Ras-related protein R-Ras

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

• GTP

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  + H₂O

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  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  = GDP

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  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  + H⁺

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  • See the description of this molecule in ChEBI.

  + phosphate

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  • See the description of this molecule in ChEBI.

  By similarity

  <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toⁱ

  • UniProtKB:P62070 (RRAS2_HUMAN)
  This reaction proceeds in the forward

  • Search for this reaction in UniProtKB.
  • See the description of this reaction in Rhea.

  By similarity

  Manual assertion inferred from sequence similarity toⁱ

  • UniProtKB:P62070 (RRAS2_HUMAN)

  direction.
  Source: Rhea

  • Search for this reaction in UniProtKB.
  • See the description of this reaction in Rhea.

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  GTP

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  

  +

  H₂O

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  

  =

  GDP

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  

  +

  H⁺

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  

  +

  phosphate

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  zoom

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• GDP binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.13

    "Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype."
    Carta C., Pantaleoni F., Bocchinfuso G., Stella L., Vasta I., Sarkozy A., Digilio C., Palleschi A., Pizzuti A., Grammatico P., Zampino G., Dallapiccola B., Gelb B.D., Tartaglia M.
    Am. J. Hum. Genet. 79:129-135(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 23-201 IN COMPLEX WITH GDP.
• GTPase activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.13

    "Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype."
    Carta C., Pantaleoni F., Bocchinfuso G., Stella L., Vasta I., Sarkozy A., Digilio C., Palleschi A., Pizzuti A., Grammatico P., Zampino G., Dallapiccola B., Gelb B.D., Tartaglia M.
    Am. J. Hum. Genet. 79:129-135(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 23-201 IN COMPLEX WITH GDP.
• GTP binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex binding Source: MGIInferred from direct assayⁱ
  • "KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression."
    Ahmed S.M., Theriault B.L., Uppalapati M., Chiu C.W., Gallie B.L., Sidhu S.S., Angers S.
    J. Cell Biol. 199:951-967(2012) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• face morphogenesis Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis."
    Flex E., Jaiswal M., Pantaleoni F., Martinelli S., Strullu M., Fansa E.K., Caye A., De Luca A., Lepri F., Dvorsky R., Pannone L., Paolacci S., Zhang S.C., Fodale V., Bocchinfuso G., Rossi C., Burkitt-Wright E.M., Farrotti A.

    , Stellacci E., Cecchetti S., Ferese R., Bottero L., Castro S., Fenneteau O., Brethon B., Sanchez M., Roberts A.E., Yntema H.G., Van Der Burgt I., Cianci P., Bondeson M.L., Cristina Digilio M., Zampino G., Kerr B., Aoki Y., Loh M.L., Palleschi A., Di Schiavi E., Care A., Selicorni A., Dallapiccola B., Cirstea I.C., Stella L., Zenker M., Gelb B.D., Cave H., Ahmadian M.R., Tartaglia M.
    Hum Mol Genet 23:4315-4327(2014) [PubMed] [Europe PMC] [Abstract]
• leukocyte differentiation Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis."
    Flex E., Jaiswal M., Pantaleoni F., Martinelli S., Strullu M., Fansa E.K., Caye A., De Luca A., Lepri F., Dvorsky R., Pannone L., Paolacci S., Zhang S.C., Fodale V., Bocchinfuso G., Rossi C., Burkitt-Wright E.M., Farrotti A.

    , Stellacci E., Cecchetti S., Ferese R., Bottero L., Castro S., Fenneteau O., Brethon B., Sanchez M., Roberts A.E., Yntema H.G., Van Der Burgt I., Cianci P., Bondeson M.L., Cristina Digilio M., Zampino G., Kerr B., Aoki Y., Loh M.L., Palleschi A., Di Schiavi E., Care A., Selicorni A., Dallapiccola B., Cirstea I.C., Stella L., Zenker M., Gelb B.D., Cave H., Ahmadian M.R., Tartaglia M.
    Hum Mol Genet 23:4315-4327(2014) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell migration Source: Ensembl
• positive regulation of angiogenesis Source: UniProtKBInferred from mutant phenotypeⁱ
  • "A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells."
    Wilson L.S., Baillie G.S., Pritchard L.M., Umana B., Terrin A., Zaccolo M., Houslay M.D., Maurice D.H.
    J. Biol. Chem. 286:16285-16296(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of endothelial cell-matrix adhesion via fibronectin Source: CACAOInferred from mutant phenotypeⁱ
  • "The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling."
    Sandri C., Caccavari F., Valdembri D., Camillo C., Veltel S., Santambrogio M., Lanzetti L., Bussolino F., Ivaska J., Serini G.
    Cell Res 22:1479-1501(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of endothelial cell migration Source: CACAOInferred from mutant phenotypeⁱ
  • "The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling."
    Sandri C., Caccavari F., Valdembri D., Camillo C., Veltel S., Santambrogio M., Lanzetti L., Bussolino F., Ivaska J., Serini G.
    Cell Res 22:1479-1501(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of vasculogenesis Source: CACAOInferred from mutant phenotypeⁱ
  • "The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling."
    Sandri C., Caccavari F., Valdembri D., Camillo C., Veltel S., Santambrogio M., Lanzetti L., Bussolino F., Ivaska J., Serini G.
    Cell Res 22:1479-1501(2012) [PubMed] [Europe PMC] [Abstract]
• Ras protein signal transduction Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of ERK1 and ERK2 cascade Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis."
    Flex E., Jaiswal M., Pantaleoni F., Martinelli S., Strullu M., Fansa E.K., Caye A., De Luca A., Lepri F., Dvorsky R., Pannone L., Paolacci S., Zhang S.C., Fodale V., Bocchinfuso G., Rossi C., Burkitt-Wright E.M., Farrotti A.

    , Stellacci E., Cecchetti S., Ferese R., Bottero L., Castro S., Fenneteau O., Brethon B., Sanchez M., Roberts A.E., Yntema H.G., Van Der Burgt I., Cianci P., Bondeson M.L., Cristina Digilio M., Zampino G., Kerr B., Aoki Y., Loh M.L., Palleschi A., Di Schiavi E., Care A., Selicorni A., Dallapiccola B., Cirstea I.C., Stella L., Zenker M., Gelb B.D., Cave H., Ahmadian M.R., Tartaglia M.
    Hum Mol Genet 23:4315-4327(2014) [PubMed] [Europe PMC] [Abstract]
• regulation of protein kinase B signaling Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis."
    Flex E., Jaiswal M., Pantaleoni F., Martinelli S., Strullu M., Fansa E.K., Caye A., De Luca A., Lepri F., Dvorsky R., Pannone L., Paolacci S., Zhang S.C., Fodale V., Bocchinfuso G., Rossi C., Burkitt-Wright E.M., Farrotti A.

    , Stellacci E., Cecchetti S., Ferese R., Bottero L., Castro S., Fenneteau O., Brethon B., Sanchez M., Roberts A.E., Yntema H.G., Van Der Burgt I., Cianci P., Bondeson M.L., Cristina Digilio M., Zampino G., Kerr B., Aoki Y., Loh M.L., Palleschi A., Di Schiavi E., Care A., Selicorni A., Dallapiccola B., Cirstea I.C., Stella L., Zenker M., Gelb B.D., Cave H., Ahmadian M.R., Tartaglia M.
    Hum Mol Genet 23:4315-4327(2014) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Miscellaneous databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Motif

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MSSGAASGTG RGRPRGGGPG PGDPPPSETH KLVVVGGGGV GKSALTIQFI 
        60         70         80         90        100
QSYFVSDYDP TIEDSYTKIC SVDGIPARLD ILDTAGQEEF GAMREQYMRA 
       110        120        130        140        150
GHGFLLVFAI NDRQSFNEVG KLFTQILRVK DRDDFPVVLV GNKADLESQR 
       160        170        180        190        200
QVPRSEASAF GASHHVAYFE ASAKLRLNVD EAFEQLVRAV RKYQEQELPP 
       210 
SPPSAPRKKG GGCPCVLL                                    

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
3. SIMILARITY comments
   Index of protein domains and families
4. Human chromosome 19
   Human chromosome 19: entries, gene names and cross-references to MIM