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Protein

Nuclear egress protein 2

Gene

NEC2

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.UniRule annotation3 Publications

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear egress protein 2UniRule annotation
Gene namesi
Name:NEC2UniRule annotation
Ordered Locus Names:UL34
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 251Perinuclear spaceUniRule annotationAdd BLAST251
Transmembranei252 – 272HelicalUniRule annotationAdd BLAST21
Topological domaini273 – 275NuclearUniRule annotation3

GO - Cellular componenti

Keywords - Cellular componenti

Host membrane, Host nucleus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001160261 – 275Nuclear egress protein 2Add BLAST275

Post-translational modificationi

Phosphorylated by viral kinase US3.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP10218

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Forms a heterohexameric complex with NEC1. Interacts with glycoprotein D; this interaction recruits glycoprotein D and glycoprotein M to the inner nuclear membrane.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LMNAP025452EBI-7183680,EBI-351935From Homo sapiens.

Protein-protein interaction databases

IntActiP10218, 1 interactor
MINTiP10218

Structurei

Secondary structure

1275
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiP10218
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni137 – 181Interaction with NEC1Add BLAST45

Sequence similaritiesi

Belongs to the herpesviridae NEC2 protein family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090000L5

Family and domain databases

HAMAPiMF_04024 HSV_NEC2, 1 hit
InterProiView protein in InterPro
IPR007626 Herpesvirus_viron_egress-type
PfamiView protein in Pfam
PF04541 Herpes_U34, 1 hit

Sequencei

Sequence statusi: Complete.

P10218-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGLGKPYTG HPGDAFEGLV QRIRLIVPST LRGGDGEAGP YSPSSLPSRC
60 70 80 90 100
AFQFHGHDGS DESFPIEYVL RLMNDWAEVP CNPYLRIQNT GVSVLFQGFF
110 120 130 140 150
HRPHNAPGGA ITPERTNVIL GSTETTGLSL GDLDTIKGRL GLDARPMMAS
160 170 180 190 200
MWISCFVRMP RVQLAFRFMG PEDAGRTRRI LCRAAEQAIT RRRRTRRSRE
210 220 230 240 250
AYGAEAGLGV AGTGFRARGD GFGPLPLLTQ GPSRPWHQAL RGLKHLRIGP
260 270
PALVLAAGLV LGAAIWWVVG AGARL
Length:275
Mass (Da):29,790
Last modified:July 1, 1989 - v1
Checksum:iBA45B62F68838EC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32309.1
PIRiG30085 WMBEH4
RefSeqiYP_009137109.1, NC_001806.2

Genome annotation databases

GeneIDi2703355
KEGGivg:2703355

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32309.1
PIRiG30085 WMBEH4
RefSeqiYP_009137109.1, NC_001806.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZXSX-ray2.77A/C15-185[»]
SMRiP10218
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP10218, 1 interactor
MINTiP10218

Proteomic databases

PRIDEiP10218

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703355
KEGGivg:2703355

Phylogenomic databases

OrthoDBiVOG090000L5

Family and domain databases

HAMAPiMF_04024 HSV_NEC2, 1 hit
InterProiView protein in InterPro
IPR007626 Herpesvirus_viron_egress-type
PfamiView protein in Pfam
PF04541 Herpes_U34, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNEC2_HHV11
AccessioniPrimary (citable) accession number: P10218
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: February 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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