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Protein

DNA primase

Gene

UL52

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.UniRule annotation2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei628Essential for primase activityUniRule annotation1
Sitei630Essential for primase activityUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri988 – 1028CHC2-typeUniRule annotation1 PublicationAdd BLAST41

GO - Molecular functioni

GO - Biological processi

  • bidirectional double-stranded viral DNA replication Source: UniProtKB

Keywordsi

Molecular functionTransferase
Biological processDNA replication
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DNA primaseUniRule annotation (EC:2.7.7.-UniRule annotation)
Gene namesi
ORF Names:UL52
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome
  • UP000180652 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi628D → Q: Complete loss of primase activity. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL4380

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001161041 – 1058DNA primaseAdd BLAST1058

Proteomic databases

PRIDEiP10236

Interactioni

Subunit structurei

Associates with the helicase and the primase-associated factor to form the helicase-primase factor.UniRule annotation1 Publication

Protein-protein interaction databases

BioGridi971449, 2 interactors
DIPiDIP-1092N

Chemistry databases

BindingDBiP10236

Structurei

3D structure databases

SMRiP10236
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi177 – 180Poly-Ala4
Compositional biasi310 – 313Poly-Ala4

Sequence similaritiesi

Belongs to the herpesviridae DNA primase family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri988 – 1028CHC2-typeUniRule annotation1 PublicationAdd BLAST41

Keywords - Domaini

Zinc-finger

Phylogenomic databases

OrthoDBiVOG0900001H

Family and domain databases

HAMAPiMF_04011 HSV_PRIM, 1 hit
InterProiView protein in InterPro
IPR033685 HSV_PRIM

Sequencei

Sequence statusi: Complete.

P10236-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQEDGNRGE RRAAGTPVEV TALYATDGCV ITSSIALLTN SLLGAEPVYI
60 70 80 90 100
FSYDAYTHDG RADGPTEQDR FEESRALYQA SGGLNGDSFR VTFCLLGTEV
110 120 130 140 150
GGTHQARGRT RPMFVCRFER ADDVAALQDA LAHGTPLQPD HIAATLDAEA
160 170 180 190 200
TFALHANMIL ALTVAINNAS PRTGRDAAAA QYDQGASLRS LVGRTSLGQR
210 220 230 240 250
GLTTLYVHHE VRVLAAYRRA YYGSAQSPFW FLSKFGPDEK SLVLTTRYYL
260 270 280 290 300
LQAQRLGGAG ATYDLQAIKD ICATYAIPHA PRPDTVSAAS LTSFAAITRF
310 320 330 340 350
CCTSQYARGA AAAGFPLYVE RRIAADVRET SALEKFITHD RSCLRVSDRE
360 370 380 390 400
FITYIYLAHF ECFSPPRLAT HLRAVTTHDP NPAASTEQPS PLGREAVEQF
410 420 430 440 450
FCHVRAQLNI GEYVKHNVTP RETVLDGDTA KAYLRARTYA PGALTPAPAY
460 470 480 490 500
CGAVDSATKM MGRLADAEKL LVPRGWPAFA PASPGEDTAG GTPPPQTCGI
510 520 530 540 550
VKRLLRLAAT EQQGPTPPAI AALIRNAAVQ TPLPVYRISM VPTGQAFAAL
560 570 580 590 600
AWDDWARITR DARLAEAVVS AEAAAHPDHG ALGRRLTDRI RAQGPVMPPG
610 620 630 640 650
GLDAGGQMYV NRNEIFNGAL AITNIILDLD IALKEPVPFR RLHEALGHFR
660 670 680 690 700
RGALAAVQLL FPAARVDPDA YPCYFFKSAC RPGPASVGSG SGLGNDDDGD
710 720 730 740 750
WFPCYDDAGD EEWAEDPGAM DTSHDPPDDE VAYFDLCHEV GPTAEPRETD
760 770 780 790 800
SPVCSCTDKI GLRVCMPVPA PYVVHGSLTM RGVARVIQQA VLLDRDFVEA
810 820 830 840 850
IGSYVKNFLL IDTGVYAHGH SLRLPYFAKI APDGPACGRL LPVFVIPPAC
860 870 880 890 900
KDVPAFVAAH ADPRRFHFHA PPTYLASPRE IRVLHSLGGD YVSFFERKAS
910 920 930 940 950
RNALEHFGRR ETLTEVLGRY NVQPDAGGTV EGFASELLGR IVACIETHFP
960 970 980 990 1000
EHAGEYQAVS VRRAVSKDDW VLLQLVPVRG TLQQSLSCLR FKHGRASRAT
1010 1020 1030 1040 1050
ARTFVALSVG ANNRLCVSLC QQCFAAKCDS NRLHTLFTID AGTPCSPSVP

CSTSQPSS
Length:1,058
Mass (Da):114,424
Last modified:July 1, 1989 - v1
Checksum:iCB39341C31B768B4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti211V → A in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti364S → N in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti515P → T in strain: Nonneuroinvasive mutant HF10. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32288.1
M19122 Genomic DNA Translation: AAA45826.1
DQ889502 Genomic DNA Translation: ABI63513.1
FJ593289 Genomic DNA Translation: ACM62276.1
PIRiE29890 WMBE52
RefSeqiYP_009137128.1, NC_001806.2

Genome annotation databases

GeneIDi2703423
KEGGivg:2703423

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32288.1
M19122 Genomic DNA Translation: AAA45826.1
DQ889502 Genomic DNA Translation: ABI63513.1
FJ593289 Genomic DNA Translation: ACM62276.1
PIRiE29890 WMBE52
RefSeqiYP_009137128.1, NC_001806.2

3D structure databases

SMRiP10236
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971449, 2 interactors
DIPiDIP-1092N

Chemistry databases

BindingDBiP10236
ChEMBLiCHEMBL4380

Proteomic databases

PRIDEiP10236

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703423
KEGGivg:2703423

Phylogenomic databases

OrthoDBiVOG0900001H

Family and domain databases

HAMAPiMF_04011 HSV_PRIM, 1 hit
InterProiView protein in InterPro
IPR033685 HSV_PRIM
ProtoNetiSearch...

Entry informationi

Entry nameiPRIM_HHV11
AccessioniPrimary (citable) accession number: P10236
Secondary accession number(s): B9VQI1, Q09I82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 10, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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