UniProtKB - P10242 (MYB_HUMAN)
Transcriptional activator Myb
MYB
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 63 – 86 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 24 | |
DNA bindingi | 115 – 138 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 24 | |
DNA bindingi | 166 – 189 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
GO - Biological processi
- cellular response to hydrogen peroxide Source: Ensembl
- cellular response to retinoic acid Source: Ensembl
- chromatin remodeling Source: UniProtKB
- mitotic cell cycle Source: GO_Central
- negative regulation of transcription, DNA-templated Source: BHF-UCL
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of collagen biosynthetic process Source: Ensembl
- positive regulation of glial cell proliferation Source: Ensembl
- positive regulation of hepatic stellate cell activation Source: Ensembl
- positive regulation of hepatic stellate cell proliferation Source: Ensembl
- positive regulation of histone H3-K4 methylation Source: UniProtKB
- positive regulation of histone H3-K9 methylation Source: UniProtKB
- positive regulation of neuron apoptotic process Source: Ensembl
- positive regulation of smooth muscle cell proliferation Source: Ensembl
- positive regulation of testosterone secretion Source: Ensembl
- positive regulation of T-helper cell differentiation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of transforming growth factor beta production Source: Ensembl
- regulation of hematopoietic stem cell differentiation Source: Reactome
- regulation of transcription, DNA-templated Source: GO_Central
- response to hypoxia Source: Ensembl
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P10242 |
Reactomei | R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-9018519, Estrogen-dependent gene expression R-HSA-9616222, Transcriptional regulation of granulopoiesis R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
SignaLinki | P10242 |
SIGNORi | P10242 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcriptional activator MybAlternative name(s): Proto-oncogene c-Myb |
Gene namesi | Name:MYB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000118513.18 |
HGNCi | HGNC:7545, MYB |
MIMi | 189990, gene |
neXtProti | NX_P10242 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear matrix Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 4602 |
MalaCardsi | MYB |
OpenTargetsi | ENSG00000118513 |
Orphaneti | 86849, Acute basophilic leukemia 251671, Angiocentric glioma 99861, Precursor T-cell acute lymphoblastic leukemia |
PharmGKBi | PA31345 |
Miscellaneous databases
Pharosi | P10242, Tbio |
Polymorphism and mutation databases
BioMutai | MYB |
DMDMi | 2815504 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000197048 | 1 – 640 | Transcriptional activator MybAdd BLAST | 640 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 471 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 480 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 480 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 532 | PhosphoserineCombined sources | 1 | |
Modified residuei | 534 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | P10242 |
MassIVEi | P10242 |
PaxDbi | P10242 |
PeptideAtlasi | P10242 |
PRIDEi | P10242 |
ProteomicsDBi | 20651 21951 22356 22452 23398 52578 [P10242-1] 52579 [P10242-2] 52580 [P10242-3] 52581 [P10242-4] 52582 [P10242-5] 52583 [P10242-6] |
PTM databases
iPTMneti | P10242 |
PhosphoSitePlusi | P10242 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSG00000118513, Expressed in oviduct epithelium and 146 other tissues |
ExpressionAtlasi | P10242, baseline and differential |
Genevisiblei | P10242, HS |
Organism-specific databases
HPAi | ENSG00000118513, Tissue enriched (lymphoid) |
Interactioni
Subunit structurei
Binds MYBBP1A.
Interacts with HIPK2, MAF and NLK (By similarity). Binds to HIPK1.
By similarity2 PublicationsBinary interactionsi
Hide detailsP10242
Protein-protein interaction databases
BioGRIDi | 110687, 59 interactors |
ComplexPortali | CPX-504, c-Myb-C/EBPbeta complex |
DIPi | DIP-1057N |
ELMi | P10242 |
IntActi | P10242, 35 interactors |
MINTi | P10242 |
STRINGi | 9606.ENSP00000339992 |
Miscellaneous databases
RNActi | P10242, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 86 | HTH myb-type 1PROSITE-ProRule annotationAdd BLAST | 52 | |
Domaini | 87 – 142 | HTH myb-type 2PROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 143 – 193 | HTH myb-type 3PROSITE-ProRule annotationAdd BLAST | 51 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 90 – 193 | Interaction with HIPK2 and NLKBy similarityAdd BLAST | 104 | |
Regioni | 275 – 327 | Transcription activation domain (PubMed:2189102)1 PublicationAdd BLAST | 53 | |
Regioni | 328 – 465 | Negative regulatory domainBy similarityAdd BLAST | 138 | |
Regioni | 376 – 397 | Leucine-zipperAdd BLAST | 22 |
Domaini
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0048, Eukaryota |
GeneTreei | ENSGT00940000156248 |
HOGENOMi | CLU_015440_2_1_1 |
InParanoidi | P10242 |
OMAi | CGKTEEH |
OrthoDBi | 219341at2759 |
PhylomeDBi | P10242 |
TreeFami | TF326257 |
Family and domain databases
CDDi | cd00167, SANT, 3 hits |
InterProi | View protein in InterPro IPR015395, C-myb_C IPR009057, Homeobox-like_sf IPR017930, Myb_dom IPR001005, SANT/Myb IPR012642, Tscrpt_reg_Wos2-domain |
Pfami | View protein in Pfam PF09316, Cmyb_C, 1 hit PF07988, LMSTEN, 1 hit PF00249, Myb_DNA-binding, 3 hits |
SMARTi | View protein in SMART SM00717, SANT, 3 hits |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS51294, HTH_MYB, 3 hits |
s (12+)i Sequence
Sequence statusi: Complete.
This entry describes 12 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 12 described isoforms and 22 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MARRPRHSIY SSDEDDEDFE MCDHDYDGLL PKSGKRHLGK TRWTREEDEK
60 70 80 90 100
LKKLVEQNGT DDWKVIANYL PNRTDVQCQH RWQKVLNPEL IKGPWTKEED
110 120 130 140 150
QRVIELVQKY GPKRWSVIAK HLKGRIGKQC RERWHNHLNP EVKKTSWTEE
160 170 180 190 200
EDRIIYQAHK RLGNRWAEIA KLLPGRTDNA IKNHWNSTMR RKVEQEGYLQ
210 220 230 240 250
ESSKASQPAV ATSFQKNSHL MGFAQAPPTA QLPATGQPTV NNDYSYYHIS
260 270 280 290 300
EAQNVSSHVP YPVALHVNIV NVPQPAAAAI QRHYNDEDPE KEKRIKELEL
310 320 330 340 350
LLMSTENELK GQQVLPTQNH TCSYPGWHST TIADHTRPHG DSAPVSCLGE
360 370 380 390 400
HHSTPSLPAD PGSLPEESAS PARCMIVHQG TILDNVKNLL EFAETLQFID
410 420 430 440 450
SFLNTSSNHE NSDLEMPSLT STPLIGHKLT VTTPFHRDQT VKTQKENTVF
460 470 480 490 500
RTPAIKRSIL ESSPRTPTPF KHALAAQEIK YGPLKMLPQT PSHLVEDLQD
510 520 530 540 550
VIKQESDESG IVAEFQENGP PLLKKIKQEV ESPTDKSGNF FCSHHWEGDS
560 570 580 590 600
LNTQLFTQTS PVADAPNILT SSVLMAPASE DEDNVLKAFT VPKNRSLASP
610 620 630 640
LQPCSSTWEP ASCGKMEEQM TSSSQARKYV NAFSARTLVM
The sequence of this isoform differs from the canonical sequence as follows:
317-350: TQNHTCSYPGWHSTTIADHTRPHGDSAPVSCLGE → LCGPLLNSDIFSDWAANWDGSLCFATYIVNQQRQ
351-640: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
402-402: F → M
403-640: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
567-640: NILTSSVLMA...NAFSARTLVM → TGVQWHDFGS...LRFNGTSIRR
The sequence of this isoform differs from the canonical sequence as follows:
530-566: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
317-401: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
317-640: TQNHTCSYPG...NAFSARTLVM → VRLSSCA
Computationally mapped potential isoform sequencesi
There are 22 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ708E1 | Q708E1_HUMAN | C-myb v-myb myeloblastosis viral on... | MYB c-myb, hCG_32380 | 612 | Annotation score: | ||
E9PLN0 | E9PLN0_HUMAN | Transcriptional activator Myb | MYB | 611 | Annotation score: | ||
F8W8G5 | F8W8G5_HUMAN | Transcriptional activator Myb | MYB | 726 | Annotation score: | ||
A0A087WTI6 | A0A087WTI6_HUMAN | Transcriptional activator Myb | MYB | 660 | Annotation score: | ||
E9PJF1 | E9PJF1_HUMAN | Transcriptional activator Myb | MYB | 581 | Annotation score: | ||
E9PQQ2 | E9PQQ2_HUMAN | Transcriptional activator Myb | MYB | 581 | Annotation score: | ||
E9PPL8 | E9PPL8_HUMAN | Transcriptional activator Myb | MYB | 554 | Annotation score: | ||
Q708E3 | Q708E3_HUMAN | C-myb v-myb myeloblastosis viral on... | MYB c-myb, hCG_32380 | 449 | Annotation score: | ||
E9PNH6 | E9PNH6_HUMAN | Transcriptional activator Myb | MYB | 419 | Annotation score: | ||
E9PKZ3 | E9PKZ3_HUMAN | Transcriptional activator Myb | MYB | 446 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 511 | I → F in AAA52032 (PubMed:3540945).Curated | 1 | ||
Sequence conflicti | 511 | I → F in AY787447 (Ref. 6) Curated | 1 | ||
Sequence conflicti | 511 | I → F in AY787448 (Ref. 6) Curated | 1 | ||
Sequence conflicti | 563 | A → R in AAA52032 (PubMed:3540945).Curated | 1 | ||
Sequence conflicti | 563 | A → R in AY787447 (Ref. 6) Curated | 1 | ||
Sequence conflicti | 563 | A → R in AY787448 (Ref. 6) Curated | 1 | ||
Isoform 4 (identifier: P10242-4) | |||||
Sequence conflicti | 433 | L → F in CAA35503 (Ref. 8) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050188 | 336 | T → I. Corresponds to variant dbSNP:rs2229999EnsemblClinVar. | 1 | |
Natural variantiVAR_050189 | 422 | T → N. Corresponds to variant dbSNP:rs2230000Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046658 | 282 – 316 | Missing in isoform 9. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_003293 | 314 – 316 | Missing in isoform 2 and isoform 7. 3 Publications | 3 | |
Alternative sequenceiVSP_053389 | 317 – 640 | TQNHT…RTLVM → VRLSSCA in isoform 12. 1 PublicationAdd BLAST | 324 | |
Alternative sequenceiVSP_046659 | 317 – 401 | Missing in isoform 11. 1 PublicationAdd BLAST | 85 | |
Alternative sequenceiVSP_003294 | 317 – 350 | TQNHT…SCLGE → LCGPLLNSDIFSDWAANWDG SLCFATYIVNQQRQ in isoform 3. CuratedAdd BLAST | 34 | |
Alternative sequenceiVSP_003295 | 351 – 640 | Missing in isoform 3. CuratedAdd BLAST | 290 | |
Alternative sequenceiVSP_046660 | 386 – 401 | VKNLL…QFIDS → DSSSWCDLSSFEFFEEADFS PSQHHTGKALQLQQREGNGT KPAGEPSPRVNKRMLSESSL DPPKVLPPARHSTIPLVILR KKRGQASPLATGDCSSFIFA DVSSSTPKRSPVKSLPFSPS Q in isoform 8. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_003296 | 401 | S → SDSSSWCDLSSFEFFEEADF SPSQHHTGKALQLQQREGNG TKPAGEPSPRVNKRMLSESS LDPPKVLPPARHSTIPLVIL RKKRGQASPLATGDCSSFIF ADVSSSTPKRSPVKSLPFSP SQ in isoform 4 and isoform 7. 2 Publications | 1 | |
Alternative sequenceiVSP_003297 | 402 | F → M in isoform 5. Curated | 1 | |
Alternative sequenceiVSP_003298 | 403 – 640 | Missing in isoform 5. CuratedAdd BLAST | 238 | |
Alternative sequenceiVSP_046661 | 530 – 566 | Missing in isoform 10. 1 PublicationAdd BLAST | 37 | |
Alternative sequenceiVSP_003299 | 567 – 640 | NILTS…RTLVM → TGVQWHDFGSLQPLPPGFKR FSCLSLPRSWDYRHPPPRPA NFEFLVETGFLHVGQAGLEL LTSGDLPASASQSARITGVS HRARPEYSYKLRFNGTSIRR in isoform 6. CuratedAdd BLAST | 74 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
3D structure databases
SMRi | P10242 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110687, 59 interactors |
ComplexPortali | CPX-504, c-Myb-C/EBPbeta complex |
DIPi | DIP-1057N |
ELMi | P10242 |
IntActi | P10242, 35 interactors |
MINTi | P10242 |
STRINGi | 9606.ENSP00000339992 |
PTM databases
iPTMneti | P10242 |
PhosphoSitePlusi | P10242 |
Polymorphism and mutation databases
BioMutai | MYB |
DMDMi | 2815504 |
Proteomic databases
jPOSTi | P10242 |
MassIVEi | P10242 |
PaxDbi | P10242 |
PeptideAtlasi | P10242 |
PRIDEi | P10242 |
ProteomicsDBi | 20651 21951 22356 22452 23398 52578 [P10242-1] 52579 [P10242-2] 52580 [P10242-3] 52581 [P10242-4] 52582 [P10242-5] 52583 [P10242-6] |
Protocols and materials databases
Antibodypediai | 4486, 900 antibodies |
DNASUi | 4602 |
Genome annotation databases
Organism-specific databases
CTDi | 4602 |
DisGeNETi | 4602 |
EuPathDBi | HostDB:ENSG00000118513.18 |
GeneCardsi | MYB |
HGNCi | HGNC:7545, MYB |
HPAi | ENSG00000118513, Tissue enriched (lymphoid) |
MalaCardsi | MYB |
MIMi | 189990, gene |
neXtProti | NX_P10242 |
OpenTargetsi | ENSG00000118513 |
Orphaneti | 86849, Acute basophilic leukemia 251671, Angiocentric glioma 99861, Precursor T-cell acute lymphoblastic leukemia |
PharmGKBi | PA31345 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0048, Eukaryota |
GeneTreei | ENSGT00940000156248 |
HOGENOMi | CLU_015440_2_1_1 |
InParanoidi | P10242 |
OMAi | CGKTEEH |
OrthoDBi | 219341at2759 |
PhylomeDBi | P10242 |
TreeFami | TF326257 |
Enzyme and pathway databases
PathwayCommonsi | P10242 |
Reactomei | R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-9018519, Estrogen-dependent gene expression R-HSA-9616222, Transcriptional regulation of granulopoiesis R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
SignaLinki | P10242 |
SIGNORi | P10242 |
Miscellaneous databases
BioGRID-ORCSi | 4602, 96 hits in 867 CRISPR screens |
ChiTaRSi | MYB, human |
GeneWikii | MYB_(gene) |
GenomeRNAii | 4602 |
Pharosi | P10242, Tbio |
PROi | PR:P10242 |
RNActi | P10242, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000118513, Expressed in oviduct epithelium and 146 other tissues |
ExpressionAtlasi | P10242, baseline and differential |
Genevisiblei | P10242, HS |
Family and domain databases
CDDi | cd00167, SANT, 3 hits |
InterProi | View protein in InterPro IPR015395, C-myb_C IPR009057, Homeobox-like_sf IPR017930, Myb_dom IPR001005, SANT/Myb IPR012642, Tscrpt_reg_Wos2-domain |
Pfami | View protein in Pfam PF09316, Cmyb_C, 1 hit PF07988, LMSTEN, 1 hit PF00249, Myb_DNA-binding, 3 hits |
SMARTi | View protein in SMART SM00717, SANT, 3 hits |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS51294, HTH_MYB, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MYB_HUMAN | |
Accessioni | P10242Primary (citable) accession number: P10242 Secondary accession number(s): E9PI07 Q9UE83 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 205 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations