPRO_0000281300	216 – 218	Removed in mature formBy similarity		3

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	215	Cysteine methyl esterBy similarity		1
Lipidationⁱ	215	S-geranylgeranyl cysteineBy similarity		1

Keywords - PTMⁱ

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDⁱ	P10301
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P10301
PaxDbⁱ	P10301
PeptideAtlas More...PeptideAtlasⁱ	P10301
PRIDEⁱ	P10301
ProteomicsDBⁱ	52595

2D gel databases

SWISS-2DPAGEⁱ	P10301

SWISS-2DPAGEⁱ

P10301

PTM databases

iPTMnetⁱ	P10301
PhosphoSitePlusⁱ	P10301
SwissPalmⁱ	P10301

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000126458 Expressed in 190 organ(s), highest expression level in tibial artery
CleanExⁱ	HS_RRAS
ExpressionAtlasⁱ	P10301 baseline and differential
Genevisibleⁱ	P10301 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB010160 CAB069439 HPA060364

HPAⁱ

CAB010160
CAB069439
HPA060364

Interactionⁱ

Subunit structureⁱ

Interacts with PLCE1 (PubMed:16537651). Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts with OSBPL3 (PubMed:18270267).By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NCK1	P16333	3	EBI-968703,EBI-389883

With

Entry

#Exp.

IntAct

Notes

NCK1

P16333

3

EBI-968703,EBI-389883

Protein-protein interaction databases

BioGridⁱ	112151, 33 interactors
IntActⁱ	P10301, 25 interactors
Molecular INTeraction database More...MINTⁱ	P10301
STRINGⁱ	9606.ENSP00000246792

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	29 – 36	Combined sources	8
Helixⁱ	42 – 51	Combined sources	10
Beta strandⁱ	64 – 72	Combined sources	9
Beta strandⁱ	75 – 83	Combined sources	9
Turnⁱ	87 – 90	Combined sources	4
Helixⁱ	94 – 100	Combined sources	7
Beta strandⁱ	102 – 109	Combined sources	8
Helixⁱ	113 – 130	Combined sources	18
Beta strandⁱ	137 – 142	Combined sources	6
Helixⁱ	144 – 149	Combined sources	6
Helixⁱ	154 – 163	Combined sources	10
Beta strandⁱ	167 – 170	Combined sources	4
Turnⁱ	173 – 176	Combined sources	4
Helixⁱ	179 – 193	Combined sources	15

Show more details

3D structure databases

ProteinModelPortalⁱ	P10301
SMRⁱ	P10301
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P10301

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	58 – 66	Effector region		9

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0395 Eukaryota COG1100 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133672
HOGENOMⁱ	HOG000233973
HOVERGENⁱ	HBG009351
InParanoidⁱ	P10301
KEGG Orthology (KO) More...KOⁱ	K07829
OMAⁱ	RSEASTF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0UAU
PhylomeDBⁱ	P10301
TreeFamⁱ	TF312796

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase IPR020849 Small_GTPase_Ras-type
PANTHERⁱ	PTHR24070 PTHR24070, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51421 RAS, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P10301-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSGAASGTG RGRPRGGGPG PGDPPPSETH KLVVVGGGGV GKSALTIQFI 
        60         70         80         90        100
QSYFVSDYDP TIEDSYTKIC SVDGIPARLD ILDTAGQEEF GAMREQYMRA 
       110        120        130        140        150
GHGFLLVFAI NDRQSFNEVG KLFTQILRVK DRDDFPVVLV GNKADLESQR 
       160        170        180        190        200
QVPRSEASAF GASHHVAYFE ASAKLRLNVD EAFEQLVRAV RKYQEQELPP 
       210 
SPPSAPRKKG GGCPCVLL

Length:218

Mass (Da):23,480

Last modified:July 1, 1989 - v1

Checksum:ⁱ437F73170670EB28

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M14949, M14948 Genomic DNA Translation: AAA60256.1 AF493920 mRNA Translation: AAM12634.1 BT006805 mRNA Translation: AAP35451.1 CR541944 mRNA Translation: CAG46742.1 CR541967 mRNA Translation: CAG46765.1 CH471177 Genomic DNA Translation: EAW52506.1 BC016286 mRNA Translation: AAH16286.1 BC016318 mRNA Translation: AAH16318.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12774.1
PIRⁱ	A26159 TVHURR
NCBI Reference Sequences More...RefSeqⁱ	NP_006261.1, NM_006270.4
UniGeneⁱ	Hs.515536

Genome annotation databases

Ensemblⁱ	ENST00000246792; ENSP00000246792; ENSG00000126458
GeneIDⁱ	6237
KEGGⁱ	hsa:6237
UCSC genome browser More...UCSCⁱ	uc002pop.2 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P10301	Related RAS viral (R-ras) oncogene homolog, isoform CRA_a		HUMAN		218	UniRef100_P10301
RRAS isoform 1		PANTR		218

Protein	Similar proteins		Species	Score	Length	Source
P10301	Related RAS viral (R-ras) oncogene homolog, isoform CRA_a		HUMAN		218	UniRef90_P10301
RRAS isoform 1		PANTR		218
Uncharacterized protein		PROCO		220
Ras-related protein R-Ras		MACMU		218
RAS related		PONAB		218
+61

Protein	Similar proteins		Species	Score	Length	Source
P10301	Related RAS viral (R-ras) oncogene homolog, isoform CRA_a		HUMAN		218	UniRef50_P10301
RRAS isoform 1		PANTR		218
Uncharacterized protein		PROCO		220
Ras-related protein R-Ras		MACMU		218
RAS related		PONAB		218
+88

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M14949, M14948 Genomic DNA Translation: AAA60256.1 AF493920 mRNA Translation: AAM12634.1 BT006805 mRNA Translation: AAP35451.1 CR541944 mRNA Translation: CAG46742.1 CR541967 mRNA Translation: CAG46765.1 CH471177 Genomic DNA Translation: EAW52506.1 BC016286 mRNA Translation: AAH16286.1 BC016318 mRNA Translation: AAH16318.1
CCDSⁱ	CCDS12774.1
PIRⁱ	A26159 TVHURR
RefSeqⁱ	NP_006261.1, NM_006270.4
UniGeneⁱ	Hs.515536

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2FN4	X-ray	1.65	A	23-201	[»]
ProteinModelPortalⁱ	P10301
SMRⁱ	P10301
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112151, 33 interactors
IntActⁱ	P10301, 25 interactors
MINTⁱ	P10301
STRINGⁱ	9606.ENSP00000246792

PTM databases

iPTMnetⁱ	P10301
PhosphoSitePlusⁱ	P10301
SwissPalmⁱ	P10301

Polymorphism and mutation databases

BioMutaⁱ	RRAS
DMDMⁱ	133486

2D gel databases

SWISS-2DPAGEⁱ	P10301

SWISS-2DPAGEⁱ

P10301

Proteomic databases

EPDⁱ	P10301
MaxQBⁱ	P10301
PaxDbⁱ	P10301
PeptideAtlasⁱ	P10301
PRIDEⁱ	P10301
ProteomicsDBⁱ	52595

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6237
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000246792; ENSP00000246792; ENSG00000126458
GeneIDⁱ	6237
KEGGⁱ	hsa:6237
UCSCⁱ	uc002pop.2 human

Organism-specific databases

CTDⁱ	6237
DisGeNETⁱ	6237
EuPathDBⁱ	HostDB:ENSG00000126458.3
GeneCardsⁱ	RRAS
HGNCⁱ	HGNC:10447 RRAS
HPAⁱ	CAB010160 CAB069439 HPA060364
MalaCardsⁱ	RRAS
MIMⁱ	165090 gene
neXtProtⁱ	NX_P10301
OpenTargetsⁱ	ENSG00000126458
PharmGKBⁱ	PA34861
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0395 Eukaryota COG1100 LUCA
GeneTreeⁱ	ENSGT00860000133672
HOGENOMⁱ	HOG000233973
HOVERGENⁱ	HBG009351
InParanoidⁱ	P10301
KOⁱ	K07829
OMAⁱ	RSEASTF
OrthoDBⁱ	EOG091G0UAU
PhylomeDBⁱ	P10301
TreeFamⁱ	TF312796

Enzyme and pathway databases

Reactomeⁱ	R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-416550 Sema4D mediated inhibition of cell attachment and migration R-HSA-442742 CREB phosphorylation through the activation of Ras
SignaLinkⁱ	P10301
SIGNORⁱ	P10301

Miscellaneous databases

EvolutionaryTraceⁱ	P10301
GeneWikiⁱ	RRAS
GenomeRNAiⁱ	6237
Protein Ontology More...PROⁱ	PR:P10301
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000126458 Expressed in 190 organ(s), highest expression level in tibial artery
CleanExⁱ	HS_RRAS
ExpressionAtlasⁱ	P10301 baseline and differential
Genevisibleⁱ	P10301 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase IPR020849 Small_GTPase_Ras-type
PANTHERⁱ	PTHR24070 PTHR24070, 1 hit
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51421 RAS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RRAS_HUMAN
Accessionⁱ	P10301Primary (citable) accession number: P10301 Secondary accession number(s): Q6FH12
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	July 1, 1989
	Last modified:	September 12, 2018
	This is version 191 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P10301 (RRAS_HUMAN)

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Ras-related protein R-Ras

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ