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Protein

Tegument protein UL47

Gene

UL47

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tegument protein that can bind to various RNA transcripts. Plays a role in the attenuation of selective viral and cellular mRNA degradation by modulating the activity of host shutoff RNase UL41/VHS. Plays also a role in the primary envelopement of virions in the perinuclear space, probably by interacting with two nuclear egress proteins UL31 and UL34.2 Publications

Miscellaneous

Expressed in late in the infection.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Tegument protein UL47
Alternative name(s):
82/81 kDa tegument protein
VMW82/81
VP13/14
Gene namesi
ORF Names:UL47
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome
  • UP000180652 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001160731 – 693Tegument protein UL47Add BLAST693

Post-translational modificationi

Phosphorylated by US3. This phosphorylation is required for proper nuclear localization.1 Publication

Proteomic databases

PRIDEiP10231

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Interacts with US3 kinase. Interacts with UL31 and UL34; these interactions seem important for efficient virion nuclear egress. Interacts with UL41/VHS.3 Publications

Protein-protein interaction databases

BioGridi971442, 3 interactors
IntActiP10231, 1 interactor
MINTiP10231

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni50 – 75RNA-bindingAdd BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi63 – 75Nuclear localization signal2 PublicationsAdd BLAST13
Motifi647 – 670Nuclear export signalAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 12Poly-Arg4
Compositional biasi107 – 110Poly-Asp4

Domaini

The nuclear export signal is CRM1-dependent.1 Publication

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG0900002D

Family and domain databases

InterProiView protein in InterPro
IPR005029 Herpes_UL47
PfamiView protein in Pfam
PF03362 Herpes_UL47, 1 hit

Sequencei

Sequence statusi: Complete.

P10231-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAREPAGRR RRASTRPRAS PVADEPAGDG VGFMGYLRAV FRGDDDSELE
60 70 80 90 100
ALEEMAGDEP PVRRRREGPR ARRRRASEAP PTSHRRASRQ RPGPDAARSQ
110 120 130 140 150
SVRGRLDDDD EVPRGPPQAR QGGYLGPVDA RAILGRVGGS RVAPSPLFLE
160 170 180 190 200
ELQYEEDDYP EAVGPEDGGG ARSPPKVEVL EGRVPGPELR AAFPLDRLAP
210 220 230 240 250
QVAVWDESVR SALALGHPAG FYPCPDSAFG LSRVGVMHFA SPDNPAVFFR
260 270 280 290 300
QTLQQGEALA WYITGDGILD LTDRRTKTSP AQAMSFLADA VVRLAINGWV
310 320 330 340 350
CGTRLHAEAR GSDLDDRAAE LRRQFASLTA LRPVGAAAVP LLSAGGLVSP
360 370 380 390 400
QSGPDAAVFR SSLGSLLYWP GVRALLDRDC RVAARYAGRM TYLATGALLA
410 420 430 440 450
RFNPDAVRCV LTREAAFLGR VLDVLAVMAE QTVQWLSVVV GARLHPHVHH
460 470 480 490 500
PAFADVAREE LFRALPLGSP AVVGAEHEAL GDTAARRLLA NSGLNAVLGA
510 520 530 540 550
AVYALHTALA TVTLKYARAC GDAHRRRDDA AATRAILAAG LVLQRLLGFA
560 570 580 590 600
DTVVACVTLA AFDGGFTAPE VGTYTPLRYA CVLRATQPLY ARTTPAKFWA
610 620 630 640 650
DVRAAAEHVD LRPASSAPRA PVSGTADPAF LLKDLEPFPP APVSGGSVLG
660 670 680 690
PRVRVVDIMS QFRKLLMGDE GAAALRAHVS GRRATGLGGP PRP
Length:693
Mass (Da):73,817
Last modified:July 1, 1989 - v1
Checksum:i283737D7D33B5C93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32297.1
DQ889502 Genomic DNA Translation: ABI63508.1
FJ593289 Genomic DNA Translation: ACM62270.1
PIRiB30089 TNBEF7
RefSeqiYP_009137122.1, NC_001806.2

Genome annotation databases

GeneIDi2703415
KEGGivg:2703415

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32297.1
DQ889502 Genomic DNA Translation: ABI63508.1
FJ593289 Genomic DNA Translation: ACM62270.1
PIRiB30089 TNBEF7
RefSeqiYP_009137122.1, NC_001806.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971442, 3 interactors
IntActiP10231, 1 interactor
MINTiP10231

Proteomic databases

PRIDEiP10231

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703415
KEGGivg:2703415

Phylogenomic databases

OrthoDBiVOG0900002D

Family and domain databases

InterProiView protein in InterPro
IPR005029 Herpes_UL47
PfamiView protein in Pfam
PF03362 Herpes_UL47, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTEG5_HHV11
AccessioniPrimary (citable) accession number: P10231
Secondary accession number(s): Q09I87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 7, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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