UniProtKB - P10240 (UL56_HHV11)
Protein
Protein UL56
Gene
UL56
Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Functioni
Plays a role in the transport and release of virions form the host cytoplasm to the extracellular space. Relocalizes host NEDD4, a cytosolic E3 ligase, to cytoplasmic vesicles.By similarity
Names & Taxonomyi
Protein namesi | Recommended name: Protein UL56 |
Gene namesi | Name:UL56 |
Organismi | Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) |
Taxonomic identifieri | 10299 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Peploviricota › Herviviricetes › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Host Golgi apparatus membrane By similarity; Single-pass membrane protein Sequence analysis
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 211 – 231 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- host cell Golgi membrane Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
Host Golgi apparatus, Host membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 26 | Y → A: Complete loss of interaction with host ITCH; when associated with A-52 and A-147. 1 Publication | 1 | |
Mutagenesisi | 52 | Y → A: Complete loss of interaction with host ITCH; when associated with A-26 and A-147. 1 Publication | 1 | |
Mutagenesisi | 147 | Y → A: Complete loss of interaction with host ITCH; when associated with A-26 and A-52. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000116123 | 1 – 234 | Protein UL56Add BLAST | 234 |
Proteomic databases
PRIDEi | P10240 |
Interactioni
Subunit structurei
Interacts with host ITCH; this interaction induces ubiquitination and probably degradation of ITCH (PubMed:29535361).
Interacts with host NEDD4; this interaction increases NEDD4 ubiquitination (By similarity).
Interacts with UL11 (By similarity).
By similarity1 PublicationProtein-protein interaction databases
BioGRIDi | 971453, 2 interactors |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 23 – 26 | PPXY motif1 Publication | 4 | |
Motifi | 49 – 52 | PPXY motif1 Publication | 4 | |
Motifi | 144 – 147 | PPXY motif1 Publication | 4 |
Domaini
Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. UL56 contains three L domains: the PPXY motifs which are involved in the interaction with ITCH, a member of the NEDD4 family.1 Publication
Sequence similaritiesi
Belongs to the herpesviridae UL56 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
InterProi | View protein in InterPro IPR007620, Herpes_UL56 |
Pfami | View protein in Pfam PF04534, Herpes_UL56, 1 hit |
i Sequence
Sequence statusi: Complete.
P10240-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASEAAQPDA GLWSAGNAFA DPPPPYDSLS GRNEGPFVVI DLDTPTDPPP
60 70 80 90 100
PYSAGPLLSV PIPPTSSGEG EASERGRSRQ AAQRAARRAR RRAERRAQRR
110 120 130 140 150
SFGPGGLLAT PLFLPETRLV APPDITRDLL SGLPTYAEAM SDHPPTYATV
160 170 180 190 200
VAVRSTEQPS GALAPDDQRR TQNSGAWRPP RVNSRELYRA QRAARGSSDH
210 220 230
APYRRQGCCG VVWRHAVFGV VAIVVVIILV FLWR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14112 Genomic DNA Translation: CAA32292.1 |
PIRi | B30090, WMBEY6 |
RefSeqi | YP_009137132.1, NC_001806.2 |
Genome annotation databases
GeneIDi | 2703428 |
KEGGi | vg:2703428 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14112 Genomic DNA Translation: CAA32292.1 |
PIRi | B30090, WMBEY6 |
RefSeqi | YP_009137132.1, NC_001806.2 |
3D structure databases
SMRi | P10240 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 971453, 2 interactors |
Proteomic databases
PRIDEi | P10240 |
Genome annotation databases
GeneIDi | 2703428 |
KEGGi | vg:2703428 |
Family and domain databases
InterProi | View protein in InterPro IPR007620, Herpes_UL56 |
Pfami | View protein in Pfam PF04534, Herpes_UL56, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UL56_HHV11 | |
Accessioni | P10240Primary (citable) accession number: P10240 Secondary accession number(s): O09801 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | October 16, 2019 | |
Last modified: | December 2, 2020 | |
This is version 68 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families