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Protein

Envelope protein UL45

Gene

UL45

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Important virulence factor of HSV neurotropism. Seems to be required for glycoprotein B-induced fusion. Dispensable for growth in vitro (By similarity).By similarity1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope protein UL45
Alternative name(s):
18 kDa protein
Gene namesi
ORF Names:UL45
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome
  • UP000180652 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27IntravirionSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini49 – 172Virion surfaceSequence analysisAdd BLAST124

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001160861 – 172Envelope protein UL45Add BLAST172

Proteomic databases

PRIDEiP10229

Structurei

3D structure databases

SMRiP10229
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae HHV-1 UL45 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090002L7

Family and domain databases

InterProiView protein in InterPro
IPR018002 Herpes_UL45
IPR008646 Herpes_UL45-like
PfamiView protein in Pfam
PF05473 UL45, 1 hit
PIRSFiPIRSF003509 Herpes_UL45, 1 hit

Sequencei

Sequence statusi: Complete.

P10229-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLRASEHAY RPLGPGTPPM RARLPAAAWV GVGTIIGGVV IIAALVLVPS
60 70 80 90 100
RASWALSPCD SGWHEFNLGC ISWDPTPMEH EQAVGGCSAP ATLIPRAAAK
110 120 130 140 150
QLAAVARVQS ARSSGYWWVS GDGIRACLRL VDGVGGIDQF CEEPALRICY
160 170
YPRSPGGFVQ FVTSTRNALG LP
Length:172
Mass (Da):18,180
Last modified:July 1, 1989 - v1
Checksum:iEA57EF40D40003D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32295.1
DQ889502 Genomic DNA Translation: ABI63506.1
FJ593289 Genomic DNA Translation: ACM62268.1
PIRiI30088 WMBEF5
RefSeqiYP_009137120.1, NC_001806.2

Genome annotation databases

GeneIDi24271472
KEGGivg:24271472

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32295.1
DQ889502 Genomic DNA Translation: ABI63506.1
FJ593289 Genomic DNA Translation: ACM62268.1
PIRiI30088 WMBEF5
RefSeqiYP_009137120.1, NC_001806.2

3D structure databases

SMRiP10229
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP10229

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24271472
KEGGivg:24271472

Phylogenomic databases

OrthoDBiVOG090002L7

Family and domain databases

InterProiView protein in InterPro
IPR018002 Herpes_UL45
IPR008646 Herpes_UL45-like
PfamiView protein in Pfam
PF05473 UL45, 1 hit
PIRSFiPIRSF003509 Herpes_UL45, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEV45_HHV11
AccessioniPrimary (citable) accession number: P10229
Secondary accession number(s): Q09I89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 20, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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