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Protein

Myb-related protein A

Gene

MYBL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3' (PubMed:8058310, PubMed:7987850). Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi58 – 81H-T-H motifPROSITE-ProRule annotationAdd BLAST24
DNA bindingi110 – 133H-T-H motifPROSITE-ProRule annotationAdd BLAST24
DNA bindingi161 – 184H-T-H motifPROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processDifferentiation, Spermatogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P10243

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myb-related protein A2 Publications
Short name:
A-Myb2 Publications
Alternative name(s):
Myb-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYBL1
Synonyms:AMYB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000185697.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7547 MYBL1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
159405 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P10243

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4603

Open Targets

More...
OpenTargetsi
ENSG00000185697

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31347

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MYBL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1171089

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001970541 – 752Myb-related protein AAdd BLAST752

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki199Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei394N6-acetyllysineCombined sources1
Cross-linki592Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki602Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P10243

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P10243

PeptideAtlas

More...
PeptideAtlasi
P10243

PRoteomics IDEntifications database

More...
PRIDEi
P10243

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52584
52585 [P10243-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P10243

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P10243

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in a variety of lymphoid and solid tumor lines cultured in vitro.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185697 Expressed in 223 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_MYBL1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P10243 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P10243 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA008791

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110688, 9 interactors

Database of interacting proteins

More...
DIPi
DIP-624N

Protein interaction database and analysis system

More...
IntActi
P10243, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000429633

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P10243

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P10243

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 81HTH myb-type 1PROSITE-ProRule annotationAdd BLAST52
Domaini82 – 137HTH myb-type 2PROSITE-ProRule annotationAdd BLAST56
Domaini138 – 188HTH myb-type 3PROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni230 – 295Transcriptional activation domainBy similarityAdd BLAST66
Regioni298 – 553Negative regulatory domainBy similarityAdd BLAST256

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0048 Eukaryota
COG5147 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157709

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231021

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG007964

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P10243

KEGG Orthology (KO)

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KOi
K09421

Identification of Orthologs from Complete Genome Data

More...
OMAi
FFNTCSG

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0I6P

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P10243

TreeFam database of animal gene trees

More...
TreeFami
TF326257

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00167 SANT, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015395 C-myb_C
IPR009057 Homeobox-like_sf
IPR015495 Myb-like_TF
IPR017930 Myb_dom
IPR001005 SANT/Myb
IPR012642 Tscrpt_reg_Wos2-domain

The PANTHER Classification System

More...
PANTHERi
PTHR10641 PTHR10641, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09316 Cmyb_C, 1 hit
PF07988 LMSTEN, 1 hit
PF00249 Myb_DNA-binding, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00717 SANT, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51294 HTH_MYB, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P10243-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKRSRSEDE DDDLQYADHD YEVPQQKGLK KLWNRVKWTR DEDDKLKKLV
60 70 80 90 100
EQHGTDDWTL IASHLQNRSD FQCQHRWQKV LNPELIKGPW TKEEDQRVIE
110 120 130 140 150
LVQKYGPKRW SLIAKHLKGR IGKQCRERWH NHLNPEVKKS SWTEEEDRII
160 170 180 190 200
YEAHKRLGNR WAEIAKLLPG RTDNSIKNHW NSTMRRKVEQ EGYLQDGIKS
210 220 230 240 250
ERSSSKLQHK PCAAMDHMQT QNQFYIPVQI PGYQYVSPEG NCIEHVQPTS
260 270 280 290 300
AFIQQPFIDE DPDKEKKIKE LEMLLMSAEN EVRRKRIPSQ PGSFSSWSGS
310 320 330 340 350
FLMDDNMSNT LNSLDEHTSE FYSMDENQPV SAQQNSPTKF LAVEANAVLS
360 370 380 390 400
SLQTIPEFAE TLELIESDPV AWSDVTSFDI SDAAASPIKS TPVKLMRIQH
410 420 430 440 450
NEGAMECQFN VSLVLEGKKN TCNGGNSEAV PLTSPNIAKF STPPAILRKK
460 470 480 490 500
RKMRVGHSPG SELRDGSLND GGNMALKHTP LKTLPFSPSQ FFNTCPGNEQ
510 520 530 540 550
LNIENPSFTS TPICGQKALI TTPLHKETTP KDQKENVGFR TPTIRRSILG
560 570 580 590 600
TTPRTPTPFK NALAAQEKKY GPLKIVSQPL AFLEEDIREV LKEETGTDLF
610 620 630 640 650
LKEEDEPAYK SCKQENTASG KKVRKSLVLD NWEKEESGTQ LLTEDISDMQ
660 670 680 690 700
SENRFTTSLL MIPLLEIHDN RCNLIPEKQD INSTNKTYTL TKKKPNPNTS
710 720 730 740 750
KVVKLEKNLQ SNCEWETVVY GKTEDQLIMT EQARRYLSTY TATSSTSRAL

IL
Length:752
Mass (Da):85,887
Last modified:November 1, 1995 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4C6D1823A7CAFCDA
GO
Isoform 2 (identifier: P10243-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     650-709: Missing.

Note: No experimental confirmation available.
Show »
Length:692
Mass (Da):78,951
Checksum:i6925E52F9A3FC52D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EWZ1E7EWZ1_HUMAN
Myb-related protein A
MYBL1
410Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042912650 – 709Missing in isoform 2. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC083928 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW86912.1
BC101188 mRNA Translation: AAI01189.1
X13294 mRNA Translation: CAA31656.1
X66087 mRNA Translation: CAA46886.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47867.1 [P10243-1]
CCDS55241.1 [P10243-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
S03423

NCBI Reference Sequences

More...
RefSeqi
NP_001073885.1, NM_001080416.3 [P10243-1]
NP_001138227.1, NM_001144755.2 [P10243-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.445898

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000522677; ENSP00000429633; ENSG00000185697 [P10243-1]
ENST00000524176; ENSP00000428011; ENSG00000185697 [P10243-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4603

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4603

UCSC genome browser

More...
UCSCi
uc003xwj.4 human [P10243-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC083928 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW86912.1
BC101188 mRNA Translation: AAI01189.1
X13294 mRNA Translation: CAA31656.1
X66087 mRNA Translation: CAA46886.1
CCDSiCCDS47867.1 [P10243-1]
CCDS55241.1 [P10243-2]
PIRiS03423
RefSeqiNP_001073885.1, NM_001080416.3 [P10243-1]
NP_001138227.1, NM_001144755.2 [P10243-2]
UniGeneiHs.445898

3D structure databases

ProteinModelPortaliP10243
SMRiP10243
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110688, 9 interactors
DIPiDIP-624N
IntActiP10243, 4 interactors
STRINGi9606.ENSP00000429633

PTM databases

iPTMnetiP10243
PhosphoSitePlusiP10243

Polymorphism and mutation databases

BioMutaiMYBL1
DMDMi1171089

Proteomic databases

MaxQBiP10243
PaxDbiP10243
PeptideAtlasiP10243
PRIDEiP10243
ProteomicsDBi52584
52585 [P10243-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000522677; ENSP00000429633; ENSG00000185697 [P10243-1]
ENST00000524176; ENSP00000428011; ENSG00000185697 [P10243-2]
GeneIDi4603
KEGGihsa:4603
UCSCiuc003xwj.4 human [P10243-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4603
DisGeNETi4603
EuPathDBiHostDB:ENSG00000185697.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MYBL1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0034339
HGNCiHGNC:7547 MYBL1
HPAiHPA008791
MIMi159405 gene
neXtProtiNX_P10243
OpenTargetsiENSG00000185697
PharmGKBiPA31347

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0048 Eukaryota
COG5147 LUCA
GeneTreeiENSGT00940000157709
HOGENOMiHOG000231021
HOVERGENiHBG007964
InParanoidiP10243
KOiK09421
OMAiFFNTCSG
OrthoDBiEOG091G0I6P
PhylomeDBiP10243
TreeFamiTF326257

Enzyme and pathway databases

ReactomeiR-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis
SIGNORiP10243

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MYBL1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4603

Protein Ontology

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PROi
PR:P10243

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000185697 Expressed in 223 organ(s), highest expression level in testis
CleanExiHS_MYBL1
ExpressionAtlasiP10243 baseline and differential
GenevisibleiP10243 HS

Family and domain databases

CDDicd00167 SANT, 3 hits
InterProiView protein in InterPro
IPR015395 C-myb_C
IPR009057 Homeobox-like_sf
IPR015495 Myb-like_TF
IPR017930 Myb_dom
IPR001005 SANT/Myb
IPR012642 Tscrpt_reg_Wos2-domain
PANTHERiPTHR10641 PTHR10641, 1 hit
PfamiView protein in Pfam
PF09316 Cmyb_C, 1 hit
PF07988 LMSTEN, 1 hit
PF00249 Myb_DNA-binding, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 3 hits
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51294 HTH_MYB, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYBA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10243
Secondary accession number(s): E7EW29, Q495F9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1995
Last modified: December 5, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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