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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

DUT

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
Short name:
dUTPaseUniRule annotation
Alternative name(s):
dUTP pyrophosphataseUniRule annotation
Gene namesi
Name:DUTUniRule annotation
Ordered Locus Names:UL50
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome
  • UP000180652 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001829521 – 371Deoxyuridine 5'-triphosphate nucleotidohydrolaseAdd BLAST371

Proteomic databases

PRIDEiP10234

Interactioni

Protein-protein interaction databases

BioGridi971447, 1 interactor
DIPiDIP-62052N
IntActiP10234, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliP10234
SMRiP10234
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni260 – 262Substrate bindingUniRule annotation3
Regioni366 – 367Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the dUTPase family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900009U

Family and domain databases

Gene3Di2.70.40.10, 2 hits
HAMAPiMF_04031 HSV_DUT, 1 hit
InterProiView protein in InterPro
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR008181 dUTPase_1
IPR034745 HSV_DUT
PANTHERiPTHR11241 PTHR11241, 1 hit
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 2 hits

Sequencei

Sequence statusi: Complete.

P10234-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQWGSGAIL VQPDSLGRGY DGDWHTAVAT RGGGVVQLNL VNRRAVAFMP
60 70 80 90 100
KVSGDSGWAV GRVSLDLRMA MPADFCAIIH APALASPGHH VILGLIDSGY
110 120 130 140 150
RGTVMAVVVA PKRTREFAPG TLRVDVTFLD ILATPPALTE PISLRQFPQL
160 170 180 190 200
APPPPTGAGI REDPWLEGAL GAPSVTTALP ARRRGRSLVY AGELTPVQTE
210 220 230 240 250
HGDGVREAIA FLPKREEDAG FDIVVRRPVT VPANGTTVVQ PSLRMLHADA
260 270 280 290 300
GPAACYVLGR SSLNARGLLV VPTRWLPGHV CAFVVYNLTG VPVTLEAGAK
310 320 330 340 350
VAQLLVAGAD ALPWIPPDNF HGTKALRNYP RGVPDSTAEP RNPPLLVFTN
360 370
EFDAEAPPSE RGTGGFGSTG I
Length:371
Mass (Da):39,128
Last modified:July 1, 1989 - v1
Checksum:i5FFA2556AD2F7158
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32301.1
DQ889502 Genomic DNA Translation: ABI63511.1
FJ593289 Genomic DNA Translation: ACM62274.1
PIRiE30089 WMBEY0
RefSeqiYP_009137126.1, NC_001806.2

Genome annotation databases

GeneIDi2703421
KEGGivg:2703421

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32301.1
DQ889502 Genomic DNA Translation: ABI63511.1
FJ593289 Genomic DNA Translation: ACM62274.1
PIRiE30089 WMBEY0
RefSeqiYP_009137126.1, NC_001806.2

3D structure databases

ProteinModelPortaliP10234
SMRiP10234
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971447, 1 interactor
DIPiDIP-62052N
IntActiP10234, 1 interactor

Proteomic databases

PRIDEiP10234

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703421
KEGGivg:2703421

Phylogenomic databases

OrthoDBiVOG0900009U

Family and domain databases

Gene3Di2.70.40.10, 2 hits
HAMAPiMF_04031 HSV_DUT, 1 hit
InterProiView protein in InterPro
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR008181 dUTPase_1
IPR034745 HSV_DUT
PANTHERiPTHR11241 PTHR11241, 1 hit
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiDUT_HHV11
AccessioniPrimary (citable) accession number: P10234
Secondary accession number(s): Q09I84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 7, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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