UniProtKB - P10301 (RRAS_HUMAN)
Protein
Ras-related protein R-Ras
Gene
RRAS
Organism
Homo sapiens (Human)
Status
Functioni
Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267).2 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 36 – 44 | GTP1 Publication | 9 | |
Nucleotide bindingi | 83 – 87 | GTPBy similarity | 5 | |
Nucleotide bindingi | 142 – 145 | GTP1 Publication | 4 | |
Nucleotide bindingi | 172 – 174 | GTP1 Publication | 3 |
GO - Molecular functioni
- GDP binding Source: UniProtKB
- GTPase activity Source: UniProtKB
- GTP binding Source: GO_Central
- protein-containing complex binding Source: MGI
GO - Biological processi
- face morphogenesis Source: UniProtKB
- leukocyte differentiation Source: UniProtKB
- negative regulation of cell migration Source: Ensembl
- positive regulation of angiogenesis Source: UniProtKB
- Ras protein signal transduction Source: GO_Central
- regulation of ERK1 and ERK2 cascade Source: UniProtKB
- regulation of protein kinase B signaling Source: UniProtKB
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-416550 Sema4D mediated inhibition of cell attachment and migration |
SignaLinki | P10301 |
SIGNORi | P10301 |
Names & Taxonomyi
Protein namesi | Recommended name: Ras-related protein R-RasAlternative name(s): p23 |
Gene namesi | Name:RRAS |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10447 RRAS |
MIMi | 165090 gene |
neXtProti | NX_P10301 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
Note: Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- focal adhesion Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 38 | G → V: No effect on interaction with OSBPL3. 1 Publication | 1 | |
Mutagenesisi | 43 | S → N: No effect on interaction with OSBPL3. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 6237 |
MalaCardsi | RRAS |
OpenTargetsi | ENSG00000126458 |
Orphaneti | 86834 Juvenile myelomonocytic leukemia 648 Noonan syndrome |
PharmGKBi | PA34861 |
Miscellaneous databases
Pharosi | P10301 |
Polymorphism and mutation databases
BioMutai | RRAS |
DMDMi | 133486 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000082650 | 1 – 215 | Ras-related protein R-RasAdd BLAST | 215 | |
PropeptideiPRO_0000281300 | 216 – 218 | Removed in mature formBy similarity | 3 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 215 | Cysteine methyl esterBy similarity | 1 | |
Lipidationi | 215 | S-geranylgeranyl cysteineBy similarity | 1 |
Post-translational modificationi
S-palmitoylated by ZDHHC19, leading to increased association with membranes and with rafts/caveolae as well as enhanced cell viability.1 Publication
Keywords - PTMi
Lipoprotein, Methylation, Palmitate, PrenylationProteomic databases
EPDi | P10301 |
jPOSTi | P10301 |
MassIVEi | P10301 |
MaxQBi | P10301 |
PaxDbi | P10301 |
PeptideAtlasi | P10301 |
PRIDEi | P10301 |
ProteomicsDBi | 52595 |
2D gel databases
SWISS-2DPAGEi | P10301 |
PTM databases
iPTMneti | P10301 |
PhosphoSitePlusi | P10301 |
SwissPalmi | P10301 |
Expressioni
Gene expression databases
Bgeei | ENSG00000126458 Expressed in 190 organ(s), highest expression level in tibial artery |
ExpressionAtlasi | P10301 baseline and differential |
Genevisiblei | P10301 HS |
Organism-specific databases
HPAi | CAB010160 CAB069439 HPA060364 |
Interactioni
Subunit structurei
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
P16333 | 3 | EBI-968703,EBI-389883 |
Protein-protein interaction databases
BioGridi | 112151, 38 interactors |
IntActi | P10301, 39 interactors |
MINTi | P10301 |
STRINGi | 9606.ENSP00000246792 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P10301 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P10301 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 58 – 66 | Effector region | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0395 Eukaryota COG1100 LUCA |
GeneTreei | ENSGT00940000160972 |
HOGENOMi | HOG000233973 |
InParanoidi | P10301 |
KOi | K07829 |
OMAi | SGGCPCV |
OrthoDBi | 1259506at2759 |
PhylomeDBi | P10301 |
TreeFami | TF312796 |
Family and domain databases
InterProi | View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase IPR020849 Small_GTPase_Ras-type |
PANTHERi | PTHR24070 PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071 Ras, 1 hit |
SUPFAMi | SSF52540 SSF52540, 1 hit |
TIGRFAMsi | TIGR00231 small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421 RAS, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P10301-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSGAASGTG RGRPRGGGPG PGDPPPSETH KLVVVGGGGV GKSALTIQFI
60 70 80 90 100
QSYFVSDYDP TIEDSYTKIC SVDGIPARLD ILDTAGQEEF GAMREQYMRA
110 120 130 140 150
GHGFLLVFAI NDRQSFNEVG KLFTQILRVK DRDDFPVVLV GNKADLESQR
160 170 180 190 200
QVPRSEASAF GASHHVAYFE ASAKLRLNVD EAFEQLVRAV RKYQEQELPP
210
SPPSAPRKKG GGCPCVLL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14949, M14948 Genomic DNA Translation: AAA60256.1 AF493920 mRNA Translation: AAM12634.1 BT006805 mRNA Translation: AAP35451.1 CR541944 mRNA Translation: CAG46742.1 CR541967 mRNA Translation: CAG46765.1 CH471177 Genomic DNA Translation: EAW52506.1 BC016286 mRNA Translation: AAH16286.1 BC016318 mRNA Translation: AAH16318.1 |
CCDSi | CCDS12774.1 |
PIRi | A26159 TVHURR |
RefSeqi | NP_006261.1, NM_006270.4 |
Genome annotation databases
Ensembli | ENST00000246792; ENSP00000246792; ENSG00000126458 |
GeneIDi | 6237 |
KEGGi | hsa:6237 |
UCSCi | uc002pop.2 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14949, M14948 Genomic DNA Translation: AAA60256.1 AF493920 mRNA Translation: AAM12634.1 BT006805 mRNA Translation: AAP35451.1 CR541944 mRNA Translation: CAG46742.1 CR541967 mRNA Translation: CAG46765.1 CH471177 Genomic DNA Translation: EAW52506.1 BC016286 mRNA Translation: AAH16286.1 BC016318 mRNA Translation: AAH16318.1 |
CCDSi | CCDS12774.1 |
PIRi | A26159 TVHURR |
RefSeqi | NP_006261.1, NM_006270.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2FN4 | X-ray | 1.65 | A | 23-201 | [»] | |
SMRi | P10301 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 112151, 38 interactors |
IntActi | P10301, 39 interactors |
MINTi | P10301 |
STRINGi | 9606.ENSP00000246792 |
PTM databases
iPTMneti | P10301 |
PhosphoSitePlusi | P10301 |
SwissPalmi | P10301 |
Polymorphism and mutation databases
BioMutai | RRAS |
DMDMi | 133486 |
2D gel databases
SWISS-2DPAGEi | P10301 |
Proteomic databases
EPDi | P10301 |
jPOSTi | P10301 |
MassIVEi | P10301 |
MaxQBi | P10301 |
PaxDbi | P10301 |
PeptideAtlasi | P10301 |
PRIDEi | P10301 |
ProteomicsDBi | 52595 |
Protocols and materials databases
DNASUi | 6237 |
Genome annotation databases
Ensembli | ENST00000246792; ENSP00000246792; ENSG00000126458 |
GeneIDi | 6237 |
KEGGi | hsa:6237 |
UCSCi | uc002pop.2 human |
Organism-specific databases
CTDi | 6237 |
DisGeNETi | 6237 |
GeneCardsi | RRAS |
HGNCi | HGNC:10447 RRAS |
HPAi | CAB010160 CAB069439 HPA060364 |
MalaCardsi | RRAS |
MIMi | 165090 gene |
neXtProti | NX_P10301 |
OpenTargetsi | ENSG00000126458 |
Orphaneti | 86834 Juvenile myelomonocytic leukemia 648 Noonan syndrome |
PharmGKBi | PA34861 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0395 Eukaryota COG1100 LUCA |
GeneTreei | ENSGT00940000160972 |
HOGENOMi | HOG000233973 |
InParanoidi | P10301 |
KOi | K07829 |
OMAi | SGGCPCV |
OrthoDBi | 1259506at2759 |
PhylomeDBi | P10301 |
TreeFami | TF312796 |
Enzyme and pathway databases
Reactomei | R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-416550 Sema4D mediated inhibition of cell attachment and migration |
SignaLinki | P10301 |
SIGNORi | P10301 |
Miscellaneous databases
ChiTaRSi | RRAS human |
EvolutionaryTracei | P10301 |
GeneWikii | RRAS |
GenomeRNAii | 6237 |
Pharosi | P10301 |
PROi | PR:P10301 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000126458 Expressed in 190 organ(s), highest expression level in tibial artery |
ExpressionAtlasi | P10301 baseline and differential |
Genevisiblei | P10301 HS |
Family and domain databases
InterProi | View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase IPR020849 Small_GTPase_Ras-type |
PANTHERi | PTHR24070 PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071 Ras, 1 hit |
SUPFAMi | SSF52540 SSF52540, 1 hit |
TIGRFAMsi | TIGR00231 small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421 RAS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RRAS_HUMAN | |
Accessioni | P10301Primary (citable) accession number: P10301 Secondary accession number(s): Q6FH12 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | November 13, 2019 | |
This is version 200 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references