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Protein

Cadherin-3

Gene

Cdh3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-418990 Adherens junctions interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-3
Alternative name(s):
Placental cadherin
Short name:
P-cadherin
Gene namesi
Name:Cdh3
Synonyms:Cdhp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:88356 Cdh3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini100 – 647ExtracellularSequence analysisAdd BLAST548
Transmembranei648 – 670HelicalSequence analysisAdd BLAST23
Topological domaini671 – 822CytoplasmicSequence analysisAdd BLAST152

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000000374726 – 99Add BLAST74
ChainiPRO_0000003748100 – 822Cadherin-3Add BLAST723

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi558N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

MaxQBiP10287
PaxDbiP10287
PeptideAtlasiP10287
PRIDEiP10287

PTM databases

iPTMnetiP10287
PhosphoSitePlusiP10287

Miscellaneous databases

PMAP-CutDBiP10287

Expressioni

Developmental stagei

Expression is high in both fetal and newborn testis but minimal in testis of 7-day-old animals. Not detected in testis of 21-day-old or adult.1 Publication

Gene expression databases

BgeeiENSMUSG00000061048 Expressed in 180 organ(s), highest expression level in decidua
CleanExiMM_CDH3
GenevisibleiP10287 MM

Interactioni

Subunit structurei

Interacts with CDCP1 and CTNNB1.By similarity

Protein-protein interaction databases

CORUMiP10287
STRINGi10090.ENSMUSP00000079613

Structurei

Secondary structure

1822
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP10287
SMRiP10287
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 207Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini208 – 320Cadherin 2PROSITE-ProRule annotationAdd BLAST113
Domaini321 – 432Cadherin 3PROSITE-ProRule annotationAdd BLAST112
Domaini433 – 538Cadherin 4PROSITE-ProRule annotationAdd BLAST106
Domaini539 – 645Cadherin 5PROSITE-ProRule annotationAdd BLAST107

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi778 – 793Ser-richAdd BLAST16

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118906
HOGENOMiHOG000231254
HOVERGENiHBG106438
InParanoidiP10287
KOiK06796
OMAiAGWLAMD
OrthoDBiEOG091G05OA
TreeFamiTF316817

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PfamiView protein in Pfam
PF00028 Cadherin, 4 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 4 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10287-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELLSGPHAF LLLLLQVCWL RSVVSEPYRA GFIGEAGVTL EVEGTDLEPS
60 70 80 90 100
QVLGKVALAG QGMHHADNGD IIMLTRGTVQ GGKDAMHSPP TRILRRRKRE
110 120 130 140 150
WVMPPIFVPE NGKGPFPQRL NQLKSNKDRG TKIFYSITGP GADSPPEGVF
160 170 180 190 200
TIEKESGWLL LHMPLDREKI VKYELYGHAV SENGASVEEP MNISIIVTDQ
210 220 230 240 250
NDNKPKFTQD TFRGSVLEGV MPGTSVMQVT ATDEDDAVNT YNGVVAYSIH
260 270 280 290 300
SQEPKEPHDL MFTIHKSTGT ISVISSGLDR EKVPEYRLTV QATDMDGEGS
310 320 330 340 350
TTTAEAVVQI LDANDNAPEF EPQKYEAWVP ENEVGHEVQR LTVTDLDVPN
360 370 380 390 400
SPAWRATYHI VGGDDGDHFT ITTHPETNQG VLTTKKGLDF EAQDQHTLYV
410 420 430 440 450
EVTNEAPFAV KLPTATATVV VHVKDVNEAP VFVPPSKVIE AQEGISIGEL
460 470 480 490 500
VCIYTAQDPD KEDQKISYTI SRDPANWLAV DPDSGQITAA GILDREDEQF
510 520 530 540 550
VKNNVYEVMV LATDSGNPPT TGTGTLLLTL TDINDHGPIP EPRQIIICNQ
560 570 580 590 600
SPVPQVLNIT DKDLSPNSSP FQAQLTHDSD IYWMAEVSEK GDTVALSLKK
610 620 630 640 650
FLKQDTYDLH LSLSDHGNRE QLTMIRATVC DCHGQVFNDC PRPWKGGFIL
660 670 680 690 700
PILGAVLALL TLLLALLLLV RKKRKVKEPL LLPEDDTRDN VFYYGEEGGG
710 720 730 740 750
EEDQDYDITQ LHRGLEARPE VVLRNDVVPT FIPTPMYRPR PANPDEIGNF
760 770 780 790 800
IIENLKAANT DPTAPPYDSL LVFDYEGSGS DAASLSSLTT SASDQDQDYN
810 820
YLNEWGSRFK KLADMYGGGE DD
Length:822
Mass (Da):90,612
Last modified:July 27, 2011 - v2
Checksum:i7C653D58210A595A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti351S → W in CAA29646 (PubMed:3428270).Curated1
Sequence conflicti757A → P in CAA29646 (PubMed:3428270).Curated1
Sequence conflicti771L → M in CAA29646 (PubMed:3428270).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06340 mRNA Translation: CAA29646.1
X68057 Genomic DNA No translation available.
AK031265 mRNA Translation: BAC27327.1
CH466525 Genomic DNA Translation: EDL11370.1
BC098459 mRNA Translation: AAH98459.1
D12688 Genomic DNA Translation: BAA02186.1
CCDSiCCDS22637.1
PIRiS03163 IJMSCP
RefSeqiNP_001032898.1, NM_001037809.5
UniGeneiMm.4658

Genome annotation databases

EnsembliENSMUST00000080797; ENSMUSP00000079613; ENSMUSG00000061048
GeneIDi12560
KEGGimmu:12560
UCSCiuc009ngh.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06340 mRNA Translation: CAA29646.1
X68057 Genomic DNA No translation available.
AK031265 mRNA Translation: BAC27327.1
CH466525 Genomic DNA Translation: EDL11370.1
BC098459 mRNA Translation: AAH98459.1
D12688 Genomic DNA Translation: BAA02186.1
CCDSiCCDS22637.1
PIRiS03163 IJMSCP
RefSeqiNP_001032898.1, NM_001037809.5
UniGeneiMm.4658

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NQQX-ray3.20A/B/C/D100-312[»]
ProteinModelPortaliP10287
SMRiP10287
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiP10287
STRINGi10090.ENSMUSP00000079613

PTM databases

iPTMnetiP10287
PhosphoSitePlusiP10287

Proteomic databases

MaxQBiP10287
PaxDbiP10287
PeptideAtlasiP10287
PRIDEiP10287

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080797; ENSMUSP00000079613; ENSMUSG00000061048
GeneIDi12560
KEGGimmu:12560
UCSCiuc009ngh.2 mouse

Organism-specific databases

CTDi1001
MGIiMGI:88356 Cdh3

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118906
HOGENOMiHOG000231254
HOVERGENiHBG106438
InParanoidiP10287
KOiK06796
OMAiAGWLAMD
OrthoDBiEOG091G05OA
TreeFamiTF316817

Enzyme and pathway databases

ReactomeiR-MMU-418990 Adherens junctions interactions

Miscellaneous databases

PMAP-CutDBiP10287
PROiPR:P10287
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000061048 Expressed in 180 organ(s), highest expression level in decidua
CleanExiMM_CDH3
GenevisibleiP10287 MM

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PfamiView protein in Pfam
PF00028 Cadherin, 4 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 4 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCADH3_MOUSE
AccessioniPrimary (citable) accession number: P10287
Secondary accession number(s): Q61465, Q8BSL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 27, 2011
Last modified: October 10, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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