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Protein

DNA polymerase processivity factor

Gene

UL42

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an essential role in viral DNA replication by acting as the polymerase accessory subunit. Associates with the viral polymerase to increase its processivity and forms high-affinity direct interactions with DNA. Facilitates the origin-binding protein UL9 loading onto DNA thus increasing its ability to assemble into a functional complex capable of unwinding duplex DNA.1 Publication

GO - Molecular functioni

  • DNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase processivity factor
Alternative name(s):
DNA-binding protein UL42
Polymerase accessory protein
Short name:
PAP
Gene namesi
ORF Names:UL42
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome
  • UP000180652 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001160611 – 488DNA polymerase processivity factorAdd BLAST488

Proteomic databases

PRIDEiP10226

Interactioni

Subunit structurei

Interacts with the DNA polymerase catalytic subunit UL30. Interacts with the origin-binding protein.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi971437, 1 interactor
IntActiP10226, 6 interactors
MINTiP10226

Structurei

Secondary structure

1488
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP10226
SMRiP10226
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10226

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi394 – 413Bipartite nuclear localization signalAdd BLAST20

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG090000IO

Family and domain databases

InterProiView protein in InterPro
IPR003202 Herpes_UL42
PfamiView protein in Pfam
PF02282 Herpes_UL42, 2 hits

Sequencei

Sequence statusi: Complete.

P10226-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDSPGGVAP ASPVEDASDA SLGQPEEGAP CQVVLQGAEL NGILQAFAPL
60 70 80 90 100
RTSLLDSLLV MGDRGILIHN TIFGEQVFLP LEHSQFSRYR WRGPTAAFLS
110 120 130 140 150
LVDQKRSLLS VFRANQYPDL RRVELAITGQ APFRTLVQRI WTTTSDGEAV
160 170 180 190 200
ELASETLMKR ELTSFVVLVP QGTPDVQLRL TRPQLTKVLN ATGADSATPT
210 220 230 240 250
TFELGVNGKF SVFTTSTCVT FAAREEGVSS STSTQVQILS NALTKAGQAA
260 270 280 290 300
ANAKTVYGEN THRTFSVVVD DCSMRAVLRR LQVGGGTLKF FLTTPVPSLC
310 320 330 340 350
VTATGPNAVS AVFLLKPQKI CLDWLGHSQG SPSAGSSASR ASGSEPTDSQ
360 370 380 390 400
DSASDAVSHG DPEDLDGAAR AGEAGALHAC PMPSSTTRVT PTTKRGRSGG
410 420 430 440 450
EDARADTALK KPKTGSPTAP PPADPVPLDT EDDSDAADGT AARPAAPDAR
460 470 480
SGSRYACYFR DLPTGEASPG AFSAFRGGPQ TPYGFGFP
Length:488
Mass (Da):51,159
Last modified:July 1, 1989 - v1
Checksum:i432974563DF0A81B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti349S → N in strain: Nonneuroinvasive mutant HF10. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32305.1
M19121 Genomic DNA Translation: AAA45824.1
DQ889502 Genomic DNA Translation: ABI63504.1
FJ593289 Genomic DNA Translation: ACM62265.1
PIRiD29890 WMBE42
RefSeqiYP_009137117.1, NC_001806.2

Genome annotation databases

GeneIDi24271471
KEGGivg:24271471

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32305.1
M19121 Genomic DNA Translation: AAA45824.1
DQ889502 Genomic DNA Translation: ABI63504.1
FJ593289 Genomic DNA Translation: ACM62265.1
PIRiD29890 WMBE42
RefSeqiYP_009137117.1, NC_001806.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DMLX-ray2.70A/C/E/G1-319[»]
ProteinModelPortaliP10226
SMRiP10226
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971437, 1 interactor
IntActiP10226, 6 interactors
MINTiP10226

Proteomic databases

PRIDEiP10226

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24271471
KEGGivg:24271471

Phylogenomic databases

OrthoDBiVOG090000IO

Miscellaneous databases

EvolutionaryTraceiP10226

Family and domain databases

InterProiView protein in InterPro
IPR003202 Herpes_UL42
PfamiView protein in Pfam
PF02282 Herpes_UL42, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPAP_HHV11
AccessioniPrimary (citable) accession number: P10226
Secondary accession number(s): B9VQH0, Q09I91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: February 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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