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Entry version 196 (16 Oct 2019)
Sequence version 2 (01 Nov 1991)
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Protein

Major prion protein

Gene

PRNP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).By similarity

Miscellaneous

This protein is produced by a bicistronic gene which also produces the major prion protein/PRNP from an overlapping reading frame.
The alternative prion protein/AltPrP (AC F7VJQ2) and PRNP have no apparent direct functional relation since a mutation that removes the start codon of the AltPrP has no apparent effect on the biology of PRNP (By similarity). In mouse and hamster, the alternative initiation AUG codon is absent and is replaced by a GUG codon.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi72Copper or zinc 1By similarity1
Metal bindingi73Copper or zinc 1; via amide nitrogenBy similarity1
Metal bindingi74Copper or zinc 1; via amide nitrogen and carbonyl oxygenBy similarity1
Metal bindingi80Copper or zinc 2By similarity1
Metal bindingi81Copper or zinc 2; via amide nitrogenBy similarity1
Metal bindingi82Copper or zinc 2; via amide nitrogen and carbonyl oxygenBy similarity1
Metal bindingi88Copper or zinc 3By similarity1
Metal bindingi89Copper or zinc 3; via amide nitrogenBy similarity1
Metal bindingi90Copper or zinc 3; via amide nitrogen and carbonyl oxygenBy similarity1
Metal bindingi96Copper or zinc 4By similarity1
Metal bindingi98Copper or zinc 4; via amide nitrogenBy similarity1
Metal bindingi99Copper or zinc 4; via amide nitrogen and carbonyl oxygenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • copper ion binding Source: UniProtKB
  • identical protein binding Source: IntAct

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionPrion
LigandCopper, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Major prion protein
Short name:
PrP
Alternative name(s):
Major scrapie-associated fibril protein 1
CD_antigen: CD230
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRNP
Synonyms:PRP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, Cell membrane, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Variations in PRNP are responsible of transmissible bovine spongiform encephalopathies (BSE), a class of neurodegenerative diseases that affect various mammals. These diseases are caused by abnormally folded prion proteins. BSE can be subdivided into at least three groups: classical, H-type and L-type, with the latter 2 collectively referred to as atypical BSE. Susceptibility or resistance to a BSE disease can be influenced by at least 3 factors related to the host prion protein: protein expression levels, number of octapeptide repeats, and specific polymorphisms. In cattle, as in humans, BSEs can occur as infectious, spontaneous and genetic diseases.Curated

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 241 PublicationAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002562725 – 241Major prion proteinAdd BLAST217
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000025628242 – 264Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi190 ↔ 225
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi192N-linked (GlcNAc...) asparagineCurated1
Glycosylationi208N-linked (GlcNAc...) asparagineCurated1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi241GPI-anchor amidated alanineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P10279

PRoteomics IDEntifications database

More...
PRIDEi
P10279

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000027937 Expressed in 9 organ(s), highest expression level in prefrontal cortex

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization.

Interacts with GRB2, APP, ERI3/PRNPIP and SYN1 (By similarity). Mislocalized cytosolically exposed PrP interacts with MGRN1; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement (By similarity).

Interacts with APP.

Interacts with KIAA1191 (By similarity).

Interacts with ADGRG6 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
158758, 3 interactors

Protein interaction database and analysis system

More...
IntActi
P10279, 1 interactor

Molecular INTeraction database

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MINTi
P10279

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000043233

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1264
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P10279

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P10279

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati54 – 6219
Repeati63 – 7028
Repeati71 – 7838
Repeati79 – 8648
Repeati87 – 9458
Repeati95 – 10369

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni25 – 241Interaction with GRB2, ERI3 and SYN1By similarityAdd BLAST217
Regioni25 – 41Interaction with ADGRG6By similarityAdd BLAST17
Regioni54 – 1036 X 8 AA tandem repeats of P-H-G-G-G-W-G-QAdd BLAST50

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The normal, monomeric form has a mainly alpha-helical structure. The disease-associated, protease-resistant form forms amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Disease mutations may favor intermolecular contacts via short beta strands, and may thereby trigger oligomerization.By similarity
Contains an N-terminal region composed of octamer repeats. At low copper concentrations, the sidechains of His residues from three or four repeats contribute to the binding of a single copper ion. Alternatively, a copper ion can be bound by interaction with the sidechain and backbone amide nitrogen of a single His residue. The observed copper binding stoichiometry suggests that two repeat regions cooperate to stabilize the binding of a single copper ion. At higher copper concentrations, each octamer can bind one copper ion by interactions with the His sidechain and Gly backbone atoms. A mixture of binding types may occur, especially in the case of octamer repeat expansion. Copper binding may stabilize the conformation of this region and may promote oligomerization.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the prion family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJMM Eukaryota
ENOG410YXUU LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P10279

Identification of Orthologs from Complete Genome Data

More...
OMAi
DVGLCKK

Database of Orthologous Groups

More...
OrthoDBi
1403854at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105188

Family and domain databases

Database of protein disorder

More...
DisProti
DP00783

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.790.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000817 Prion
IPR036924 Prion/Doppel_b-ribbon_dom_sf
IPR022416 Prion/Doppel_prot_b-ribbon_dom
IPR025860 Prion_N_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00377 Prion, 1 hit
PF11587 Prion_bPrPp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00341 PRION

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00157 PRP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54098 SSF54098, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00291 PRION_1, 1 hit
PS00706 PRION_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P10279-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKSHIGSWI LVLFVAMWSD VGLCKKRPKP GGGWNTGGSR YPGQGSPGGN
60 70 80 90 100
RYPPQGGGGW GQPHGGGWGQ PHGGGWGQPH GGGWGQPHGG GWGQPHGGGG
110 120 130 140 150
WGQGGTHGQW NKPSKPKTNM KHVAGAAAAG AVVGGLGGYM LGSAMSRPLI
160 170 180 190 200
HFGSDYEDRY YRENMHRYPN QVYYRPVDQY SNQNNFVHDC VNITVKEHTV
210 220 230 240 250
TTTTKGENFT ETDIKMMERV VEQMCITQYQ RESQAYYQRG ASVILFSSPP
260
VILLISFLIF LIVG
Length:264
Mass (Da):28,614
Last modified:November 1, 1991 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD6D214038316A231
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti106 – 108THG → SHS in BAA01469 (PubMed:1362024).Curated3
Sequence conflicti218E → K in BAA01467 (PubMed:1362024).Curated1
Sequence conflicti218E → K in BAA19253 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti60W → R1 Publication1
Natural varianti71 – 78Missing in allele 2. 8
Natural varianti84 – 99Missing 1 PublicationAdd BLAST16
Natural varianti92 – 99Missing 2 Publications8
Natural varianti94Q → R1 Publication1
Natural varianti98G → GGWGQPHGG1 Publication1
Natural varianti154S → N2 Publications1
Natural varianti211E → K1 Publication1
Natural varianti234Q → R1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X55882 Genomic DNA Translation: CAA39368.1
D10612 mRNA Translation: BAA01467.1
D10613 Genomic DNA Translation: BAA01468.1
D10614 Genomic DNA Translation: BAA01469.1
S55629 mRNA Translation: AAB25514.1
AB001468 mRNA Translation: BAA19253.1
AJ298878 Genomic DNA Translation: CAC37367.1
AF455119 Genomic DNA Translation: AAM73856.1
AF517842 mRNA Translation: AAM66709.1
AY335912 Genomic DNA Translation: AAP84097.2
AY367638 Genomic DNA Translation: AAQ64645.1
AY367639 Genomic DNA Translation: AAQ64646.1
AY367640 Genomic DNA Translation: AAQ64647.1
AY367641 Genomic DNA Translation: AAQ64648.1
AY367642 Genomic DNA Translation: AAQ64649.1
AY367643 Genomic DNA Translation: AAQ64650.1
AY720445 Genomic DNA Translation: AAV30252.1
AY720446 Genomic DNA Translation: AAV30253.1
AY720448 Genomic DNA Translation: AAV30255.1
AY720449 Genomic DNA Translation: AAV30256.1
AY720450 Genomic DNA Translation: AAV30257.1
AY720451 Genomic DNA Translation: AAV30258.1
AY720452 Genomic DNA Translation: AAV30259.1
AY720453 Genomic DNA Translation: AAV30260.1
AY720454 Genomic DNA Translation: AAV30261.1
AY720455 Genomic DNA Translation: AAV30262.1
AY720458 Genomic DNA Translation: AAV30265.1
AY720459 Genomic DNA Translation: AAV30266.1
AY720460 Genomic DNA Translation: AAV30267.1
AY720461 Genomic DNA Translation: AAV30268.1
AY720462 Genomic DNA Translation: AAV30269.1
AY720463 Genomic DNA Translation: AAV30270.1
AY720464 Genomic DNA Translation: AAV30271.1
AY720465 Genomic DNA Translation: AAV30272.1
AY720466 Genomic DNA Translation: AAV30273.1
AY720467 Genomic DNA Translation: AAV30274.1
AY720468 Genomic DNA Translation: AAV30275.1
AY720469 Genomic DNA Translation: AAV30276.1
AY720470 Genomic DNA Translation: AAV30277.1
AY720471 Genomic DNA Translation: AAV30278.1
AY720472 Genomic DNA Translation: AAV30279.1
AY720473 Genomic DNA Translation: AAV30280.1
AY720474 Genomic DNA Translation: AAV30281.1
AY720475 Genomic DNA Translation: AAV30282.1
AY720476 Genomic DNA Translation: AAV30283.1
AY720477 Genomic DNA Translation: AAV30284.1
AY720478 Genomic DNA Translation: AAV30285.1
AY720479 Genomic DNA Translation: AAV30286.1
AY720480 Genomic DNA Translation: AAV30287.1
AY720481 Genomic DNA Translation: AAV30288.1
AY720482 Genomic DNA Translation: AAV30289.1
AY720483 Genomic DNA Translation: AAV30290.1
AY720484 Genomic DNA Translation: AAV30291.1
AY720485 Genomic DNA Translation: AAV30292.1
AY720486 Genomic DNA Translation: AAV30293.1
AY720488 Genomic DNA Translation: AAV30295.1
AY720489 Genomic DNA Translation: AAV30296.1
AY720492 Genomic DNA Translation: AAV30299.1
AY720493 Genomic DNA Translation: AAV30300.1
AY720494 Genomic DNA Translation: AAV30301.1
AY720495 Genomic DNA Translation: AAV30302.1
AY720496 Genomic DNA Translation: AAV30303.1
AY720497 Genomic DNA Translation: AAV30304.1
AY720498 Genomic DNA Translation: AAV30305.1
AY720503 Genomic DNA Translation: AAV30310.1
AY720504 Genomic DNA Translation: AAV30311.1
AY720505 Genomic DNA Translation: AAV30312.1
AY720506 Genomic DNA Translation: AAV30313.1
AY720507 Genomic DNA Translation: AAV30314.1
AY720508 Genomic DNA Translation: AAV30315.1
AY720509 Genomic DNA Translation: AAV30316.1
AY720510 Genomic DNA Translation: AAV30317.1
AY720511 Genomic DNA Translation: AAV30318.1
AY720512 Genomic DNA Translation: AAV30319.1
AY720513 Genomic DNA Translation: AAV30320.1
AY720514 Genomic DNA Translation: AAV30321.1
AY720525 Genomic DNA Translation: AAV30332.1
AY720530 Genomic DNA Translation: AAV30337.1
AY720531 Genomic DNA Translation: AAV30338.1
AY720532 Genomic DNA Translation: AAV30339.1
AY720533 Genomic DNA Translation: AAV30340.1
AY720534 Genomic DNA Translation: AAV30341.1
AY720535 Genomic DNA Translation: AAV30342.1
AY720540 Genomic DNA Translation: AAV30347.1
AY720541 Genomic DNA Translation: AAV30348.1
AY720544 Genomic DNA Translation: AAV30351.1
AY720545 Genomic DNA Translation: AAV30352.1
AY720546 Genomic DNA Translation: AAV30353.1
AY720547 Genomic DNA Translation: AAV30354.1
AY720548 Genomic DNA Translation: AAV30355.1
AY720549 Genomic DNA Translation: AAV30356.1
AY720550 Genomic DNA Translation: AAV30357.1
AY720551 Genomic DNA Translation: AAV30358.1
AY720552 Genomic DNA Translation: AAV30359.1
AY720553 Genomic DNA Translation: AAV30360.1
AY720554 Genomic DNA Translation: AAV30361.1
AY720555 Genomic DNA Translation: AAV30362.1
AY720556 Genomic DNA Translation: AAV30363.1
AY720557 Genomic DNA Translation: AAV30364.1
AY720558 Genomic DNA Translation: AAV30365.1
AY720559 Genomic DNA Translation: AAV30366.1
AY720560 Genomic DNA Translation: AAV30367.1
AY720561 Genomic DNA Translation: AAV30368.1
AY720562 Genomic DNA Translation: AAV30369.1
AY720563 Genomic DNA Translation: AAV30370.1
AY720564 Genomic DNA Translation: AAV30371.1
AY720565 Genomic DNA Translation: AAV30372.1
AY720566 Genomic DNA Translation: AAV30373.1
AY720567 Genomic DNA Translation: AAV30374.1
AY720568 Genomic DNA Translation: AAV30375.1
AY720569 Genomic DNA Translation: AAV30376.1
AY720570 Genomic DNA Translation: AAV30377.1
AY720571 Genomic DNA Translation: AAV30378.1
AY720572 Genomic DNA Translation: AAV30379.1
AY720573 Genomic DNA Translation: AAV30380.1
AY720574 Genomic DNA Translation: AAV30381.1
AY720581 Genomic DNA Translation: AAV30388.1
AY720582 Genomic DNA Translation: AAV30389.1
AY720583 Genomic DNA Translation: AAV30390.1
AY720584 Genomic DNA Translation: AAV30391.1
AY720585 Genomic DNA Translation: AAV30392.1
AY720588 Genomic DNA Translation: AAV30395.1
AY720591 Genomic DNA Translation: AAV30398.1
AY720594 Genomic DNA Translation: AAV30401.1
AY720595 Genomic DNA Translation: AAV30402.1
AY720596 Genomic DNA Translation: AAV30403.1
AY720597 Genomic DNA Translation: AAV30404.1
AY720600 Genomic DNA Translation: AAV30407.1
AY720601 Genomic DNA Translation: AAV30408.1
AY720602 Genomic DNA Translation: AAV30409.1
AY720603 Genomic DNA Translation: AAV30410.1
AY720604 Genomic DNA Translation: AAV30411.1
AY720605 Genomic DNA Translation: AAV30412.1
AY720606 Genomic DNA Translation: AAV30413.1
AY720607 Genomic DNA Translation: AAV30414.1
AY720608 Genomic DNA Translation: AAV30415.1
AY720609 Genomic DNA Translation: AAV30416.1
AY720610 Genomic DNA Translation: AAV30417.1
AY720611 Genomic DNA Translation: AAV30418.1
AY720612 Genomic DNA Translation: AAV30419.1
AY720613 Genomic DNA Translation: AAV30420.1
AY720622 Genomic DNA Translation: AAV30429.1
AY720623 Genomic DNA Translation: AAV30430.1
AY720624 Genomic DNA Translation: AAV30431.1
AY720625 Genomic DNA Translation: AAV30432.1
AY720626 Genomic DNA Translation: AAV30433.1
AY720627 Genomic DNA Translation: AAV30434.1
AY720628 Genomic DNA Translation: AAV30435.1
AY720629 Genomic DNA Translation: AAV30436.1
AY720630 Genomic DNA Translation: AAV30437.1
AY720631 Genomic DNA Translation: AAV30438.1
AY720632 Genomic DNA Translation: AAV30439.1
AY720633 Genomic DNA Translation: AAV30440.1
AY720634 Genomic DNA Translation: AAV30441.1
AY720635 Genomic DNA Translation: AAV30442.1
AY720636 Genomic DNA Translation: AAV30443.1
AY720637 Genomic DNA Translation: AAV30444.1
AY720640 Genomic DNA Translation: AAV30447.1
AY720641 Genomic DNA Translation: AAV30448.1
AY720642 Genomic DNA Translation: AAV30449.1
AY720643 Genomic DNA Translation: AAV30450.1
AY720644 Genomic DNA Translation: AAV30451.1
AY720645 Genomic DNA Translation: AAV30452.1
AY720648 Genomic DNA Translation: AAV30455.1
AY720649 Genomic DNA Translation: AAV30456.1
AY720650 Genomic DNA Translation: AAV30457.1
AY720651 Genomic DNA Translation: AAV30458.1
AY720652 Genomic DNA Translation: AAV30459.1
AY720653 Genomic DNA Translation: AAV30460.1
AY720654 Genomic DNA Translation: AAV30461.1
AY720655 Genomic DNA Translation: AAV30462.1
AY720656 Genomic DNA Translation: AAV30463.1
AY720657 Genomic DNA Translation: AAV30464.1
AY720662 Genomic DNA Translation: AAV30469.1
AY720663 Genomic DNA Translation: AAV30470.1
AY720664 Genomic DNA Translation: AAV30471.1
AY720667 Genomic DNA Translation: AAV30474.1
AY720668 Genomic DNA Translation: AAV30475.1
AY720669 Genomic DNA Translation: AAV30476.1
AY720670 Genomic DNA Translation: AAV30477.1
AY720671 Genomic DNA Translation: AAV30478.1
AY720672 Genomic DNA Translation: AAV30479.1
AY720673 Genomic DNA Translation: AAV30480.1
AY720674 Genomic DNA Translation: AAV30481.1
AY720675 Genomic DNA Translation: AAV30482.1
AY720676 Genomic DNA Translation: AAV30483.1
AY720677 Genomic DNA Translation: AAV30484.1
AY720678 Genomic DNA Translation: AAV30485.1
DQ205538 Genomic DNA Translation: ABB51165.1
AY944236 Genomic DNA Translation: AAY21624.1
AB248079 Genomic DNA Translation: BAE78586.1
AB247937 Genomic DNA Translation: BAE78583.1
EF139165 Genomic DNA Translation: ABL75501.1
BC119821 mRNA Translation: AAI19822.1
D26151 Genomic DNA Translation: BAA05138.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A54330
JU0268

NCBI Reference Sequences

More...
RefSeqi
NP_001258555.1, NM_001271626.2
NP_851358.2, NM_181015.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
281427

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55882 Genomic DNA Translation: CAA39368.1
D10612 mRNA Translation: BAA01467.1
D10613 Genomic DNA Translation: BAA01468.1
D10614 Genomic DNA Translation: BAA01469.1
S55629 mRNA Translation: AAB25514.1
AB001468 mRNA Translation: BAA19253.1
AJ298878 Genomic DNA Translation: CAC37367.1
AF455119 Genomic DNA Translation: AAM73856.1
AF517842 mRNA Translation: AAM66709.1
AY335912 Genomic DNA Translation: AAP84097.2
AY367638 Genomic DNA Translation: AAQ64645.1
AY367639 Genomic DNA Translation: AAQ64646.1
AY367640 Genomic DNA Translation: AAQ64647.1
AY367641 Genomic DNA Translation: AAQ64648.1
AY367642 Genomic DNA Translation: AAQ64649.1
AY367643 Genomic DNA Translation: AAQ64650.1
AY720445 Genomic DNA Translation: AAV30252.1
AY720446 Genomic DNA Translation: AAV30253.1
AY720448 Genomic DNA Translation: AAV30255.1
AY720449 Genomic DNA Translation: AAV30256.1
AY720450 Genomic DNA Translation: AAV30257.1
AY720451 Genomic DNA Translation: AAV30258.1
AY720452 Genomic DNA Translation: AAV30259.1
AY720453 Genomic DNA Translation: AAV30260.1
AY720454 Genomic DNA Translation: AAV30261.1
AY720455 Genomic DNA Translation: AAV30262.1
AY720458 Genomic DNA Translation: AAV30265.1
AY720459 Genomic DNA Translation: AAV30266.1
AY720460 Genomic DNA Translation: AAV30267.1
AY720461 Genomic DNA Translation: AAV30268.1
AY720462 Genomic DNA Translation: AAV30269.1
AY720463 Genomic DNA Translation: AAV30270.1
AY720464 Genomic DNA Translation: AAV30271.1
AY720465 Genomic DNA Translation: AAV30272.1
AY720466 Genomic DNA Translation: AAV30273.1
AY720467 Genomic DNA Translation: AAV30274.1
AY720468 Genomic DNA Translation: AAV30275.1
AY720469 Genomic DNA Translation: AAV30276.1
AY720470 Genomic DNA Translation: AAV30277.1
AY720471 Genomic DNA Translation: AAV30278.1
AY720472 Genomic DNA Translation: AAV30279.1
AY720473 Genomic DNA Translation: AAV30280.1
AY720474 Genomic DNA Translation: AAV30281.1
AY720475 Genomic DNA Translation: AAV30282.1
AY720476 Genomic DNA Translation: AAV30283.1
AY720477 Genomic DNA Translation: AAV30284.1
AY720478 Genomic DNA Translation: AAV30285.1
AY720479 Genomic DNA Translation: AAV30286.1
AY720480 Genomic DNA Translation: AAV30287.1
AY720481 Genomic DNA Translation: AAV30288.1
AY720482 Genomic DNA Translation: AAV30289.1
AY720483 Genomic DNA Translation: AAV30290.1
AY720484 Genomic DNA Translation: AAV30291.1
AY720485 Genomic DNA Translation: AAV30292.1
AY720486 Genomic DNA Translation: AAV30293.1
AY720488 Genomic DNA Translation: AAV30295.1
AY720489 Genomic DNA Translation: AAV30296.1
AY720492 Genomic DNA Translation: AAV30299.1
AY720493 Genomic DNA Translation: AAV30300.1
AY720494 Genomic DNA Translation: AAV30301.1
AY720495 Genomic DNA Translation: AAV30302.1
AY720496 Genomic DNA Translation: AAV30303.1
AY720497 Genomic DNA Translation: AAV30304.1
AY720498 Genomic DNA Translation: AAV30305.1
AY720503 Genomic DNA Translation: AAV30310.1
AY720504 Genomic DNA Translation: AAV30311.1
AY720505 Genomic DNA Translation: AAV30312.1
AY720506 Genomic DNA Translation: AAV30313.1
AY720507 Genomic DNA Translation: AAV30314.1
AY720508 Genomic DNA Translation: AAV30315.1
AY720509 Genomic DNA Translation: AAV30316.1
AY720510 Genomic DNA Translation: AAV30317.1
AY720511 Genomic DNA Translation: AAV30318.1
AY720512 Genomic DNA Translation: AAV30319.1
AY720513 Genomic DNA Translation: AAV30320.1
AY720514 Genomic DNA Translation: AAV30321.1
AY720525 Genomic DNA Translation: AAV30332.1
AY720530 Genomic DNA Translation: AAV30337.1
AY720531 Genomic DNA Translation: AAV30338.1
AY720532 Genomic DNA Translation: AAV30339.1
AY720533 Genomic DNA Translation: AAV30340.1
AY720534 Genomic DNA Translation: AAV30341.1
AY720535 Genomic DNA Translation: AAV30342.1
AY720540 Genomic DNA Translation: AAV30347.1
AY720541 Genomic DNA Translation: AAV30348.1
AY720544 Genomic DNA Translation: AAV30351.1
AY720545 Genomic DNA Translation: AAV30352.1
AY720546 Genomic DNA Translation: AAV30353.1
AY720547 Genomic DNA Translation: AAV30354.1
AY720548 Genomic DNA Translation: AAV30355.1
AY720549 Genomic DNA Translation: AAV30356.1
AY720550 Genomic DNA Translation: AAV30357.1
AY720551 Genomic DNA Translation: AAV30358.1
AY720552 Genomic DNA Translation: AAV30359.1
AY720553 Genomic DNA Translation: AAV30360.1
AY720554 Genomic DNA Translation: AAV30361.1
AY720555 Genomic DNA Translation: AAV30362.1
AY720556 Genomic DNA Translation: AAV30363.1
AY720557 Genomic DNA Translation: AAV30364.1
AY720558 Genomic DNA Translation: AAV30365.1
AY720559 Genomic DNA Translation: AAV30366.1
AY720560 Genomic DNA Translation: AAV30367.1
AY720561 Genomic DNA Translation: AAV30368.1
AY720562 Genomic DNA Translation: AAV30369.1
AY720563 Genomic DNA Translation: AAV30370.1
AY720564 Genomic DNA Translation: AAV30371.1
AY720565 Genomic DNA Translation: AAV30372.1
AY720566 Genomic DNA Translation: AAV30373.1
AY720567 Genomic DNA Translation: AAV30374.1
AY720568 Genomic DNA Translation: AAV30375.1
AY720569 Genomic DNA Translation: AAV30376.1
AY720570 Genomic DNA Translation: AAV30377.1
AY720571 Genomic DNA Translation: AAV30378.1
AY720572 Genomic DNA Translation: AAV30379.1
AY720573 Genomic DNA Translation: AAV30380.1
AY720574 Genomic DNA Translation: AAV30381.1
AY720581 Genomic DNA Translation: AAV30388.1
AY720582 Genomic DNA Translation: AAV30389.1
AY720583 Genomic DNA Translation: AAV30390.1
AY720584 Genomic DNA Translation: AAV30391.1
AY720585 Genomic DNA Translation: AAV30392.1
AY720588 Genomic DNA Translation: AAV30395.1
AY720591 Genomic DNA Translation: AAV30398.1
AY720594 Genomic DNA Translation: AAV30401.1
AY720595 Genomic DNA Translation: AAV30402.1
AY720596 Genomic DNA Translation: AAV30403.1
AY720597 Genomic DNA Translation: AAV30404.1
AY720600 Genomic DNA Translation: AAV30407.1
AY720601 Genomic DNA Translation: AAV30408.1
AY720602 Genomic DNA Translation: AAV30409.1
AY720603 Genomic DNA Translation: AAV30410.1
AY720604 Genomic DNA Translation: AAV30411.1
AY720605 Genomic DNA Translation: AAV30412.1
AY720606 Genomic DNA Translation: AAV30413.1
AY720607 Genomic DNA Translation: AAV30414.1
AY720608 Genomic DNA Translation: AAV30415.1
AY720609 Genomic DNA Translation: AAV30416.1
AY720610 Genomic DNA Translation: AAV30417.1
AY720611 Genomic DNA Translation: AAV30418.1
AY720612 Genomic DNA Translation: AAV30419.1
AY720613 Genomic DNA Translation: AAV30420.1
AY720622 Genomic DNA Translation: AAV30429.1
AY720623 Genomic DNA Translation: AAV30430.1
AY720624 Genomic DNA Translation: AAV30431.1
AY720625 Genomic DNA Translation: AAV30432.1
AY720626 Genomic DNA Translation: AAV30433.1
AY720627 Genomic DNA Translation: AAV30434.1
AY720628 Genomic DNA Translation: AAV30435.1
AY720629 Genomic DNA Translation: AAV30436.1
AY720630 Genomic DNA Translation: AAV30437.1
AY720631 Genomic DNA Translation: AAV30438.1
AY720632 Genomic DNA Translation: AAV30439.1
AY720633 Genomic DNA Translation: AAV30440.1
AY720634 Genomic DNA Translation: AAV30441.1
AY720635 Genomic DNA Translation: AAV30442.1
AY720636 Genomic DNA Translation: AAV30443.1
AY720637 Genomic DNA Translation: AAV30444.1
AY720640 Genomic DNA Translation: AAV30447.1
AY720641 Genomic DNA Translation: AAV30448.1
AY720642 Genomic DNA Translation: AAV30449.1
AY720643 Genomic DNA Translation: AAV30450.1
AY720644 Genomic DNA Translation: AAV30451.1
AY720645 Genomic DNA Translation: AAV30452.1
AY720648 Genomic DNA Translation: AAV30455.1
AY720649 Genomic DNA Translation: AAV30456.1
AY720650 Genomic DNA Translation: AAV30457.1
AY720651 Genomic DNA Translation: AAV30458.1
AY720652 Genomic DNA Translation: AAV30459.1
AY720653 Genomic DNA Translation: AAV30460.1
AY720654 Genomic DNA Translation: AAV30461.1
AY720655 Genomic DNA Translation: AAV30462.1
AY720656 Genomic DNA Translation: AAV30463.1
AY720657 Genomic DNA Translation: AAV30464.1
AY720662 Genomic DNA Translation: AAV30469.1
AY720663 Genomic DNA Translation: AAV30470.1
AY720664 Genomic DNA Translation: AAV30471.1
AY720667 Genomic DNA Translation: AAV30474.1
AY720668 Genomic DNA Translation: AAV30475.1
AY720669 Genomic DNA Translation: AAV30476.1
AY720670 Genomic DNA Translation: AAV30477.1
AY720671 Genomic DNA Translation: AAV30478.1
AY720672 Genomic DNA Translation: AAV30479.1
AY720673 Genomic DNA Translation: AAV30480.1
AY720674 Genomic DNA Translation: AAV30481.1
AY720675 Genomic DNA Translation: AAV30482.1
AY720676 Genomic DNA Translation: AAV30483.1
AY720677 Genomic DNA Translation: AAV30484.1
AY720678 Genomic DNA Translation: AAV30485.1
DQ205538 Genomic DNA Translation: ABB51165.1
AY944236 Genomic DNA Translation: AAY21624.1
AB248079 Genomic DNA Translation: BAE78586.1
AB247937 Genomic DNA Translation: BAE78583.1
EF139165 Genomic DNA Translation: ABL75501.1
BC119821 mRNA Translation: AAI19822.1
D26151 Genomic DNA Translation: BAA05138.1
PIRiA54330
JU0268
RefSeqiNP_001258555.1, NM_001271626.2
NP_851358.2, NM_181015.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DWYNMR-A132-241[»]
1DWZNMR-A132-241[»]
1DX0NMR-A25-241[»]
1DX1NMR-A25-241[»]
1SKHNMR-A1-30[»]
2HH0X-ray2.85P107-115[»]
2RSKNMR-C/D108-119[»]
2RU7NMR-C/D108-119[»]
4YX2X-ray2.19A103-242[»]
SMRiP10279
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi158758, 3 interactors
IntActiP10279, 1 interactor
MINTiP10279
STRINGi9913.ENSBTAP00000043233

Proteomic databases

PaxDbiP10279
PRIDEiP10279

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P10279

Genome annotation databases

GeneIDi281427

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5621

Phylogenomic databases

eggNOGiENOG410IJMM Eukaryota
ENOG410YXUU LUCA
InParanoidiP10279
OMAiDVGLCKK
OrthoDBi1403854at2759
TreeFamiTF105188

Miscellaneous databases

EvolutionaryTraceiP10279

Gene expression databases

BgeeiENSBTAG00000027937 Expressed in 9 organ(s), highest expression level in prefrontal cortex

Family and domain databases

DisProtiDP00783
Gene3Di1.10.790.10, 1 hit
InterProiView protein in InterPro
IPR000817 Prion
IPR036924 Prion/Doppel_b-ribbon_dom_sf
IPR022416 Prion/Doppel_prot_b-ribbon_dom
IPR025860 Prion_N_dom
PfamiView protein in Pfam
PF00377 Prion, 1 hit
PF11587 Prion_bPrPp, 1 hit
PRINTSiPR00341 PRION
SMARTiView protein in SMART
SM00157 PRP, 1 hit
SUPFAMiSSF54098 SSF54098, 1 hit
PROSITEiView protein in PROSITE
PS00291 PRION_1, 1 hit
PS00706 PRION_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRIO_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10279
Secondary accession number(s): A1YVV9
, Q01880, Q0VD57, Q5UJJ5, Q5UJM6, Q5UK69, Q5UK71, Q6UL03, Q6UL04, Q6UL05, Q6UL06, Q7YRN3, Q8MJI7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1991
Last modified: October 16, 2019
This is version 196 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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