Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutathione S-transferase P

Gene

gst-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). Prevents dopaminergic CEP neuron degeneration in response to Mn2+ (PubMed:23721876).By similarity1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei7GlutathioneBy similarity1
Binding sitei38GlutathioneBy similarity1
Binding sitei42GlutathioneBy similarity1

GO - Molecular functioni

  • glutathione transferase activity Source: WormBase

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-CEL-156590 Glutathione conjugation
R-CEL-3299685 Detoxification of Reactive Oxygen Species
R-CEL-6798695 Neutrophil degranulation
R-CEL-9026762 Biosynthesis of maresin conjugates in tissue regeneration (MCTR)

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase P (EC:2.5.1.18By similarity)
Alternative name(s):
GST class-pi
Gene namesi
Name:gst-1
ORF Names:R107.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiR107.7 ; CE00302 ; WBGene00001749 ; gst-1

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown causes an increase in Mn2+-mediated dopaminergic CEP neuron degeneration.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001859111 – 208Glutathione S-transferase PAdd BLAST208

Proteomic databases

EPDiP10299
PaxDbiP10299
PeptideAtlasiP10299
PRIDEiP10299

Expressioni

Tissue specificityi

Expressed in dopaminergic (DA) neuron (at protein levels).1 Publication

Inductioni

By manganese.1 Publication

Gene expression databases

BgeeiWBGene00001749 Expressed in 5 organ(s), highest expression level in germ line (C elegans)

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
gst-23P915055EBI-326030,EBI-326040

Protein-protein interaction databases

BioGridi41480, 1 interactor
DIPiDIP-24298N
IntActiP10299, 1 interactor
STRINGi6239.R107.7.2

Structurei

3D structure databases

ProteinModelPortaliP10299
SMRiP10299
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 78GST N-terminalAdd BLAST78
Domaini80 – 202GST C-terminalAdd BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 50Glutathione bindingBy similarity2
Regioni62 – 63Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Pi family.Curated

Phylogenomic databases

eggNOGiKOG1695 Eukaryota
ENOG4111VAU LUCA
GeneTreeiENSGT00550000074559
HOGENOMiHOG000115733
InParanoidiP10299
KOiK00799
OMAiLRCKYAT
OrthoDBiEOG091G0K2E
PhylomeDBiP10299

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR003082 GST_pi
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit
PRINTSiPR01268 GSTRNSFRASEP
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

P10299-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLKLTYFDI HGLAEPIRLL LADKQVAYED HRVTYEQWAD IKPKMIFGQV
60 70 80 90 100
PCLLSGDEEI VQSGAIIRHL ARLNGLNGSN ETETTFIDMF YEGLRDLHTK
110 120 130 140 150
YTTMIYRNYE DGKAPYIKDV LPGELARLEK LFHTYKNGEH YVIGDKESYA
160 170 180 190 200
DYVLFEELDI HLILTPNALD GVPALKKFHE RFAERPNIKA YLNKRAAINP

PVNGNGKQ
Length:208
Mass (Da):23,901
Last modified:July 1, 1989 - v1
Checksum:i3A0DC439FF8FFFBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13689 mRNA Translation: CAA31979.1
Z14092 Genomic DNA Translation: CAA78471.1
PIRiS03615
RefSeqiNP_499006.1, NM_066605.5
UniGeneiCel.19723

Genome annotation databases

EnsemblMetazoaiR107.7.1; R107.7.1; WBGene00001749
R107.7.2; R107.7.2; WBGene00001749
GeneIDi176281
KEGGicel:CELE_R107.7
UCSCiR107.7.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiGSTP1_CAEEL
AccessioniPrimary (citable) accession number: P10299
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 12, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again