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Protein

Membrane protein UL43

Gene

UL43

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane protein UL43
Gene namesi
ORF Names:UL43
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome
  • UP000180652 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Transmembranei389 – 409HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001160811 – 417Membrane protein UL43Add BLAST417

Structurei

3D structure databases

SMRiP10227
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi181 – 188Poly-Ala8
Compositional biasi225 – 250Pro-richAdd BLAST26

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090002GO

Family and domain databases

InterProiView protein in InterPro
IPR007764 Herpes_UL43
PfamiView protein in Pfam
PF05072 Herpes_UL43, 1 hit

Sequencei

Sequence statusi: Complete.

P10227-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRNDSHRAV SPEDGQGRVD DGRPHLACVG ALARGFMHIW LQAATLGFAG
60 70 80 90 100
SVVMSRGPYA NAASGAFAVG CAVLGFMRAP PPLARPTARI YAWLKLAAGG
110 120 130 140 150
AALVLWSLGE PGTQPGAPAP GPATQCLALG AAYAALLVLA DDVYPLFLLA
160 170 180 190 200
PGPLFVGTLG MVVGGLTIGG SARYWWIGGP AAAALAAAVL AGPGATTARD
210 220 230 240 250
CFSRACPDHR RVCVITAGES LSRRPPEDPE RPGVPGPPSP PTPQRSHGPP
260 270 280 290 300
ADEVAPARVA RPENVWVPVV TFLGAGALAV KTVREHARGT PGPGLPLWPQ
310 320 330 340 350
VFLGGHVAVA LTELCQALPP WDLTDPLLFV HAGLQVINLG LVFRFSEVVV
360 370 380 390 400
YAALGGAVWI SLAQVLGLRR RLHRKDPGDG ARLAATLRGL FFSVYALGFG
410
VGVLLCPPGS TGGRSGD
Length:417
Mass (Da):42,948
Last modified:September 22, 2009 - v2
Checksum:iD6D48868B4323C5A
GO

Sequence cautioni

The sequence CAA32306 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti319P → A in strain: 17 syn+ and Nonneuroinvasive mutant HF10. 1
Natural varianti382 – 384RLA → LPVQ in strain: Nonneuroinvasive mutant HF10. 3
Natural varianti403V → A in strain: Nonneuroinvasive mutant HF10. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32306.1 Different initiation.
DQ889502 Genomic DNA No translation available.
FJ593289 Genomic DNA Translation: ACM62266.1
PIRiG30088 WMBEF3
RefSeqiYP_009137118.1, NC_001806.2

Genome annotation databases

GeneIDi2703408
KEGGivg:2703408

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32306.1 Different initiation.
DQ889502 Genomic DNA No translation available.
FJ593289 Genomic DNA Translation: ACM62266.1
PIRiG30088 WMBEF3
RefSeqiYP_009137118.1, NC_001806.2

3D structure databases

SMRiP10227
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703408
KEGGivg:2703408

Phylogenomic databases

OrthoDBiVOG090002GO

Family and domain databases

InterProiView protein in InterPro
IPR007764 Herpes_UL43
PfamiView protein in Pfam
PF05072 Herpes_UL43, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMB43_HHV11
AccessioniPrimary (citable) accession number: P10227
Secondary accession number(s): B9VQH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: September 22, 2009
Last modified: March 15, 2017
This is version 64 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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