UniProtKB - P10231 (TEG5_HHV11)
Protein
Tegument protein UL47
Gene
UL47
Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Functioni
Tegument protein that can bind to various RNA transcripts. Plays a role in the attenuation of selective viral and cellular mRNA degradation by modulating the activity of host shutoff RNase UL41/VHS. Plays also a role in the primary envelopement of virions in the perinuclear space, probably by interacting with two nuclear egress proteins UL31 and UL34.2 Publications
Miscellaneous
Expressed in late in the infection.
GO - Molecular functioni
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- regulation of transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | RNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Tegument protein UL47Alternative name(s): 82/81 kDa tegument protein VMW82/81 VP13/14 |
Gene namesi | ORF Names:UL47 |
Organismi | Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) |
Taxonomic identifieri | 10299 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Peploviricota › Herviviricetes › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Virion tegument 1 Publication
- Host nucleus 3 Publications
- Host cytoplasm 2 Publications Note: Major tegument protein of the virion. Undergoes nucleocytoplasmic shuttling during infection. Localizes to the major sites of transcription in the infected cell nucleus.
GO - Cellular componenti
- host cell cytoplasm Source: UniProtKB-SubCell
- host cell nucleus Source: UniProtKB-SubCell
- viral tegument Source: UniProtKB-SubCell
Keywords - Cellular componenti
Host cytoplasm, Host nucleus, Virion, Virion tegumentPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000116073 | 1 – 693 | Tegument protein UL47Add BLAST | 693 |
Post-translational modificationi
Phosphorylated by US3. This phosphorylation is required for proper nuclear localization.1 Publication
Proteomic databases
PRIDEi | P10231 |
Interactioni
Subunit structurei
Interacts with US3 kinase.
Interacts with UL31 and UL34; these interactions seem important for efficient virion nuclear egress.
Interacts with UL41/VHS.
3 PublicationsProtein-protein interaction databases
BioGRIDi | 971442, 4 interactors |
IntActi | P10231, 1 interactor |
MINTi | P10231 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 50 – 75 | RNA-bindingAdd BLAST | 26 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 63 – 75 | Nuclear localization signal2 PublicationsAdd BLAST | 13 | |
Motifi | 647 – 670 | Nuclear export signalAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 9 – 12 | Poly-Arg | 4 | |
Compositional biasi | 107 – 110 | Poly-Asp | 4 |
Domaini
The nuclear export signal is CRM1-dependent.1 Publication
Sequence similaritiesi
Belongs to the alphaherpesvirinae HHV-1 UL47 family.Curated
Family and domain databases
InterProi | View protein in InterPro IPR005029, Herpes_UL47 |
Pfami | View protein in Pfam PF03362, Herpes_UL47, 1 hit |
i Sequence
Sequence statusi: Complete.
P10231-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAREPAGRR RRASTRPRAS PVADEPAGDG VGFMGYLRAV FRGDDDSELE
60 70 80 90 100
ALEEMAGDEP PVRRRREGPR ARRRRASEAP PTSHRRASRQ RPGPDAARSQ
110 120 130 140 150
SVRGRLDDDD EVPRGPPQAR QGGYLGPVDA RAILGRVGGS RVAPSPLFLE
160 170 180 190 200
ELQYEEDDYP EAVGPEDGGG ARSPPKVEVL EGRVPGPELR AAFPLDRLAP
210 220 230 240 250
QVAVWDESVR SALALGHPAG FYPCPDSAFG LSRVGVMHFA SPDNPAVFFR
260 270 280 290 300
QTLQQGEALA WYITGDGILD LTDRRTKTSP AQAMSFLADA VVRLAINGWV
310 320 330 340 350
CGTRLHAEAR GSDLDDRAAE LRRQFASLTA LRPVGAAAVP LLSAGGLVSP
360 370 380 390 400
QSGPDAAVFR SSLGSLLYWP GVRALLDRDC RVAARYAGRM TYLATGALLA
410 420 430 440 450
RFNPDAVRCV LTREAAFLGR VLDVLAVMAE QTVQWLSVVV GARLHPHVHH
460 470 480 490 500
PAFADVAREE LFRALPLGSP AVVGAEHEAL GDTAARRLLA NSGLNAVLGA
510 520 530 540 550
AVYALHTALA TVTLKYARAC GDAHRRRDDA AATRAILAAG LVLQRLLGFA
560 570 580 590 600
DTVVACVTLA AFDGGFTAPE VGTYTPLRYA CVLRATQPLY ARTTPAKFWA
610 620 630 640 650
DVRAAAEHVD LRPASSAPRA PVSGTADPAF LLKDLEPFPP APVSGGSVLG
660 670 680 690
PRVRVVDIMS QFRKLLMGDE GAAALRAHVS GRRATGLGGP PRP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14112 Genomic DNA Translation: CAA32297.1 DQ889502 Genomic DNA Translation: ABI63508.1 FJ593289 Genomic DNA Translation: ACM62270.1 |
PIRi | B30089, TNBEF7 |
RefSeqi | YP_009137122.1, NC_001806.2 |
Genome annotation databases
GeneIDi | 2703415 |
KEGGi | vg:2703415 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14112 Genomic DNA Translation: CAA32297.1 DQ889502 Genomic DNA Translation: ABI63508.1 FJ593289 Genomic DNA Translation: ACM62270.1 |
PIRi | B30089, TNBEF7 |
RefSeqi | YP_009137122.1, NC_001806.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 971442, 4 interactors |
IntActi | P10231, 1 interactor |
MINTi | P10231 |
Proteomic databases
PRIDEi | P10231 |
Genome annotation databases
GeneIDi | 2703415 |
KEGGi | vg:2703415 |
Family and domain databases
InterProi | View protein in InterPro IPR005029, Herpes_UL47 |
Pfami | View protein in Pfam PF03362, Herpes_UL47, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TEG5_HHV11 | |
Accessioni | P10231Primary (citable) accession number: P10231 Secondary accession number(s): Q09I87 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | August 12, 2020 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families