UniProtKB - P10301 (RRAS_HUMAN)
Protein
Ras-related protein R-Ras
Gene
RRAS
Organism
Homo sapiens (Human)
Status
Functioni
Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267).2 Publications
Catalytic activityi
- This reaction proceeds in the forwardBy similarity direction.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 36 – 44 | GTP1 Publication | 9 | |
Nucleotide bindingi | 83 – 87 | GTPBy similarity | 5 | |
Nucleotide bindingi | 142 – 145 | GTP1 Publication | 4 | |
Nucleotide bindingi | 172 – 174 | GTP1 Publication | 3 |
GO - Molecular functioni
- GDP binding Source: UniProtKB
- GTPase activity Source: UniProtKB
- GTP binding Source: GO_Central
- protein-containing complex binding Source: MGI
GO - Biological processi
- face morphogenesis Source: UniProtKB
- leukocyte differentiation Source: UniProtKB
- negative regulation of cell migration Source: Ensembl
- positive regulation of angiogenesis Source: UniProtKB
- positive regulation of endothelial cell-matrix adhesion via fibronectin Source: CACAO
- positive regulation of endothelial cell migration Source: CACAO
- positive regulation of vasculogenesis Source: CACAO
- Ras protein signal transduction Source: GO_Central
- regulation of ERK1 and ERK2 cascade Source: UniProtKB
- regulation of protein kinase B signaling Source: UniProtKB
Keywordsi
Molecular function | Hydrolase |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P10301 |
Reactomei | R-HSA-399955, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-416550, Sema4D mediated inhibition of cell attachment and migration |
SignaLinki | P10301 |
SIGNORi | P10301 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:RRAS |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000126458.3 |
HGNCi | HGNC:10447, RRAS |
MIMi | 165090, gene |
neXtProti | NX_P10301 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
Note: Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- focal adhesion Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 38 | G → V: No effect on interaction with OSBPL3. 1 Publication | 1 | |
Mutagenesisi | 43 | S → N: No effect on interaction with OSBPL3. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 6237 |
MalaCardsi | RRAS |
OpenTargetsi | ENSG00000126458 |
Orphaneti | 86834, Juvenile myelomonocytic leukemia 648, Noonan syndrome |
PharmGKBi | PA34861 |
Miscellaneous databases
Pharosi | P10301, Tbio |
Polymorphism and mutation databases
BioMutai | RRAS |
DMDMi | 133486 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000082650 | 1 – 215 | Ras-related protein R-RasAdd BLAST | 215 | |
PropeptideiPRO_0000281300 | 216 – 218 | Removed in mature formBy similarity | 3 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 215 | Cysteine methyl esterBy similarity | 1 | |
Lipidationi | 215 | S-geranylgeranyl cysteineBy similarity | 1 |
Post-translational modificationi
S-palmitoylated by ZDHHC19, leading to increased association with membranes and with rafts/caveolae as well as enhanced cell viability.1 Publication
Keywords - PTMi
Lipoprotein, Methylation, Palmitate, PrenylationProteomic databases
EPDi | P10301 |
jPOSTi | P10301 |
MassIVEi | P10301 |
MaxQBi | P10301 |
PaxDbi | P10301 |
PeptideAtlasi | P10301 |
PRIDEi | P10301 |
ProteomicsDBi | 52595 |
2D gel databases
SWISS-2DPAGEi | P10301 |
PTM databases
iPTMneti | P10301 |
MetOSitei | P10301 |
PhosphoSitePlusi | P10301 |
SwissPalmi | P10301 |
Expressioni
Gene expression databases
Bgeei | ENSG00000126458, Expressed in tibial artery and 204 other tissues |
ExpressionAtlasi | P10301, baseline and differential |
Genevisiblei | P10301, HS |
Organism-specific databases
HPAi | ENSG00000126458, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsP10301
With | #Exp. | IntAct |
---|---|---|
NCK1 [P16333] | 3 | EBI-968703,EBI-389883 |
RAP1GDS1 - isoform 5 [P52306-5] | 3 | EBI-968703,EBI-12832744 |
Protein-protein interaction databases
BioGRIDi | 112151, 39 interactors |
IntActi | P10301, 39 interactors |
MINTi | P10301 |
STRINGi | 9606.ENSP00000246792 |
Miscellaneous databases
RNActi | P10301, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P10301 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P10301 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 58 – 66 | Effector region | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000160972 |
HOGENOMi | CLU_041217_9_8_1 |
InParanoidi | P10301 |
OMAi | SGGCPCV |
OrthoDBi | 1259506at2759 |
PhylomeDBi | P10301 |
TreeFami | TF312796 |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P10301-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSGAASGTG RGRPRGGGPG PGDPPPSETH KLVVVGGGGV GKSALTIQFI
60 70 80 90 100
QSYFVSDYDP TIEDSYTKIC SVDGIPARLD ILDTAGQEEF GAMREQYMRA
110 120 130 140 150
GHGFLLVFAI NDRQSFNEVG KLFTQILRVK DRDDFPVVLV GNKADLESQR
160 170 180 190 200
QVPRSEASAF GASHHVAYFE ASAKLRLNVD EAFEQLVRAV RKYQEQELPP
210
SPPSAPRKKG GGCPCVLL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14949, M14948 Genomic DNA Translation: AAA60256.1 AF493920 mRNA Translation: AAM12634.1 BT006805 mRNA Translation: AAP35451.1 CR541944 mRNA Translation: CAG46742.1 CR541967 mRNA Translation: CAG46765.1 CH471177 Genomic DNA Translation: EAW52506.1 BC016286 mRNA Translation: AAH16286.1 BC016318 mRNA Translation: AAH16318.1 |
CCDSi | CCDS12774.1 |
PIRi | A26159, TVHURR |
RefSeqi | NP_006261.1, NM_006270.4 |
Genome annotation databases
Ensembli | ENST00000246792; ENSP00000246792; ENSG00000126458 |
GeneIDi | 6237 |
KEGGi | hsa:6237 |
UCSCi | uc002pop.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14949, M14948 Genomic DNA Translation: AAA60256.1 AF493920 mRNA Translation: AAM12634.1 BT006805 mRNA Translation: AAP35451.1 CR541944 mRNA Translation: CAG46742.1 CR541967 mRNA Translation: CAG46765.1 CH471177 Genomic DNA Translation: EAW52506.1 BC016286 mRNA Translation: AAH16286.1 BC016318 mRNA Translation: AAH16318.1 |
CCDSi | CCDS12774.1 |
PIRi | A26159, TVHURR |
RefSeqi | NP_006261.1, NM_006270.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2FN4 | X-ray | 1.65 | A | 23-201 | [»] | |
SMRi | P10301 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112151, 39 interactors |
IntActi | P10301, 39 interactors |
MINTi | P10301 |
STRINGi | 9606.ENSP00000246792 |
PTM databases
iPTMneti | P10301 |
MetOSitei | P10301 |
PhosphoSitePlusi | P10301 |
SwissPalmi | P10301 |
Polymorphism and mutation databases
BioMutai | RRAS |
DMDMi | 133486 |
2D gel databases
SWISS-2DPAGEi | P10301 |
Proteomic databases
EPDi | P10301 |
jPOSTi | P10301 |
MassIVEi | P10301 |
MaxQBi | P10301 |
PaxDbi | P10301 |
PeptideAtlasi | P10301 |
PRIDEi | P10301 |
ProteomicsDBi | 52595 |
Protocols and materials databases
Antibodypediai | 32074, 219 antibodies |
DNASUi | 6237 |
Genome annotation databases
Ensembli | ENST00000246792; ENSP00000246792; ENSG00000126458 |
GeneIDi | 6237 |
KEGGi | hsa:6237 |
UCSCi | uc002pop.2, human |
Organism-specific databases
CTDi | 6237 |
DisGeNETi | 6237 |
EuPathDBi | HostDB:ENSG00000126458.3 |
GeneCardsi | RRAS |
HGNCi | HGNC:10447, RRAS |
HPAi | ENSG00000126458, Low tissue specificity |
MalaCardsi | RRAS |
MIMi | 165090, gene |
neXtProti | NX_P10301 |
OpenTargetsi | ENSG00000126458 |
Orphaneti | 86834, Juvenile myelomonocytic leukemia 648, Noonan syndrome |
PharmGKBi | PA34861 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000160972 |
HOGENOMi | CLU_041217_9_8_1 |
InParanoidi | P10301 |
OMAi | SGGCPCV |
OrthoDBi | 1259506at2759 |
PhylomeDBi | P10301 |
TreeFami | TF312796 |
Enzyme and pathway databases
PathwayCommonsi | P10301 |
Reactomei | R-HSA-399955, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-416550, Sema4D mediated inhibition of cell attachment and migration |
SignaLinki | P10301 |
SIGNORi | P10301 |
Miscellaneous databases
BioGRID-ORCSi | 6237, 4 hits in 844 CRISPR screens |
ChiTaRSi | RRAS, human |
EvolutionaryTracei | P10301 |
GeneWikii | RRAS |
GenomeRNAii | 6237 |
Pharosi | P10301, Tbio |
PROi | PR:P10301 |
RNActi | P10301, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000126458, Expressed in tibial artery and 204 other tissues |
ExpressionAtlasi | P10301, baseline and differential |
Genevisiblei | P10301, HS |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RRAS_HUMAN | |
Accessioni | P10301Primary (citable) accession number: P10301 Secondary accession number(s): Q6FH12 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | December 2, 2020 | |
This is version 207 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM