UniProtKB - P10276 (RARA_HUMAN)
Retinoic acid receptor alpha
RARA
Functioni
Caution
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 88 – 153 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 66 | |
Zinc fingeri | 88 – 108 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 124 – 148 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- alpha-actinin binding Source: UniProtKB
- chromatin binding Source: UniProtKB
- chromatin DNA binding Source: UniProtKB
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- drug binding Source: Ensembl
- enzyme binding Source: UniProtKB
- histone deacetylase binding Source: Ensembl
- mRNA 5'-UTR binding Source: Ensembl
- nuclear receptor activity Source: ARUK-UCL
- protein domain specific binding Source: UniProtKB
- protein kinase A binding Source: UniProtKB
- protein kinase B binding Source: UniProtKB
- retinoic acid binding Source: BHF-UCL
- retinoic acid-responsive element binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: UniProtKB
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: UniProtKB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- signaling receptor binding Source: UniProtKB
- transcription factor binding Source: UniProtKB
- translation repressor activity, mRNA regulatory element binding Source: Ensembl
- zinc ion binding Source: InterPro
GO - Biological processi
- apoptotic cell clearance Source: UniProtKB
- cell differentiation Source: GO_Central
- cellular response to estrogen stimulus Source: UniProtKB
- cellular response to lipopolysaccharide Source: Ensembl
- chondroblast differentiation Source: Ensembl
- embryonic camera-type eye development Source: Ensembl
- face development Source: Ensembl
- female pregnancy Source: Ensembl
- germ cell development Source: Ensembl
- glandular epithelial cell development Source: Ensembl
- growth plate cartilage development Source: Ensembl
- hippocampus development Source: Ensembl
- hormone-mediated signaling pathway Source: GO_Central
- limb development Source: Ensembl
- liver development Source: Ensembl
- multicellular organism growth Source: Ensembl
- negative regulation of apoptotic process Source: Ensembl
- negative regulation of cartilage development Source: Ensembl
- negative regulation of cell population proliferation Source: Ensembl
- negative regulation of granulocyte differentiation Source: UniProtKB
- negative regulation of interferon-gamma production Source: BHF-UCL
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- negative regulation of tumor necrosis factor production Source: BHF-UCL
- neural tube closure Source: Ensembl
- outflow tract septum morphogenesis Source: Ensembl
- positive regulation of binding Source: UniProtKB
- positive regulation of cell cycle Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of interleukin-13 production Source: BHF-UCL
- positive regulation of interleukin-4 production Source: BHF-UCL
- positive regulation of interleukin-5 production Source: BHF-UCL
- positive regulation of neuron differentiation Source: Ensembl
- positive regulation of T-helper 2 cell differentiation Source: BHF-UCL
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- prostate gland development Source: Ensembl
- protein phosphorylation Source: UniProtKB
- regulation of myelination Source: Ensembl
- regulation of synaptic plasticity Source: Ensembl
- response to cytokine Source: Ensembl
- response to estradiol Source: Ensembl
- response to ethanol Source: Ensembl
- response to retinoic acid Source: BHF-UCL
- response to vitamin A Source: Ensembl
- retinoic acid receptor signaling pathway Source: UniProtKB
- Sertoli cell fate commitment Source: Ensembl
- signal transduction Source: BHF-UCL
- spermatogenesis Source: Ensembl
- trachea cartilage development Source: Ensembl
- transcription initiation from RNA polymerase II promoter Source: Reactome
- ureteric bud development Source: Ensembl
- ventricular cardiac muscle cell differentiation Source: Ensembl
Keywordsi
Molecular function | DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P10276 |
Reactomei | R-HSA-383280, Nuclear Receptor transcription pathway R-HSA-4090294, SUMOylation of intracellular receptors R-HSA-5362517, Signaling by Retinoic Acid R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-9616222, Transcriptional regulation of granulopoiesis |
SignaLinki | P10276 |
SIGNORi | P10276 |
Protein family/group databases
MoonDBi | P10276, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Retinoic acid receptor alphaShort name: RAR-alpha Alternative name(s): Nuclear receptor subfamily 1 group B member 1 |
Gene namesi | Name:RARA Synonyms:NR1B1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000131759.17 |
HGNCi | HGNC:9864, RARA |
MIMi | 180240, gene |
neXtProti | NX_P10276 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Other locations
- Cytoplasm 2 Publications
Note: Nuclear localization depends on ligand binding, phosphorylation and sumoylation (PubMed:19850744). Translocation to the nucleus in the absence of ligand is dependent on activation of PKC and the downstream MAPK phosphorylation (By similarity). Increased nuclear localization upon pulsatile shear stress (PubMed:28167758).By similarity2 Publications
Cytoskeleton
- actin cytoskeleton Source: HPA
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear chromatin Source: BHF-UCL
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cell surface Source: BHF-UCL
- cytoplasm Source: UniProtKB
- dendrite Source: Ensembl
- perinuclear region of cytoplasm Source: Ensembl
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 95 | S → A: No effect on PKB/AKT1-mediated phosphorylation. Repressed transactivation. 1 Publication | 1 | |
Mutagenesisi | 96 | S → A: Abolishes PKB/AKT1-mediated phosphorylation. Repressed transactivation. 1 Publication | 1 | |
Mutagenesisi | 147 | K → R: Abrogates sumoylation in the presence or absence of ATRA and primarily nuclear localization and enhanced ATRA-mediated transcriptional activity; when associated with R-166; R-171 and R-399. 1 Publication | 1 | |
Mutagenesisi | 154 | S → A: No effect on PKB/AKT1-mediated phosphorylation. No repression of transactivation. 1 Publication | 1 | |
Mutagenesisi | 157 | S → A: No effect on PKB/AKT1-mediated phosphorylation. Repressed transactivation. 1 Publication | 1 | |
Mutagenesisi | 166 | K → R: Cytoplasmic in the absence of ATRA and reduced transcriptional activity in the presence of ATRA. Low sumoylation levels in the presence of ATRA; when associated with R-399. Nuclear localization and enhanced transcriptional activity; when associated with R-171 and R-399. Primarily nuclear localization and enhanced ATRA-mediated transcriptional activity; when associated with R-147; R-171 and R-399. 1 Publication | 1 | |
Mutagenesisi | 171 | K → R: Cytoplasmic in the absence of ATRA and reduced transcriptional activity in the presence of ATRA. Low sumoylation levels in the presence of ATRA; when associated with R-399. Nuclear localization and enhanced transcriptional activity; when associated with R-166 and R-399. Primarily nuclear localization and enhanced ATRA-mediated transcriptional activity; when associated with R-147; R-166 and R-399. 1 Publication | 1 | |
Mutagenesisi | 219 | S → A: No effect on heterodimerization with RARA. On ATRA treatment, localizes to the nucleus, and increased protein levels; when associated with A-369. 1 Publication | 1 | |
Mutagenesisi | 219 | S → E: No effect on heterodimerization with RARA. On ATRA treatment, localizes to both nucleus and cytoplasm, no increase in protein levels, and decrease in RARA-mediated transcriptional activity; when associated with E-369. 1 Publication | 1 | |
Mutagenesisi | 369 | S → A: No effect on heterodimerization with RARA. On ATRA treatment, localizes to the nucleus, and increased protein levels; when associated with A-219. 1 Publication | 1 | |
Mutagenesisi | 369 | S → E: Some inhibition of heterodimerization with RARA. On ATRA treatment, localizes to both nucleus and cytoplasm, increase in protein levels, and decrease in RARA-mediated transcriptional activity; when associated with E-219. 1 Publication | 1 | |
Mutagenesisi | 396 | I → E: Abrogates interaction with NCOR1 or NCOR2. Increased affinity for NCOR1 and NCOR2 in the presence of BMS493. Increased transcriptional activity in the presence of agonist and decreased activity in the presence of neutral antagonist. 1 Publication | 1 | |
Mutagenesisi | 399 | K → R in the absence of ATRA, abolishes sumoylation and is mainly nuclear. In the presence of ATRA, some sumoylation, cytoplasmic location, reduced transcriptional activity and no SENP6 binding. Low sumoylation levels in the presence of ATRA and nuclear location in the absence of ATRA; when associated with R-166 or with R-171. Primarily nuclear localization and enhanced ATRA-mediated transcriptional activity; when associated with R-147; R-166 and R-171. 1 Publication | 1 | |
Mutagenesisi | 409 – 410 | LI → AA: Abolishes interaction with ASXL1 and NCOA1. 1 Publication | 2 | |
Mutagenesisi | 412 | E → Q: Impairs interaction with ASXL1 and NCOA1; when associated with Q-415. 1 Publication | 1 | |
Mutagenesisi | 413 – 414 | ML → AA: Abolishes interaction with ASXL1 and NCOA1. 1 Publication | 2 | |
Mutagenesisi | 415 | E → Q: Impairs interaction with ASXL1 and NCOA1; when associated with Q-412. 1 Publication | 1 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 60 – 61 | Breakpoint for translocation to form PLZF-RAR-alpha, RAR-alpha1-PLZF and PML-RAR-alpha oncogenes | 2 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 5914 |
MalaCardsi | RARA |
MIMi | 612376, phenotype |
OpenTargetsi | ENSG00000131759 |
Orphaneti | 520, Acute promyelocytic leukemia |
PharmGKBi | PA34225 |
Miscellaneous databases
Pharosi | P10276, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2055 |
DrugBanki | DB00459, Acitretin DB00210, Adapalene DB00523, Alitretinoin DB00926, Etretinate DB00982, Isotretinoin DB05785, LGD-1550 DB04942, Tamibarotene DB00799, Tazarotene DB00755, Tretinoin DB12808, Trifarotene |
DrugCentrali | P10276 |
GuidetoPHARMACOLOGYi | 590 |
Polymorphism and mutation databases
BioMutai | RARA |
DMDMi | 133483 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053461 | 1 – 462 | Retinoic acid receptor alphaAdd BLAST | 462 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 77 | Phosphoserine; by CDK7By similarity | 1 | |
Modified residuei | 96 | Phosphoserine; by PKB/AKT11 Publication | 1 | |
Cross-linki | 166 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication | ||
Cross-linki | 171 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication | ||
Modified residuei | 219 | Phosphoserine; by PKA1 Publication | 1 | |
Modified residuei | 369 | Phosphoserine; by PKA1 Publication | 1 | |
Cross-linki | 399 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | P10276 |
MassIVEi | P10276 |
PaxDbi | P10276 |
PeptideAtlasi | P10276 |
PRIDEi | P10276 |
ProteomicsDBi | 52592 [P10276-1] 52593 [P10276-2] 52594 [P10276-3] |
PTM databases
iPTMneti | P10276 |
PhosphoSitePlusi | P10276 |
SwissPalmi | P10276 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000131759, Expressed in nasal cavity epithelium and 232 other tissues |
ExpressionAtlasi | P10276, baseline and differential |
Genevisiblei | P10276, HS |
Organism-specific databases
HPAi | ENSG00000131759, Low tissue specificity |
Interactioni
Subunit structurei
Heterodimer; with RXRA (via C-terminus); association with RXRA is enhanced by pulsatile shear stress (PubMed:28167758, PubMed:10698945, PubMed:10882070, PubMed:20215566, PubMed:15509776). Binds DNA preferentially as a heterodimer (PubMed:10698945, PubMed:28167758). RXRA serves as enhancer to induce RARA binding to RARE (PubMed:30468856).
Interacts with RXRG (PubMed:28167758).
Interacts with coactivators NCOA3 and NCOA6 (PubMed:9267036, PubMed:10567404).
Interacts with NCOA7; the interaction requires ligand-binding (PubMed:11971969).
Interacts (via the ligand-binding domain) with PRAME; the interaction is ligand (retinoic acid)-dependent (PubMed:16179254).
Interacts with AKT1; the interaction phosphorylates RARA and represses transactivation (PubMed:16417524).
Interacts with PRKAR1A; the interaction negatively regulates RARA transcriptional activity (PubMed:20215566).
Interacts with NCOR1 and NCOR2 (PubMed:20543827).
Interacts with PRMT2 (PubMed:12039952).
Interacts with LRIF1 (PubMed:17455211).
Interacts with ASXL1 and NCOA1 (PubMed:16606617).
Interacts with ACTN4 (PubMed:22351778). In a complex with HDAC3, HDAC5 and HDAC7; the HDACs serve as corepressors of RARA, causing its deacetylation and inhibition of RARE DNA element binding; association with HDAC3, HDAC5 and HDAC7 is increased upon oscillatory shear stress (PubMed:28167758).
Interacts with CDK7 (By similarity). In the absence of hormonal ligand, interacts with TACC1 (PubMed:20078863).
By similarity17 PublicationsBinary interactionsi
Hide detailsP10276
Isoform Alpha-2 [P10276-2]
With | #Exp. | IntAct |
---|---|---|
NRIP1 [P48552] | 3 | EBI-10197061,EBI-746484 |
RXRB [P28702] | 4 | EBI-10197061,EBI-748576 |
RXRG [P48443] | 6 | EBI-10197061,EBI-712405 |
TEKT4 [Q8WW24] | 3 | EBI-10197061,EBI-750487 |
GO - Molecular functioni
- alpha-actinin binding Source: UniProtKB
- enzyme binding Source: UniProtKB
- histone deacetylase binding Source: Ensembl
- protein domain specific binding Source: UniProtKB
- protein kinase A binding Source: UniProtKB
- protein kinase B binding Source: UniProtKB
- signaling receptor binding Source: UniProtKB
- transcription factor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 111849, 157 interactors |
ComplexPortali | CPX-508, RXRalpha-RARalpha retinoic acid receptor complex CPX-525, RARalpha-NCOA1 activated retinoic acid receptor complex CPX-666, RARalpha-NCOA2 activated retinoic acid receptor complex CPX-816, RXRalpha-RARalpha-NCOA2 retinoic acid receptor complex |
CORUMi | P10276 |
DIPi | DIP-34N |
IntActi | P10276, 71 interactors |
MINTi | P10276 |
STRINGi | 9606.ENSP00000254066 |
Chemistry databases
BindingDBi | P10276 |
Miscellaneous databases
RNActi | P10276, protein |
Structurei
Secondary structure
3D structure databases
SASBDBi | P10276 |
SMRi | P10276 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P10276 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 183 – 417 | NR LBDPROSITE-ProRule annotationAdd BLAST | 235 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 87 | ModulatingAdd BLAST | 87 | |
Regioni | 154 – 182 | HingeAdd BLAST | 29 | |
Regioni | 404 – 419 | Required for binding corepressor NCOR1Add BLAST | 16 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 408 – 416 | 9aaTAD1 Publication | 9 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 88 – 108 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 124 – 148 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000159997 |
HOGENOMi | CLU_007368_18_2_1 |
InParanoidi | P10276 |
OMAi | AECSESY |
OrthoDBi | 1165737at2759 |
PhylomeDBi | P10276 |
TreeFami | TF328382 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
IDEALi | IID00365 |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003078, Retinoic_acid_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01292, RETNOICACIDR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASNSSSCPT PGGGHLNGYP VPPYAFFFPP MLGGLSPPGA LTTLQHQLPV
60 70 80 90 100
SGYSTPSPAT IETQSSSSEE IVPSPPSPPP LPRIYKPCFV CQDKSSGYHY
110 120 130 140 150
GVSACEGCKG FFRRSIQKNM VYTCHRDKNC IINKVTRNRC QYCRLQKCFE
160 170 180 190 200
VGMSKESVRN DRNKKKKEVP KPECSESYTL TPEVGELIEK VRKAHQETFP
210 220 230 240 250
ALCQLGKYTT NNSSEQRVSL DIDLWDKFSE LSTKCIIKTV EFAKQLPGFT
260 270 280 290 300
TLTIADQITL LKAACLDILI LRICTRYTPE QDTMTFSDGL TLNRTQMHNA
310 320 330 340 350
GFGPLTDLVF AFANQLLPLE MDDAETGLLS AICLICGDRQ DLEQPDRVDM
360 370 380 390 400
LQEPLLEALK VYVRKRRPSR PHMFPKMLMK ITDLRSISAK GAERVITLKM
410 420 430 440 450
EIPGSMPPLI QEMLENSEGL DTLSGQPGGG GRDGGGLAPP PGSCSPSLSP
460
SSNRSSPATH SP
The sequence of this isoform differs from the canonical sequence as follows:
1-60: MASNSSSCPT...SGYSTPSPAT → MYESVEVGGP...TPLWNGSNHS
The sequence of this isoform differs from the canonical sequence as follows:
61-157: Missing.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA8MUP8 | A8MUP8_HUMAN | Retinoic acid receptor alpha | RARA hCG_2007196 | 478 | Annotation score: | ||
J3KSJ4 | J3KSJ4_HUMAN | Retinoic acid receptor alpha | RARA | 186 | Annotation score: | ||
J3QRM2 | J3QRM2_HUMAN | Retinoic acid receptor alpha | RARA | 66 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 241 | E → D in AAD05222 (PubMed:10337631).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003629 | 1 – 60 | MASNS…PSPAT → MYESVEVGGPTPNPFLVVDF YNQNRACLLPEKGLPAPGPY STPLRTPLWNGSNHS in isoform Alpha-2. 1 PublicationAdd BLAST | 60 | |
Alternative sequenceiVSP_043143 | 61 – 157 | Missing in isoform Alpha-1-deltaBC. 1 PublicationAdd BLAST | 97 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000254066; ENSP00000254066; ENSG00000131759 [P10276-1] ENST00000394081; ENSP00000377643; ENSG00000131759 [P10276-2] ENST00000394089; ENSP00000377649; ENSG00000131759 [P10276-1] ENST00000425707; ENSP00000389993; ENSG00000131759 [P10276-3] |
GeneIDi | 5914 |
KEGGi | hsa:5914 |
UCSCi | uc002hun.3, human [P10276-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Wikipedia Retinoic acid receptor entry |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1DKF | X-ray | 2.50 | B | 182-416 | [»] | |
1DSZ | X-ray | 1.70 | A | 82-167 | [»] | |
3A9E | X-ray | 2.75 | B | 153-421 | [»] | |
3KMR | X-ray | 1.80 | A | 176-421 | [»] | |
3KMZ | X-ray | 2.10 | A/B | 176-421 | [»] | |
4DQM | X-ray | 2.75 | A/C | 182-415 | [»] | |
5K13 | X-ray | 1.85 | A | 181-426 | [»] | |
6XWG | X-ray | 2.40 | D | 82-167 | [»] | |
SASBDBi | P10276 | |||||
SMRi | P10276 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111849, 157 interactors |
ComplexPortali | CPX-508, RXRalpha-RARalpha retinoic acid receptor complex CPX-525, RARalpha-NCOA1 activated retinoic acid receptor complex CPX-666, RARalpha-NCOA2 activated retinoic acid receptor complex CPX-816, RXRalpha-RARalpha-NCOA2 retinoic acid receptor complex |
CORUMi | P10276 |
DIPi | DIP-34N |
IntActi | P10276, 71 interactors |
MINTi | P10276 |
STRINGi | 9606.ENSP00000254066 |
Chemistry databases
BindingDBi | P10276 |
ChEMBLi | CHEMBL2055 |
DrugBanki | DB00459, Acitretin DB00210, Adapalene DB00523, Alitretinoin DB00926, Etretinate DB00982, Isotretinoin DB05785, LGD-1550 DB04942, Tamibarotene DB00799, Tazarotene DB00755, Tretinoin DB12808, Trifarotene |
DrugCentrali | P10276 |
GuidetoPHARMACOLOGYi | 590 |
Protein family/group databases
MoonDBi | P10276, Predicted |
PTM databases
iPTMneti | P10276 |
PhosphoSitePlusi | P10276 |
SwissPalmi | P10276 |
Polymorphism and mutation databases
BioMutai | RARA |
DMDMi | 133483 |
Proteomic databases
jPOSTi | P10276 |
MassIVEi | P10276 |
PaxDbi | P10276 |
PeptideAtlasi | P10276 |
PRIDEi | P10276 |
ProteomicsDBi | 52592 [P10276-1] 52593 [P10276-2] 52594 [P10276-3] |
Protocols and materials databases
Antibodypediai | 16473, 762 antibodies |
DNASUi | 5914 |
Genome annotation databases
Ensembli | ENST00000254066; ENSP00000254066; ENSG00000131759 [P10276-1] ENST00000394081; ENSP00000377643; ENSG00000131759 [P10276-2] ENST00000394089; ENSP00000377649; ENSG00000131759 [P10276-1] ENST00000425707; ENSP00000389993; ENSG00000131759 [P10276-3] |
GeneIDi | 5914 |
KEGGi | hsa:5914 |
UCSCi | uc002hun.3, human [P10276-1] |
Organism-specific databases
CTDi | 5914 |
DisGeNETi | 5914 |
EuPathDBi | HostDB:ENSG00000131759.17 |
GeneCardsi | RARA |
HGNCi | HGNC:9864, RARA |
HPAi | ENSG00000131759, Low tissue specificity |
MalaCardsi | RARA |
MIMi | 180240, gene 612376, phenotype |
neXtProti | NX_P10276 |
OpenTargetsi | ENSG00000131759 |
Orphaneti | 520, Acute promyelocytic leukemia |
PharmGKBi | PA34225 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000159997 |
HOGENOMi | CLU_007368_18_2_1 |
InParanoidi | P10276 |
OMAi | AECSESY |
OrthoDBi | 1165737at2759 |
PhylomeDBi | P10276 |
TreeFami | TF328382 |
Enzyme and pathway databases
PathwayCommonsi | P10276 |
Reactomei | R-HSA-383280, Nuclear Receptor transcription pathway R-HSA-4090294, SUMOylation of intracellular receptors R-HSA-5362517, Signaling by Retinoic Acid R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-9616222, Transcriptional regulation of granulopoiesis |
SignaLinki | P10276 |
SIGNORi | P10276 |
Miscellaneous databases
BioGRID-ORCSi | 5914, 15 hits in 869 CRISPR screens |
ChiTaRSi | RARA, human |
EvolutionaryTracei | P10276 |
GeneWikii | Retinoic_acid_receptor_alpha |
GenomeRNAii | 5914 |
Pharosi | P10276, Tclin |
PROi | PR:P10276 |
RNActi | P10276, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000131759, Expressed in nasal cavity epithelium and 232 other tissues |
ExpressionAtlasi | P10276, baseline and differential |
Genevisiblei | P10276, HS |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
IDEALi | IID00365 |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003078, Retinoic_acid_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01292, RETNOICACIDR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RARA_HUMAN | |
Accessioni | P10276Primary (citable) accession number: P10276 Secondary accession number(s): B8Y636 Q9NQS0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | October 1, 1989 | |
Last modified: | December 2, 2020 | |
This is version 250 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM