UniProtKB - P10244 (MYBB_HUMAN)

BLAST

>sp|P10244|MYBB_HUMAN Myb-related protein B OS=Homo sapiens OX=9606 GN=MYBL2 PE=1 SV=1
MSRRTRCEDLDELHYQDTDSDVPEQRDSKCKVKWTHEEDEQLRALVRQFGQQDWKFLASH
FPNRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQ
CRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNSTI
KRKVDTGGFLSESKDCKPPVYLLLELEDKDGLQSAQPTEGQGSLLTNWPSVPPTIKEEEN
SEEELAAATTSKEQEPIGTDLDAVRTPEPLEEFPKREDQEGSPPETSLPYKWVVEAANLL
IPAVGSSLSEALDLIESDPDAWCDLSKFDLPEEPSAEDSINNSLVQLQASHQQQVLPPRQ
PSALVPSVTEYRLDGHTISDLSRSSRGELIPISPSTEVGGSGIGTPPSVLKRQRKRRVAL
SPVTENSTSLSFLDSCNSLTPKSTPVKTLPFSPSQFLNFWNKQDTLELESPSLTSTPVCS
QKVVVTTPLHRDKTPLHQKHAAFVTPDQKYSMDNTPHTPTPFKNALEKYGPLKPLPQTPH
LEEDLKEVLRSEAGIELIIEDDIRPEKQKRKPGLRRSPIKKVRKSLALDIVDEDVKLMMS
TLPKSLSLPTTAPSNSSSLTLSGIKEDNSLLNQGFLQAKPEKAAVAQKPRSHFTTPAPMS
SAWKTVACGGTRDQLFMQEKARQLLGRLKPSHTSRTLILS

Align

Format
Add to basket Added to basket
History
Entry version 201 (07 Nov 2018)
Sequence version 1 (01 Jul 1989)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Myb-related protein B

Gene

MYBL2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	54 – 77	H-T-H motifPROSITE-ProRule annotationAdd BLAST	24
DNA bindingⁱ	106 – 129	H-T-H motifPROSITE-ProRule annotationAdd BLAST	24
DNA bindingⁱ	157 – 180	H-T-H motifPROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: ProtInc
Traceable author statementⁱ
- 10770937
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 10770937
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 10770937

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to leukemia inhibitory factor Source: Ensembl
mitotic cell cycle
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
mitotic spindle assembly Source: Ensembl
positive regulation of neuron apoptotic process Source: Ensembl
positive regulation of transcription, DNA-templated
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 10770937
regulation of cell cycle Source: Reactome
regulation of transcription by RNA polymerase II Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-156711 Polo-like kinase mediated events R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
SIGNORⁱ	P10244

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Myb-related protein B Short name: B-Myb Alternative name(s): Myb-like protein 2
Gene namesⁱ	Name:MYBL2 Synonyms:BMYB
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000101057.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7548 MYBL2
MIMⁱ	601415 gene
neXtProtⁱ	NX_P10244

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4605
Open Targets More...OpenTargetsⁱ	ENSG00000101057
PharmGKBⁱ	PA31348

Polymorphism and mutation databases

BioMutaⁱ	MYBL2
DMDMⁱ	127584

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000197058	1 – 700	Myb-related protein BAdd BLAST		700

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	104	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	194	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	197	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	241	PhosphoserineCombined sources	1
Modified residueⁱ	266	PhosphothreonineCombined sources	1
Cross-linkⁱ	275	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	282	PhosphoserineCombined sources	1
Modified residueⁱ	393	PhosphoserineCombined sources	1
Cross-linkⁱ	411	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	440	Phosphothreonine; by CDK21 Publication	1
Modified residueⁱ	444	Phosphothreonine; by CDK22 Publications	1
Cross-linkⁱ	447	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	482	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	487	Phosphothreonine; by CDK21 Publication	1
Modified residueⁱ	494	Phosphothreonine; by CDK22 Publications	1
Cross-linkⁱ	499	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	505	PhosphothreonineCombined sources	1
Cross-linkⁱ	509	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	520	Phosphothreonine; by CDK21 Publication	1
Cross-linkⁱ	523	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	533	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	546	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	577	Phosphoserine; by CDK22 Publications	1
Cross-linkⁱ	584	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	596	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	625	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	639	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	648	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationⁱ

Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity.2 Publications

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P10244
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P10244
PaxDbⁱ	P10244
PeptideAtlas More...PeptideAtlasⁱ	P10244
PRIDEⁱ	P10244
ProteomicsDBⁱ	52586

PTM databases

iPTMnetⁱ	P10244
PhosphoSitePlusⁱ	P10244

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000101057 Expressed in 171 organ(s), highest expression level in endometrium epithelium
CleanExⁱ	HS_MYBL2
Genevisibleⁱ	P10244 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB017114 HPA030530 HPA055416

HPAⁱ

CAB017114
HPA030530
HPA055416

Interactionⁱ

Subunit structureⁱ

Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL22.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
LIN54	Q6MZP7	4	EBI-1389468,EBI-1389411
LIN9	Q5TKA1	7	EBI-1389468,EBI-1389424

Protein-protein interaction databases

BioGridⁱ	110690, 47 interactors
CORUMⁱ	P10244
IntActⁱ	P10244, 21 interactors
Molecular INTeraction database More...MINTⁱ	P10244
STRINGⁱ	9606.ENSP00000217026

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P10244
SMRⁱ	P10244
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	26 – 77	HTH myb-type 1PROSITE-ProRule annotationAdd BLAST	52
Domainⁱ	78 – 133	HTH myb-type 2PROSITE-ProRule annotationAdd BLAST	56
Domainⁱ	134 – 184	HTH myb-type 3PROSITE-ProRule annotationAdd BLAST	51

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	411 – 417	Nuclear localization signal1 Publication		7
Motifⁱ	564 – 584	Bipartite nuclear localization signalAdd BLAST		21

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0048 Eukaryota COG5147 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001038
HOGENOMⁱ	HOG000231021
HOVERGENⁱ	HBG007964
InParanoidⁱ	P10244
KEGG Orthology (KO) More...KOⁱ	K21769
OMAⁱ	SDPDGWC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0I6P
PhylomeDBⁱ	P10244
TreeFamⁱ	TF326257

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00167 SANT, 3 hits
InterProⁱ	View protein in InterPro IPR015395 C-myb_C IPR009057 Homeobox-like_sf IPR015495 Myb-like_TF IPR017930 Myb_dom IPR001005 SANT/Myb
PANTHERⁱ	PTHR10641 PTHR10641, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09316 Cmyb_C, 1 hit PF00249 Myb_DNA-binding, 1 hit
SMARTⁱ	View protein in SMART SM00717 SANT, 3 hits
SUPFAMⁱ	SSF46689 SSF46689, 2 hits
PROSITEⁱ	View protein in PROSITE PS51294 HTH_MYB, 3 hits

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P10244-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRRTRCEDL DELHYQDTDS DVPEQRDSKC KVKWTHEEDE QLRALVRQFG 
        60         70         80         90        100
QQDWKFLASH FPNRTDQQCQ YRWLRVLNPD LVKGPWTKEE DQKVIELVKK 
       110        120        130        140        150
YGTKQWTLIA KHLKGRLGKQ CRERWHNHLN PEVKKSCWTE EEDRIICEAH 
       160        170        180        190        200
KVLGNRWAEI AKMLPGRTDN AVKNHWNSTI KRKVDTGGFL SESKDCKPPV 
       210        220        230        240        250
YLLLELEDKD GLQSAQPTEG QGSLLTNWPS VPPTIKEEEN SEEELAAATT 
       260        270        280        290        300
SKEQEPIGTD LDAVRTPEPL EEFPKREDQE GSPPETSLPY KWVVEAANLL 
       310        320        330        340        350
IPAVGSSLSE ALDLIESDPD AWCDLSKFDL PEEPSAEDSI NNSLVQLQAS 
       360        370        380        390        400
HQQQVLPPRQ PSALVPSVTE YRLDGHTISD LSRSSRGELI PISPSTEVGG 
       410        420        430        440        450
SGIGTPPSVL KRQRKRRVAL SPVTENSTSL SFLDSCNSLT PKSTPVKTLP 
       460        470        480        490        500
FSPSQFLNFW NKQDTLELES PSLTSTPVCS QKVVVTTPLH RDKTPLHQKH 
       510        520        530        540        550
AAFVTPDQKY SMDNTPHTPT PFKNALEKYG PLKPLPQTPH LEEDLKEVLR 
       560        570        580        590        600
SEAGIELIIE DDIRPEKQKR KPGLRRSPIK KVRKSLALDI VDEDVKLMMS 
       610        620        630        640        650
TLPKSLSLPT TAPSNSSSLT LSGIKEDNSL LNQGFLQAKP EKAAVAQKPR 
       660        670        680        690        700
SHFTTPAPMS SAWKTVACGG TRDQLFMQEK ARQLLGRLKP SHTSRTLILS

Length:700

Mass (Da):78,764

Last modified:July 1, 1989 - v1

Checksum:ⁱD91B28B3DAB94061

Isoform 2 (identifier: P10244-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
39-62: Missing.

« Hide

        10         20         30         40         50
MSRRTRCEDL DELHYQDTDS DVPEQRDSKC KVKWTHEENR TDQQCQYRWL 
        60         70         80         90        100
RVLNPDLVKG PWTKEEDQKV IELVKKYGTK QWTLIAKHLK GRLGKQCRER 
       110        120        130        140        150
WHNHLNPEVK KSCWTEEEDR IICEAHKVLG NRWAEIAKML PGRTDNAVKN 
       160        170        180        190        200
HWNSTIKRKV DTGGFLSESK DCKPPVYLLL ELEDKDGLQS AQPTEGQGSL 
       210        220        230        240        250
LTNWPSVPPT IKEEENSEEE LAAATTSKEQ EPIGTDLDAV RTPEPLEEFP 
       260        270        280        290        300
KREDQEGSPP ETSLPYKWVV EAANLLIPAV GSSLSEALDL IESDPDAWCD 
       310        320        330        340        350
LSKFDLPEEP SAEDSINNSL VQLQASHQQQ VLPPRQPSAL VPSVTEYRLD 
       360        370        380        390        400
GHTISDLSRS SRGELIPISP STEVGGSGIG TPPSVLKRQR KRRVALSPVT 
       410        420        430        440        450
ENSTSLSFLD SCNSLTPKST PVKTLPFSPS QFLNFWNKQD TLELESPSLT 
       460        470        480        490        500
STPVCSQKVV VTTPLHRDKT PLHQKHAAFV TPDQKYSMDN TPHTPTPFKN 
       510        520        530        540        550
ALEKYGPLKP LPQTPHLEED LKEVLRSEAG IELIIEDDIR PEKQKRKPGL 
       560        570        580        590        600
RRSPIKKVRK SLALDIVDED VKLMMSTLPK SLSLPTTAPS NSSSLTLSGI 
       610        620        630        640        650
KEDNSLLNQG FLQAKPEKAA VAQKPRSHFT TPAPMSSAWK TVACGGTRDQ 
       660        670 
LFMQEKARQL LGRLKPSHTS RTLILS

Note: No experimental confirmation available.

Show »

Length:676

Mass (Da):75,865

Checksum:ⁱ322D482BEFD9A724

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	184	V → A in BAD97202 (Ref. 3) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_050190	341	N → S. Corresponds to variant dbSNP:rs6017146Ensembl.	1
Natural variantⁱVAR_020422	427	S → G1 PublicationCorresponds to variant dbSNP:rs2070235Ensembl.	1
Natural variantⁱVAR_050191	595	V → M. Corresponds to variant dbSNP:rs7660Ensembl.	1
Natural variantⁱVAR_050192	624	I → M. Corresponds to variant dbSNP:rs11556379Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_053987	39 – 62	Missing in isoform 2. 1 PublicationAdd BLAST		24

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X13293 mRNA Translation: CAA31655.1 AK303249 mRNA Translation: BAH13925.1 AK314791 mRNA Translation: BAG37322.1 AK223482 mRNA Translation: BAD97202.1 AL121886 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75951.1 BC007585 mRNA Translation: AAH07585.1 BC053555 mRNA Translation: AAH53555.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13322.1 [P10244-1] CCDS63276.1 [P10244-2]
PIRⁱ	S01991
NCBI Reference Sequences More...RefSeqⁱ	NP_001265539.1, NM_001278610.1 [P10244-2] NP_002457.1, NM_002466.3 [P10244-1]
UniGeneⁱ	Hs.179718

Genome annotation databases

Ensemblⁱ	ENST00000217026; ENSP00000217026; ENSG00000101057 [P10244-1] ENST00000396863; ENSP00000380072; ENSG00000101057 [P10244-2]
GeneIDⁱ	4605
KEGGⁱ	hsa:4605
UCSC genome browser More...UCSCⁱ	uc002xlb.3 human [P10244-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P10244	Uncharacterized protein		RHIRO		868	UniRef90_P10244
Myb-related protein B		MACMU		715
Uncharacterized protein		MANLE		703
Uncharacterized protein		FELCA		702
Uncharacterized protein		NOMLE		701
+57
P10244-2	Uncharacterized protein		RHIBE		679	UniRef90_P10244-2
Uncharacterized protein		MACMU		676
Uncharacterized protein		MACFA		676
Uncharacterized protein		MACNE		676
MYB proto-oncogene like 2		CALJA		676
+11

Protein	Similar proteins		Species	Score	Length	Source
P10244	Myb-related protein B	)	CHICK		686	UniRef50_P10244
Uncharacterized protein		RHIRO		868
Myb-related protein B		MACMU		715
Uncharacterized protein		MANLE		703
Uncharacterized protein		FELCA		702
+224
P10244-2	Uncharacterized protein		RHIBE		679	UniRef50_P10244-2
Uncharacterized protein		MACMU		676
Uncharacterized protein		MACFA		676
Uncharacterized protein		MACNE		676
Uncharacterized protein		PAPAN		676
+58

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X13293 mRNA Translation: CAA31655.1 AK303249 mRNA Translation: BAH13925.1 AK314791 mRNA Translation: BAG37322.1 AK223482 mRNA Translation: BAD97202.1 AL121886 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75951.1 BC007585 mRNA Translation: AAH07585.1 BC053555 mRNA Translation: AAH53555.1
CCDSⁱ	CCDS13322.1 [P10244-1] CCDS63276.1 [P10244-2]
PIRⁱ	S01991
RefSeqⁱ	NP_001265539.1, NM_001278610.1 [P10244-2] NP_002457.1, NM_002466.3 [P10244-1]
UniGeneⁱ	Hs.179718

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	6C48	X-ray	2.32	C/F	657-688	[»]
ProteinModelPortalⁱ	P10244
SMRⁱ	P10244
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110690, 47 interactors
CORUMⁱ	P10244
IntActⁱ	P10244, 21 interactors
MINTⁱ	P10244
STRINGⁱ	9606.ENSP00000217026

PTM databases

iPTMnetⁱ	P10244
PhosphoSitePlusⁱ	P10244

Polymorphism and mutation databases

BioMutaⁱ	MYBL2
DMDMⁱ	127584

Proteomic databases

EPDⁱ	P10244
MaxQBⁱ	P10244
PaxDbⁱ	P10244
PeptideAtlasⁱ	P10244
PRIDEⁱ	P10244
ProteomicsDBⁱ	52586

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4605
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000217026; ENSP00000217026; ENSG00000101057 [P10244-1] ENST00000396863; ENSP00000380072; ENSG00000101057 [P10244-2]
GeneIDⁱ	4605
KEGGⁱ	hsa:4605
UCSCⁱ	uc002xlb.3 human [P10244-1]

Organism-specific databases

CTDⁱ	4605
DisGeNETⁱ	4605
EuPathDBⁱ	HostDB:ENSG00000101057.15
GeneCardsⁱ	MYBL2
HGNCⁱ	HGNC:7548 MYBL2
HPAⁱ	CAB017114 HPA030530 HPA055416
MIMⁱ	601415 gene
neXtProtⁱ	NX_P10244
OpenTargetsⁱ	ENSG00000101057
PharmGKBⁱ	PA31348
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0048 Eukaryota COG5147 LUCA
GeneTreeⁱ	ENSGT00390000001038
HOGENOMⁱ	HOG000231021
HOVERGENⁱ	HBG007964
InParanoidⁱ	P10244
KOⁱ	K21769
OMAⁱ	SDPDGWC
OrthoDBⁱ	EOG091G0I6P
PhylomeDBⁱ	P10244
TreeFamⁱ	TF326257

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-156711 Polo-like kinase mediated events R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
SIGNORⁱ	P10244

Miscellaneous databases

ChiTaRSⁱ	MYBL2 human
GeneWikiⁱ	MYBL2
GenomeRNAiⁱ	4605
Protein Ontology More...PROⁱ	PR:P10244
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000101057 Expressed in 171 organ(s), highest expression level in endometrium epithelium
CleanExⁱ	HS_MYBL2
Genevisibleⁱ	P10244 HS

Family and domain databases

CDDⁱ	cd00167 SANT, 3 hits
InterProⁱ	View protein in InterPro IPR015395 C-myb_C IPR009057 Homeobox-like_sf IPR015495 Myb-like_TF IPR017930 Myb_dom IPR001005 SANT/Myb
PANTHERⁱ	PTHR10641 PTHR10641, 1 hit
Pfamⁱ	View protein in Pfam PF09316 Cmyb_C, 1 hit PF00249 Myb_DNA-binding, 1 hit
SMARTⁱ	View protein in SMART SM00717 SANT, 3 hits
SUPFAMⁱ	SSF46689 SSF46689, 2 hits
PROSITEⁱ	View protein in PROSITE PS51294 HTH_MYB, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MYBB_HUMAN
Accessionⁱ	P10244Primary (citable) accession number: P10244 Secondary accession number(s): B2RBS5 , B7Z8D9, F8W6N6, Q53F07
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	July 1, 1989
	Last modified:	November 7, 2018
	This is version 201 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P10244 (MYBB_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Myb-related protein B

MYBL2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ