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Entry version 168 (07 Apr 2021)
Sequence version 2 (01 Feb 1991)
Previous versions | rss
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Protein

H-2 class II histocompatibility antigen gamma chain

Gene

Cd74

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44.By similarity
Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome.By similarity
Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-202733, Cell surface interactions at the vascular wall
R-RNO-2132295, MHC class II antigen presentation

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I31.002

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
H-2 class II histocompatibility antigen gamma chainCurated
Alternative name(s):
Ia antigen-associated invariant chain
Short name:
Ii
MHC class II-associated invariant chain
CD_antigen: CD74
Cleaved into the following chain:
Class-II-associated invariant chain peptideBy similarity
Short name:
CLIPBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cd74Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Rat genome database

More...
RGDi
2313, Cd74

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 30CytoplasmicSequence analysisAdd BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei31 – 56Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST26
Topological domaini57 – 280ExtracellularSequence analysisAdd BLAST224

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000679561 – 280H-2 class II histocompatibility antigen gamma chainAdd BLAST280
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000044888881 – 104Class-II-associated invariant chain peptideBy similarityAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei9PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi197 ↔ 216PROSITE-ProRule annotation
Disulfide bondi227 ↔ 234PROSITE-ProRule annotation
Disulfide bondi236 ↔ 255PROSITE-ProRule annotation
Glycosylationi266O-linked (Xyl...) (glycosaminoglycan) serineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P10247

PRoteomics IDEntifications database

More...
PRIDEi
P10247

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P10247, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P10247

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P10247

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000018735, Expressed in spleen and 21 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P10247, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P10247, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Nonamer composed of three alpha/beta/gamma heterotrimers.

Interacts with CD44; this complex is essential for the MIF-induced signaling cascade that results in B cell survival.

By similarity

Interacts with the mature form of CTSL; the complex survive in neutral pH environment.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000025354

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P10247

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini194 – 255Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST62

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1214, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008961

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_086066_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P10247

Identification of Orthologs from Complete Genome Data

More...
OMAi
GTFRPQC

Database of Orthologous Groups

More...
OrthoDBi
1190626at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P10247

TreeFam database of animal gene trees

More...
TreeFami
TF317779

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00191, TY, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.870.10, 1 hit
4.10.800.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043530, CD74_antigen
IPR015386, MHC_II-assoc_invar/CLIP_MHC-bd
IPR022339, MHC_II-assoc_invar_chain
IPR011988, MHC_II-assoc_invariant_trimer
IPR036613, MHCII_invariant_trimer_sf
IPR000716, Thyroglobulin_1
IPR036857, Thyroglobulin_1_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09307, MHC2-interact, 1 hit
PF08831, MHCassoc_trimer, 1 hit
PF00086, Thyroglobulin_1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001992, CD74_antigen, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01990, CD74ANTIGEN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00211, TY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48305, SSF48305, 1 hit
SSF57610, SSF57610, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00484, THYROGLOBULIN_1_1, 1 hit
PS51162, THYROGLOBULIN_1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Long (identifier: P10247-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDDQRDLISN HEQLPILGQR ARAPESNCNR GVLYTSVSVL VALLLAGQAT
60 70 80 90 100
TAYFLYQQQG RLDKLTVTSQ NLQLENLRMK LPKSAKPVSP MRMATPLLMR
110 120 130 140 150
PLSMDNMLQA PVKNVTKYGN MTQDHVMHLL TKSGPVNYPQ LKGSFPENLK
160 170 180 190 200
HLKNSMNGLD WKVFESWMKQ WLLFEMSKNS LEEKQPTQTP PKVLTKCQEE
210 220 230 240 250
VSHIPDVHPG AFRPKCDENG NYMPLQCHGS TGYCWCVFPN GTEVPHTKSR
260 270 280
GRHNCSEPLD MEDPSSGLGV TKQDMGQMFL
Length:280
Mass (Da):31,642
Last modified:February 1, 1991 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD935D169A98B5732
GO
Isoform Short (identifier: P10247-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     193-256: Missing.

Show »
Length:216
Mass (Da):24,503
Checksum:i33677FA259B84F8E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_005333193 – 256Missing in isoform Short. CuratedAdd BLAST64

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X14254 mRNA Translation: CAA32468.1
X13044 mRNA Translation: CAA31450.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S04362

NCBI Reference Sequences

More...
RefSeqi
NP_037201.1, NM_013069.2 [P10247-2]
XP_006254823.1, XM_006254761.3 [P10247-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000025344; ENSRNOP00000025342; ENSRNOG00000018735 [P10247-2]
ENSRNOT00000025354; ENSRNOP00000025354; ENSRNOG00000018735 [P10247-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25599

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:25599

UCSC genome browser

More...
UCSCi
RGD:2313, rat [P10247-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14254 mRNA Translation: CAA32468.1
X13044 mRNA Translation: CAA31450.1
PIRiS04362
RefSeqiNP_037201.1, NM_013069.2 [P10247-2]
XP_006254823.1, XM_006254761.3 [P10247-1]

3D structure databases

SMRiP10247
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025354

Protein family/group databases

MEROPSiI31.002

PTM databases

GlyGeniP10247, 3 sites
iPTMnetiP10247
PhosphoSitePlusiP10247

Proteomic databases

PaxDbiP10247
PRIDEiP10247

Genome annotation databases

EnsembliENSRNOT00000025344; ENSRNOP00000025342; ENSRNOG00000018735 [P10247-2]
ENSRNOT00000025354; ENSRNOP00000025354; ENSRNOG00000018735 [P10247-1]
GeneIDi25599
KEGGirno:25599
UCSCiRGD:2313, rat [P10247-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
972
RGDi2313, Cd74

Phylogenomic databases

eggNOGiKOG1214, Eukaryota
GeneTreeiENSGT00390000008961
HOGENOMiCLU_086066_1_0_1
InParanoidiP10247
OMAiGTFRPQC
OrthoDBi1190626at2759
PhylomeDBiP10247
TreeFamiTF317779

Enzyme and pathway databases

ReactomeiR-RNO-202733, Cell surface interactions at the vascular wall
R-RNO-2132295, MHC class II antigen presentation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P10247

Gene expression databases

BgeeiENSRNOG00000018735, Expressed in spleen and 21 other tissues
ExpressionAtlasiP10247, baseline and differential
GenevisibleiP10247, RN

Family and domain databases

CDDicd00191, TY, 1 hit
Gene3Di1.10.870.10, 1 hit
4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR043530, CD74_antigen
IPR015386, MHC_II-assoc_invar/CLIP_MHC-bd
IPR022339, MHC_II-assoc_invar_chain
IPR011988, MHC_II-assoc_invariant_trimer
IPR036613, MHCII_invariant_trimer_sf
IPR000716, Thyroglobulin_1
IPR036857, Thyroglobulin_1_sf
PfamiView protein in Pfam
PF09307, MHC2-interact, 1 hit
PF08831, MHCassoc_trimer, 1 hit
PF00086, Thyroglobulin_1, 1 hit
PIRSFiPIRSF001992, CD74_antigen, 1 hit
PRINTSiPR01990, CD74ANTIGEN
SMARTiView protein in SMART
SM00211, TY, 1 hit
SUPFAMiSSF48305, SSF48305, 1 hit
SSF57610, SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00484, THYROGLOBULIN_1_1, 1 hit
PS51162, THYROGLOBULIN_1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHG2A_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10247
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 1, 1991
Last modified: April 7, 2021
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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