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Protein

Inner tegument protein

Gene

UL37

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an essential role in cytoplasmic secondary envelopment during viral egress. Interacts with the capsid via the large tegument protein/LTP and participates in its transport to the host trans-Golgi network (TGN) where secondary envelopment occurs. Modulates tegumentation and capsid accumulation at the viral assembly complex (By similarity). Plays a role in microtubule-based retrograde axonal transport to promote neuroinvasion (PubMed:29216315). Plays also a role in the inhibition of host immune response by acting as a viral deamidase (PubMed:27866900). Deamidates host DDX58/RIG-I on two asparagines which becomes unable to sense viral dsRNA. In turn, its ability to trigger antiviral immune response and restrict viral replication is inhibited (PubMed:27866900). Deamidates also a critical asparagine on host CGAS which abolishes cGAMP synthesis and downstream innate immune activation (PubMed:30092200).UniRule annotation6 Publications

Catalytic activityi

Protein L-asparagine + H2O = protein L-aspartate + NH3.2 Publications
Protein L-glutamine + H2O = protein L-glutamate + NH3.1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein-glutamine glutaminase activity Source: UniProtKB-EC

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RIG-I by virus, Inhibition of host RLR pathway by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Inner tegument proteinUniRule annotation (EC:3.5.1.-2 Publications, EC:3.5.1.441 Publication)
Alternative name(s):
Viral deamidase UL37
Gene namesi
Name:UL37
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host Golgi apparatus, Host nucleus, Virion, Virion tegument

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi819C → S: Complete loss of deamidase activity. 2 Publications1
Mutagenesisi850C → S: Complete loss of deamidase activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001160441 – 1123Inner tegument proteinAdd BLAST1123

Proteomic databases

PRIDEiP10221

Interactioni

Subunit structurei

Interacts (via C-teminus) with the large tegument protein/LTP (via N-terminus) (By similarity) (PubMed:18787001, PubMed:24725933). Interacts with host DST (PubMed:23269794). Interacts with host DDX58; this interaction inhibits DDX58 activation (PubMed:27866900). Interacts with host CGAS; this interaction inhibits host CGAS activation (PubMed:30092200).UniRule annotation5 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi971403, 7 interactors
ELMiP10221
IntActiP10221, 7 interactors
MINTiP10221

Structurei

3D structure databases

ProteinModelPortaliP10221
SMRiP10221
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni568 – 1123Interaction with large tegument proteinUniRule annotationAdd BLAST556

Sequence similaritiesi

Belongs to the herpesviridae inner tegument protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG09000013

Family and domain databases

HAMAPiMF_04043 HSV_ITP, 1 hit
InterProiView protein in InterPro
IPR005655 Herpes_UL37
IPR034738 HSV_ITP
PfamiView protein in Pfam
PF03970 Herpes_UL37_1, 1 hit

Sequencei

Sequence statusi: Complete.

P10221-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADRGLPSEA PVVTTSPAGP PSDGPMQRLL ASLAGLRQPP TPTAETANGA
60 70 80 90 100
DDPAFLATAK LRAAMAAFLL SGTAIAPADA RDCWRPLLEH LCALHRAHGL
110 120 130 140 150
PETALLAENL PGLLVHRLVV ALPEAPDQAF REMEVIKDTI LAVTGSDTSH
160 170 180 190 200
ALDSAGLRTA AALGPVRVRQ CAVEWIDRWQ TVTKSCLAMS PRTSIEALGE
210 220 230 240 250
TSLKMAPVPL GQPSANLTTP AYSLLFPAPF VQEGLRFLAL VSNRVTLFSA
260 270 280 290 300
HLQRIDDATL TPLTRALFTL ALVDEYLTTP ERGAVVPPPL LAQFQHTVRE
310 320 330 340 350
IDPAIMIPPL EANKMVRSRE EVRVSTALSR VSPRSACAPP GTLMARVRTD
360 370 380 390 400
VAVFDPDVPF LSSSALAVFQ PAVSSLLQLG EQPSAGAQQR LLALLQQTWT
410 420 430 440 450
LIQNTNSPSV VINTLIDAGF TPSHCTHYLS ALEGFLAAGV PARTPTGHGL
460 470 480 490 500
GEVQQLFGCI ALAGSNVFGL AREYGYYANY VKTFRRVQGA SEHTHGRLCE
510 520 530 540 550
AVGLSGGVLS QTLARIMGPA VPTEHLASLR RALVGEFETA ERRFSSGQPS
560 570 580 590 600
LLRETALIWI DVYGQTHWDI TPTTPATPLS ALLPVGQPSH APSVHLAAAT
610 620 630 640 650
QIRFPALEGI HPNVLADPGF VPYVLALVVG DALRATCSAA YLPRPVEFAL
660 670 680 690 700
RVLAWARDFG LGYLPTVEGH RTKLGALITL LEPAARGGLG PTMQMADNIE
710 720 730 740 750
QLLRELYVIS RGAVEQLRPL VQLQPPPPPE VGTSLLLISM YALAARGVLQ
760 770 780 790 800
DLAERADPLI RQLEDAIVLL RLHMRTLSAF FECRFESDGR RLYAVVGDTP
810 820 830 840 850
DRLGPWPPEA MGDAVSQYCS MYHDAKRALV ASLASLRSVI TETTAHLGVC
860 870 880 890 900
DELAAQVSHE DNVLAVVRRE IHGFLSVVSG IHARASKLLS GDQVPGFCFM
910 920 930 940 950
GQFLARWRRL SACYQAARAA AGPEPVAEFV QELHDTWKGL QTERAVVVAP
960 970 980 990 1000
LVSSADQRAA AIREVMAHAP EDAPPQSPAA DRVVLTSRRD LGAWGDYSLG
1010 1020 1030 1040 1050
PLGQTTAVPD SVDLSRQGLA VTLSMDWLLM NELLRVTDGV FRASAFRPLA
1060 1070 1080 1090 1100
GPESPRDLEV RDAGNSLPAP MPMDAQKPEA YGHGPRQADR EGAPHSNTPV
1110 1120
EDDEMIPEDT VAPPTDLPLT SYQ
Length:1,123
Mass (Da):120,556
Last modified:July 1, 1989 - v1
Checksum:i18425792B4D7EC9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32312.1
PIRiA30088 WMBEH7

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32312.1
PIRiA30088 WMBEH7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5VYLX-ray3.51A1-575[»]
ProteinModelPortaliP10221
SMRiP10221
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971403, 7 interactors
ELMiP10221
IntActiP10221, 7 interactors
MINTiP10221

Proteomic databases

PRIDEiP10221

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG09000013

Family and domain databases

HAMAPiMF_04043 HSV_ITP, 1 hit
InterProiView protein in InterPro
IPR005655 Herpes_UL37
IPR034738 HSV_ITP
PfamiView protein in Pfam
PF03970 Herpes_UL37_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiITP_HHV11
AccessioniPrimary (citable) accession number: P10221
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 7, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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