UniProtKB - P10244 (MYBB_HUMAN)
Protein
Myb-related protein B
Gene
MYBL2
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 54 – 77 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 24 | |
DNA bindingi | 106 – 129 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 24 | |
DNA bindingi | 157 – 180 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- cellular response to leukemia inhibitory factor Source: Ensembl
- mitotic cell cycle Source: GO_Central
- mitotic spindle assembly Source: Ensembl
- positive regulation of neuron apoptotic process Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of cell cycle Source: Reactome
- regulation of transcription, DNA-templated Source: GO_Central
- regulation of transcription by RNA polymerase II Source: Reactome
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P10244 |
Reactomei | R-HSA-1362300, Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-156711, Polo-like kinase mediated events R-HSA-8869496, TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation |
SIGNORi | P10244 |
Names & Taxonomyi
Protein namesi | Recommended name: Myb-related protein BShort name: B-Myb Alternative name(s): Myb-like protein 2 |
Gene namesi | Name:MYBL2 Synonyms:BMYB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7548, MYBL2 |
MIMi | 601415, gene |
neXtProti | NX_P10244 |
VEuPathDBi | HostDB:ENSG00000101057.15 |
Subcellular locationi
Nucleus
Nucleus
- Myb complex Source: Ensembl
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 4605 |
OpenTargetsi | ENSG00000101057 |
PharmGKBi | PA31348 |
Miscellaneous databases
Pharosi | P10244, Tbio |
Genetic variation databases
BioMutai | MYBL2 |
DMDMi | 127584 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000197058 | 1 – 700 | Myb-related protein BAdd BLAST | 700 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 104 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 194 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 197 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 241 | PhosphoserineCombined sources | 1 | |
Modified residuei | 266 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 275 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 282 | PhosphoserineCombined sources | 1 | |
Modified residuei | 393 | PhosphoserineCombined sources | 1 | |
Cross-linki | 411 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 440 | Phosphothreonine; by CDK21 Publication | 1 | |
Modified residuei | 444 | Phosphothreonine; by CDK22 Publications | 1 | |
Cross-linki | 447 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 482 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 487 | Phosphothreonine; by CDK21 Publication | 1 | |
Modified residuei | 494 | Phosphothreonine; by CDK22 Publications | 1 | |
Cross-linki | 499 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 505 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 509 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 520 | Phosphothreonine; by CDK21 Publication | 1 | |
Cross-linki | 523 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 533 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 546 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 577 | Phosphoserine; by CDK22 Publications | 1 | |
Cross-linki | 584 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 596 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 625 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 639 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 648 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Post-translational modificationi
Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity.2 Publications
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P10244 |
jPOSTi | P10244 |
MassIVEi | P10244 |
MaxQBi | P10244 |
PaxDbi | P10244 |
PeptideAtlasi | P10244 |
PRIDEi | P10244 |
ProteomicsDBi | 29817 52586 [P10244-1] |
PTM databases
iPTMneti | P10244 |
PhosphoSitePlusi | P10244 |
Expressioni
Gene expression databases
Bgeei | ENSG00000101057, Expressed in bone marrow and 184 other tissues |
Genevisiblei | P10244, HS |
Organism-specific databases
HPAi | ENSG00000101057, Tissue enhanced (blood, bone marrow, lymphoid tissue) |
Interactioni
Subunit structurei
Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL22.
2 PublicationsBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 110690, 60 interactors |
CORUMi | P10244 |
IntActi | P10244, 24 interactors |
MINTi | P10244 |
STRINGi | 9606.ENSP00000217026 |
Miscellaneous databases
RNActi | P10244, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P10244 |
SMRi | P10244 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 77 | HTH myb-type 1PROSITE-ProRule annotationAdd BLAST | 52 | |
Domaini | 78 – 133 | HTH myb-type 2PROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 134 – 184 | HTH myb-type 3PROSITE-ProRule annotationAdd BLAST | 51 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 411 – 417 | Nuclear localization signal1 Publication | 7 | |
Motifi | 564 – 584 | Bipartite nuclear localization signalAdd BLAST | 21 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0048, Eukaryota |
GeneTreei | ENSGT00940000156091 |
HOGENOMi | CLU_015440_1_0_1 |
InParanoidi | P10244 |
OMAi | YGQNDWK |
OrthoDBi | 219341at2759 |
PhylomeDBi | P10244 |
TreeFami | TF326257 |
Family and domain databases
InterProi | View protein in InterPro IPR015395, C-myb_C IPR009057, Homeobox-like_sf IPR017930, Myb_dom IPR028311, MYBL2 IPR001005, SANT/Myb |
PANTHERi | PTHR45614:SF30, PTHR45614:SF30, 2 hits |
Pfami | View protein in Pfam PF09316, Cmyb_C, 1 hit PF00249, Myb_DNA-binding, 1 hit |
SMARTi | View protein in SMART SM00717, SANT, 3 hits |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS51294, HTH_MYB, 3 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: P10244-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSRRTRCEDL DELHYQDTDS DVPEQRDSKC KVKWTHEEDE QLRALVRQFG
60 70 80 90 100
QQDWKFLASH FPNRTDQQCQ YRWLRVLNPD LVKGPWTKEE DQKVIELVKK
110 120 130 140 150
YGTKQWTLIA KHLKGRLGKQ CRERWHNHLN PEVKKSCWTE EEDRIICEAH
160 170 180 190 200
KVLGNRWAEI AKMLPGRTDN AVKNHWNSTI KRKVDTGGFL SESKDCKPPV
210 220 230 240 250
YLLLELEDKD GLQSAQPTEG QGSLLTNWPS VPPTIKEEEN SEEELAAATT
260 270 280 290 300
SKEQEPIGTD LDAVRTPEPL EEFPKREDQE GSPPETSLPY KWVVEAANLL
310 320 330 340 350
IPAVGSSLSE ALDLIESDPD AWCDLSKFDL PEEPSAEDSI NNSLVQLQAS
360 370 380 390 400
HQQQVLPPRQ PSALVPSVTE YRLDGHTISD LSRSSRGELI PISPSTEVGG
410 420 430 440 450
SGIGTPPSVL KRQRKRRVAL SPVTENSTSL SFLDSCNSLT PKSTPVKTLP
460 470 480 490 500
FSPSQFLNFW NKQDTLELES PSLTSTPVCS QKVVVTTPLH RDKTPLHQKH
510 520 530 540 550
AAFVTPDQKY SMDNTPHTPT PFKNALEKYG PLKPLPQTPH LEEDLKEVLR
560 570 580 590 600
SEAGIELIIE DDIRPEKQKR KPGLRRSPIK KVRKSLALDI VDEDVKLMMS
610 620 630 640 650
TLPKSLSLPT TAPSNSSSLT LSGIKEDNSL LNQGFLQAKP EKAAVAQKPR
660 670 680 690 700
SHFTTPAPMS SAWKTVACGG TRDQLFMQEK ARQLLGRLKP SHTSRTLILS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 184 | V → A in BAD97202 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050190 | 341 | N → S. Corresponds to variant dbSNP:rs6017146EnsemblClinVar. | 1 | |
Natural variantiVAR_020422 | 427 | S → G1 PublicationCorresponds to variant dbSNP:rs2070235Ensembl. | 1 | |
Natural variantiVAR_050191 | 595 | V → M. Corresponds to variant dbSNP:rs7660EnsemblClinVar. | 1 | |
Natural variantiVAR_050192 | 624 | I → M. Corresponds to variant dbSNP:rs11556379Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053987 | 39 – 62 | Missing in isoform 2. 1 PublicationAdd BLAST | 24 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X13293 mRNA Translation: CAA31655.1 AK303249 mRNA Translation: BAH13925.1 AK314791 mRNA Translation: BAG37322.1 AK223482 mRNA Translation: BAD97202.1 AL121886 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75951.1 BC007585 mRNA Translation: AAH07585.1 BC053555 mRNA Translation: AAH53555.1 |
CCDSi | CCDS13322.1 [P10244-1] CCDS63276.1 [P10244-2] |
PIRi | S01991 |
RefSeqi | NP_001265539.1, NM_001278610.1 [P10244-2] NP_002457.1, NM_002466.3 [P10244-1] |
Genome annotation databases
Ensembli | ENST00000217026; ENSP00000217026; ENSG00000101057 [P10244-1] ENST00000396863; ENSP00000380072; ENSG00000101057 [P10244-2] |
GeneIDi | 4605 |
KEGGi | hsa:4605 |
UCSCi | uc002xlb.3, human [P10244-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X13293 mRNA Translation: CAA31655.1 AK303249 mRNA Translation: BAH13925.1 AK314791 mRNA Translation: BAG37322.1 AK223482 mRNA Translation: BAD97202.1 AL121886 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75951.1 BC007585 mRNA Translation: AAH07585.1 BC053555 mRNA Translation: AAH53555.1 |
CCDSi | CCDS13322.1 [P10244-1] CCDS63276.1 [P10244-2] |
PIRi | S01991 |
RefSeqi | NP_001265539.1, NM_001278610.1 [P10244-2] NP_002457.1, NM_002466.3 [P10244-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6C48 | X-ray | 2.32 | C/F | 657-688 | [»] | |
BMRBi | P10244 | |||||
SMRi | P10244 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110690, 60 interactors |
CORUMi | P10244 |
IntActi | P10244, 24 interactors |
MINTi | P10244 |
STRINGi | 9606.ENSP00000217026 |
PTM databases
iPTMneti | P10244 |
PhosphoSitePlusi | P10244 |
Genetic variation databases
BioMutai | MYBL2 |
DMDMi | 127584 |
Proteomic databases
EPDi | P10244 |
jPOSTi | P10244 |
MassIVEi | P10244 |
MaxQBi | P10244 |
PaxDbi | P10244 |
PeptideAtlasi | P10244 |
PRIDEi | P10244 |
ProteomicsDBi | 29817 52586 [P10244-1] |
Protocols and materials databases
Antibodypediai | 4478, 388 antibodies |
DNASUi | 4605 |
Genome annotation databases
Ensembli | ENST00000217026; ENSP00000217026; ENSG00000101057 [P10244-1] ENST00000396863; ENSP00000380072; ENSG00000101057 [P10244-2] |
GeneIDi | 4605 |
KEGGi | hsa:4605 |
UCSCi | uc002xlb.3, human [P10244-1] |
Organism-specific databases
CTDi | 4605 |
DisGeNETi | 4605 |
GeneCardsi | MYBL2 |
HGNCi | HGNC:7548, MYBL2 |
HPAi | ENSG00000101057, Tissue enhanced (blood, bone marrow, lymphoid tissue) |
MIMi | 601415, gene |
neXtProti | NX_P10244 |
OpenTargetsi | ENSG00000101057 |
PharmGKBi | PA31348 |
VEuPathDBi | HostDB:ENSG00000101057.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0048, Eukaryota |
GeneTreei | ENSGT00940000156091 |
HOGENOMi | CLU_015440_1_0_1 |
InParanoidi | P10244 |
OMAi | YGQNDWK |
OrthoDBi | 219341at2759 |
PhylomeDBi | P10244 |
TreeFami | TF326257 |
Enzyme and pathway databases
PathwayCommonsi | P10244 |
Reactomei | R-HSA-1362300, Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-156711, Polo-like kinase mediated events R-HSA-8869496, TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation |
SIGNORi | P10244 |
Miscellaneous databases
BioGRID-ORCSi | 4605, 388 hits in 1030 CRISPR screens |
ChiTaRSi | MYBL2, human |
GeneWikii | MYBL2 |
GenomeRNAii | 4605 |
Pharosi | P10244, Tbio |
PROi | PR:P10244 |
RNActi | P10244, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000101057, Expressed in bone marrow and 184 other tissues |
Genevisiblei | P10244, HS |
Family and domain databases
InterProi | View protein in InterPro IPR015395, C-myb_C IPR009057, Homeobox-like_sf IPR017930, Myb_dom IPR028311, MYBL2 IPR001005, SANT/Myb |
PANTHERi | PTHR45614:SF30, PTHR45614:SF30, 2 hits |
Pfami | View protein in Pfam PF09316, Cmyb_C, 1 hit PF00249, Myb_DNA-binding, 1 hit |
SMARTi | View protein in SMART SM00717, SANT, 3 hits |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS51294, HTH_MYB, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MYBB_HUMAN | |
Accessioni | P10244Primary (citable) accession number: P10244 Secondary accession number(s): B2RBS5 Q53F07 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | April 7, 2021 | |
This is version 217 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references