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Protein

H-2 class II histocompatibility antigen gamma chain

Gene

Cd74

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-RNO-202733 Cell surface interactions at the vascular wall
R-RNO-2132295 MHC class II antigen presentation

Protein family/group databases

MEROPSiI31.002

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen gamma chain
Alternative name(s):
Ia antigen-associated invariant chain
Short name:
Ii
MHC class II-associated invariant chain
CD_antigen: CD74
Gene namesi
Name:Cd74
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi2313 Cd74

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30CytoplasmicSequence analysisAdd BLAST30
Transmembranei31 – 56Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST26
Topological domaini57 – 280ExtracellularSequence analysisAdd BLAST224

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000679561 – 280H-2 class II histocompatibility antigen gamma chainAdd BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi197 ↔ 216PROSITE-ProRule annotation
Disulfide bondi227 ↔ 234PROSITE-ProRule annotation
Disulfide bondi236 ↔ 255PROSITE-ProRule annotation
Glycosylationi266O-linked (Xyl...) (glycosaminoglycan) serineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbiP10247
PRIDEiP10247

PTM databases

iPTMnetiP10247
PhosphoSitePlusiP10247

Expressioni

Gene expression databases

BgeeiENSRNOG00000018735 Expressed in 9 organ(s), highest expression level in spleen
ExpressionAtlasiP10247 baseline and differential
GenevisibleiP10247 RN

Interactioni

Subunit structurei

Nonamer composed of three alpha/beta/gamma heterotrimers.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025354

Structurei

3D structure databases

ProteinModelPortaliP10247
SMRiP10247
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini194 – 255Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST62

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMYW Eukaryota
ENOG410Z4PR LUCA
GeneTreeiENSGT00390000008961
HOGENOMiHOG000013145
HOVERGENiHBG004444
InParanoidiP10247
KOiK06505
OMAiKCSRGAL
OrthoDBiEOG091G0FT7
PhylomeDBiP10247
TreeFamiTF317779

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di1.10.870.10, 1 hit
4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR015386 MHC_II-assoc_invar/CLIP_MHC-bd
IPR022339 MHC_II-assoc_invar_chain
IPR011988 MHC_II-assoc_invariant_trimer
IPR036613 MHCII_invariant_trimer_sf
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF09307 MHC2-interact, 1 hit
PF08831 MHCassoc_trimer, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01990 CD74ANTIGEN
SMARTiView protein in SMART
SM00211 TY, 1 hit
SUPFAMiSSF48305 SSF48305, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Long (identifier: P10247-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDDQRDLISN HEQLPILGQR ARAPESNCNR GVLYTSVSVL VALLLAGQAT
60 70 80 90 100
TAYFLYQQQG RLDKLTVTSQ NLQLENLRMK LPKSAKPVSP MRMATPLLMR
110 120 130 140 150
PLSMDNMLQA PVKNVTKYGN MTQDHVMHLL TKSGPVNYPQ LKGSFPENLK
160 170 180 190 200
HLKNSMNGLD WKVFESWMKQ WLLFEMSKNS LEEKQPTQTP PKVLTKCQEE
210 220 230 240 250
VSHIPDVHPG AFRPKCDENG NYMPLQCHGS TGYCWCVFPN GTEVPHTKSR
260 270 280
GRHNCSEPLD MEDPSSGLGV TKQDMGQMFL
Length:280
Mass (Da):31,642
Last modified:February 1, 1991 - v2
Checksum:iD935D169A98B5732
GO
Isoform Short (identifier: P10247-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     193-256: Missing.

Show »
Length:216
Mass (Da):24,503
Checksum:i33677FA259B84F8E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005333193 – 256Missing in isoform Short. CuratedAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14254 mRNA Translation: CAA32468.1
X13044 mRNA Translation: CAA31450.1
PIRiS04362
RefSeqiNP_037201.1, NM_013069.2 [P10247-2]
XP_006254823.1, XM_006254761.3 [P10247-1]
UniGeneiRn.33804

Genome annotation databases

EnsembliENSRNOT00000025344; ENSRNOP00000025342; ENSRNOG00000018735 [P10247-2]
ENSRNOT00000025354; ENSRNOP00000025354; ENSRNOG00000018735 [P10247-1]
GeneIDi25599
KEGGirno:25599
UCSCiRGD:2313 rat [P10247-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHG2A_RAT
AccessioniPrimary (citable) accession number: P10247
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 1, 1991
Last modified: September 12, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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